@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00821_PCKGC_: (2014-09-16 )
MPPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPPQLHNGLDF
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
EGNAQLCQP
E
Y
I
H
ICDG
S
E
E
E
Y
G
R
L
L
A
H
M
Q
EE
G
V
I
R
K
L
K
KYDN
C
W
L
A
LTDP
R
D
V
A
RIES
K
T
V
I
I
TQEQRDTVPIPKS
G
Q
S
Q
L
G
R
WM
S
E
E
D
F
E
K
A
F
NARFPGCMKG
R
T
M
Y
V
I
PFSMGPLGS
P
L
A
K
I
G
I
E
LTDSP
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
LGD
G
E
F
I
K
C
L
H
SVGCPLPLKKPLVNNWACNP
E
L
T
L
I
AHLP
D
R
R
E
I
I
SFGSGYGGNSLLG
K
K
C
F
A
L
R
I
A
S
R
L
A
K
EE
G
W
L
A
E
H
M
L
I
L
G
ITNPEGK
K
K
Y
L
A
AAFPSACGKT
N
L
A
M
MNPTLPG
W
K
V
E
C
VGDD
I
A
W
M
K
FDAQG
N
L
R
A
INPEN
G
F
F
GVAPGTSVKTNP
N
A
I
K
T
IQKN
T
I
F
T
NVAETSDG
G
V
Y
WEGIDEPLAPG
V
T
I
TSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPI
E
G
I
I
FGGRRPA
G
V
P
L
V
Y
E
A
LSWQH
G
V
F
V
G
A
AMRSEATAAAEHK
G
K
V
I
MHDPFAMRPFFGY
N
F
G
K
Y
L
A
H
W
L
S
M
AHR
P
A
A
KL
P
K
I
F
H
V
N
W
F
R
KDKNG
K
F
LWPGFGEN
S
R
V
L
E
W
M
F
G
RIEGEDSAKLTPIGYVPKEDALNLKGLGDV
N
V
E
E
L
FG
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
QVNADL
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
SQM
9
PsiBlast_PDB
99.29
100%
-100
- C5 -
2RKE
1
PCKGC_RAT
A:
[6-624]
---
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
-------
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
8
PsiBlast_PDB
99.27
100%
-99
- C5 -
2RKD
1
PCKGC_RAT
A:
[5-624]
--
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
-------
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
10
PsiBlast_PDB
99.26
100%
-95
- C5 -
3DT2
2
PCKGC_RAT
A:
[4-624]
-
P
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
T
A
A
A
E
H
K
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
23
PsiBlast_CBE
99.13
100%
-95
- C5 -
3DT4
1
PCKGC_RAT
C:
[5-624]
--
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
T
A
A
A
E
H
K
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
6
PsiBlast_PDB
99.10
100%
-96
- C5 -
2RK8
3
PCKGC_RAT
A:
[3-624]
M
P
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
T
A
A
A
E
H
K
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
14
PsiBlast_PDB
98.62
99%
-95
- C5 -
3MOF
6
PCKGC_RAT
A:
[3-624]
M
P
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
T
A
G
A
E
H
K
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
11
PsiBlast_PDB
98.60
100%
-96
- C5 -
3DT4
2
PCKGC_RAT
A:
[6-624]
---
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
T
A
A
A
E
H
K
G
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
51
HHSearch
98.51
100%
-99
- C5 -
4GMU
1
PCKGC_RAT
A:
[3-612]
--
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
----------
G
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
31
PsiBlast_CBE
98.43
98%
-102
- C5 -
4GMW
2
PCKGC_RAT
A:
[2-612]
-
P
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
G
----------
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
25
PsiBlast_CBE
98.41
100%
-99
- C5 -
2RK8
2
PCKGC_RAT
B:
[6-624]
---
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
--------
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
28
PsiBlast_CBE
98.33
99%
-99
- C5 -
3MOH
3
PCKGC_RAT
B:
[5-624]
--
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
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P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
T
-------
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
16
PsiBlast_PDB
98.08
98%
-98
- C5 -
4GNO
3
PCKGC_RAT
A:
[2-614]
-
P
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
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H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
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W
K
V
E
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V
