@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00787_P3C2A_: (2014-09-16 )
MAQISSNSGFKECPSSHPEPTRAKDVDKEEALQMEAEALAKLQKDRQVTDNQRGFELSSSTRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKLLLDDSFETKKTPVLPVTPILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPSTYSKQAAFQNGFNPRMPTFPSTEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPVVSTDMAKLFDKIASTSEFLKNGKARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPLSKPKVDNVEVLDHEEEKNVSSLLAKDPWDAVLLEERSTANCHLERKVNGKSLSVATVTRSQSLNIRTTQLAKAQGHISQKDPNGTSSLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENASVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCKEAMTRHPVEELLDSYHNQVELALQIENQHRAVDQVIKAVRKICSALDGVETLAITESVKKLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHANSGRSPTDCAQSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKETVKWYQLTAATYL
Atome Classification :
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760....-...770.......780.......790---.........800.......810.......820....----------...830.......840.-......850.......860.......870.......880.......890.......900.......910.......920-.......930.---.--.....940.......950.......960.......970.......980.......-------------------990.......1000......1010.....-.-------1020......1030.....------.1040......1050......1060......----1070--.--.....1080..-...-.1090......1100......1110......1120......1130.........1140......1150......1160......1170......1180......1190......-1200......1210......1220.-.---....1230......1240......1250......1260......1270......1280......1290......1300.......1310......1320......1330......1340.....--.1350......1360......1370......1380.-.....1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAQISSNSGFKECPSSHPEPTRAKDV
D
K
E
E
A
L
Q
M
E
A
E
A
L
A
K
L
Q
K
DRQVTDNQRGFELSSST
R
K
K
A
Q
VYNKQDY
D
L
M
V
FPESDSQK
R
A
L
DI
D
V
E
K
L
T
Q
A
E
L
E
K
L
LLDDSFETKKTPVLPVTPILSPSF
S
A
Q
L
Y
F
R
PTIQRGQWPPGLPGPSTYALPSIYPSTYS
K
Q
A
A
FQNGFNPRMPTFPSTE
P
I
Y
L
SLPGQSP
Y
F
SYPLTPATPFHPQGSL
P
I
YRPVVS
T
D
M
A
K
L
F
D
K
I
A
S
T
S
E
F
L
KNGKART
D
L
E
ITDSKVS
N
L
Q
VSPKSEDISKFDWLDLDPLSKPKVDN
V
E
VLD
H
E
E
EK
N
V
S
S
L
L
AKDPWD
A
V
L
L
EERSTA
N
C
H
L
E
R
KVNGK
S
L
S
V
A
T
V
TRSQSLN
I
R
T
T
Q
L
A
K
AQGHISQKDPNGTSSLP
T
G
S
S
L
L
Q
E
V
EVQ
N
E
E
M
A
A
F
C
R
S
I
T
K
L
KTKFPYTNHRTNPG
Y
L
LSP
V
T
A
Q
RNICGEN
A
S
V
K
V
S
I
D
IE
G
F
Q
L
P
V
T
F
TCDVS
S
T
V
E
I
I
I
M
Q
A
L
C
W
V
HDDLNQV
D
V
G
S
Y
V
L
K
VC
G
Q
E
E
V
L
QNNHCLGS
H
E
H
I
Q
N
C
R
KW
D
T
E
I
R
L
Q
L
L
T
F
S
A
M
C
Q
N
L
A
R
TAEDDETPV
D
L
N
K
H
L
Y
Q
I
E
K
P
C
K
E
A
M
T
RH
P
V
E
E
L
L
D
S
YHN
Q
V
E
L
A
L
Q
IE
N
Q
H
R
A
V
D
Q
V
I
K
A
V
R
K
I
C
S
A
LDGV
E
T
L
A
I
T
E
S
V
K
K
L
K
R
A
VNLPRSKTA
D
V
T
S
LFGGEDTSRSSTRGSLNPEN
P
V
Q
V
S
I
N
Q
L
T
A
A
I
Y
D
L
L
R
L
HANSGRSP
T
D
C
A
Q
S
S
K
S
V
K
E
A
WTTT
E
Q
L
Q
F
T
I
F
A
AHGIS
S
N
W
V
SNY
E
K
Y
Y
L
I
C
SLSHN
G
K
D
L
F
K
P
I
Q
SKKVGTY
K
N
F
F
Y
L
I
K
WD
E
L
I
I
F
P
I
QISQL
P
L
E
S
V
L
H
L
T
L
F
G
-
I
LNQSSGSSPDSNKQRK
G
P
E
A
LGK-----VSL
P
L
F
D
F
K
R
F
L
T
CG
T
K
L
L
Y
L
W
TSSHTNSVPGTVTK----------KG
Y
V
M
E
R
I
V
L
Q
VDFPSP-
A
F
D
I
I
Y
TTPQV
D
R
S
I
I
Q
QH
N
L
E
T
L
E
N
D
I
K
G
K
L
L
D
I
LHKDSSLGLSKE
D
K
A
F
L
W
EK
R
Y
Y
C
FKHP
N
C
L
P
K
I
LASAPN
W
K
W
V
-
N
L
A
K
T
Y
S
L
L
H
Q---W--P
A
L
Y
P
L
I
A
L
E
L
L
D
S
K
F
A
D
Q
E
V
R
S
L
A
V
T
W
I
E
AISD
D
E
L
T
D
L
L
P
Q
F
V
Q
A
L
K
Y
E
I
Y
L
N
-------------------
S
S
L
V
Q
F
L
L
S
RALG
N
I
Q
I
A
H
N
L
Y
W
L
L
K
D
A
L
-
H
-------
D
V
Q
F
S
T
R
Y
E
H
V
L
G
A
L
L
S
V
G
------
G
K
R
L
R
E
E
L
L
K
Q
T
K
L
V
Q
L
L
G
G
V
A
E
K
V
R
Q
ASG
S
----
A
R
Q
V
--
V
--
L
Q
R
S
M
E
R
V
Q
S
F
-
F
Q
K-NKCRLPLKP
S
L
V
A
KELNI
K
S
C
S
FFSSNA
V
P
L
K
V
T
M
VNADPMG---E
E
I
N
V
M
F
KV
G
E
D
L
R
Q
D
M
L
A
L
Q
M
I
