@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00439_BRD2_HUMAN: (2014-09-07 )
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
Atome Classification :
(43 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRK
P
S
L
L
Y
EGFESPTMASVP
A
L
Q
LTPANPPPPEVSNPKKP
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
HQFAWPFRQ
P
V
D
A
V
KLGL
P
D
Y
H
K
I
I
KQPM
D
M
G
T
I
K
R
R
L
ENN
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
YNKPTD
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
ASMPQEEQ
E
L
V
V
T
IPKNSHKKG
A
K
L
A
A
LQGSVTSAHQVPAVSSVSHTALYTPPPEIP
T
T
V
LNIP
H
P
S
V
I
S
S
P
L
L
K
S
L
H
SAGP
P
L
L
A
V
TAAPPAQ
P
L
A
K
K
KGVKRKADTTTPTP
T
A
I
LAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLP
D
S
Q
Q
Q
H
Q
SSKKG
K
L
S
E
Q
L
K
H
C
N
G
I
L
K
E
L
L
SKKHAAYAWPFYKPVDASALG
L
H
D
Y
H
D
I
I
KHPM
D
L
S
T
V
K
R
K
MENRDYR
D
A
Q
E
F
A
A
D
V
R
L
M
F
S
NCYKYNPPD
H
D
V
V
A
M
A
R
K
L
Q
D
V
F
E
F
R
Y
AKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEED
E
E
E
EESESSD
S
E
E
E
R
A
H
R
L
A
E
L
Q
E
Q
L
R
A
V
H
E
Q
L
A
A
LSQGPISK
P
K
R
K
R
E
K
K
E
K
K
K
K
R
K
A
E
K
HRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDS
E
E
E
E
ESRPMS
Y
D
E
K
R
Q
L
S
L
D
I
NKL
P
G
E
K
L
G
R
V
V
H
I
I
QAREPSLRDSNP
E
E
I
E
I
D
F
E
TLK
P
S
T
L
R
E
L
E
R
Y
V
L
S
C
L
RKKPRKP
Y
T
IKKPVGK
T
K
E
E
L
A
L
E
K
K
R
E
L
E
K
R
L
Q
D
VSGQLNSTKKPPKKANEKTESSS
A
Q
Q
V
A
V
S
R
LSASSSSSDSSSSSSSSSSSDTSDSDSG
50
PsiBlast_CBE
79.63
87%
-95
- C6 -
2NXB
6
BRD3_HUMAN
B:
[3-122]
---------------------------------------------------------------
P
E
V
S
N
P
S
K
P
G
R
K
T
N
Q
L
Q
Y
M
Q
N
V
V
V
K
T
L
W
K
H
Q
F
A
W
P
F
Y
Q
P
V
D
A
I
K
L
N
L
P
D
Y
H
K
I
I
K
N
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
S
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
A
L
E
K
I
F
L
Q
K
V
A
Q
M
P
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
79.60
95%
-113
- C6 -
4AKN
2
BRD2_HUMAN
B:
[27-137]
------------------------------------------------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.33
96%
-104
- C6 -
4A9M
2
BRD2_HUMAN
A:
[29-140]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.90
94%
-99
- C6 -
2DVR
2
BRD2_HUMAN
A:
[1-114]
------------------------------------------------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.74
94%
-96
- C6 -
2DVQ
2
BRD2_HUMAN
A:
[1-114]
------------------------------------------------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.57
96%
-102
- C6 -
4A9N
5
BRD2_HUMAN
A:
[29-140]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.56
96%
-102
- C6 -
4A9M
1
BRD2_HUMAN
B:
[27-140]
------------------------------------------------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.95
95%
-100
- C6 -
4AKN
2
BRD2_HUMAN
A:
[29-140]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.61
96%
-104
- C6 -
4A9J
2
BRD2_HUMAN
A:
[29-140]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.92
96%
-101
- C6 -
4A9E
3
BRD2_HUMAN
A:
[29-140]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
76.63
81%
-83
- C6 -
4BJX
1
BRD4_HUMAN
A:
[14-138]
-----------------------------------------------------------
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.48
96%
-100
- C6 -
4A9H
3
BRD2_HUMAN
A:
[29-140]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
76.46
94%
-97
- C6 -
1X0J
1
BRD2_HUMAN
A:
[1-114]
------------------------------------------------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.96
96%
-116
- C6 -
4A9H
1
BRD2_HUMAN
B:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.74
96%
-113
- C6 -
4A9O
2
BRD2_HUMAN
B:
[30-137]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.64
96%
-111
- C6 -
4ALH
1
BRD2_HUMAN
B:
[30-137]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.17
95%
-106
- C6 -
2YDW
2
BRD2_HUMAN
A:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
75.16
96%
-105
- C6 -
4A9F
2
BRD2_HUMAN
B:
