@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00439_BRD3_H: (2014-09-07 )
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
Atome Classification :
(56 SA)
.........10........20........30........40........50...--.....60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRK
T
N
Q
L
Q
Y
M
Q
N
V
V
V
K
T
L
W
K
HQ--FAWPFYQPV
D
A
I
KLNLP
D
Y
H
K
I
IKNPM
D
M
G
T
I
K
K
R
LENN
Y
Y
W
S
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
YNKPT
D
D
I
V
L
M
A
Q
A
L
E
K
I
F
L
Q
K
V
A
QM
P
Q
E
E
V
ELLPPAPKGKGRKPAAGAQSAGT
Q
Q
V
A
A
VSSVSPATPFQSVPPTVSQT
P
V
I
AATPV
P
T
I
T
ANVTSVPVPPAAAPPPPAT
P
I
V
PVVPPTP
P
V
V
K
K
KGVKRKADTTTPTT
S
A
I
TASRSESPPPLSD
P
K
Q
A
K
V
V
A
RRESGGRPIKPPKKDLEDGEVPQHAGKKG
K
L
S
E
H
L
R
Y
C
D
S
I
L
R
E
M
L
SKKHAAYAWPFYKPVDA
E
A
L
E
LH
D
Y
H
D
I
I
KHPM
D
L
S
T
V
K
R
K
MDGREYPDAQG
F
A
A
D
V
R
L
M
F
S
NCYKYNPP
D
H
E
V
V
A
M
A
R
K
L
Q
D
V
F
E
M
R
F
AKMPDEPVEAPALPAPAA
P
M
V
SKGAESSRSSEESSSDSGSSD
S
E
E
E
R
A
T
R
L
A
E
L
Q
E
Q
L
K
A
V
H
E
Q
L
A
A
L
S
QAPVNK
P
K
K
K
K
E
K
K
E
K
E
K
K
KK
D
K
E
K
E
K
E
K
HKVK
A
E
E
EKKAKVAP
P
A
K
Q
A
Q
Q
KKAPAKKANST
T
T
A
G
R
Q
L
K
KGGKQASASYDS
E
E
E
EEGLPMSYDEK
R
Q
L
S
L
DINRL
P
G
E
K
L
G
R
V
V
H
I
I
QSREPSLRDSNPD
E
I
E
I
D
F
ETLK
P
T
T
L
R
E
L
E
R
Y
V
K
S
C
L
Q
K
K
QRKPFSASG
K
K
Q
A
A
K
S
K
E
E
L
A
Q
E
K
K
K
E
L
E
K
R
L
Q
D
V
S
GQLSSSKKPARKEKPGSAPSG
G
P
S
RLSSSSSSESGSSSSSGSSSDSSDSE
21
PsiBlast_CBE
82.99
100%
-88
- C7 -
2NXB
6
BRD3_HUMAN
B:
[3-122]
-----------------------
P
E
V
S
N
P
S
K
P
G
R
K
T
N
Q
L
Q
Y
M
Q
N
V
V
V
K
T
L
W
K
H
Q
--
F
A
W
P
F
Y
Q
P
V
D
A
I
K
L
N
L
P
D
Y
H
K
I
I
K
N
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
S
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
A
L
E
K
I
F
L
Q
K
V
A
Q
M
P
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
82.24
81%
-87
- C7 -
4DON
1
BRD4_HUMAN
A:
[22-144]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
80.74
80%
-82
- C7 -
3MUK
2
BRD4_MOUSE
A:
[4-129]
----------------
G
S
T
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
80.24
80%
-86
- C7 -
3JVK
2
BRD4_MOUSE
A:
[4-129]
----------------
G
S
T
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
80.09
80%
-78
- C7 -
4LYW
1
?
A:
[2-127]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
79.72
80%
-72
- C7 -
4LRG
1
BRD4_HUMAN
A:
[1-128]
----------------
G
S
T
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
79.54
80%
-78
- C7 -
4OGI
3
?
A:
[2-127]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
79.43
81%
-81
- C7 -
4J3I
3
?
A:
[2-127]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
79.34
80%
-80
- C7 -
4OGJ
3
?
B:
[2-127]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
79.10
80%
-82
- C7 -
4OGJ
4
?
A:
[2-127]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
78.71
80%
-88
- C7 -
4LYS
1
?
A:
[1-124]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.44
78%
-77
- C7 -
4BJX
1
BRD4_HUMAN
A:
[13-138]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
77.87
80%
-79
- C7 -
4OGI
3
?
