@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00433_PKN1_H: (2014-09-07 )
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630..---.....640.......650.-......660.......670.......680.......690.......700.......-----710........720.......730.-......740.......750.......760.......770...-....780.......-----790.......800.......810...-...---.----820.......830-....---....840.......850.......860.-...-....870.......880.......890....-----...900.......910......-.920..---.....-930.......940
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAS
D
A
VQSEPR
S
W
S
L
L
E
Q
LGLAGADLAAP
G
V
Q
Q
Q
L
E
L
E
R
E
R
L
R
R
E
I
R
K
E
LK
L
K
E
G
A
E
N
L
R
R
A
T
T
D
L
GRSL
G
P
V
E
L
L
LRGSS
R
R
L
D
L
L
H
Q
Q
L
Q
E
LHA
H
V
VLPDPAATHDGPQSPGAGGPTCSAT
N
L
S
R
V
AGLE
K
Q
L
A
I
E
L
K
VKQG
A
E
N
M
I
Q
T
YSNGSTKDR
K
L
L
L
T
A
Q
Q
M
L
Q
DSKT
K
I
D
I
I
R
M
Q
L
R
R
A
L
Q
AGQLENQAAPDDTQGSPDLG
A
V
E
L
R
I
E
E
L
R
H
H
F
R
V
E
H
A
V
A
E
G
A
K
N
V
L
R
L
L
S
AAKAP
D
R
K
A
V
S
E
A
Q
E
K
L
T
ES
N
Q
K
L
G
L
L
R
E
A
L
E
R
R
L
GELPADHPK
G
R
L
L
R
E
E
L
A
A
ASSAAFSTRLAGPFPAT
H
Y
S
TLCKPAPLT
G
T
L
E
V
R
V
V
GCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRP
A
R
G
L
YSRSGSLSGRSSLKAEAEN
T
S
E
V
S
T
V
L
KLD
N
T
VVGQTSWKPCGPNAWDQ
S
F
T
L
E
L
E
RARE
L
E
L
A
V
F
W
RDQRGL
C
A
L
K
F
L
K
L
E
D
F
LDNER
H
E
V
Q
L
DMEPQ
G
C
L
V
A
E
V
TFRN
P
V
I
E
R
I
P
R
L
R
R
Q
K
K
I
F
S
K
Q
Q
G
K
A
F
Q
R
A
R
QMNI
D
V
A
T
W
V
R
L
L
R
R
LIPNATGTGTFSPGASPGSEARTTG
D
I
S
V
E
K
L
NLGTDSDSSPQKSSRDPPSSP
S
S
LSSPIQESTAPELPSETQETPG
P
A
L
C
SPLRKSPL
T
L
E
D
F
K
F
L
A
V
LGRG
H
F
G
K
V
L
L
S
EF---RPSG
E
L
F
A
I
K
ALKKGD
I
V
A
-
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
V
TSAG
H
P
F
L
V
N
L
F
G
C
FQTP
E
H
V
C
F
V
M
E
YSAG
G
D
L
M
L
H
I
H
S
-----D-VFSE
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E-HK
I
V
Y
R
DLKL
D
N
L
L
LDTEG
Y
V
K
I
A
D
F
G
L
C
KEGMGYGDRTSTF-CG
T
P
E
FLA
P
E
VLTD-----TSY
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
VGESPF-PGD---
D
----
E
E
E
V
F
D
S
I
VNDE--VRYP---RFL
S
A
E
A
I
G
I
M
R
R
L
L
RR
N
P
E
R
RLGSS-E-R
D
A
-
E
D
V
K
KQ
P
F
F
R
T
L
G
W
E
A
L
L
A
RRLPPPFVPTLS-----GRTDVSNF
D
E
E
FTGEAPTLSPP-RDARPL---
T
A
A
E
Q
-
A
A
F
L
D
F
D
FVAGGC
32
HHSearch
92.57
47%
-113
* C1 *
4GV1
5
AKT1_HUMAN
A:
[4-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
---
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
-----
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
------
S
M
ECV
D
S
E
R
R
-
P
H
F
P
Q
F
D
Y
S
A
S
--
7
PsiBlast_PDB
89.26
45%
-113
- C1 -
2JDR
2
AKT2_HUMAN
A:
[7-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
-
E
M
F
E
D
F
D
Y
I
A
---
8
PsiBlast_PDB
88.67
45%
-111
- C1 -
2UW9
2
AKT2_HUMAN
A:
[7-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
-
E
M
F
E
D
F
D
Y
I
A
---
14
PsiBlast_PDB
88.63
45%
-113
- C1 -
3E87
2
AKT2_HUMAN
A:
[2-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
--------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
11
PsiBlast_PDB
88.41
45%
-113
- C1 -
1O6L
2
AKT2_HUMAN
A:
[2-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
-
E
M
F
E
D
F
D
Y
I
A
---
17
PsiBlast_PDB
88.39
45%
-110
- C1 -
3D0E
1
AKT2_HUMAN
A:
[2-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
D-------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
9
PsiBlast_PDB
88.24
45%
-113
- C1 -
2X39
2
AKT2_HUMAN
A:
[7-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
-
E
M
F
E
D
F
D
Y
I
A
---
13
PsiBlast_PDB
87.96
45%
-112
- C1 -
1O6K
2
AKT2_HUMAN
A:
[2-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
6
PsiBlast_PDB
87.96
45%
-113
- C1 -
2JDO
3
AKT2_HUMAN
A:
[7-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------------
M
F
E
D
F
D
Y
I
A
---
10
PsiBlast_PDB
87.49
45%
-114
- C1 -
2XH5
2
AKT2_HUMAN
A:
[7-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
-
E
M
F
E
D
F
D
Y
I
A
---
16
PsiBlast_PDB
87.14
45%
-111
- C1 -
3E8D
2
AKT2_HUMAN
A:
[2-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------------
H
F
P
Q
F
D
Y
S
A
---
15
PsiBlast_PDB
86.68
45%
-110
- C1 -
3E88
2
AKT2_HUMAN
A:
[2-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
---
D
----
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
P
-
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
----------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
33
HHSearch
85.61
48%
-112
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
--
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
----
R
-
