@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00595_NOS1_H: (2014-09-12 )
MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQVDRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
Atome Classification :
(66 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......-350...-.....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530........540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MED
H
M
F
G
V
Q
QIQPN
V
I
S
V
R
L
F
K
R
K
VGG
L
G
F
L
V
K
E
RVSKP
P
V
I
I
S
D
L
I
RGGAAEQSG
L
I
QAG
D
I
I
L
A
VNG
R
P
L
V
D
L
S
Y
D
S
A
L
E
V
L
R
G
IASE
T
H
V
V
L
I
L
RGPEG
F
T
T
H
L
E
T
T
FTGDGTP
K
T
I
R
VTQPLGPPTKAVDLSHQPPAGKEQ
P
L
A
VDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRPPGQ
D
P
AKK
A
T
R
V
S
L
Q
GRGE
N
N
E
L
L
K
E
I
E
P
V
L
S
L
L
TSGSRGVKGGAPAK
A
E
M
K
DMG
I
Q
V
DRDLDGKSHKPLPLGVEND
R
V
F
N
D
LWGKGNV
P
V
V
LNNPYSEKEQPPTSGKQSPTKNG
S
P
S
KC
P
R
F
L
K
V
KNWE
T
E
V
V
L
T
D
T
L
H
L
K
S
T
L
E
TG
C
T
E
Y
I
C
MGSIMH
P
S
Q
HARR-
P
-
E
D
VR-TKGQ
L
F
P
L
A
K
E
F
I
D
Q
Y
Y
S
S
I
K
R
FG
S
K
A
H
M
E
R
L
E
E
V
N
K
EIDTTS
T
Y
Q
LKDT
E
L
I
YG
A
K
H
A
W
R
N
A
S
R
C
VG
R
I
Q
W
S
K
L
Q
V
F
DARDC
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
KYATNKGNL
R
S
A
I
T
I
F
PQRTDGKH
D
F
R
V
W
N
S
Q
L
I
R
YAGYKQPDGSTLGDPAN
V
Q
F
T
E
I
C
I
QQGWKPPRGRF
D
V
L
P
L
L
LQA-NGNDP
E
L
FQI
P
P
E
L
V
L
EVPIRHP
K
F
E
W
F
K
DLG
L
K
W
YG
L
P
A
V
S
N
M
L
L
E
IGG
L
E
FSACPFSG
W
Y
M
GTEIGVRDYCDN
S
R
Y
N
I
L
E
E
V
A
K
K
MNL
D
M
R
K
T
S
S
LWKD
Q
A
L
V
E
I
N
I
A
V
L
Y
S
FQSD
K
V
T
I
V
DH
H
S
A
T
E
S
F
I
K
H
M
E
N
EYRCRGGCPA
D
W
V
W
I
VPPMSGSI
T
P
V
F
H
Q
E
M
LNYRLTPSFEYQPDPWNTHVWKGTNGTP
T
K
R
RAI
G
F
K
K
L
A
E
A
V
K
F
S
A
K
L
M
G
Q
A
M
A
K
R
V
K
A
T
I
L
Y
A
TETGK
S
Q
A
Y
A
K
T
L
C
E
I
F
K
H
A
FDAK
V
M
S
M
E
E
Y
D
I
V
H
L
EH
E
T
L
V
L
V
V
T
STFGNGDPPENG
E
K
F
G
C
A
L
M
EMRHP
N
S
V
Q
E
E
R
K
S
Y
K
V
R
F
NSVSSYSDSQKSSGDGP
D
L
R
D
NFESAGPL
A
N
V
R
F
S
V
F
GLGSRAYP
H
F
C
A
F
G
H
A
V
D
T
L
L
E
ELG
G
E
R
I
LKMREG
D
E
LC
G
Q
E
E
A
F
R
T
W
A
K
K
V
F
K
AAC
D
V
F
C
VGDD
V
N
I
EKANNSLISNDRSWKR
N
K
F
R
L
T
F
VAE
A
P
E
L
T
Q
G
L
S
N
V
H
K
K
R
V
S
A
A
R
L
L
S
R
Q
NLQSPKSSR
S
T
I
F
V
R
L
HTNGSQELQYQPGDHLGVFPG
N
H
E
D
L
V
N
A
L
I
E
RLEDAPPVN
Q
M
V
K
V
E
L
LEERNT
A
L
G
V
ISNWTDELRLP
P
C
T
I
F
Q
A
F
K
Y
Y
L
DITTPPT
P
L
Q
L
Q
Q
F
A
S
L
AT
S
E
K
E
K
Q
R
L
L
V
L
S
K
G
L
Q
E
Y
E
E
WKWGKN
P
T
I
V
E
V
L
E
EFPSIQM
P
A
T
L
L
L
T
Q
L
S
LLQ
P
R
Y
YSISSSPDMYPD
E
V
H
L
T
V
A
I
V
S
Y
RTRDGEGP
I
H
H
G
V
C
S
S
W
L
N
R
I
Q
A
D
E
L
V
P
C
F
VRGAPSFHLPRNPQV
P
C
I
L
VGPGTG
I
A
P
F
R
S
F
W
Q
Q
R
QF
D
I
QHKGMNPC
P
M
V
L
V
FGCRQS
K
I
D
H
I
Y
R
E
E
T
LQAKN
K
G
V
F
R
E
L
Y
T
A
YSREPD
K
P
K
K
Y
V
Q
D
I
L
Q
E
Q
L
A
E
S
V
Y
R
A
L
K
EQG
G
H
I
Y
V
CG
D
V
T
M
A
A
D
V
L
K
A
I
Q
R
I
M
T
QQGKLSA
E
D
A
G
V
F
I
S
R
MRDDN
R
Y
H
E
DI
F
G
V
T
L
R
T
Y
E
V
T
N
R
LRS
E
S
I
A
F
I
E
ESKK
D
T
D
E
VFSS
55
PsiBlast_CBE
67.78
96%
-96
- C4 -
4JSE
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
S
-------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
