@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00439_BRDT_H: (2014-09-07 )
MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
Atome Classification :
(60 SA)
.........10........20........30........40......---..50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLPSR
Q
T
A
I
I
VNPPPPEYINTKKNGR
L
T
N
Q
L
Q
Y
L
Q
K
V
V
L
K
D
L
W
K
HS---FSWPFQRPV
D
A
V
K
L
QLP
D
Y
Y
T
I
IKNPM
D
L
N
T
I
K
K
R
LENKYYA
K
A
S
E
C
I
E
D
F
N
T
M
F
SN
C
Y
L
YNKPGD
D
I
V
L
M
A
Q
A
L
E
K
L
F
M
Q
K
L
S
QMP
Q
E
E
Q
V
V
G
V
K
E
R
I
K
KGTQQ
N
I
A
VSSAKEKSSP
S
A
T
E
K
V
F
K
QQEIPSVFPKTSISP
L
N
V
VQGASVNSS
S
Q
T
A
A
Q
V
T
K
G
VKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPD
S
Q
Q
Q
Y
N
V
V
K
T
V
K
V
T
E
Q
L
R
H
C
S
E
I
L
K
E
M
L
A
K
KHFSYAWPFYNPVD
V
N
A
L
G
L
H
N
Y
Y
D
V
VKNPM
D
L
G
T
I
K
E
K
MD
N
Q
E
Y
K
D
A
Y
K
F
A
A
D
V
R
L
M
F
M
N
C
YKYNPP
D
H
E
V
V
T
M
A
R
M
L
Q
D
V
F
E
T
H
F
S
KIPIEPVESM
P
L
C
Y
I
KTDITETTGRENTNEASSEGNSSDD
S
E
D
E
R
V
K
R
L
A
K
L
Q
E
Q
L
K
A
V
H
Q
Q
L
Q
V
L
S
QV
P
F
R
K
L
N
K
K
K
E
K
S
K
K
E
K
K
K
E
KVNNSNE
N
P
R
K
M
C
E
Q
M
R
L
K
E
K
SKRNQ
P
K
K
R
K
Q
Q
F
IGLKSEDEDNAKPMN
Y
D
E
K
R
Q
L
S
L
N
INKL
P
G
D
K
L
G
R
V
V
H
I
I
QSREPSLSNSNPD
E
I
E
I
D
F
E
T
L
K
A
S
T
L
R
E
L
E
K
Y
V
S
A
C
L
RKRPLKP
P
A
K
K
I
M
M
S
K
E
E
L
H
S
Q
K
K
Q
E
L
E
K
R
L
L
D
V
N
N
Q
L
N
S
R
KRQTKSDKTQ
P
S
K
A
V
E
N
V
S
R
L
SESSSSSSSSSESESSSSDLSSSDSSD
S
E
S
EMFPKFTEVKPNDSP
S
K
E
N
V
K
K
M
K
N
ECIPPEGRTGV
T
Q
I
G
Y
C
VQDTTSA
N
T
T
L
V
HQTTPSHVMPPNH
H
Q
L
A
F
N
Y
Q
E
L
E
H
L
Q
T
V
KNISP
L
Q
I
LPPSG
D
S
E
Q
LSN
G
I
T
V
MHPSGDSD
T
T
M
L
E
S
E
CQAP
V
Q
KD
I
K
IKN
A
D
S
W
K
SLGKPVKPSGVMK
S
S
D
E
L
F
N
Q
F
R
K
A
A
I
E
K
E
V
K
A
R
T
Q
E
L
I
R
K
H
L
E
Q
N
T
K
E
L
K
ASQE
N
Q
R
DLGN
G
L
T
V
E
S
F
S
N
K
I
Q
N
KCS
G
E
E
Q
K
E
H
QQSSEAQDKS
K
L
W
L
LKD
R
D
L
A
R
Q
K
E
Q
E
R
R
R
R
E
AMV
G
T
I
D
M
T
L
Q
S
D
I
M
T
M
F
ENNFD
4
PsiBlast_PDB
75.61
90%
-76
- C6 -
2WP2
1
BRDT_MOUSE
A:
[2-120]
------------------
Y
I
N
T
-----
L
T
N
Q
L
Q
F
L
Q
R
V
V
L
K
A
L
W
K
H
G
---
F
S
W
P
F
Q
Q
P
V
D
A
V
K
L
K
L
P
D
Y
Y
T
I
I
K
T
P
M
D
L
N
T
I
K
K
R
L
E
N
K
Y
Y
E
K
A
S
E
C
I
E
D
F
N
T
M
F
S
N
C
Y
L
Y
N
K
T
G
D
D
I
V
V
M
A
Q
A
L
E
K
L
F
M
Q
K
L
S
Q
M
P
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.59
99%
-83
- C6 -
4FLP
1
BRDT_HUMAN
A:
[11-116]
----------------------------
T
N
Q
L
Q
Y
L
Q
K
V
V
L
K
D
L
W
K
H
S
---
F
S
W
P
F
Q
R
P
V
D
A
V
K
L
Q
L
P
D
Y
Y
T
I
I
K
N
P
M
D
L
N
T
I
K
K
R
L
E
N
K
Y
Y
A
K
A
S
E
C
I
E
D
F
N
T
M
F
S
N
C
Y
L
Y
N
K
P
G
D
D
I
V
L
M
A
Q
A
L
E
K
L
F
M
Q
K
L
S
Q
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
