@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00856_EHMT1_: (2014-09-17 )
MAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDG
T
N
T
L
T
R
I
A
ENGVSER
D
S
E
A
AKQNHV
T
A
D
D
F
V
Q
T
S
V
IGSN
G
Y
I
LNKPALQAQPL
R
T
T
S
T
L
A
S
SLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGAD
V
K
V
H
R
A
RKTM
P
K
S
V
V
G
L
HAASK
D
P
R
E
V
R
E
A
RDHK
E
P
K
E
E
I
N
K
N
I
S
D
F
G
R
QQLLPPF
P
S
L
H
Q
SLPQN
Q
C
Y
M
A
TTKSQT
A
C
L
P
F
V
L
A
A
A
V
S
R
K
K
K
RRMGTYSLVP
K
K
K
T
K
V
L
K
Q
R
T
V
I
E
M
F
K
S
I
T
H
S
TVGSKGEKDLGAS
S
L
H
VNGESLEMDSDED
D
S
E
E
L
EEDDGHGAEQAAAFPTEDSRT
S
K
E
S
M
S
E
A
D
R
A
Q
KMDGE
S
E
E
E
Q
ESVDTGEEEEGGDESDLS
S
E
S
S
I
K
K
K
F
L
K
RKGKTDSP
W
I
K
P
A
R
K
R
R
R
RSRKKPSGALGSESYKSSAGSAEQTAPGDST
G
Y
M
E
V
S
LDS
L
D
L
R
V
K
G
I
L
S
S
Q
A
EGLANGPDVLETDGLQEVPLCSCRMETPKSR
E
I
T
T
LANNQCMA
T
E
S
V
D
H
E
L
G
R
C
T
N
S
V
V
K
Y
E
L
MRPSNKA
P
L
L
V
L
CEDHRGRMVKHQCCPGCG
Y
F
CTAGN
F
M
ECQPE
S
S
I
S
H
R
F
H
K
D
C
A
S
RVNNASYCPHCGEESSKA
K
E
V
T
I
A
KADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSE
D
D
K
LQ
G
A
A
SHVPEGFDPTGPAGLGRPTPGLSQGP
G
K
E
T
L
E
S
A
L
I
ALDSEKPK
K
L
RF
H
P
K
Q
L
Y
FSARQG
E
L
Q
K
V
L
L
M
L
VDGIDPNF
K
M
EHQNKRSP
L
H
A
AAEAG
H
V
D
I
C
H
M
L
V
QAGANIDTCSEDQRTP
L
M
E
A
AENN
H
L
E
A
V
K
Y
L
I
KAGALVDPKDAEG
S
T
C
L
H
L
AAKKG
H
Y
E
V
V
Q
Y
L
L
SNG
Q
M
D
V
N
CQDDGG
W
T
P
M
I
W
A
TEY
K
H
V
D
L
V
K
L
L
L
SKGS
D
I
N
I
RDNEE
N
I
C
L
H
W
A
A
FS
G
C
V
D
I
A
E
I
L
L
AAKC
D
L
H
A
V
N
IHGDS
P
L
H
I
A
ARENR
Y
D
C
V
V
L
F
LSRDS
D
V
T
L
KNKEGETPL
Q
C
A
S
L
N
S
Q
V
W
S
A
L
Q
M
S
K
A
L
QDSAPDR
P
S
P
V
E
R
I
V
S
R
D
I
A
RGYERIPIPCVNAVDSEPCPSN
Y
K
Y
V
S
QNCVTSPMNIDRNI
T
H
L
Q
Y
C
V
C
IDDCSSSN
C
M
CGQ
L
S
M
R
C
W
YDKDGRLLPEFNMAEP
P
L
I
F
ECN
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
RTRDMGWGV
R
S
L
QDIPP
G
T
F
V
C
E
Y
V
G
E
L
ISDSEADVREED
S
Y
L
F
D
LDNKDG
E
V
Y
C
I
D
A
R
FYG
N
V
S
R
F
I
N
HHCEPN
L
V
P
V
R
V
F
M
AHQDLRF
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
QLG
F
D
Y
G
E
R
F
W
D
IK
G
K
L
F
S
C
RCGSPKCR
H
S
S
A
A
L
A
Q
R
Q
A
S
A
A
Q
E
A
Q
EDGLPDTSSAAAADPL
8
PsiBlast_PDB
96.89
100%
-103
- C2 -
3HNA
2
EHMT1_HUMAN
A:
[3-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
Q
V
W
S
A
L
Q
M
S
K
A
L
-------
P
S
P
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
32
PsiBlast_CBE
93.62
100%
-107
- C2 -
3HNA
2
B:
[28-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
2
PsiBlast_PDB
93.39
100%
-108
- C2 -
2RFI
2
EHMT1_HUMAN
A:
[25-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
6
PsiBlast_PDB
92.66
100%
-103
- C2 -
3SWC
2
EHMT1_HUMAN
A:
[25-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
9
PsiBlast_PDB
92.45
99%
-106
- C2 -
4I51
5
EHMT1_HUMAN
A:
[26-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
A
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
10
PsiBlast_PDB
92.36
100%
-106
- C2 -
3FPD
2
EHMT1_HUMAN
A:
[1-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
25
PsiBlast_CBE
91.50
100%
-106
- C2 -
3MO5
1
EHMT1_HUMAN
B:
[26-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
--
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
24
PsiBlast_CBE
91.49
100%
-107
- C2 -
3MO5
2
EHMT1_HUMAN
C:
[25-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
---
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
27
PsiBlast_CBE
91.34
100%
-109
- C2 -
3MO2
2
EHMT1_HUMAN
C:
[25-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
---
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
33
PsiBlast_CBE
91.27
99%
-105
- C2 -
4I51
5
B:
[24-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
-----
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
A
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
23
PsiBlast_CBE
91.00
100%
-107
- C2 -
3MO5
2
D:
[26-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
----
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
28
PsiBlast_CBE
90.87
100%
-105
- C2 -
3MO2
1
EHMT1_HUMAN
B:
[26-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
--
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
1
PsiBlast_PDB
90.77
100%
-105
- C2 -
2IGQ
