@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01030_ERBB4_: (2014-09-19 )
LETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Atome Classification :
(56 SA)
.........10........20.....---...30..-......40........-50--........60.......-.70........80........90........100--.-.......110.......120.-..------....130.......140.......150.......160.-----......170.......180......-.190-........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300..-.....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LETELVEPLTPSGTAP
N
Q
A
Q
L
R
I
L
KE---TE
L
K
R
V
K
-
V
LGSGA
F
G
T
V
Y
K
G
I
WV-PE--G
E
T
V
K
I
P
V
A
I
K
I
LNETT-GPKA
N
V
E
F
M
D
E
A
L
I
M
ASMD
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
--
T
-
I
Q
L
V
T
Q
LMP
H
G
C
L
L
E
Y
V
H
E
H
K
-DN------I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
AR
N
V
L
VK-----SP
N
H
V
K
I
T
D
F
G
L
A
R
L
LEGDEKEYNA-DGG--KM
P
I
K
W
M
A
L
E
C
I
H
Y
R
KFTHQSD
V
W
S
Y
G
V
T
I
W
E
L
M
TFGGKPYDGIP
T
R
E
I
P
D
L
L
E
KGERLPQPP
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
IDADSRP
K
F
K
E
L
A
A
E
F
S
R
MARDP
Q
R
Y
L
V
I
QGDDRM-KLPSP
N
D
S
K
F
F
Q
N
LL
D
E
E
D
L
E
D
M
M
D
A
E
E
YLVPQAFNIPPPIYT
S
R
A
RIDS
N
R
S
EIGHSPPPAYTPMSGN
Q
F
V
Y
RDGGFAAEQGVSVPYRAPTSTIPEAPVAQGA
T
A
E
IFDDSCCNGTLRKPVAPHVQEDSSTQRYSADP
T
V
FAPERSPRGELDEEGYMTPMRDK
P
K
Q
E
YLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNE
P
L
Y
L
N
T
F
A
N
T
LG
K
A
E
Y
L
K
N
N
I
LSM
P
E
K
A
K
K
AFDNPDYWNHSLPPRSTLQH
P
D
Y
L
Q
E
Y
S
T
K
Y
F
Y
KQNG
R
I
R
P
I
VAEN
P
E
Y
L
S
E
FSLKPGTVLPPPPYRHRNTVV
4
PsiBlast_PDB
93.08
100%
-141
- C3 -
2R4B
1
ERBB4_HUMAN
A:
[16-313]
----
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
---
T
E
L
K
R
V
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
E
--
G
E
T
V
K
I
P
V
A
I
K
I
L
N
-------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
N
------
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
-
D
G
G
--
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.55
100%
-136
- C3 -
3BCE
2
C:
[2-289]
-------------
T
A
P
N
Q
A
Q
L
R
I
L
K
E
---
T
E
L
K
R
V
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
E
--
G
E
T
V
K
I
P
V
A
I
K
I
L
N
E
T
T
-
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
N
------
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
-
D
E
K
E
Y
N
A
-
D
G
---
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
92.14
100%
-141
- C3 -
2R4B
1
B:
[16-313]
----
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
---
T
E
L
K
R
V
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
E
--
G
E
T
V
K
I
P
V
A
I
K
I
L
--------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
N
------
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
-
D
G
G
--
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.63
77%
-132
- C3 -
1M17
1
A:
[7-330]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
90.31
77%
-126
- C3 -
2GS6
2
A:
[4-327]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
-------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
90.28
77%
-137
- C3 -
3VJN
1
A:
[9-330]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
-
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
90.24
77%
-124
- C3 -
3W32
1
A:
[9-325]
-----------------
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
90.01
77%
-134
- C3 -
4JR3
1
A:
[3-326]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
89.91
77%
-123
- C3 -
3IKA
1
EGFR_HUMAN
A:
[5-329]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
---------------
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
89.88
77%
-137
- C3 -
4JRV
1
A:
[3-326]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.88
100%
-145
- C3 -
3BBT
1
ERBB4_HUMAN
B:
[7-297]
------------------
A
Q
L
R
I
L
K
E
---
T
E
L
K
R
V
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
E
--
G
E
T
V
K
I
P
V
A
I
K
I
L
N
E
---
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
N
------
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-----------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-
D
D
R
M
-
K
L
P
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.65
77%
-129
- C3 -
4I23
1
A:
[2-325]
-----------
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
--
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
89.63
77%
-133
- C3 -
2ITN
1
A:
[1-324]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
-----------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
89.27
77%
-132
- C3 -
2ITV
1
A:
[1-324]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
89.19
77%
-134
- C3 -
4G5P
1
EGFR_HUMAN
A:
[4-324]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-----------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
89.19
77%
-134
- C3 -
4JQ8
1
A:
[3-326]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
89.05
77%
-132
- C3 -
3UG2
2
A:
[9-330]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
------
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
---------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
88.86
77%
-130
- C3 -
2ITU
1
A:
[1-324]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
----------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
88.81
77%
-131
- C3 -
4JQ7
1
