@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00515_FKBP5_: (2014-09-10 )
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
Atome Classification :
(20 SA)
.........10........20........30........40..--......50........60.-.......70........80........90........100.......110.......120.......130.......140.--......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNG--EETPMIGDKVYVHYKGKLS-NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLF--EDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
35
HHSearch
92.52
60%
-74
- C1 -
4LAY
1
FKBP4_HUMAN
A:
[42-275]
---------------------
G
V
D
I
S
P
K
Q
D
E
G
V
L
K
V
I
K
R
E
G
T
G
--
T
E
M
P
M
I
G
D
R
V
F
V
H
Y
T
G
W
L
L
-
D
G
T
K
F
D
S
S
L
D
R
K
D
K
F
S
F
D
L
G
K
G
E
V
I
K
A
W
D
I
A
I
A
T
M
K
V
G
E
V
C
H
I
T
C
K
P
E
Y
A
Y
G
S
A
G
S
P
P
K
I
P
P
N
A
T
L
V
F
E
V
E
L
F
E
F
K
G
E
D
L
T
EE
E
D
G
G
I
I
R
R
I
Q
T
R
G
E
G
Y
A
K
P
N
E
G
A
I
V
E
V
A
L
E
G
Y
Y
K
D
K
L
F
D
Q
R
E
L
R
F
E
I
G
E
G
E
N
L
D
L
P
Y
G
L
E
R
A
I
Q
R
M
E
K
G
E
H
S
I
V
Y
L
K
P
S
Y
A
F
G
S
V
G
K
E
K
F
Q
I
P
P
N
A
E
L
K
Y
E
L
H
L
K
S
F
E
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_CBE
68.16
100%
-75
- C1 -
4DRH
1
FKBP5_HUMAN
A:
[13-144]
--------
N
N
E
E
S
P
T
A
T
V
A
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_CBE
67.77
100%
-78
- C1 -
4DRH
1
FKBP5_HUMAN
D:
[14-144]
---------
N
E
E
S
P
T
A
T
V
A
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_CBE
67.02
99%
-81
- C1 -
3O5Q
2
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_CBE
65.99
99%
-80
- C1 -
4DRQ
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
65.98
99%
-80
- C1 -
4JFK
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_CBE
65.85
99%
-80
- C1 -
4JFM
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_CBE
65.80
99%
-84
- C1 -
3O5R
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_CBE
65.48
99%
-77
- C1 -
4DRO
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_CBE
65.19
99%
-78
- C1 -
4JFL
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_CBE
65.10
99%
-78
- C1 -
4DRM
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_CBE
65.01
99%
-80
- C1 -
4JFJ
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_CBE
64.33
99%
-78
- C1 -
4DRN
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
63.91
99%
-75
- C1 -
3O5L
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_CBE
63.70
99%
-78
- C1 -
4DRK
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_CBE
63.66
99%
-77
- C1 -
4DRP
1
FKBP5_HUMAN
A:
[4-128]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_CBE
63.38
99%
-83
- C1 -
4DRK
1
FKBP5_HUMAN
B:
[4-127]
---------------
A
T
V
T
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_CBE
61.37
100%
-76
- C1 -
4DRI
1
FKBP5_HUMAN
A:
[24-144]
-------------------
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
K
I
V
K
R
V
G
N
G
--
E
E
T
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
S
-
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
K
A
W
D
I
G
V
A
T
M
K
K
G
E
I
C
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
A
T
L
F
F
E
I
E
L
L
D
F
K
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
42.71
47%
-55
- C1 -
2VN1
1
?
A:
[7-127]
-------------------
F
E
K
V
E
L
T
--
A
D
G
G
V
I
K
T
I
L
K
K
G
D
E
GE
E
N
I
P
K
K
G
N
E
V
T
V
H
Y
V
G
K
L
E
S
T
G
K
V
F
D
S
S
F
D
R
N
V
P
F
K
F
H
L
E
Q
G
E
V
I
K
G
W
D
I
C
V
S
S
M
R
K
N
E
K
C
L
V
R
I
E
S
M
Y
G
Y
G
D
E
G
C
G
E
S
I
P
G
N
S
V
L
L
F
E
I
E
L
L
S
F
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
34.79
44%
-46
- C1 -
1YAT
1
FKBP_YEAST
A:
[4-113]
----------------------------
I
E
G
N
V
K
I
D
R
I
S
P
G
D
G
--
A
T
F
P
K
T
G
D
L
V
T
I
H
Y
T
G
T
L
E
-
N
G
Q
K
F
D
S
S
V
D
R
G
S
P
F
Q
C
N
I
G
V
G
Q
V
I
K
G
W
D
V
G
I
P
K
L
S
V
G
E
K
A
R
L
T
I
P
G
P
Y
A
Y
G
P
R
G
F
P
G
L
I
P
P
N
S
T
L
V
F
D
V
E
L
L
K
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------