@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00439_BRD4_HUMAN: (2014-09-07 )
MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKR
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
HQFAWPFQQPV
D
A
V
KLNL
P
D
Y
Y
K
I
I
KTPM
D
M
G
T
I
K
K
R
LENN
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
MFT
N
C
Y
I
YNKPGD
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
ELPTEET
E
I
M
I
V
Q
AKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAV
T
P
D
L
I
V
QTP
V
M
T
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHP
P
I
I
AATPQPV
K
T
K
KGVKRKADTTTPTTIDPIHEPPSLPPEPKT
T
K
L
GQRRESSRPVKPPKKDVPDSQQHPAPE
K
S
S
K
V
S
E
Q
L
K
C
C
S
G
I
L
K
E
M
F
A
K
KHAAYAWPFYKPVD
V
E
A
LG
L
H
D
Y
C
D
I
I
KHPM
D
M
S
T
I
K
S
K
L
E
A
R
E
YR
D
A
Q
E
FGA
D
V
R
L
M
F
SNCYKYNPP
D
H
E
V
V
A
M
A
R
K
L
Q
D
V
F
E
M
R
F
A
KMPDEPEE
P
V
V
AVSSPAVPPPT
K
V
VAPPSSSDSSSDSSSDSDSSTDD
S
E
E
E
R
A
Q
R
L
A
E
L
Q
E
Q
L
K
A
V
H
E
Q
L
A
A
LSQPQQNKPKK
K
E
K
D
K
K
E
K
K
K
E
K
H
K
R
K
E
E
V
E
E
N
K
KSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPM
S
Y
E
E
K
R
Q
L
S
L
D
I
NKL
P
G
E
K
L
G
R
V
V
H
I
I
QSREPSLKNSNPD
E
I
E
I
D
F
E
TLK
P
S
T
L
R
E
L
E
R
Y
V
T
S
C
L
R
KKRKPQAE
K
V
D
V
I
AGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPG
R
E
Q
K
K
H
H
H
H
H
H
Q
Q
M
Q
QAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSM
P
Q
Q
AAPAMKSSPP
P
F
I
A
TQVPVLEPQLPG
S
V
FD
P
I
G
H
F
T
Q
P
I
LHLPQPELPPHLPQPPEHSTPPHLNQHAVVS
P
P
A
L
H
NALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQ
V
L
LEDEEPPAPP
L
T
S
M
Q
M
Q
L
Y
L
Q
Q
L
Q
KVQPPTPLLPSVKVQSQPPPPLPPPPH
P
S
V
Q
Q
Q
L
QQQPPPPPPPQPQPPPQQQHQPPPRP
V
H
L
QP
M
Q
FSTHIQQPPPPQGQQPPHPPPGQQPPPPQPA
K
P
Q
Q
V
I
Q
HHHSPRHHKSDPYSTGHLREAPS
P
L
M
I
HSP
Q
M
S
Q
F
Q
S
L
THQSPPQQNVQ
P
K
K
Q
E
L
R
AASVVQPQ
P
L
V
V
V
KEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKD
L
K
IKNM
G
S
W
A
S
L
V
Q
KHPTTPSSTAKSS
S
D
S
F
E
Q
F
R
R
A
A
R
E
K
E
E
R
E
K
A
L
K
A
Q
A
E
H
A
E
K
E
K
E
R
L
R
Q
E
R
M
RSRE
D
E
D
A
L
E
Q
A
R
R
A
H
E
E
A
R
R
R
Q
E
Q
Q
Q
Q
Q
R
Q
E
Q
Q
Q
Q
Q
Q
Q
Q
A
A
A
V
AAAATPQAQSS
Q
P
Q
S
M
L
D
Q
Q
R
E
L
A
R
K
R
E
Q
E
R
R
R
R
E
A
M
A
A
T
I
DMN
F
Q
S
D
L
L
S
I
F
E
ENLF
34
PsiBlast_CBE
90.47
99%
-61
- C6 -
4MEN
2
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
90.41
99%
-61
- C6 -
4MR4
4
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
90.18
99%
-60
- C6 -
4MEO
3
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
89.81
99%
-53
- C6 -
3MXF
5
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
89.70
99%
-54
- C6 -
4F3I
3
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
89.52
99%
-58
- C6 -
4GPJ
3
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
89.50
99%
-58
- C6 -
3SVG
4
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
89.33
99%
-56
- C6 -
4OGI
3
?
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
89.30
99%
-63
- C6 -
4MEQ
2
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
89.28
99%
-57
- C6 -
4J0S
5
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
88.96
99%
-52
- C6 -
4J0R
5
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
87.93
99%
-61
- C6 -
4E96
3
BRD4_HUMAN
A:
[1-124]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.93
99%
-57
- C6 -
3U5J
5
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
87.62
99%
-55
- C6 -
4HBV
3
BRD4_HUMAN
A:
[1-127]
-----------------------------------------
S
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------