67.55
96%
-93
- C4 -
4LUX
4
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
67.52
96%
-95
- C4 -
4KCL
5
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
67.47
96%
-94
- C4 -
4IMU
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
67.39
96%
-95
- C4 -
4JSF
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
67.30
96%
-92
- C4 -
4IMW
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.29
96%
-94
- C4 -
4KCO
4
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.25
96%
-95
- C4 -
3HSN
9
NOS1_RAT
A:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
67.24
96%
-94
- C4 -
4K5F
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.18
96%
-91
- C4 -
4K5F
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.17
96%
-92
- C4 -
4JSF
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
67.16
96%
-92
- C4 -
4KCO
5
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
67.14
96%
-93
- C4 -
4K5G
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
67.09
96%
-94
- C4 -
4KCN
6
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
67.08
96%
-93
- C4 -
4IMU
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
67.06
96%
-92
- C4 -
4KCN
8
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.04
96%
-93
- C4 -
4K5G
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
67.02
97%
-94
- C4 -
4FVY
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.96
96%
-92
- C4 -
3HSP
7
NOS1_RAT
A:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
S
----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
66.95
96%
-91
- C4 -
4JSJ
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
66.95
96%
-92
- C4 -
4KCL
5
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
66.94
96%
-92
- C4 -
4JSI
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.94
96%
-91
- C4 -
3HSO
5
NOS1_RAT
A:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.93
96%
-93
- C4 -
3JT4
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
66.88
96%
-88
- C4 -
4JSH
4
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
S
Q
H
T
R
K
-
P
-
E
D
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.84
96%
-95
- C4 -
3JT9
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.83
96%
-93
- C4 -
4KCH
5
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.82
96%
-92
- C4 -
4LUX
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.76
96%
-94
- C4 -
1OM4
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
66.72
96%
-90
- C4 -
4KCI
5
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
66.66
96%
-92
- C4 -
4JSJ
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
66.63
96%
-92
- C4 -
4KCK
5
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
66.59
96%
-90
- C4 -
4K5D
4
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
66.59
96%
-93
- C4 -
4KCM
5
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.59
96%
-93
- C4 -
3JTA
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
