@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00615_ARBK1_: (2014-09-12 )
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
Atome Classification :
(18 SA)
.........10........20........30--.........40.--.......50.......-.60........70........80........90........100......---.110.....-..-120.......130.......140.......150.......160.......170.......180.......190.......200.......210---.......220.......230.......240.......250.......260.......270.......280-...----....--..290.......300.......310.......320.......330.......340--.--.--...-.-.350.......360.......370.......380.......390.....-..400........410.......420.......430.......440-........450.......460.......470.......480.......490.-...-..--------.500-------........510-........520..-.....530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
D
L
E
A
V
L
A
D
V
S
Y
L
M
A
M
E
KSKATPAARAS
K
---
K
I
LLP
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
DRGE
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
KLE
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A-CSHPFSKS
A
T
E
H
V
Q
G
HLGKKQV
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
SDKF
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
MNDF
S
V
H
R
I
IGRGGFGEVYGCRKAD---TG
K
M
Y
A
M
K
C
L
D
K
K
R
I
KMKQG
E
T
L
ALN
E
R
I
M
L
S
L
VSTGDC
P
F
I
V
C
M
S
Y
AFHT
P
D
K
L
S
F
I
L
D
LMNGG
D
L
H
---
Y
H
L
----
S
QHG--VF
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
MHN
R
F
V
V
Y
R
DLK
P
A
N
I
L
LDEHG
H
V
R
I
S
D
L
G
L
ACDF--S--K--KKP-H-ASVGTHGYM
A
P
E
V
L
Q
K
GVAYDSSA
D
W
F
S
L
G
C
M
L
F
K
L
L
RGHS
P
F
R
QHKTK-
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
ELPDSF
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
CL-G-R
G
A
Q
E
V
K
ESPFFRSLD
W
Q
M
V
F
L
QKYPPPLIPPRGEVNAADAFDIGSFDEEDT-K
G
I
-
K
L--------LDS--------
D
Q
E
L
Y
R
NFP-L-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
TINA
E
T
D
R
L
E
A
R
K
KAKNKQLGHEEDYAL
G
K
D
C
I
M
H
G
Y
M
S
KMG
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
LFPN
R
L
E
WRGEGEA
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
IKER
K
C
L
L
L
K
IRGG
K
Q
F
I
L
QCDSD
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
MKNKPRSP
V
V
ELSKV
P
L
V
QRGSANGL
1
PsiBlast_PDB
98.81
100%
-108
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-670]
-----------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A
---
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
--
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
--
K
--
K
K
P
-
H
-
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
-
K
G
I
-
K
L
--------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
------------------
2
PsiBlast_PDB
98.58
100%
-106
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-670]
-----------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A
---
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
--
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
--
K
--
K
K
P
-
H
-
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
D
T
-
K
G
I
-
K
L
--------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
------------------
11
PsiBlast_PDB
98.53
100%
-107
- C1 -
4MK0
2
?