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
-
E
A
E
---
N
----
E
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
---
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
-
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
-----
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
-
D
E
-
G
H
L
---
P
M
I
N
Q
-
D
E
F
R
N
F
E
Y
V
S
P
--
38
HHSearch
85.13
42%
-112
- C1 -
4DC2
2
KPCI_MOUSE
A:
[49-387]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
--
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
----
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
-
D
I
V
GSN
T
----
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
-
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
-----
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
-
D
D
-
D
I
V
---
R
K
I
D
Q
-
S
E
F
E
G
F
E
Y
I
N
P
--
35
HHSearch
84.68
50%
-120
- C1 -
1XJD
1
A:
[16-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
--
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
----
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-
H
G
Q
---
D
----
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-------
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
------------------------------------------------
Q
-
N
M
F
R
N
F
S
F
-----
19
PsiBlast_PDB
80.14
40%
-110
- C1 -
3A8W
1
KPCI_HUMAN
A:
[4-342]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
--
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-----
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D------
T
----
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
-----
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
-
P
V
Q
L
T
P
-
D
D
D
D
I
V
---
R
K
I
D
Q
-
S
E
F
E
G
F
E
Y
I
----
37
HHSearch
79.65
42%
-114
- C1 -
4L42
1
KS6B1_HUMAN
A:
[13-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
---
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
----
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-
T
G
E
---
N
----
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-----------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
-
43
HHSearch
78.75
40%
-100
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[35-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I----
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
T
L
-
C
G
T
P
E
A
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
D
---
Q
----
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
-----------
E
K
C
G
-
K
E
F
T
E
F
-------
45
HHSearch
76.30
37%
-106
- C1 -
3C4Z
1
RK_BOVIN
A:
[178-509]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
---
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
VDED
N
P
-
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
Y
-
A
G
T
P
G
F
M
A
P
E
L
L
L
G
-----
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
-
R
A
R
---
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
---
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
-
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
TVYAK
N
----
G
A
F
S
----------------
G
V
A
F
---
E
K
A
D
T
-
E
F
F
Q
E
F
A
S
G
----
40
HHSearch
75.42
34%
-101
- C1 -
4AW2
3
MRCKA_RAT
A:
[68-408]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
---
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
---
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E---
D
-
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGK
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
-
Y
A
E
---
S
----
L
V
E
T
Y
G
K
I
M
N
H
K
ER
F
Q
F
P
TQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
Q
----
N
G
I
-
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
-----
S
P
T
D
T
S
N
F
D
V
D
----------------------
S
G
H
H
-
L
P
F
V
G
F
T
Y
T
S
S
C
V
51
HHSearch
72.94
43%
-108
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[14-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
---
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-----
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-
T
G
E
---
N
----
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-----
S
--------------------------------------------------
34
HHSearch
70.90
40%
-124
- C1 -
2R5T
1
SGK1_HUMAN
A:
[33-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
----
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-
Y
S
R
---
N
----
T
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
-
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
-----
G
--------------------------------------------------