1
EHMT1_HUMAN
A:
[26-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
------
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
---
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
30
PsiBlast_CBE
90.68
100%
-111
- C2 -
2RFI
2
B:
[28-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
------
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
34
PsiBlast_CBE
90.66
100%
-103
- C2 -
3FPD
2
B:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
21
PsiBlast_CBE
89.99
100%
-105
- C2 -
3SWC
2
B:
[25-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
31
PsiBlast_CBE
89.95
100%
-108
- C2 -
2IGQ
1
B:
[26-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
----
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
--
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
7
PsiBlast_PDB
89.47
100%
-102
- C2 -
3SW9
2
EHMT1_HUMAN
A:
[25-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
5
PsiBlast_PDB
89.25
100%
-107
- C2 -
3MO5
1
EHMT1_HUMAN
A:
[28-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
---
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
26
PsiBlast_CBE
89.21
100%
-104
- C2 -
3MO2
2
D:
[26-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
----
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
22
PsiBlast_CBE
89.18
100%
-101
- C2 -
3SW9
2
B:
[25-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
4
PsiBlast_PDB
88.43
100%
-108
- C2 -
3MO2
1
EHMT1_HUMAN
A:
[28-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
---
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
14
PsiBlast_PDB
88.29
75%
-100
- C2 -
3K5K
2
EHMT2_HUMAN
A:
[7-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
D
N
K
--
E
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
--------------------
39
PsiBlast_CBE
88.16
75%
-99
- C2 -
3K5K
2
B:
[9-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
D
N
---
E
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
--------------------
42
PsiBlast_CBE
87.96
75%
-97
- C2 -
2O8J
1
EHMT2_HUMAN
B:
[10-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
R
-------------------
37
PsiBlast_CBE
87.04
74%
-102
- C2 -
4NVQ
2
?
B:
[10-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
-----
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
D
-----
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
--------------------
15
PsiBlast_PDB
86.65
75%
-97
- C2 -
3RJW
2
EHMT2_HUMAN
A:
[8-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
--
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
-----------------------
3
PsiBlast_PDB
86.37
100%
-96
- C2 -
3MO0
2
EHMT1_HUMAN
A:
[27-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
-------
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
---------------------------------
13
PsiBlast_PDB
85.90
74%
-101
- C2 -
4NVQ
2
?
A:
[8-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
----
G
E
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
-
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
-----------------------
41
PsiBlast_CBE
84.87
75%
-102
- C2 -
2O8J
1
EHMT2_HUMAN
C:
[10-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
-----
E
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
----------------------
16
PsiBlast_PDB
84.22
75%
-102
- C2 -
2O8J
1
EHMT2_HUMAN
A:
[8-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
D
----
E
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
----
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
-----------------------------
40
PsiBlast_CBE
83.90
75%
-105
- C2 -
2O8J
1
D:
[10-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
E
D
D
S
Y
L
F
D
L
------
V
Y
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
------
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
-----------------------------
29
PsiBlast_CBE
81.00
100%
-93
- C2 -
3MO0
4
B:
[28-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
----------------
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
E
E
D
S
Y
L
F
D
L
D
N
K
D
G
E
V
Y
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------