K
I
M
D
K
I
W
L
K
EGL
D
L
R
M
V
I
F
K
C
L
STGRDRG
M
V
E
L
VPASD
T
L
R
K
I
Q
V
E
-YGVTGSFKDK
P
L
A
E
W
L
R
KYNP
S
E
E
E
-
Y
---
E
K
A
S
E
N
F
I
Y
S
C
A
G
C
C
V
A
T
Y
V
L
G
I
CDRHND
N
I
M
L
RSTG
H
M
F
H
I
D
F
G
K
F
L
G
H
A
Q
M
F
G
S
FKRDRA
P
F
V
L
TSD
M
A
Y
V
IN-GGEK
P
T
I
R
F
Q
L
F
V
D
L
C
C
Q
A
Y
N
L
I
R
K
Q
T
N
L
F
L
N
L
L
S
L
MIPSGLP
E
L
T
S
I
--
Q
D
L
K
Y
V
R
D
ALQPQTTDA
E
A
T
I
F
F
T
R
L
I
E
S
S
L
G
S
I
A
T
-
K
F
N
F
F
I
H
N
L
A
Q
L
R
FSGLPSNDE
P
I
L
S
FSPKT
Y
S
FRQDG
R
I
K
E
V
S
V
F
T
Y
HKKYNPDK
H
Y
I
Y
V
V
R
I
L
REGQI
E
P
S
F
V
F
R
T
F
D
E
F
Q
E
L
H
N
K
L
S
I
I
F
P
L
W
KLPGFPN
R
M
V
LG
R
T
H
I
K
D
V
A
A
KRK
I
E
L
N
S
Y
L
Q
S
L
M
NAST
D
V
A
E
C
D
L
V
C
T
F
F
H
P
L
L
R
D
E
K
AEGIARSADAGSFSPTPGQIG
G
A
V
K
L
S
I
S
YRN
G
T
L
F
I
M
V
M
H
I
K
D
L
V
TEDGADPNP
Y
V
K
T
Y
LLPDNHKT
S
K
R
K
T
KISRKTRNPTFN
E
M
L
V
YSGY
S
K
E
T
L
R
Q
R
E
L
Q
L
S
VL
S
A
E
S
L
R
EN
F
F
LG
G
V
T
L
PLKDFNLSK
E
T
V
K
W
Y
Q
L
T
AATYL
7
PsiBlast_PDB
85.55
35%
-106
- C1 -
3PRZ
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
-------------------
V
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
H
P
I
A
L
P
-------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
------
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
G
N
Y
--------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.49
35%
-106
- C1 -
3PS6
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
-------------------
V
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
--
P
I
A
L
P
-------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
------
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
G
N
Y
--------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.15
35%
-104
- C1 -
3QJZ
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
-------------------
V
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
---------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
------------------------
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
--DV--
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
----
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
----
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
-------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
---
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.91
35%
-104
- C1 -
4FA6
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
-------------------
V
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
H
P
-----------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
A
E
KYDV
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
-------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.02
35%
-108
- C1 -
4FAD
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
-------------------
V
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
----I
A
L
P
-------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
------
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
G
N
Y
----------
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.86
35%
-107
- C1 -
3L08
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
G------------------
V
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
------
S
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
------I
A
L
P
K
H
Q
----------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
REV
W
DQ
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
---DV--
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
---
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
-----
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
G
-----------
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.85
35%
-106
- C1 -
3QK0
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