[30-139]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
75.03
96%
-98
- C6 -
4A9E
3
BRD2_HUMAN
B:
[27-139]
------------------------------------------------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.84
96%
-102
- C6 -
4A9J
2
BRD2_HUMAN
B:
[27-139]
------------------------------------------------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.78
95%
-102
- C6 -
2YEK
2
BRD2_HUMAN
A:
[28-141]
-------------------------------------------------------------------------
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.64
96%
-99
- C6 -
4A9N
5
BRD2_HUMAN
B:
[26-140]
-----------------------------------------------------------------------
P
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.42
96%
-114
- C6 -
4A9F
1
BRD2_HUMAN
A:
[29-136]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.35
96%
-112
- C6 -
4ALH
3
BRD2_HUMAN
A:
[29-136]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
74.32
95%
-111
- C6 -
2YEK
1
BRD2_HUMAN
C:
[30-135]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.16
96%
-104
- C6 -
4ALG
2
BRD2_HUMAN
A:
[26-143]
-----------------------------------------------------------------------
P
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
L
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.10
96%
-98
- C6 -
4A9O
3
BRD2_HUMAN
A:
[28-142]
-------------------------------------------------------------------------
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.63
96%
-111
- C6 -
4A9N
2
BRD2_HUMAN
C:
[31-136]
----------------------------------------------------------------------------
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.62
96%
-108
- C6 -
4ALH
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
73.60
87%
-115
* C6 *
3S91
2
BRD3_HUMAN
A:
[15-121]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
M
Q
N
V
V
V
K
T
L
W
K
H
Q
F
A
W
P
F
Y
Q
P
V
D
A
I
K
L
N
L
P
D
Y
H
K
I
I
K
N
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
S
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
A
L
E
K
I
F
L
Q
K
V
A
Q
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
73.47
96%
-110
- C6 -
4A9H
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.44
96%
-106
- C6 -
4A9I
2
BRD2_HUMAN
A:
[29-138]
--------------------------------------------------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.41
96%
-111
- C6 -
4A9O
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
72.93
95%
-118
- C6 -
2YEK
1
BRD2_HUMAN
B:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.67
96%
-111
- C6 -
4A9J
2
BRD2_HUMAN
C:
[31-136]
----------------------------------------------------------------------------
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
72.48
96%
-113
- C6 -
4A9M
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.31
96%
-110
- C6 -
4A9F
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.17
96%
-112
- C6 -
4A9I
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
72.16
96%
-109
- C6 -
4A9E
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
72.08
95%
-108
- C6 -
2YDW
1
BRD2_HUMAN
B:
[31-135]
----------------------------------------------------------------------------
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
72.01
95%
-110
- C6 -
4AKN
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.38
87%
-107
- C6 -
2NXB
4
BRD3_HUMAN
A:
[13-123]
-------------------------------------------------------------------------
R
K
T
N
Q
L
Q
Y
M
Q
N
V
V
V
K
T
L
W
K
H
Q
F
A
W
P
F
Y
Q
P
V
D
A
I
K
L
N
L
P
D
Y
H
K
I
I
K
N
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
S
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
A
L
E
K
I
F
L
Q
K
V
A
Q
M
P
Q
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.21
95%
-112
- C6 -
2YDW
1
BRD2_HUMAN
C:
[30-136]
---------------------------------------------------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------