@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00613_PK3CG_: (2014-09-12 )
MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA
Atome Classification :
(7 SA)
.........10........20........30...-------.....40........50........60........70........80........90...-.....100.......110.......120.......130.......140.......150.......160.......170.......180.......190.------......200....-...210.......220....--...230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.-......410.......420.......430.......440.......450.......460.......470.......480.....-..490.......500.......510.......520..-.....530.......----540.......-550.......560.......570.......580..-.....590.......600.......610.......620.......630.......640.......650.......660.......670..-------------------.....680.......690.......700...-------....710....----...720...--....730.......740.......750.......760.......770.......--780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.....--..900.......910.......920---........930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040....--..1050......1060......1070......1080......1090......1100
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELENYKQ
P
V
V
L
RED
N
C
R
R
R
RRMK
P
R
S
A
AASLSS-------
M
E
L
I
P
I
E
F
V
LPTSQRKCKSPE
T
A
L
L
H
V
AGHG
N
V
E
Q
M
K
A
Q
V
W
L
R
A
L
E
T
S
V
A
A
D
F
Y
H
RLGP
H
-
H
F
L
L
L
Y
QKKG
Q
W
Y
E
I
Y
D
K
Y
Q
V
V
Q
T
L
D
C
L
R
Y
W
K
A
THRSP
G
Q
I
H
L
V
QRHPP
S
E
E
S
Q
A
F
Q
R
Q
L
T
A
L
IGYDVTDVSNVHD
D
E
L
E
F
T
RRGLVT
P
R
M
A
E
V
ASRDP------
K
L
Y
A
MHPWVTSKP-
L
P
E
Y
L
W
K
K
IANN
C
I
F
I
V
I
HR--STTS
Q
T
I
K
VSPDDT
P
G
A
I
L
Q
S
F
F
T
K
M
AKK
K
S
L
MDIPESQSEQD
F
V
L
R
VCGRD
E
Y
LVGETPIK
N
F
Q
W
V
R
H
C
LKNG
E
E
I
H
V
V
L
DTPPDP
A
L
D
E
V
R
K
EEWPLVDDCTGVT
G
Y
H
E
Q
L
T
I
HGKDH
E
S
V
F
T
V
S
LWDCD
R
K
F
R
V
K
I
RGIDIPVLPRNT
D
L
T
V
F
V
E
ANIQ
H
G
Q
Q
V
L
C
QRRTSPK
P
-
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
KDLPK
G
A
L
L
N
L
Q
I
Y
CGKAPALSSKASAESPSSESK
G
K
V
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
RRG
E
Y
V
L
H
M
W
Q
I-SGKGEDQGSFN
A
D
KLTSATNPDKEN
S
M
S
I
S
I
L
LDNYC-HPIALPKHQPTPDPE----GD
R
V
R
A
EM
P
N
-
Q
L
R
K
Q
L
E
A
I
IATDPLNPLTAE
D
K
E
L
L
W
H
F
R
Y
E
SLK-HP
K
A
Y
P
K
L
F
S
S
VKW
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
R
R
E
VW
D
Q
SALDVG
L
T
M
Q
L
L
DCNFSDEN
V
R
A
I
A
V
Q
K
L
E
SLED
D
D
V
L
H
Y
L
L
Q
L
V
Q
AVKFEPY
H
D
-------------------
S
A
L
A
R
F
L
L
K
RGLRNK
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
----
L
E
A
Y
L
R
GC
G
--
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
SLSAEKYD
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
QNSQL--
P
E
SFRVPYDPGLK
A
G
A
L
A
I
E
K
C
K
V
M
ASKKK
P
L
W
L
E
F
KCADPTALSNE
T
I
G
I
I
F
KHG
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
WETESL
D
L
C
LLPYGCISTGDKI
G
M
I
E
I
VKD
A
T
T
I
A
K
I
Q
Q
STVG--NTGA
F
K
D
E
V
L
N
H
W
L
KEKSP
T
E
E
K
F
----
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
GIGDRHND
N
I
M
I
TETG
N
L
F
H
I
D
F
G
H
I
LG
N
Y
K
S
F
LGINKERV
P
F
V
LTPD
F
L
F
V
MGTSGKKTS
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
HHT
N
L
L
I
I
L
F
S
M
M
L
MTGMPQLT
S
K
E
D
--
I
E
Y
I
R
D
A
L
TVGK
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
RDKG
W
T
V
Q
F
N
W
F
L
H
L
V
L
GIKQGEKHSA
2
PsiBlast_PDB
98.82
100%
-125
- C2 -
4FJY
1
PK3CG_HUMAN
A:
[2-946]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
E
S
Q
A
F
Q
R
Q
L
T
A
L
I
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
E
F
T
R
R
G
L
V
T
P
R
M
A
E
V
A
S
R
D
P
------
K
L
Y
A
M
H
P
W
V
T
S
K
P
-
L
P
E
Y
L
W
K
K
I
A
N
N
C
I
F
I
V
I
H
R
--
S
T
T
S
Q
T
I
K
V
S
P
D
D
T
P
G
A
I
L
Q
S
F
--------------------
D
F
V
L
R
V
C
G