G
D
D
I
A
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M
K
F
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N
L
R
A
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E
N
G
F
F
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A
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G
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K
T
N
P
N
A
I
K
T
I
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K
N
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A
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D
G
G
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Y
W
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L
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N
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E
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A
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I
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V
P
I
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G
I
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G
G
R
R
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P
L
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Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
--------
G
G
G
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
30
PsiBlast_CBE
97.96
98%
-99
- C5 -
4GNM
1
PCKGC_RAT
A:
[4-613]
---
Q
L
H
--
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
G
G
---------
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
18
PsiBlast_PDB
97.96
98%
-101
- C5 -
4GNQ
1
PCKGC_RAT
A:
[3-614]
--
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
--------
G
G
G
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
33
PsiBlast_CBE
97.91
98%
-100
- C5 -
4GMM
2
PCKGC_RAT
A:
[3-612]
--
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
G
----------
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
15
PsiBlast_PDB
97.88
99%
-98
- C5 -
3MOH
4
PCKGC_RAT
A:
[14-624]
-----------
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
T
-------
K
V
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
19
PsiBlast_PDB
97.72
98%
-101
- C5 -
4GMZ
2
PCKGC_RAT
A:
[2-613]
-
P
P
Q
L
H
N
G
L
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
G
G
---------
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
17
PsiBlast_PDB
97.72
98%
-99
- C5 -
4GNP
2
PCKGC_RAT
A:
[10-614]
---------
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
--------
G
G
G
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
20
PsiBlast_PDB
97.36
98%
-100
- C5 -
4GNL
2
PCKGC_RAT
A:
[10-613]
---------
D
F
S
A
K
V
I
Q
G
S
L
D
S
L
P
Q
E
V
R
K
F
V
E
G
N
A
Q
L
C
Q
P
E
Y
I
H
I
C
D
G
S
E
E
E
Y
G
R
L
L
A
H
M
Q
E
E
G
V
I
R
K
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
I
T
Q
E
Q
R
D
T
V
P
I
P
K
S
G
Q
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
A
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
S
V
L
E
A
L
G
D
G
E
F
I
K
C
L
H
S
V
G
C
P
L
P
L
K
K
P
L
V
N
N
W
A
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
I
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
I
L
G
I
T
N
P
E
G
K
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
T
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
N
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
P
G
V
T
I
T
S
W
K
N
K
E
W
R
P
Q
D
E
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
P
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
G
G
---------
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
H
R
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
N
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
G
R
I
E
G
E
D
S
A
K
L
T
P
I
G
Y
V
P
K
E
D
A
L
N
L
K
G
L
G
D
V
N
V
E
E
L
F
G
I
S
K
E
F
W
E
K
E
V
E
E
I
D
