@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00648_CAN2_H: (2014-09-13 )
MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
Atome Classification :
(13 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310......-.-320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
G
I
A
A
K
L
A
K
D
R
E
A
A
E
GLG
S
H
D
R
A
I
K
Y
L
N
Q
D
Y
E
A
L
R
N
E
C
L
EAGTLFQDPSFPAIPSALG
F
K
ELGPYSSKTRGIEWKRPTEICADP
Q
F
I
IGGA
T
R
T
D
I
C
QG
A
L
G
D
C
W
L
L
A
A
I
A
S
LTL
N
E
E
I
L
A
R
VVPLN
Q
S
F
Q
E
NY
A
G
I
F
H
F
Q
F
WQYG
E
W
V
E
V
V
VDDRLPTKDG
E
L
L
F
V
HSAE
G
S
E
F
W
S
A
L
L
E
K
A
Y
A
K
I
N
G
C
Y
E
A
LSGGATTE
G
F
E
D
F
T
G
G
I
A
E
W
Y
ELKKPP
P
N
L
F
K
I
I
Q
K
A
L
QKGS
L
L
G
C
S
I
D
ITSAADSE
A
I
T
F
Q
K
L
VKGHAYSVT
G
A
E
E
VESNG
S
L
Q
K
L
I
R
IRNPWGE
V
E
W
TGRWNDNCPSWNTI
D
P
E
E
R
E
R
L
T
R
R-H-EDG
E
F
W
M
S
F
S
D
F
L
R
H
Y
S
R
L
E
I
CNLTPDTLTSDTY
K
K
W
K
L
TKMDGNWRRGSTAGGCRNYPN
T
F
WM
N
P
Q
Y
L
I
K
LEEEDEDEEDGE
S
G
C
T
F
L
V
G
L
I
Q
K
H
R
R
R
Q
R
K
MGEDM
H
T
I
G
F
G
I
Y
E
V
P
E
E
LSGQ
T
N
I
H
L
SK
N
F
F
L
TNRARERSD
T
F
I
N
L
R
E
V
L
N
R
FKLPPG
E
Y
I
L
VPSTFEPNKDG
D
F
C
I
R
V
F
S
EKKADYQAV
D
D
E
I
E
A
N
L
E
EFDISE
D
D
I
D
D
G
F
R
R
L
F
A
Q
LAGEDAE
I
S
A
F
E
L
Q
T
I
L
R
R
V
L
A
K
R
QDIKSDG
F
S
I
E
T
C
K
I
M
V
D
M
LDSDGSGKL
G
L
K
E
F
Y
I
L
W
T
K
I
Q
K
Y
Q
K
I
Y
R
E
IDVDRSGTM
N
S
Y
E
M
R
K
A
L
E
EAGFKM
P
C
Q
L
H
Q
V
I
V
A
RFAD
D
Q
L
I
I
D
F
D
N
F
V
R
C
L
V
R
L
E
T
L
F
K
I
F
K
Q
LDPENT
G
T
I
E
L
D
L
I
S
W
L
C
F
SVL
10
PsiBlast_PDB
52.49
70%
-90
- C2 -
2NQG
1
CAN1_RAT
A:
[8-329]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
52.44
71%
-92
- C2 -
2ARY
2
CAN1_HUMAN
B:
[24-345]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
Q
L
R
V
R
C
L
Q
S
G
T
L
F
R
D
E
A
F
P
P
V
P
Q
S
L
G
Y
K
D
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
D
T
L
L
H
R
V
V
P
H
G
Q
S
F
Q
N
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
I
K
D
G
K
L
V
F
V
H
S
A
E
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
S
T
S
E
G
F
E
D
F
T
G
G
V
T
E
W
Y
E
L
R
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
D
I
S
S
V
L
D
M
E
A
I
T
F
K
K
L
V
K
G
H
A
Y
S
V
T
G
A
K
Q
V
N
Y
R
G
Q
V
V
S
L
I
R
M
R
N
P
W
G
E
V
E
W
T
G
A
W
S
D
S
S
S
E
W
N
N
V
D
P
Y
E
R
D
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
M
R
E
F
T
R
L
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
52.33
70%
-88
- C2 -
2R9F
3
CAN1_RAT
A:
[8-329]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
52.17
74%
-93
- C2 -
2NQA
2
CAN2_HUMAN
A:
[3-322]
----------------------
N
A
L
K
Y
L
G
Q
D
F
K
T
L
R
Q
Q
C
L
D
S
G
V
L
F
K
D
P
E
F
P
A
C
P
S
A
L
G
Y
---------
T
Q
G
I
I
W
K
R
P
T
E
L
C
P
S
P
Q
F
I
V
G
G
A
T
R
T
D
I
C
Q
G
G
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
E
L
L
Y
R
V
V
P
R
D
Q
D
F
Q
E
N
Y
A
G
I
F
H
F
Q
F
W
Q
Y
G
E
W
V
E
V
V
I
D
D
R
L
P
T
K
N
G
Q
L
L
F
L
H
S
E
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
L
N
G
C
Y
E
A
L
A
G
G
S
T
V
E
G
F
E
D
F
T
G
G
I
S
E
F
Y
D
L
K
K
P
P
A
N
L
Y
Q
I
I
R
K
A
L
C
A
G
S
L
L
G
C
S
I
D
V
Y
S
A
A
E
A
E
A
I
T
S
Q
K
L
V
K
S
H
A
Y
S
V
T
G
V
E
E
V
N
F
Q
G
H
P
E
K
L
I
R
L
R
N
P
W
G
E
-
E
W
S
G
A
W
S
D
D
A
P
E
W
N
H
I
D
P
R
R
K
E
E
L
D
K
K
-
V
-
E
D
G
E
F
W
M
S
L
S
D
F
V
R
Q
F