A:
[1-639]
-----------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
---
F
D
S
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
--
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
--
K
--
K
K
P
-
H
-
A
S
V
G
T
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Y
M
A
P
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L
Q
K
G
V
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D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------
T
-
K
G
I
-
K
L
--------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
9
PsiBlast_PDB
97.60
98%
-111
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-668]
-----------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
---
F
D
T
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
--
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
--
K
--
K
K
P
-
H
-
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------------------
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
10
PsiBlast_PDB
97.22
98%
-109
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-668]
----------------------------
S
K
---
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
---
F
D
T
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
--
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
--
K
--
K
K
P
-
H
-
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-----------------------
K
L
--------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
---------------------
7
PsiBlast_PDB
90.40
98%
-109
- C1 -
3UZT
1
ARBK1_BOVIN
A:
[30-656]
-----------------------------
K
---
K
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
---
F
D
T
Y
I
M
K
E
L
-
L
A
-
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
---
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
H
G
--
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
--
S
--
K
--
K
K
P
-
H
-
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
-------------
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
-
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------
D
T
-
K
G
I
-
K
L
--------
L
D
S
--------
D
Q
E
L
Y
R
N
F
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
------
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
---------------------------------
21
Fugue
60.73
38%
-90
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------
K
A
R
K
G
K
S
K
K
W
R
Q
---
M
L
Q
F
P
H
I
S
Q
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
----
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
---
T
Q
N
F
L
S
H
T
G
-
P
D
-
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
---
F
H
I
----
Y
H
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
--
P
--
E
--
G
Q
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
-
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
-----------------------------
P
T
--------
D
Q
D
F
Y
Q
K
F
A
T
G
-
S
V
P
I
P
W
Q
N
E
M
V
E
T
----------------------------------------------------------
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
----------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.61
34%
-97
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-529]
--------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
---------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
--
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
--
Q
--
T
K
T
-
K
-
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
------
G
V
-
A
F
--------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.48
34%
-97
- C1 -
3C4W
1
RK_BOVIN
A:
[31-529]
--------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
------
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
VD
E
D
N
P
--
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
--
Q
--
T
K
T
-
K
-
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
T
--
V
-
K
G
V
-
A
F
--------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
58.83
34%
-94
- C1 -
3C4X
1
RK_BOVIN
A:
[30-529]
-------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
------
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
Y
N
VD
E
D
N
P
--
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
--
Q
--
T
K
T
-
K
-
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
T
--
V
-
K
G
V
-
A
F
--------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.94
34%
-94
- C1 -
3C51
1
RK_BOVIN
A:
[31-529]
--------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
D
----
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
---
R
A
A
Y
L
E
P
Q
A
Q
L
F
-
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
---------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
N
P
--
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
--
Q
--
T
K
T
-
K
-
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
-
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
T
--
V
-
K
G
V
-
A
F
--------
E
K
A
--------
D
T
E
F
F
Q
E
F
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
40.48
32%
-98
- C1 -
4DC2
2
KPCI_MOUSE
A:
[49-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
--
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
Q
R
--
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
--
L
--
R
PG
D
T
T
-
S
-
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
-
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
-N
T
E
D
-
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
-----
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-
Q
L
--------
T
P
D
D
D
D
I
V
R
KI
D
Q
S
E
F
E
G
F
E
-
Y
-
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
37.97
36%
-104
- C1 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
--
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
C
H
--
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
--
M
--
L
GD
A
K
T
-
N
-
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
----
D
E
E
-
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
------
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
----------------------------------------------------
Q
N
M
F
R
N
F
S
-
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
37.41
33%
-102
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
--
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
---
F
H
I
----
Q
K
S
R
--
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
--
I
C-------------
G
T
P
D
Y
I
A
P
E
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
----
N
E
D
-
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
P
D
F
I
-
K
E
E
P
V
L
TPIDEGHL
P
M
I
--------
N
Q
D
E
F
R
N
F
E
-
Y
-
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
34.94
39%
-101
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
E
R
--
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
--
I
E
H
N
--
S
T
T
-
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
----
N
T
A
-
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
-----
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
33.13
40%
-99
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
-
V
------
D
I
L
V
E
V
---
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
E
V
--
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--------E-
K
K
A
-
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
-
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
24.29
38%
9
- C1 -
3NYN
2
GRK6_HUMAN
A:
[4-526]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
K
S
K
K
W
--
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
----
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
---
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
--
P
--
E
--
G
Q
T
I
K
-
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
-
E
L
--------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
23.59
38%
9
- C1 -
3NYO
2
GRK6_HUMAN
A:
[4-526]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
K
S
K
K
W
--
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
----
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
-
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
---
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
G
Q
A
G
---
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
--
P
--
E
--
G
Q
T
I
K
-
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
-
K
G
V
-
E
L
--------
E
P
T
--------
D
Q
D
F
Y
Q
K
F
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------