A:
[3-326]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.79
77%
-126
- C3 -
3VJO
1
A:
[8-330]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
--
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
---
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
88.76
77%
-133
- C3 -
2ITT
1
A:
[2-324]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
88.72
77%
-125
- C3 -
2ITX
1
A:
[2-324]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
88.65
77%
-133
- C3 -
3W2S
1
A:
[9-327]
-----------------
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
---------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
88.59
77%
-129
- C3 -
2ITO
1
A:
[1-324]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
88.49
77%
-124
- C3 -
2J6M
1
A:
[2-325]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.46
77%
-131
- C3 -
4LQM
1
?
A:
[6-328]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
--------
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
--------
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
88.42
77%
-133
- C3 -
2ITY
1
A:
[2-324]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
-------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
88.35
77%
-136
- C3 -
3W33
1
A:
[9-326]
-----------------
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
---------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
----
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
88.19
77%
-128
- C3 -
2ITQ
1
A:
[2-323]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
88.17
77%
-127
- C3 -
2ITP
1
A:
[2-323]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.75
77%
-124
- C3 -
4LI5
1
A:
[4-328]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
-----------------------
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.60
77%
-136
- C3 -
3POZ
1
A:
[6-322]
-----------------
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
------
V
K
I
P
V
A
I
K
E
L
--------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
------
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
87.36
77%
-127
- C3 -
3UG1
1
A:
[9-330]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
------
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
87.34
77%
-134
- C3 -
2GS7
1
B:
[9-324]
-----------------
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
--------------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.30
77%
-139
- C3 -
1XKK
1
A:
[32-348]
------------------
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
------
V
K
I
P
V
A
I
K
E
L
R
E
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
-----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
--------
S
N
F
Y
R
A
L
M
D
E
-----
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.45
100%
-147
- C3 -
3BBT
1
D:
[8-287]
-------------------
Q
L
R
I
L
K
E
---
T
E
L
K
R
V
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
-
P
----
E
T
V
K
I
P
V
A
I
K
I
L
N
E
----
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
-
D
N
------
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
S
P
N
H
V
K
I
T
D
F
G
L
A
R
-------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
85.88
77%
-122
- C3 -
4G5J
3
A:
[4-324]
------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
----
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
-----------
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
85.64
77%
-131
- C3 -
3GT8
2
EGFR_HUMAN
C:
[7-315]
---------------
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
----------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
85.39
77%
-133
- C3 -
2GS7
1
EGFR_HUMAN
A:
[11-320]
-------------------
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
-------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
--------------------------
D
V
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.48
77%
-127
- C3 -
4LL0
1
EGFR_HUMAN
A:
[6-326]
-------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
----------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-----------------
E
E
D
M
D
-
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.84
77%
-128
- C3 -
4I24
1
EGFR_HUMAN
A:
[7-321]
----------------
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
--------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
----------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
83.64
76%
-127
- C3 -
4I22
1
A:
[7-321]
----------------
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
----------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.29
77%
-123
- C3 -
4I24
1
B:
[7-321]
----------------
N
Q
A
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
--------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
-
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
82.18
77%
-135
- C3 -
4HJO
1
A:
[18-299]
-------------------
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
------
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-
E
G
G
--
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
81.53
74%
-126
- C3 -
3RCD
1
ERBB2_HUMAN
C:
[9-321]
------------------
A
L
L
R
I
L
K
E
---
T
E
L
R
K
V
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
D
--
G
E
N
V
K
I