S
R
L
E
I
C
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
52.16
70%
-87
- C2 -
1TLO
1
CAN1_RAT
A:
[8-329]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
52.03
70%
-87
- C2 -
2NQI
1
CAN1_RAT
A:
[8-329]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.99
70%
-88
- C2 -
2R9C
3
CAN1_RAT
A:
[8-329]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
51.94
70%
-84
- C2 -
2G8E
2
CAN1_RAT
A:
[8-331]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
51.88
70%
-86
- C2 -
2G8J
1
CAN1_RAT
A:
[8-329]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
51.62
71%
-87
- C2 -
1ZCM
1
CAN1_HUMAN
A:
[2-321]
-----------------------
A
I
K
Y
L
G
Q
D
Y
E
Q
L
R
V
R
C
L
Q
S
G
T
L
F
R
D
E
A
F
P
P
V
P
Q
S
L
G
Y
K
D
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
D
T
L
L
H
R
V
V
P
H
G
Q
S
F
Q
N
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
I
K
D
G
K
L
V
F
V
H
S
A
E
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
S
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
E
L
R
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
D
I
S
S
V
L
D
M
E
A
I
T
F
K
K
L
V
K
G
H
A
Y
S
V
T
G
A
K
Q
V
N
Y
R
G
Q
V
V
S
L
I
R
M
R
N
P
W
G
E
V
E
W
T
G
A
W
S
D
S
S
S
E
W
N
N
V
D
P
Y
E
R
D
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
M
R
E
F
T
R
L
E
I
C
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.49
70%
-83
- C2 -
1TL9
1
CAN1_RAT
A:
[8-328]
----------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
R
V
K
-
M
-
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
47.95
58%
-78
- C2 -
2P0R
2
CAN9_HUMAN
A:
[13-330]
----------------------
R
I
T
H
S
S
G
Q
S
F
E
Q
M
R
Q
E
C
L
Q
R
G
T
L
F
E
D
A
D
F
P
A
S
N
S
S
L
F
Y
S
E
-----
R
P
Q
I
P
F
V
W
K
R
P
G
E
I
V
K
N
P
E
F
I
L
G
G
A
T
R
T
D
I
C
Q
G
E
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
Q
K
A
L
A
R
V
I
P
Q
D
Q
S
F
G
P
G
Y
A
G
I
F
H
F
Q
F
W
Q
H
S
E
W
L
D
V
V
I
D
D
R
L
P
T
F
R
D
R
L
V
F
L
H
S
A
D
H
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
L
N
G
S
Y
E
A
L
K
G
G
S
A
I
E
A
M
E
D
F
T
G
G
V
A
E
T
F
Q
T
K
E
A
P
E
N
F
Y
E
I
L
E
K
A
L
K
R
G
S
L
L
G
C
F
I
D
T
R
S
A
A
E
S
E
A
R
T
P
F
G
L
I
K
G
H
A
Y
S
V
T
G
I
D
Q
V
S
F
R
G
Q
R
I
E
L
I
R
I
R
N
P
W
G
Q
V
E
W
N
G
S
W
S
D
S
S
P
E
W
R
S
V
G
P
A
E
Q
K
R
L
C
H
T
-
A
L
D
D
G
E
F
W
M
A
F
K
D
F
K
A
H
F
D
K
V
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
46.82
59%
-92
- C2 -
1ZIV
2
CAN9_HUMAN
A:
[20-329]
------------------------------
S
F
E
Q
M
R
Q
E
C
L
Q
R
G
T
L
F
E
D
A
D
F
P
A
S
N
S
S
L
F
Y
S
--
P
Q
I
P
-----
F
V
W
K
R
P
G
E
I
V
K
N
P
E
F
I
L
G
G
A
T
R
T
D
I
C
Q
G
E
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
Q
K
A
L
A
R
V
I
P
Q
D
Q
S
F
G
P
G
Y
A
G
I
F
H
F
Q
F
W
Q
H
S
E
W
L
D
V
V
I
D
D
R
L
P
T
F
R
D
R
L
V
F
L
H
S
A
D
H
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
L
N
G
S
Y
E
A
L
K
G
G
S
A
I
E
A
M
E
D
F
T
G
G
V
A
E
T
F
Q
T
K
E
A
P
E
N
F
Y
E
I
L
E
K
A
L
K
R
G
S
L
L
G
C
F
I
D
T
R
S
A
A
E
S
E
A
R
T
P
F
G
L
I
K
G
H
A
Y
S
V
T
G
I
D
Q
V
S
F
R
G
Q
R
I
E
L
I
R
I
R
N
P
W
G
Q
V
E
W
N
G
S
W
S
D
S
S
P
E
W
R
S
V
G
P
A
E
Q
K
R
L
C
H
T
A
L
-
D
D
G
E
F
W
M
A
F
K
D
F
K
A
H
F
D
K
V
E
I
C
N
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------