R
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
V
R
H
C
L
K
N
G
E
E
I
H
V
V
L
D
T
P
P
D
P
A
L
D
E
V
R
K
E
-----------------------------
T
V
S
L
W
D
C
D
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
----
D
L
T
V
F
V
E
A
N
I
Q
H
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
-
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
G
--------------------
K
V
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
-
S
-------
S
F
N
A
D
K
L
T
S
A
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
----
P
I
A
L
P
K
H
Q
-------------
V
R
A
E
M
P
N
-
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
-
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
----
L
E
A
Y
L
R
G
C
G
--
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
A
E
--
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
L
--
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
--
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
F
----
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
E
D
--
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
--------------
3
PsiBlast_PDB
98.10
100%
-128
- C2 -
4FAD
1
PK3CG_HUMAN
A:
[2-951]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
E
S
Q
A
F
Q
R
Q
L
T
A
L
I
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
E
F
T
R
R
G
L
V
T
P
R
M
A
E
V
A
S
R
D
P
------
K
L
Y
A
M
H
P
W
V
T
S
K
P
-
L
P
E
Y
L
W
K
K
I
A
N
N
C
I
F
I
V
I
H
R
--
S
T
T
S
Q
T
I
K
V
S
P
D
D
T
P
G
A
I
L
Q
S
F
F
T
K
M
A
K
--------------
D
F
V
L
R
V
C
G
R
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
V
R
H
C
L
K
N
G
E
E
I
H
V
V
L
D
T
P
P
D
P
A
L
D
E
V
R
K
E
E
------------------------------
S
L
W
D
C
D
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
-----
L
T
V
F
V
E
A
N
I
Q
H
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
-
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
----------------------
V
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
-
S
G
-------
F
N
A
D
K
L
T
S
A
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
-----
I
A
L
P
-----------------
R
A
E
M
P
N
-
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
-
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
----
L
E
A
Y
L
R
G
C
G
--
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
------
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
L
--
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
--
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
F
----
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
G
N
Y
----------
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
E
D
--
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
G
---------
1
PsiBlast_PDB
98.02
100%
-128
- C2 -
3QK0
1
PK3CG_HUMAN
A:
[5-950]
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
A
F
Q
R
Q
L
T
A
L
I
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
E
F
T
R
R
G
L
V
T
P
R
M
A
E
V
A
S
R
D
P
------
K
L
Y
A
M
H
P
W
V
T
S
K
P
-
L
P
E
Y
L
W
K
K
I
A
N
N
C
I
F
I
V
I
H
R
--
S
T
T
S
Q
T
I
K
V
S
P
D
D
T
P
G
A
I
L
Q
S
F
--------------------
D
F
V
L
R
V
C
G
R
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
V
R
H
C
L
K
N
G
E
E
I
H
V
V
L
D
T
P
P
D
P
A
L
D
E
V
R
K
------------------------------------
C
D
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
-----
L
T
V
F
V
E
A
N
I
Q
H
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
-
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
G
--------------------
K
V
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
-
S
-------
S
F
N
A
D
K
L
T
S
A
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
---------------------------
A
E
M
P
N
-
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
