@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00850_HDAC7_: (2014-09-16 )
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
Atome Classification :
(19 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDLRVGQRPPVEPPPEP
T
L
L
A
LQ
R
P
Q
R
L
H
H
H
L
F
L
A
G
L
Q
Q
QRSVE
P
M
R
LSMDTPMPELQVGP
Q
E
Q
E
L
R
Q
L
L
H
KDK
S
K
R
S
A
V
A
S
S
V
V
K
Q
K
L
A
E
V
I
L
K
K
Q
Q
A
A
L
E
RTVHPNSPGIPYRTLEPLETEG
A
T
R
S
M
L
S
S
FLPPVPSLPSDPPEHFP
L
R
KTVSEP
N
L
K
L
R
YK
P
K
K
S
L
E
R
RKNPLLRKESA
P
P
S
L
RRR
P
A
E
TLGDSSPSSSSTPASGCSSPNDSEHGPNPILG
S
E
A
L
L
G
Q
R
L
R
L
QETSVAPFAL
P
T
V
S
L
L
P
A
I
TLGLPAPARADSDRRTHPTLGPRGPILGSPHT
P
L
F
LPHGLEPEAGGTLPSRL
Q
P
I
L
L
LDPSGSHA
P
L
L
TVPGLGPL
P
F
H
F
A
Q
S
L
M
T
T
ERLSGSGLHWPLSRTRSEPLPPSATAPPPPGP
M
Q
P
R
L
E
Q
L
K
T
H
V
Q
V
I
K
R
SAKPSEKPRLRQIPSAEDLETDGGGPG
Q
V
V
DDGLEHRELGHGQPEARGPAP
L
Q
QHP
Q
V
L
L
W
E
Q
Q
R
L
AGRLPRGSTG
D
T
V
L
L
P
LAQGGHRP
L
S
RAQSSPAAPASLSAPEP
A
S
Q
A
R
VLSSSETPARTLPF
T
T
G
L
I
Y
D
S
V
M
L
K
H
QCSCGDNSRH
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
RG
L
R
S
Q
C
E
C
L
RGRKA
S
L
E
E
L
Q
S
V
H
SE
R
H
V
L
L
Y
GTNPL
S
R
L
KLDN
G
K
L
A
G
L
L
A
QR
M
F
V
M
LPCGGVGV
D
T
D
T
I
W
N
E
L
HSSNAARWAAG
S
V
T
D
L
A
F
K
V
A
S
R
E
L
KN
G
F
A
VVRPPGHHADHSTA
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
QSKA
S
K
I
L
I
V
D
W
D
VHHGNGTQQTFYQDP
S
V
L
Y
I
S
L
H
RHDDGNFFPGSGAVDEVGAGSGE
G
F
N
V
N
V
A
WAGGLDPPMG
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
EFSP
D
L
V
L
V
SAGFDAAEGHPAPLG
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
LAG
G
A
V
V
L
A
LEGGHDL
T
A
ICD
A
S
E
A
C
V
A
A
L
LGNRVDPLSEEGWKQKP
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
A
SC
P
D
S
WVPRVPGA
D
K
E
E
V
E
A
V
T
A
L
A
S
L
S
V
G
I
L
AEDR
P
S
E
Q
L
VEEEEPMNL
3
PsiBlast_PDB
99.21
100%
-105
- C4 -
3C10
1
HDAC7_HUMAN
A:
[35-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
4
PsiBlast_PDB
98.55
100%
-105
- C4 -
3ZNR
1
HDAC7_HUMAN
A:
[36-421]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
2
PsiBlast_PDB
98.48
100%
-105
- C4 -
3C0Z
1
HDAC7_HUMAN
A:
[35-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
24
PsiBlast_CBE
98.26
100%
-106
- C4 -
3C0Z
1
HDAC7_HUMAN
B:
[36-421]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
18
PsiBlast_CBE
98.16
100%
-106
- C4 -
3ZNS
1
HDAC7_HUMAN
B:
[38-420]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
R
L
K
L
D
N
G
K
L
A
G
L
L
A
Q
---
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
----------------------------------------------------
5
PsiBlast_PDB
97.83
100%
-109
- C4 -
3ZNS
1
HDAC7_HUMAN
A:
[36-421]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
22
PsiBlast_CBE
97.32
100%
-106
- C4 -
3C10
1
HDAC7_HUMAN
B:
[36-421]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
F
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
L
S
------------------
V
M
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
R
L
---------------------------------------------------
17
PsiBlast_CBE
97.26
100%
-107
- C4 -
3ZNS
1
C:
[39-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
21
PsiBlast_CBE
96.28
100%
-107
- C4 -
3C10
1
C:
[39-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
23
PsiBlast_CBE
95.74
100%
-105
- C4 -
3C0Z
1
C:
[39-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
L
I
Y
D
S
V
M
L
K
H
Q
C
S
C
G
D
N
S
R
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
R
G
L
R
S
Q
C
E
C
L
R
G
R
K
A
S
L
E
E
L
Q
S
V
H
S
E
R
H
V
L
L
Y
G
T
N
P
----------------------
L
P
C
G
G
V
G
V
D
T
D
T
I
W
N
E
L
H
S
S
N
A
A
R
W
A
A
G
S
V
T
D
L
A
F
K
V
A
S
R
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
D
H
S
T
A
M
G
F
C
F
F
N
S
V
A
I
A
C
R
Q
L
Q
Q
Q
S
K
A
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
T
F
Y
Q
D
P
S
V
L
Y
I
S
L
H
R
H
D
D
G
N
F
F
P
G
S
G
A
V
D
E
V
G
A
G
S
G
E
G
F
N
V
N
V
A
W
A
G
G
L
D
P
P
M
G
D
P
E
Y
L
A
A
F
R
I
V
V
M
P
I
A
R
E
F
S
P
D
L
V
L
V
S
A
G
F
D
A
A
E
G
H
P
A
P
L
G
G
Y
H
V
S
A
K
C
F
G
Y
M
T
Q
Q
L
M
N
L
A
G
G
A
V
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
A
A
L
L
G
N
R
V
D
P
L
S
E
E
G
W
K
Q
K
P
N
L
N
A
I
R
S
L
E
A
V
I
R
V
H
S
K
Y
W
G
C
M
Q
-----------------------------------------------------
6
PsiBlast_PDB
92.29
72%
-101
- C4 -