G-----------------
K
V
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
-------
S
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
----------------------
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
--DV--
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.45
35%
-108
- C1 -
1E8W
1
PK3CG_PIG
A:
[261-948]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
---
C
G
---------------------QL
L
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
H
G
E
Y
V
L
H
M
W
Q
L
S
--------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
H
P
I
A
L
P
K
H
-------------
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
D
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
D
M
L
Q
K
V
T
I
D
I
K
S
L
S
A
E
KYDV
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
L
-
N
L
P
-
Q
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
V
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
S
H
W
L
K
E
K
C
P
I
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
T
G
N
L
F
H
I
D
F
G
------------
N
K
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
L
H
F
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.31
35%
-102
- C1 -
3LJ3
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
-------------------
V
R
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
-------
S
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
----------------------
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
---V---
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
-
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
-----------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.13
35%
-105
- C1 -
1E8X
1
PK3CG_PIG
A:
[261-948]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
---
C
----------------------QLL
Y
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
H
G
E
Y
V
L
H
M
W
Q
L
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
--
H
P
I
A
L
----------------
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
D
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
D
M
L
Q
K
V
T
I
D
I
K
S
L
S
A
E
KYDV
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
L
-
N
L
P
-
Q
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
V
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
S
H
W
L
K
E
K
C
P
I
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
T
G
N
L
F
H
I
D
F
G
H
---------------
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
L
H
F
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
83.03
35%
-106
- C1 -
3ML8
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
---------------------
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
------
S
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
H
P
I
A
L
P
K
------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
------
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
L
S
N
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
L
G
N
Y
--------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.82
35%
-104
- C1 -
3DPD
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
G-------------------
R
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
--------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
H
P
I
A
L
P
K
H
-------------
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
A
E
KYDV
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
------------
N
K
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.61
35%
-105
- C1 -
3R7R
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
---------------------
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
--
H
P
I------------------
