@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00659_PLK2_H: (2014-09-14 )
MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQRCN
Atome Classification :
(19 SA)
.........10........20........30........40........50........60......-..70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190......-.200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.-----......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
L
L
R
T
ITYQPAA
S
T
K
M
C
E
Q
A
L
GKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGP-
E
I
S
R
I
I
VDPTTGK
R
Y
CRGKVLGKGGF
A
K
C
Y
E
M
TDLTNN
K
V
Y
A
A
K
IIPHSRVAK
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
FEDKE
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
VLT
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
LK
L
G
N
F
F
I
NE
A
M
E
LKVGDF
G
L
A
A
R
L
E
P
L
E
H
R
R
R
TICGTPNYL
S
P
E
V
L
NKQGHGC
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
LGRPPFETT
N
L
K
E
T
Y
R
C
I
R
E
A
RYTM
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
SKNPEDRP-----
S
L
D
D
I
I
R
H
D
F
F
LQGF
T
P
D
R
LSSSCCHTVPDFHLS
S
P
A
K
N
F
F
K
K
A
A
A
A
L
FGGKKDK
A
R
Y
IDTHNRVSKE
D
E
D
I
Y
K
L
R
H
D
L
K
K
TSITQQPSKHRTDEELQPPTTTVARSGTPAVE
N
K
Q
Q
I
G
D
A
I
R
M
I
V
R
GTLGSCS
S
S
S
E
CLEDSTM
G
S
V
A
D
T
V
A
R
V
L
R
G
C
L
ENMPEADCI
P
K
E
Q
L
S
T
S
F
Q
W
V
T
K
W
VDYSNKYG
F
G
Y
QLSD
H
T
V
G
V
L
FNNGA
H
M
SLLPDK
K
T
V
H
Y
Y
A
ELGQCSVFPATD
A
P
E
Q
F
I
S
Q
V
T
V
L
K
Y
F
S
H
Y
M
E
E
NLMDGGDLPS
V
T
DIR
R
P
R
L
Y
L
L
Q
W
L
KSD
K
A
L
M
M
L
FND
G
T
F
Q
V
N
F
Y
HD
H
T
K
I
I
I
CSQNE
E
Y
L
L
T
Y
INEDRIS
T
T
F
R
L
T
T
L
L
M
S
G
C
S
S
E
L
K
N
R
M
E
Y
A
L
N
M
L
L
Q
RCN
2
PsiBlast_PDB
90.37
97%
-115
- C1 -
4I6B
1
PLK2_HUMAN
A:
[19-303]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
89.13
98%
-115
- C1 -
4I5P
1
PLK2_HUMAN
A:
[19-302]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.02
97%
-114
- C1 -
4I6F
1
PLK2_HUMAN
A:
[19-303]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.10
97%
-115
- C1 -
4I6H
1
PLK2_HUMAN
A:
[19-303]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.05
97%
-117
- C1 -
4I5M
1
PLK2_HUMAN
A:
[19-302]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
-----------
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
-----
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
80.26
50%
-115
- C1 -
2RKU
6
PLK1_HUMAN
A:
[5-293]
----------------------------------------------------------------------
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
-----
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
78.72
49%
-118
- C1 -
2OWB
1
PLK1_HUMAN
A:
[31-320]
----------------------------------------------------------------------
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
-----
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.69
50%
-117
- C1 -
3DB6
1
?
A:
[14-299]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.43
48%
-114
- C1 -
3D5W
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
--
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
78.24
68%
-109
- C1 -
4B6L
1
PLK3_HUMAN
A:
[1-281]
------------------------------------------------------------------------
L
I
T
D
P
R
S
G
R
T
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
R
H
T
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
-
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
N
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
R
Q
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
E
T
A
D
L
K
E
T
Y
R
C
I
K
Q
V
H
Y
T
L
P
A
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
-----
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.88
50%
-116
- C1 -
2YAC
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
-----
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.13
50%
-114
- C1 -
4A4L
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
-----
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.89
50%
-118
- C1 -
3D5X
1
?
A:
[14-298]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
-------
I
A
P
E
V
L
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.08
50%
-116
- C1 -
3DBE
1
?
A:
[14-299]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
L
---
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.61
48%
-126
- C1 -
3DBD
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
--------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.79
50%
-127
- C1 -
3DBF
1
?
A:
[14-299]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
--------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.40
48%
-125
- C1 -
3DBC
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
--------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.79
48%
-125
- C1 -
3DB8
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
--------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
-----
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
54.23
30%
-102
* C1 *
4GV1
5
AKT1_HUMAN
A:
[5-272]
-----------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
-
A
G
I
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------