B:
[2-127]
------------------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
77.66
80%
-85
- C7 -
3MUL
2
BRD4_MOUSE
A:
[4-129]
----------------
G
S
T
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
77.55
80%
-82
- C7 -
4LR6
2
BRD4_HUMAN
A:
[2-126]
-----------------
S
T
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.09
100%
-114
- C7 -
3S91
2
BRD3_HUMAN
A:
[15-121]
-----------------------------------
T
N
Q
L
Q
Y
M
Q
N
V
V
V
K
T
L
W
K
H
Q
--
F
A
W
P
F
Y
Q
P
V
D
A
I
K
L
N
L
P
D
Y
H
K
I
I
K
N
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
S
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
A
L
E
K
I
F
L
Q
K
V
A
Q
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
77.04
80%
-79
- C7 -
3JVJ
2
BRD4_MOUSE
A:
[4-129]
----------------
G
S
T
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
--
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
76.31
81%
-109
- C7 -
4AKN
2
BRD2_HUMAN
B:
[27-137]
--------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
75.88
78%
-98
- C7 -
4A9M
1
BRD2_HUMAN
B:
[27-140]
--------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.94
78%
-114
- C7 -
4A9O
2
BRD2_HUMAN
B:
[30-137]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.84
100%
-97
- C7 -
2NXB
4
BRD3_HUMAN
A:
[13-123]
---------------------------------
R
K
T
N
Q
L
Q
Y
M
Q
N
V
V
V
K
T
L
W
K
H
Q
--
F
A
W
P
F
Y
Q
P
V
D
A
I
K
L
N
L
P
D
Y
H
K
I
I
K
N
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
S
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
A
L
E
K
I
F
L
Q
K
V
A
Q
M
P
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.51
81%
-98
- C7 -
4AKN
2
BRD2_HUMAN
A:
[29-140]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
74.02
78%
-100
- C7 -
4A9J
2
BRD2_HUMAN
B:
[27-139]
--------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.00
78%
-100
- C7 -
4A9J
2
BRD2_HUMAN
A:
[29-140]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
73.93
78%
-111
- C7 -
4ALH
1
BRD2_HUMAN
B:
[30-137]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
73.92
81%
-112
- C7 -
2YEK
1
BRD2_HUMAN
C:
[30-135]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.81
78%
-97
- C7 -
4A9M
2
BRD2_HUMAN
A:
[29-140]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
73.77
78%
-110
- C7 -
4A9F
2
BRD2_HUMAN
B:
[30-139]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.58
78%
-99
- C7 -
4A9N
5
BRD2_HUMAN
A:
[29-140]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.41
78%
-97
- C7 -
4A9E
3
BRD2_HUMAN
A:
[29-140]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.38
78%
-97
- C7 -
4A9E
3
BRD2_HUMAN
B:
[27-139]
--------------------------------
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.03
78%
-96
- C7 -
4A9H
3
BRD2_HUMAN
A:
[29-140]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.38
78%
-94
- C7 -
4ALG
2
BRD2_HUMAN
A:
[26-143]
-------------------------------
P
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
L
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.33
81%
-107
- C7 -
2YDW
2
BRD2_HUMAN
A:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.23
78%
-101
- C7 -
4A9I
2
BRD2_HUMAN
A:
[29-138]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.22
78%
-96
- C7 -
4A9N
5
BRD2_HUMAN
B:
[26-140]
-------------------------------
P
G
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.84
81%
-110
- C7 -
4AKN
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.79
78%
-110
- C7 -
4A9F
1
BRD2_HUMAN
A:
[29-136]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
71.77
78%
-116
- C7 -
4A9H
1
BRD2_HUMAN
B:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
71.74
81%
-117
- C7 -
2YEK
1
BRD2_HUMAN
B:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
71.73
81%
-112
- C7 -
2YDW
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.36
81%
-97
- C7 -
2YEK
2
BRD2_HUMAN
A:
[28-141]
---------------------------------
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
71.35
78%
-111
- C7 -
4A9O
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.95
78%
-93
- C7 -
4A9O
3
BRD2_HUMAN
A:
[28-142]
---------------------------------
R
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
E
E
Q
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.84
78%
-110
- C7 -
4ALH
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.76
78%
-107
- C7 -
4ALH
3
BRD2_HUMAN
A:
[29-136]
----------------------------------
V
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
70.73
78%
-111
- C7 -
4A9H
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
70.70
81%
-111
- C7 -
2YDW
1
BRD2_HUMAN
B:
[31-135]
------------------------------------
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
70.32
78%
-110
- C7 -
4A9E
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
70.30
78%
-114
- C7 -
4A9M
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
70.02
78%
-113
- C7 -
4A9F
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
69.92
78%
-112
- C7 -
4A9I
1
BRD2_HUMAN
C:
[30-136]
-----------------------------------
T
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
69.88
78%
-111
- C7 -
4A9N
2
BRD2_HUMAN
C:
[31-136]
------------------------------------
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
69.48
78%
-113
- C7 -
4A9J
2
BRD2_HUMAN
C:
[31-136]
------------------------------------
N
Q
L
Q
Y
L
H
K
V
V
M
K
A
L
W
K
H
Q
--
F
A
W
P
F
R
Q
P
V
D
A
V
K
L
G
L
P
D
Y
H
K
I
I
K
Q
P
M
D
M
G
T
I
K
R
R
L
E
N
N
Y
Y
W
A
A
S
E
C
M
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
T
D
D
I
V
L
M
A
Q
T
L
E
K
I
F
L
Q
K
V
A
S
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
62.19
37%
-98
- C7 -
1E6I
1
A:
[11-120]
----------------------------------
R
G
P
H
D
A
A
I
Q
N
I
L
T
-
E
L
Q
N
H
A
--
A
A
W
P
F
L
Q
P
V
N
--
K
E
E
V
P
D
Y
Y
D
F
I
K
E
P
M
D
L
S
T
M
E
I
K
L
E
S
N
K
Y
Q
K
M
E
D
F
I
Y
D
A
R
L
V
F
N
N
C
R
M
Y
N
G
E
N
T
S
Y
Y
K
Y
A
N
R
L
E
K
F
F
N
N
K
V
K
E
I
P
-
E
Y
S
H
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
59.07
43%
-84
- C7 -
2OUO
3
A:
[19-129]
---------------------------------
K
V
S
E
Q
L
K
C
C
S
G
I
L
K
E
M
F
A
K
K
H
AA
Y
A
W
P
F
Y
K
P
V
D
V
E
A
L
G
L
H
D
Y
C
D
I
I
K
H
P
M
D
M
S
T
I
K
S
K
L
E
A
R
E
Y
R
D
A
Q
E
F
G
A
D
V
R
L
M
F
S
N
C
Y
K
Y
N
P
P
D
H
E
V
V
A
M
A
R
K
L
Q
D
V
F
E
M
R
F
A
K
M
P
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------