P
V
A
I
K
V
L
R
-----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
R
------
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
S
P
N
H
V
K
I
T
D
F
G
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
----------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
81.31
74%
-127
- C3 -
3RCD
1
ERBB2_HUMAN
A:
[9-321]
------------------
A
L
L
R
I
L
K
E
---
T
E
L
R
K
V
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
P
D
--
G
E
N
V
K
I
P
V
A
I
K
V
L
R
-----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
-
G
R
------
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
S
P
N
H
V
K
I
T
D
F
G
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
----------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
80.64
79%
-139
- C3 -
3LZB
2
EGFR_HUMAN
A:
[8-288]
-------------------
L
L
R
I
L
K
E
---
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
-
P
E
--
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
-
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
-
D
N
------
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
-----
T
P
Q
H
V
K
I
T
D
F
G
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
79.13
58%
-136
- C3 -
3KEX
1
ERBB3_HUMAN
A:
[4-300]
-----------------
K
V
L
A
R
I
F
K
E
---
T
E
L
R
K
L
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
-
P
E
--
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
S
-
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
P
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
-
G
A
------
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
-----
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
Q
L
L
--------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
R
E
S
G
P
G
I
A
P
G
P
E
P
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
66.56
41%
-125
- C3 -
4FL3
1
KSYK_HUMAN
A:
[375-630]
-----------------------------------
K
-
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
-
M
K
----
K
V
V
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
--
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
--
H
------
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
---------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
62.51
36%
-112
- C3 -
3CBL
4
A:
[111-373]
-----------------------
L
N
H
---
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-
A
D
--
N
T
----
L
V
A
V
K
S
C
R
E
T
L
-
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
--
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-
A
R
------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
--
D
G
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
62.50
41%
-116
- C3 -
1MQB
1
EPHA2_HUMAN
A:
[38-311]
-----------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
-----
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
-
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
Y
K-
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
-
G
E
------
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
-----
S
N
L
V
C
K
V
S
D
F
G
L
-------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
62.25
40%
-114
- C3 -
1U59
1
A:
[7-268]
------------------------
K
R
---
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
------
K
--
Q
I
D
V
A
I
K
V
L
K
Q
G
T
-
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
--
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-
E
E
------
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
A
R
S
A
G
--
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
61.96
40%
-120
- C3 -
2OZO
1
ZAP70_HUMAN
A:
[343-596]
-------------------------------------
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
-
M
R
--
K
K
--
Q
I
D
V
A
I
K
V
L
K
Q
G
T
-
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
--
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-
E
E
------
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
----------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
59.47
42%
-126
* C3 *
4FYO
1
A:
[23-277]
-----------------------------------
K
-
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
-
M
K
--
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
--
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
--
H
------
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
------
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
58.30
38%
-118
- C3 -
3ZBF
1
A:
[32-306]
-------------------------
R
---
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
-
D
I
LG
V
G
S
G
E
I
K
V
A
V
K
T
L
K
K
G
S
-
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
-
N
--
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
-
M
A
TFYGPL
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
---------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
57.50
38%
-119
- C3 -
1BYG
1
CSK_HUMAN
A:
[15-276]
--------------------
G
W
A
L
N
M
---
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G---------
N
K
V
A
V
K
C
I
K
------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
---EE
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
S
V
------
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
-----
E
D
N
V
A
K
V
S
D
F
G
--------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------