K
Y
L
E
D
Q
V
N
A
D
L
P
Y
E
I
E
R
E
L
R
A
L
K
Q
R
I
S
Q
M
36
PsiBlast_CBE
95.66
90%
-100
- C5 -
1NHX
4
PCKGC_HUMAN
A:
[13-625]
---------
N
L
S
A
K
V
V
Q
G
S
L
D
S
L
P
Q
A
V
R
E
F
L
E
N
N
A
E
L
C
Q
P
D
H
I
H
I
C
D
G
S
E
E
E
N
G
R
L
L
G
Q
M
E
E
E
G
I
L
R
R
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
V
T
Q
E
Q
R
D
T
V
P
I
P
K
T
G
L
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
S
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
P
V
L
E
A
L
G
D
G
E
F
V
K
C
L
H
S
V
G
C
P
L
P
L
Q
K
P
L
V
N
N
W
P
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
M
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
V
L
G
I
T
N
P
E
G
E
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
S
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
H
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
S
G
V
T
I
T
S
W
K
N
K
E
W
S
S
E
D
G
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
A
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
--------
K
I
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
Q
H
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
E
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
N
R
I
D
G
K
A
S
T
K
L
T
P
I
G
Y
I
P
K
E
D
A
L
N
L
K
G
L
G
H
I
N
M
M
E
L
F
S
I
S
K
E
F
W
D
K
E
V
E
D
I
E
K
Y
L
V
D
Q
V
N
A
D
L
P
C
E
I
E
R
E
I
L
A
L
K
Q
R
I
S
Q
M
37
PsiBlast_CBE
95.58
90%
-99
- C5 -
1M51
3
PCKGC_HUMAN
A:
[13-625]
---------
N
L
S
A
K
V
V
Q
G
S
L
D
S
L
P
Q
A
V
R
E
F
L
E
N
N
A
E
L
C
Q
P
D
H
I
H
I
C
D
G
S
E
E
E
N
G
R
L
L
G
Q
M
E
E
E
G
I
L
R
R
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
V
T
Q
E
Q
R
D
T
V
P
I
P
K
T
G
L
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
--
S
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
P
V
L
E
A
L
G
D
G
E
F
V
K
C
L
H
S
V
G
C
P
L
P
L
Q
K
P
L
V
N
N
W
P
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
M
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
V
L
G
I
T
N
P
E
G
E
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
S
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
H
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
S
G
V
T
I
T
S
W
K
N
K
E
W
S
S
E
D
G
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
A
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
--------
K
I
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
Q
H
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
E
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
N
R
I
D
G
K
A
S
T
K
L
T
P
I
G
Y
I
P
K
E
D
A
L
N
L
K
G
L
G
H
I
N
M
M
E
L
F
S
I
S
K
E
F
W
D
K
E
V
E
D
I
E
K
Y
L
V
D
Q
V
N
A
D
L
P
C
E
I
E
R
E
I
L
A
L
K
Q
R
I
S
Q
M
39
PsiBlast_CBE
95.37
90%
-97
- C5 -
1KHF
3
PCKGC_HUMAN
A:
[13-625]
---------
N
L
S
A
K
V
V
Q
G
S
L
D
S
L
P
Q
A
V
R
E
F
L
E
N
N
A
E
L
C
Q
P
D
H
I
H
I
C
D
G
S
E
E
E
N
G
R
L
L
G
Q
M
E
E
E
G
I
L
R
R
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
V
T
Q
E
Q
R
D
T
V
P
I
P
K
T
G
L
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
S
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
P
V
L
E
A
L
G
D
G
E
F
V
K
C
L
H
S
V
G
C
P
L
P
L
Q
K
P
L
V
N
N
W
P
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
M
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
V
L
G
I
T
N
P
E
G
E
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
S
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
H
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
S
G
V
T
I
T
S
W
K
N
K
E
W
S
S
E
D
G
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
A
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
--------
K
I
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
Q
H
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
E
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
N
R
I
D
G
--
S
T
K
L
T
P
I
G
Y
I
P
K
E
D
A
L
N
L
K
G