2VQJ
2
A:
[8-407]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
N
R
Q
K
L
D
S
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
----------------------------------
7
PsiBlast_PDB
91.28
72%
-104
- C4 -
2VQM
1
A:
[8-407]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
-------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
N
R
Q
----
K
K
L
L
G
S
L
A
S
-
V
F
V
R
L
P
C
G
G
V
G
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
N
E
----------------------------------
9
PsiBlast_PDB
90.35
71%
-99
- C4 -
2VQO
2
HDAC4_HUMAN
A:
[8-405]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
------------
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
31
PsiBlast_CBE
90.30
71%
-100
- C4 -
2VQO
2
B:
[8-405]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
27
PsiBlast_CBE
90.28
71%
-99
- C4 -
2VQQ
2
B:
[8-405]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
--------------
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
-----------------------------
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
8
PsiBlast_PDB
90.03
71%
-97
- C4 -
2VQQ
2
HDAC4_HUMAN
A:
[8-405]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
-----------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
----------------------------
V
D
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
30
PsiBlast_CBE
89.44
71%
-101
- C4 -
2VQV
2
B:
[8-405]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
-------------
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
A
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
-------------------------------
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
Y
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
E
L
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
R
T
T
S
T
A
G
R
S
L
I
E
A
Q
T
C
E
------------------------------------
29
PsiBlast_CBE
89.34
75%
-102
- C4 -
4CBT
1
HDAC4_HUMAN
B:
[8-388]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
-------------------------------
S
D
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
S
V
S
K
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
Q
A
F
Y
S
D
P
S
V
L
Y
M
S
L
H
R
Y
D
D
G
N
F
F
P
G
S
G
A
P
D
E
V
G
T
G
P
G
V
G
F
N
V
N
M
A
F
T
G
G
L
D
P
P
M
G
D
A
E
Y
L
A
A
F
R
T
V
V
M
P
I
A
S
E
F
A
P
D
V
V
L
V
S
S
G
F
D
A
V
E
G
H
P
T
P
L
G
G
Y
N
L
S
A
R
C
F
G
Y
L
T
K
Q
L
M
G
L
A
G
G
R
I
V
L
A
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
A
C
V
S
A
L
L
G
N
--
D
P
L
P
E
K
V
L
Q
Q
R
P
N
A
N
A
V
R
S
M
E
K
V
M
E
I
H
S
K
Y
W
R
C
L
Q
-----------------------------------------------------
28
PsiBlast_CBE
87.98
75%
-102
- C4 -
4CBT
1
C:
[8-389]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
G
L
V
Y
D
T
L
M
L
K
H
Q
C
T
C
----
S
H
P
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
T
G
L
R
G
K
C
E
C
I
R
G
R
K
A
T
L
E
E
L
Q
T
V
H
S
E
A
H
T
L
L
Y
G
T
N
P
L
--------------------------------
T
I
W
N
E
V
H
S
A
G
A
A
R
L
A
V
G
C
V
V
E
L
V
F
K
V
A
T
G
E
L
K
N
G
F
A
V
V
R
P
P
G
H
H
A
E
E
S
T
P
M
G
F
C
Y
F
N
S
V
A
V
A
A
K
L
L
Q
Q
R
L
--
S
K
I
L
I
V
D
W
D
V
H
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A
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Y
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Y
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D
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M
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G
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A
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Y
L
A
A
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I
A
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A
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V
V
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A
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K
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G
N
E
------
K
V
L
Q
Q
R
P
N
A
N
A
V
R
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M
E
K
V
M
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I
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Y
W
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C
L
Q
R
----------------------------------------------------