66.54
96%
-93
- C4 -
4KCK
5
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
66.53
96%
-92
- C4 -
4KCM
5
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.52
96%
-92
- C4 -
3JT3
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.48
96%
-93
- C4 -
3JT5
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
66.47
96%
-91
- C4 -
4JSE
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
S
----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.47
96%
-91
- C4 -
3JT6
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.46
96%
-92
- C4 -
3JT7
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.45
96%
-94
- C4 -
3JT8
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.43
96%
-92
- C4 -
3B3M
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
66.37
96%
-89
- C4 -
4IMT
5
NOS1_RAT
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
66.31
96%
-90
- C4 -
4KCJ
5
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.30
96%
-91
- C4 -
3B3O
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.28
96%
-92
- C4 -
3N2R
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
66.12
96%
-90
- C4 -
4KCH
5
?
B:
[3-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
66.09
96%
-94
- C4 -
4JSI
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
66.08
96%
-91
- C4 -
4K5D
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
66.06
96%
-90
- C4 -
4KCJ
5
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.06
96%
-92
- C4 -
2HX4
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
65.89
96%
-89
- C4 -
4KCI
4
?
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.87
96%
-87
- C4 -
4JSH
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
S
Q
H
T
R
K
-
P
-
E
D
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.79
96%
-92
- C4 -
3B3N
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.78
96%
-91
- C4 -
2HX3
4
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.68
96%
-90
- C4 -
3B3P
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
-----------
V
R
-
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
65.59
96%
-90
- C4 -
4IMW
5
NOS1_RAT
A:
[3-420]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
K
V
K
N
W
E
T
D
V
V
L
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
E
H
I
C
M
G
S
I
M
L
P
--------------
T
K
D
Q
L
F
P
L
A
K
E
F
L
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
A
H
M
D
R
L
E
E
V
N
K
E
I
E
S
T
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
N
A
S
R
C
V
G
R
I
Q
W
S
K
L
Q
V
F
D
A
R
D
C
T
T
A
H
G
M
F
N
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
R
S
A
I
T
I
F
P
Q
R
T
D
G
K
H
D
F
R
V
W
N
S
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
L
G
D
P
A
N
V
Q
F
T
E
I
C
I
Q
Q
G
W
K
A
P
R
G
R
F
D
V
L
P
L
L
L
Q
A
-
N
G
N
D
P
E
L
F
Q
I
P
P
E
L
V
L
E
V
P
I
R
H
P
K
F
D
W
F
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
C
P
F
S
G
W
Y
M
G
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
K
K
M
D