L
G
H
I
N
M
M
E
L
F
S
I
S
K
E
F
W
D
K
E
V
E
D
I
E
K
Y
L
V
D
Q
V
N
A
D
L
P
C
E
I
E
R
E
I
L
A
L
K
Q
R
I
S
Q
M
35
PsiBlast_CBE
95.11
90%
-98
- C5 -
2GMV
2
PCKGC_HUMAN
A:
[13-625]
---------
N
L
S
A
K
V
V
Q
G
S
L
D
S
L
P
Q
A
V
R
E
F
L
E
N
N
A
E
L
C
Q
P
D
H
I
H
I
C
D
G
S
E
E
E
N
G
R
L
L
G
Q
M
E
E
E
G
I
L
R
R
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
V
T
Q
E
Q
R
D
T
V
P
I
P
K
T
G
L
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
S
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
P
V
L
E
A
L
G
D
G
E
F
V
K
C
L
H
S
V
G
C
P
L
P
L
Q
K
P
L
V
N
N
W
P
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
M
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
V
L
G
I
T
N
P
E
G
E
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
S
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
H
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
S
G
V
T
I
T
S
W
K
N
K
E
W
S
S
E
D
G
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
A
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
--------
K
I
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
Q
H
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
E
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
N
R
I
D
G
---
T
K
L
T
P
I
G
Y
I
P
K
E
D
A
L
N
L
K
G
L
G
H
I
N
M
M
E
L
F
S
I
S
K
E
F
W
D
K
E
V
E
D
I
E
K
Y
L
V
D
Q
V
N
A
D
L
P
C
E
I
E
R
E
I
L
A
L
K
Q
R
I
S
Q
M
41
Fugue
94.79
90%
-98
- C5 -
1KHB
3
PCKGC_HUMAN
A:
[13-625]
---------
N
L
S
A
K
V
V
Q
G
S
L
D
S
L
P
Q
A
V
R
E
F
L
E
N
N
A
E
L
C
Q
P
D
H
I
H
I
C
D
G
S
E
E
E
N
G
R
L
L
G
Q
M
E
E
E
G
I
L
R
R
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
V
T
Q
E
Q
R
D
T
V
P
I
P
K
T
G
L
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
S
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
P
V
L
E
A
L
G
D
G
E
F
V
K
C
L
H
S
V
G
C
P
L
P
L
Q
K
P
L
V
N
N
W
P
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
M
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
V
L
G
I
T
N
P
E
G
E
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
S
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
H
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
S
G
V
T
I
T
S
W
K
N
K
E
W
S
S
E
D
G
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
A
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
K
--------
I
I
M
H
D
P
F
A
M
R
P
F
F
G
Y
N
F
G
K
Y
L
A
H
W
L
S
M
A
Q
H
P
A
A
K
L
P
K
I
F
H
V
N
W
F
R
K
D
K
E
G
K
F
L
W
P
G
F
G
E
N
S
R
V
L
E
W
M
F
N
R
I
D
G
--
S
T
K
L
T
P
I
G
Y
I
P
K
E
D
A
L
N
L
K
G
L
G
H
I
N
M
M
E
L
F
S
I
S
K
E
F
W
D
K
E
V
E
D
I
E
K
Y
L
V
D
Q
V
N
A
D
L
P
C
E
I
E
R
E
I
L
A
L
K
Q
R
I
S
Q
M
34
PsiBlast_CBE
94.24
90%
-100
- C5 -
2GMV
1
PCKGC_HUMAN
B:
[13-625]
---------
N
L
S
A
K
V
V
Q
G
S
L
D
S
L
P
Q
A
V
R
E
F
L
E
N
N
A
E
L
C
Q
P
D
H
I
H
I
C
D
G
S
E
E
E
N
G
R
L
L
G
Q
M
E
E
E
G
I
L
R
R
L
K
K
Y
D
N
C
W
L
A
L
T
D
P
R
D
V
A
R
I
E
S
K
T
V
I
V
T
Q
E
Q
R
D
T
V
P
I
P
K
T
G
L
S
Q
L
G
R
W
M
S
E
E
D
F
E
K
A
F
N
A
R
F
P
G
C
M
K
G
R
T
M
Y
V
I
P
F
S
M
G
P
L
G
S
P
L
S
K
I
G
I
E
L
T
D
S
P
Y
V
V
A
S
M
R
I
M
T
R
M
G
T
P
V
L
E
A
L
G
D
G
E
F
V
K
C
L
H
S
V
G
C
P
L
P
L
Q
K
P
L
V
N
N
W
P
C
N
P
E
L
T
L
I
A
H
L
P
D
R
R
E
I
I
S
F
G
S
G
Y
G
G
N
S
L
L
G
K
K
C
F
A
L
R
M
A
S
R
L
A
K
E
E
G
W
L
A
E
H
M
L
V
L
G
I
T
N
P
E
G
E
K
K
Y
L
A
A
A
F
P
S
A
C
G
K
T
N
L
A
M
M
N
P
S
L
P
G
W
K
V
E
C
V
G
D
D
I
A
W
M
K
F
D
A
Q
G
H
L
R
A
I
N
P
E
N
G
F
F
G
V
A
P
G
T
S
V
K
T
N
P
N
A
I
K
T
I
Q
K
N
T
I
F
T
N
V
A
E
T
S
D
G
G
V
Y
W
E
G
I
D
E
P
L
A
S
G
V
T
I
T
S
W
K
N
K
E
W
S
S
E
D
G
E
P
C
A
H
P
N
S
R
F
C
T
P
A
S
Q
C
P
I
I
D
A
A
W
E
S
P
E
G
V
P
I
E
G
I
I
F
G
G
R
R
P
A
G
V
P
L
V
Y
E
A
L
S
W
Q
H
G
V
F
V
G
A
A
M
R
S
E
A
--------
K
I
I
M
H
D
P
F
A
M
R
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---
T
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