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
A
E
K
Y
D
V
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
-------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.56
35%
-100
- C1 -
3TL5
1
PK3CG_HUMAN
A:
[260-947]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
---------------------
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
Y
C
H
P
I
A
L
P
-------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
A
E
KYDV
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
-------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.50
35%
-103
- C1 -
4ANW
1
PK3CG_HUMAN
A:
[264-949]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
--------------------
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
---------------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
A
E
KYDV
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.73
35%
-104
- C1 -
4ANU
1
PK3CG_HUMAN
A:
[264-949]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
F
T
E
E
V
L
W
N
V
W
L
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
--------------------
Q
L
L
Y
Y
-----
V
N
L
L
L
I
D
H
R
F
L
L
R
R
G
E
Y
V
L
H
M
W
Q
I
S
G
-------
F
N
A
DKLTSATNPD
K
E
N
S
M
S
I
S
I
L
L
D
N
---------------------
R
A
E
----
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
H
P
K
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
-
I
V
A
K
T
Y
Q
L
L
A
R
R
E
V
W
D
Q
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
E
N
V
R
A
I
A
V
Q
K
L
E
S
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
F
E
P
Y
H
D
-------------------
S
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
I
G
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
A
Y
L
R
G
C
------
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
V
I
E
M
L
Q
K
V
T
L
D
I
K
S
L
S
A
E
KYDV
S
S
Q
V
--
I
S
Q
L
K
Q
K
L
E
N
L
Q
N
S
-
Q
L
P
-
E
S
F
R
V
P
Y
D
P
G
L
K
A
G
A
L
A
I
E
K
C
K
V
M
A
S
K
K
K
P
L
W
L
E
F
K
C
A
D
P
T
A
LSN
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
E
S
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
D
E
V
L
N
H
W
L
K
E
K
S
P
T
E
E
K
-
F
---
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
T
E
T
G
N
L
F
H
I
D
F
G
H
I
------------
E
R
V
P
F
V
L
T
P
D
F
L
F
V
M
G
T
S
G
K
K
T
S
P
H
F
Q
K
F
Q
D
I
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
T
S
K
--
E
D
I
E
Y
I
R
D
A
L
T
V
G
K
N
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
67.46
31%
-111
- C1 -
3LS8
2
PK3C3_HUMAN
A:
[25-606]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
T
R
D
Q
L
N
I
I
V
S
Y
P
P
T
K
Q
L
T
Y
E
E
Q
D
L
V
W
K
F
R
Y
Y
L
T
N
Q
E
K
A
L
T
K
F
L
K
C
V
-
N
W
D
L
P
Q
E
A
K
Q
A
L
E
L
L
G
K
---
W
--
K
P
M
D
V
E
D
S
L
E
L
L
S
S
H
Y
T
N
P
T
V
R
R
Y
A
V
A
R
L
R
Q
A
D
D
E
D
L
L
M
Y
L
L
Q
L
V
Q
A
L
K
Y
E
N
F
D
D
I
K
N
G
LIDSSQIIT
S
P
L
P
SE
Q
D
L
C
T
F
L
I
S
R
A
C
K
N
S
T
L
A
N
Y
L
Y
W
Y
V
I
V
E
C
-
E
D
Q
D
T
Q
Q
R
D
P
K
T
H
E
M
Y
L
N
V
M
R
R
F
S
Q
A
L
L
K
GD
K
S
V
R
V
M
R
S
L
L
A
A
Q
Q
T
F
V
D
R
L
V
H
L
M
K
A
V
Q
R
E
S
G
N
----
R
K
K
K
N
E
R
--
L
Q
A
L
L
G
D
N
E
K
M
N
L
S
D
V
E
L
I
P
L
P
L
E
P
Q
V
K
I
R
G
I
I
P
E
T
A
T
L
F
K
S
A
L
M
P
A
Q
L
F
F
K
T
E
D
--
G
---
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
E
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
-
S
V
P
V
A
E
V
L
D
T
-
E
G
--------
S
I
Q
N
F
F
R
K
Y
A
P
S
E
N
G
P
N
GIS
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
T
G
K
L
F
H
I
D
F
G
Y
I
L
G
R
D
P
-----
K
P
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
---
G
G
T
Q
S
E
Q
Y
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
N
I
P
D
I
A
L
E
PD
K
T
V
K
K
V
Q
D
K
F
R
L
D
L
S
D
E
E
A
V
H
Y
M
Q
S
L
I
D
E
S
V
H
A
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------