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
V
E
I
N
I
A
V
L
Y
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
A
D
W
V
W
I
V
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
W
N
T
H
V
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
60.93
67%
-83
- C4 -
1NSE
6
NOS3_BOVIN
A:
[29-444]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
-
P
S
P
G
P
P
-
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
-
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
60.55
65%
-80
- C4 -
1D0C
7
NOS3_BOVIN
A:
[29-444]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
-
P
S
P
G
P
P
-
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
-
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
60.46
67%
-81
- C4 -
1ED5
6
NOS3_BOVIN
A:
[29-444]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
-
P
S
P
G
P
P
-
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
-
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
60.27
63%
-83
- C4 -
3E7M
5
NOS2_MOUSE
A:
[12-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
R
I
K
N
W
G
S
G
E
I
L
H
D
T
L
H
H
K
A
T
S
D
F
T
C
-----
L
G
S
I
M
N
P
K
S
L
T
R
G
P
R
-
D
K
P
T
-
P
L
E
E
L
L
P
H
A
I
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F
I
N
Q
Y
Y
G
S
F
K
E
A
K
I
E
E
H
L
A
R
L
E
A
V
T
K
E
I
E
T
T
G
T
Y
Q
L
T
L
D
E
L
I
F
A
T
K
M
A
W
R
N
A
P
R
C
I
G
R
I
Q
W
S
N
L
Q
V
F
D
A
R
N
C
S
T
A
Q
E
M
F
Q
H
I
C
R
H
I
L
Y
A
T
N
N
G
N
I
R
S
A
I
T
V
F
P
Q
R
S
D
G
K
H
D
F
R
L
W
N
S
Q
L
I
R
Y
A
G
Y
Q
M
P
D
G
T
I
R
G
D
A
A
T
L
E
F
T
Q
L
C
I
D
L
G
W
K
P
R
Y
G
R
F
D
V
L
P
L
V
L
Q
A
-
D
G
Q
D
P
E
V
F
E
I
P
P
D
L
V
L
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M
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H
P
K
Y
E
W
F
Q
E
L
G
L
K
W
Y
A
L
P
A
V
A
N
M
L
L
E
V
G
G
L
E
F
P
A
C
P
F
N
G
W
Y
M
G
T
E
I
G
V
R
D
F
C
D
T
Q
R
Y
N
I
L
E
E
V
G
R
R
M
G
L
E
T
H
T
L
A
S
L
W
K
D
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A
V
T
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I
N
V
A
V
L
H
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F
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K
Q
N
V
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M
D
H
H
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A
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E
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M
Q
N
E
Y
R
A
R
G
G
C
P
A
D
W
I
W
L
V
P
P
V
S
G
S
I
T
P
V
F
H
Q
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M
L
N
Y
V
L
S
P
F
Y
Y
Y
Q
I
E
P
W
K
T
H
I
W
Q
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
51.97
46%
-90
* C4 *
2FLQ
2
?
A:
[10-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
H
D
E
Q
L
M
T
K
A
E
Q
F
I
I
A
S
Y
R
E
L
G
K
S
E
Q
-
E
I
K
R
R
V
N
E
I
R
W
E
V
E
Q
T
G
T
Y
R
H
T
Y
E
E
L
S
Y
G
A
K
M
A
W
R
H
S
N
R
C
I
G
R
L
F
W
Q
S
L
H
V
I
D
A
R
E
A
V
T
E
E
E
V
F
S
Y
L
F
H
H
I
E
V
A
T
N
G
G
K
I
R
P
T
I
T
I
F
R
P
N
G
----
E
V
R
I
W
N
H
Q
L
I
R
Y
A
G
Y
E
T
E
E
G
-