74.42
100%
-81
- C6 -
4KCX
1
BRDT_HUMAN
B:
[9-114]
----------------------------
T
N
Q
L
Q
Y
L
Q
K
V
V
L
K
D
L
W
K
H
S
---
F
S
W
P
F
Q
R
P
V
D
A
V
K
L
Q
L
P
D
Y
Y
T
I
I
K
N
P
M
D
L
N
T
I
K
K
R
L
E
N
K
Y
Y
A
K
A
S
E
C
I
E
D
F
N
T
M
F
S
N
C
Y
L
Y
N
K
P
G
D
D
I
V
L
M
A
Q
A
L
E
K
L
F
M
Q
K
L
S
Q
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.29
100%
-79
- C6 -
4KCX
1
BRDT_HUMAN
A:
[9-114]
----------------------------
T
N
Q
L
Q
Y
L
Q
K
V
V
L
K
D
L
W
K
H
S
---
F
S
W
P
F
Q
R
P
V
D
A
V
K
L
Q
L
P
D
Y
Y
T
I
I
K
N
P
M
D
L
N
T
I
K
K
R
L
E
N
K
Y
Y
A
K
A
S
E
C
I
E
D
F
N
T
M
F
S
N
C
Y
L
Y
N
K
P
G
D
D
I
V
L
M
A
Q
A
L
E
K
L
F
M
Q
K
L
S
Q
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
73.55
73%
-59
- C6 -
4BW4
1
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
73.50
73%
-53
- C6 -
4OGI
3
?
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.44
73%
-58
- C6 -
4KV1
1
BRD4_HUMAN
B:
[3-128]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
73.26
73%
-55
- C6 -
4MR4
4
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.18
73%
-57
- C6 -
4OGJ
4
?
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.12
90%
-79
- C6 -
2WP2
1
BRDT_MOUSE
B:
[11-120]
---------------------------
L
T
N
Q
L
Q
F
L
Q
R
V
V
L
K
A
L
W
K
H
G
---
F
S
W
P
F
Q
Q
P
V
D
A
V
K
L
K
L
P
D
Y
Y
T
I
I
K
T
P
M
D
L
N
T
I
K
K
R
L
E
N
K
Y
Y
E
K
A
S
E
C
I
E
D
F
N
T
M
F
S
N
C
Y
L
Y
N
K
T
G
D
D
I
V
V
M
A
Q
A
L
E
K
L
F
M
Q
K
L
S
Q
M
P
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
73.11
73%
-58
- C6 -
3ZYU
5
BRD4_HUMAN
B:
[2-126]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
72.99
73%
-57
- C6 -
4IOR
5
BRD4_HUMAN
A:
[2-126]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.95
73%
-58
- C6 -
4MEQ
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
72.88
73%
-59
- C6 -
4IOO
6
BRD4_HUMAN
A:
[2-126]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
72.85
73%
-55
- C6 -
4J0S
5
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.83
73%
-60
- C6 -
4NQM
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.83
73%
-51
- C6 -
3SVG
4
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
72.82
73%
-58
- C6 -
4BW1
4
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.81
73%
-56
- C6 -
3ZYU
6
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
72.80
73%
-54
- C6 -
4MEO
3
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
72.79
73%
-54
- C6 -
4LZS
1
?
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
72.79
73%
-55
- C6 -
4MEN
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.79
73%
-55
- C6 -
4OGJ
3
?
B:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
72.68
73%
-58
- C6 -
4BW2
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.68
73%
-54
- C6 -
2YEL
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.64
73%
-57
- C6 -
4BW3
4
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.64
73%
-55
- C6 -
3U5L
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.64
73%
-54
- C6 -
4KV1
1
BRD4_HUMAN
A:
[3-128]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
72.62
73%
-52
- C6 -
4LYI
8
?
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.62
74%
-59
- C6 -
3JVJ
2
BRD4_MOUSE
A:
[7-129]
------------
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.60
74%
-58
- C6 -
3JVK
2
BRD4_MOUSE
A:
[7-129]
------------
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.49
99%
-79
- C6 -
4FLP
1
BRDT_HUMAN
B:
[11-117]
----------------------------
T
N
Q
L
Q
Y
L
Q
K
V
V
L
K
D
L
W
K
H
S
---
F
S
W
P
F
Q
R
P
V
D
A
V
K
L
Q
L
P
D
Y
Y
T
I
I
K
N
P
M
D
L
N
T
I
K
K
R
L
E
N
K
Y
Y
A
K
A
S
E
C
I
E
D
F
N
T
M
F
S
N
C
Y
L
Y
N
K
P
G
D
D
I
V
L
M
A
Q
A
L
E
K
L
F
M
Q
K
L
S
Q
M
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.46
74%
-60
- C6 -
3MUK
2
BRD4_MOUSE
A:
[7-129]
------------
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.44
73%
-51
- C6 -
3MXF
5
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
72.43
73%
-56
- C6 -
4IOQ
6
BRD4_HUMAN
A:
[2-126]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
72.40
73%
-53
- C6 -
4OGI
3
?
B:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.40
73%
-57
- C6 -
3U5K
1
BRD4_HUMAN
A:
[2-126]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
72.39
74%
-56
- C6 -
4J3I
3
?
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.33
73%
-55
- C6 -
4C67
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
72.24
73%
-49
- C6 -
4J0R
5
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.23
73%
-52
- C6 -
3P5O
4
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.12
73%
-56
- C6 -
3SVF
1
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
72.06
73%
-53
- C6 -
4CFK
3
?
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.99
73%
-59
- C6 -
4NR8
2
BRD4_HUMAN
A:
[2-125]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.95
73%
-49
- C6 -
4F3I
3
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
71.95
73%
-52
- C6 -
4GPJ
3
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
71.88
73%
-54
- C6 -
4MEP
1
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.83
73%
-52
- C6 -
3U5J
5
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
71.81
73%
-50
- C6 -
4MR3
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
71.69
73%
-61
* C6 *
4DON
1
BRD4_HUMAN
A:
[22-145]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.61
74%
-62
- C6 -
3MUL
2
BRD4_MOUSE
A:
[7-129]
------------
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
71.58
73%
-51
- C6 -
4CFL
3
?
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
71.58
73%
-57
- C6 -
4HBX
1
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
71.56
73%
-55
- C6 -
4HBV
3
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.49
73%
-56
- C6 -
4E96
3
BRD4_HUMAN
A:
[2-124]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.40
73%
-54
- C6 -
2OSS
3
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
71.38
73%
-55
- C6 -
4HBY
2
BRD4_HUMAN
A:
[2-127]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.24
73%
-58
- C6 -
4A9L
4
BRD4_HUMAN
A:
[2-126]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.88
70%
-55
- C6 -
4BJX
1
BRD4_HUMAN
A:
[13-138]
-----------
M
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
T
L
W
K
H
Q
---
F
A
W
P
F
Q
Q
P
V
D
A
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Q
D
F
N
T
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
V
L
M
A
E
A
L
E
K
L
F
L
Q
K
I
N
E
L
P
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
61.43
41%
-70
- C6 -
2OUO
3
A:
[19-129]
--------------------------
K
V
S
E
Q
L
K
C
C
S
G
I
L
-
K
E
M
F
A
K
K
HAA
Y
A
W
P
F
Y
K
P
V
D
V
E
A
L
G
L
H
D
Y
C
D
I
I
K
H
P
M
D
M
S
T
I
K
S
K
L
E
A
R
E
Y
R
D
A
Q
E
F
G
A
D
V
R
L
M
F
S
N
C
Y
K
Y
N
P
P
D
H
E
V
V
A
M
A
R
K
L
Q
D
V
F
E
M
R
F
A
K
M
P
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------