-
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
----
L
E
A
Y
L
R
G
C
G
--
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
----
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
L
--
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
--
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
F
----
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
E
D
--
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
----------
8
Fugue
97.86
94%
-124
- C2 -
1E8X
1
PK3CG_PIG
A:
[1-951]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
E
E
T
L
A
F
Q
R
Q
L
N
A
L
I
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
E
F
T
R
R
R
L
V
T
P
R
M
A
E
V
A
G
R
D
P
------
K
L
Y
A
M
H
P
W
V
T
S
K
P
-
L
P
E
Y
L
L
K
K
I
T
N
N
C
V
F
I
V
I
H
R
--
S
T
T
S
Q
T
I
K
V
S
A
D
D
T
P
G
T
I
L
Q
S
F
F
T
K
M
A
------------
N
E
R
D
F
V
L
R
V
C
G
R
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
V
R
Q
C
L
K
N
G
E
E
I
H
L
V
L
D
T
P
P
D
P
A
L
D
E
V
R
K
E
C
-----------------------------------
D
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
P
R
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
-
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
-----------------------
Q
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
H
G
E
Y
V
L
H
M
W
Q
L
-
S
G
F
-------
N
A
D
K
L
T
S
A
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
H
P
-
I
A
L
----------------------
E
M
P
N
-
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
-
D
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
----
L
E
A
Y
L
R
G
C
G
--
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
D
M
L
Q
K
V
T
I
D
I
K
S
L
S
A
E
K
Y
D
V
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
L
N
L
--
P
Q
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
V
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
--
N
T
G
A
F
K
D
E
V
L
S
H
W
L
K
E
K
C
P
I
E
E
K
F
----
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
T
G
N
L
F
H
I
D
F
G
H
V
---------------
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
L
H
F
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
E
D
--
I
E
Y
I
R
D
A
L
T
V
G
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
----------
4
PsiBlast_PDB
97.40
99%
-126
- C2 -
3ML8
1
PK3CG_HUMAN
A:
[2-951]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
E
S
Q
A
F
Q
R
Q
L
T
A
L
I
G
Y
D
V
T
D
V
S
N
V
H
D
D
E
L
E
F
T
R
R
G
L
V
T
P
R
M
A
E
V
A
S
R
D
P
------
K
L
Y
A
M
H
P
W
V
T
S
K
P
-
L
P
E
Y
L
W
K
K
I
A
N
N
C
I
F
I
V
I
H
R
--
S
T
T
S
Q
T
I
K
V
S
P
D
D
T
P
G
A
I
L
Q
S
F
F
T
------------------
D
F
V
L
R
V
C
G
R
D
E
Y
L
V
G
E
T
P
I
K
N
F
Q
W
V
R
H
C
L
K
N
G
E
E
I
H
V
V
L
D
T
P
P
D
P
A
L
D
E
V
R
K
E
E
----------------------------
T
V
S
L
W
D
C
D
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
-----
L
T
V
F
V
E
A
N
I
Q
H
G
Q
Q
V
L
C
Q
R
R
T
S
P
K
P
-
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
------------------------
L
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
-
S
G
------
S
F
N
A
D
K
L
T
S
A
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
-
H
P
I
A
L
P
K
----------------
R
A
E
M
P
N
-
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
-
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
----
L
E
A
Y
L
R
G
C
G
--
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
------
S
S
Q
V
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
Q
L
--
P
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
--
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
F
----
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
G
N
Y
--------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
E
D
--