I
I
G
D
S
S
S
L
T
F
T
R
A
C
E
Q
L
G
W
K
G
E
K
T
P
F
D
V
L
P
L
V
I
Q
V
-
G
G
Q
K
P
V
W
T
P
I
P
K
E
L
V
L
E
V
P
I
E
H
P
E
F
P
W
F
R
D
L
Q
L
K
W
Y
A
V
P
I
I
S
D
M
C
L
E
I
G
G
I
R
Y
M
A
A
P
F
N
G
W
Y
M
G
T
E
I
G
A
R
N
F
A
D
D
Y
R
Y
N
M
L
P
K
V
A
S
C
M
G
L
D
T
N
S
N
A
S
L
W
K
D
K
A
L
V
E
L
N
I
A
V
L
Y
S
Y
K
K
A
G
V
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I
V
D
H
H
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A
A
R
Q
F
Q
L
F
E
Q
Q
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A
A
G
R
H
V
T
G
D
W
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W
L
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P
P
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Y
D
N
T
M
M
L
P
N
F
F
Y
Q
D
R
P
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
50.77
43%
-86
- C4 -
1M7V
3
NOSO_BACSU
A:
[6-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
W
N
E
A
K
A
F
I
A
E
C
Y
Q
E
L
G
K
--
E
E
E
V
K
D
R
L
D
S
I
K
S
E
I
D
R
T
G
S
Y
V
H
T
K
E
E
L
E
H
G
A
K
M
A
W
R
N
S
N
R
C
I
G
R
L
F
W
N
S
L
N
V
I
D
R
R
D
V
R
T
K
E
D
V
R
D
A
L
F
H
H
I
E
T
A
T
N
N
G
K
I
R
P
S
I
T
I
F
P
P
E
E
K
G
E
K
Q
V
E
I
W
N
H
Q
L
I
R
Y
A
G
Y
E
--
G
E
-
R
I
G
D
P
A
S
R
S
L
T
A
A
C
E
Q
L
G
W
R
G
E
R
T
D
F
D
L
L
P
L
I
F
R
M
R
G
D
E
Q
P
V
W
Y
E
L
P
R
S
L
V
I
E
V
P
I
T
H
P
D
I
E
A
F
S
D
L
E
L
K
W
Y
G
V
P
I
I
S
D
M
K
L
E
V
G
G
I
H
Y
N
A
A
P
F
N
G
W
Y
M
G
T
E
I
G
A
R
N
L
A
D
E
K
R
Y
D
K
L
K
K
V
A
S
V
I
G
I
S
T
N
Y
N
T
D
L
W
K
D
Q
A
L
V
E
L
N
K
A
V
L
Y
S
Y
K
K
Q
G
V
S
I
V
D
H
H
T
A
A
S
Q
F
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R
F
E
E
Q
E
E
E
A
G
R
K
L
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G
D
W
T
W
L
I
P
P
I
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A
A
T
H
I
F
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R
S
Y
D
N
S
I
V
K
P
N
Y
F
Y
Q
D
K
P
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
47.49
42%
-85
- C4 -
1MJT
5
NOSO_STAAU
A:
[2-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
F
K
E
A
Q
A
F
I
E
N
M
Y
K
E
C
H
Y
E
T
Q
I
I
N
-
K
R
L
H
D
I
E
L
E
I
K
E
T
G
T
Y
T
H
T
E
E
E
L
I
Y
G
A
K
M
A
W
R
N
S
N
R
C
I
G
R
L
F
W
D
S
L
N
V
I
D
A
R
D
V
T
D
E
A
S
F
L
S
S
I
T
Y
H
I
T
Q
A
T
N
E
G
K
L
K
P
Y
I
T
I
Y
A
P
K
D
G
----
P
K
I
F
N
N
Q
L
I
R
Y
A
G
Y
D
N
-----
C
G
D
P
A
E
K
E
V
T
R
L
A
N
H
L
G
W
K
G
K
G
T
N
F
D
V
L
P
L
I
Y
Q
L
-
P
N
E
S
V
K
F
Y
E
Y
P
T
S
L
I
K
E
V
P
I
E
H
N
H
Y
P
K
L
R
K
L
N
L
K
W
Y
A
V
P
I
I
S
N
M
D
L
K
I
G
G
I
V
Y
P
T
A
P
F
N
G
W
Y
M
V
T
E
I
G
V
R
N
F
I
D
D
Y
R
Y
N
L
L
E
K
V
A
D
A
F
E
F
D
T
L
K
N
N
S
F
N
K
D
R
A
L
V
E
L
N
Y
A
V
Y
H
S
F
K
K
E
G
V
S
I
V
D
H
L
T
A
A
K
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F
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L
F
E
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N
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A
Q
Q
G
R
Q
V
T
G
K
W
S
W
L
A
P
P
L
S
P
T
L
T
S
N
Y
H
H
G
Y
D
N
T
V
K
D
P
N
F
F
Y
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------