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
L
V
L
G
---------
18
HHSearch
78.32
33%
-101
- C2 -
2Y3A
1
PK3CB_MOUSE
A:
[41-1085]
---------------------------------
A
VDSQ
I
A
S
D
G
A
I
S
V
D
F
L
L
P
T
G
I
Y
-------
I
Q
L
E
V
P
R
E
A
T
I
S
Y
I
K
Q
M
L
W
K
Q
V
H
N
Y
P
M
F
---
N
L
L
M
D
I
D
S
Y
M
F
A
C
V
N
Q
T
A
V
Y
E
E
L
E
D
E
T
R
R
L
C
D
V
R
P
F
L
P
---------
V
L
K
L
V
T
R
S
C
-
D
P
A
E
K
L
-
D
S
K
I
G
V
L
I
G
K
G
L
H
E
F
D
A
L
K
D
P
E
V
N
E
F
R
R
K
M
R
K
F
S
E
A
K
I
Q
S
L
V
G
LSW
I
D
W
L
K
H
T
Y
P
P
E
H
E
P
S
V
L
E
N
L
--
E
D
K
L
Y
G
G
K
L
V
V
A
V
H
F
EN
S
Q
D
V
F
S
F
Q
V
S
P
N
L
N
P
I
K
I
N
E
L
A
I
Q
K
R
L
T
----------
A
S
P
C
D
Y
V
L
Q
V
S
G
R
V
E
Y
V
F
G
D
H
P
L
I
Q
F
Q
Y
I
R
N
C
V
M
N
R
T
L
P
H
F
I
L
V
E
C
C
K
I
K
K
M
Y
E
Q
E
---
M
I
A
I
E
A
A
I
----------------------
I
W
D
N
N
N
P
F
Q
I
T
L
V
K
G
N
K
L
N
T
E
E
--
T
V
K
V
H
V
R
A
G
L
F
H
G
T
E
L
L
C
K
T
V
V
S
S
E
I
S
G
K
N
D
H
I
W
N
E
Q
L
E
F
D
I
N
I
C
D
L
P
R
M
A
R
L
C
F
A
V
Y
A
V
------------------------
V
A
W
V
N
T
M
V
F
D
F
K
G
Q
L
R
S
G
D
V
I
L
H
S
W
S
S
F
P
D
E
L
E
E
---
M
L
N
P
M
G
T
V
Q
T
N
P
Y
A
E
N
A
T
A
L
H
I
T
F
P
E
N
K
K
Q
P
C
Y
Y
P
P
F
D
K
I
I
E
K
A
A
E
L
A--------
G
K
-
K
F
L
A
V
L
K
E
I
L
D
R
D
P
L
S
Q
L
C
E
N
E
M
D
L
I
W
T
L
R
Q
D
C
R
E
N
F
P
Q
S
L
P
K
L
L
L
S
I
K
W
N
K
L
E
D
V
A
Q
L
Q
A
L
L
Q
I
---
W
--
P
K
L
P
P
R
E
A
L
E
L
L
D
F
N
Y
P
D
Q
Y
V
R
E
Y
A
V
G
C
L
R
Q
M
S
D
E
E
L
S
Q
Y
L
L
Q
L
V
Q
V
L
K
Y
E
P
F
L
D
-------------------
C
A
L
S
R
F
L
L
E
R
A
L
D
N
R
R
I
G
Q
F
L
F
W
H
L
R
S
E
V
-
H
-------
T
P
A
V
S
V
Q
F
G
V
I
----
L
E
A
Y
C
R
G
S
V
--
G
H
M
-
K
V
L
S
K
Q
V
E
A
L
N
K
L
K
T
L
N
S
L
I
K
L
N
A
V
--
K
L
S
R
A
K
G
K
E
A
M
H
T
C
L
K
Q
S
A
Y
R
E
A
--
L
S
D
L
Q
S
P
L
N
P
C
V
I
L
S
E
L
Y
V
E
K
C
K
Y
M
D
S
K
M
K
P
L
W
L
V
Y
S
S
R
A
F
---
G
E
D
S
V
G
V
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
L
R
L
M
D
L
L
W
K
E
A
G
L
D
L
R
M
L
P
Y
G
C
L
A
T
G
D
R
S
G
L
I
E
V
V
S
T
S
E
T
I
A
D
I
Q
L
N
S
S
N
VA
A
T
A
A
F
N
K
D
A
L
L
N
W
L
K
E
Y
N
S
G
D
-
D
L
----
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
S
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
V
K
K
T
G
Q
L
F
H
I
D
F
G
H
I
L
G
N
F
K
S
K
F
G
I
K
R
E
R
V
P
F
I
L
T
Y
D
F
I
H
V
I
Q
Q
G
K
T
G
N
T
E
K
F
G
R
F
R
Q
C
C
E
D
A
Y
L
I
L
R
R
H
G
N
L
F
I
T
L
F
A
L
M
L
T
A
G
L
P
E
L
T
S
V
K
D
--
I
Q
Y
L
K
D
S
L
A
L
G
K
S
E
E
E
A
L
K
Q
F
K
Q
K
F
D
E
A
L
R
E
S
W
T
T
K
V
N
W
M
A
H
T
------------
23
HHSearch
56.82
32%
-118
- C2 -
3LS8
2
PK3C3_HUMAN
A:
[22-606]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
N
A
A
T
R
D
Q
L
N
I
I
V
S
Y
P
P
T
K
Q
L
T
Y
E
E
Q
D
L
V
W
K
F
R
Y
Y
L
T
N
-
Q
E
K
A
L
T
K
F
L
K
C
V
N
W
D
L
P
Q
E
A
K
Q
A
L
E
L
L
G
K
---
W
--
K
P
M
D
V
E
D
S
L
E
L
L
S
S
H
Y
T
N
P
T
V
R
R
Y
A
V
A
R
L
R
Q
A
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
L
K
Y
E
N
F
D
D
I
K
N
G
LIDSSQIIT
S
P
L
P
SE
Q
D
L
C
T
F
L
I
S
R
A
C
K
N
S
T
L
A
N
Y
L
Y
W
Y
V
I
V
E
C
-
E
D
Q
D
T
Q
Q
R
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
S
Q
A
L
L
K
G
D
K
S
V
R
V
M
R
S
L
L
A
A
Q
Q
T
F
V
D
R
L
V
H
L
M
K
A
V
Q
R
E
S
G
N
R
---
K
K
-
K
N
E
R
L
Q
A
L
L
G
D
N
E
K
M
N
L
SD
V
E
L
I
P
L
P
L
E
P
Q
V
K
I
R
G
I
I
P
E
T
A
T
L
F
K
S
A
L
M
P
A
Q
L
F
F
K
T
E
D
G
-----
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
-
S
V
P
V
A
E
V
L
D
T
E
G
-----------
S
I
Q
N
F
F
R
K
Y
A
P
S
E
N
G
P
NGIS
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
T
G
K
L
F
H
I
D
F
G
Y
I
L
G
R
D
P
-----
K
P
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
---
G
T
Q
S
E
Q
Y
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
N
I
P
D
I
A
L
E
P
D
K
T
V
K
K
V
Q
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
H
-
A
L
F
---------------------