@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01126_HMOX2_: (2014-09-20 )
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
Atome Classification :
(24 SA)
.........10........20........30........40........50..-......60........70........80........90........100.......110.....-..120.......130.......140.....-..150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSEVETSEGVDESENNSTAPEKENHT
K
M
A
D
L
S
E
L
L
K
E
G
T
K
E
A
HDRAE
N
T
Q
F
V
-
K
D
F
L
K
G
N
I
K
K
E
L
F
K
L
A
T
T
A
L
Y
F
T
Y
S
A
L
E
E
E
M
DRNKDHPAFAPLYF
P
T
E
L
H
R
K
E
A
L
I
K
D
M
E
Y
F
FG-E
N
W
E
E
Q
V
K
C
S
E
A
A
Q
K
Y
V
D
R
I
H
YVGQNEP
E
L
-
L
V
A
H
A
Y
T
R
Y
MGDLS
G
G
Q
V
L
K
K
V
A
Q
R
A
LKLPSTGEG
T
Q
F
Y
L
F
EHVD
N
A
Q
Q
F
K
Q
F
Y
R
A
R
M
N
A
LDL
S
M
K
T
K
E
R
I
V
E
E
A
N
K
A
F
E
Y
N
M
Q
I
F
S
E
L
D
Q
A
G
S
M
L
T
K
E
T
L
EDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNC
P
F
R
T
A
M
A
V
LRKPS
L
Q
L
I
L
A
A
S
V
A
L
V
A
G
L
L
A
W
YYM
22
PsiBlast_CBE
98.38
90%
-91
- C2 -
2QPP
1
HMOX2_HUMAN
B:
[30-248]
----------------------------
M
A
D
L
S
E
L
L
K
E
G
T
K
E
A
H
D
R
A
E
N
T
Q
F
V
-
K
D
F
L
K
G
N
I
K
K
E
L
F
K
L
A
T
T
A
L
Y
F
T
Y
S
A
L
E
E
E
M
E
R
N
K
D
H
P
A
F
A
P
L
Y
F
P
M
E
L
H
R
K
E
A
L
T
K
D
M
E
Y
F
F
G
-
E
N
W
E
E
Q
V
Q
A
P
K
A
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
K
K
V
A
Q
R
A
L
K
L
P
S
T
G
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
A
F
E
Y
N
M
Q
I
F
N
E
L
D
Q
A
G
S
T
L
A
R
E
T
--------------------------------------------------------------------
23
PsiBlast_CBE
98.29
90%
-90
- C2 -
2Q32
1
HMOX2_HUMAN
B:
[31-248]
-----------------------------
A
D
L
S
E
L
L
K
E
G
T
K
E
A
H
D
R
A
E
N
T
Q
F
V
-
K
D
F
L
K
G
N
I
K
K
E
L
F
K
L
A
T
T
A
L
Y
F
T
Y
S
A
L
E
E
E
M
E
R
N
K
D
H
P
A
F
A
P
L
Y
F
P
M
E
L
H
R
K
E
A
L
T
K
D
M
E
Y
F
F
G
-
E
N
W
E
E
Q
V
Q
A
P
K
A
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
K
K
V
A
Q
R
A
L
K
L
P
S
T
G
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
A
F
E
Y
N
M
Q
I
F
N
E
L
D
Q
A
G
S
T
L
A
R
E
T
--------------------------------------------------------------------
34
HHSearch
96.90
90%
-91
- C2 -
2Q32
1
HMOX2_HUMAN
A:
[29-241]
---------------------------
R
M
A
D
L
S
E
L
L
K
E
G
T
K
E
A
H
D
R
A
E
N
T
Q
F
V
-
K
D
F
L
K
G
N
I
K
K
E
L
F
K
L
A
T
T
A
L
Y
F
T
Y
S
A
L
E
E
E
M
E
R
N
K
D
H
P
A
F
A
P
L
Y
F
P
M
E
L
H
R
K
E
A
L
T
K
D
M
E
Y
F
F
G
-
E
N
W
E
E
Q
V
Q
A
P
K
A
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
K
K
V
A
Q
R
A
L
K
L
P
S
T
G
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
A
F
E
Y
N
M
Q
I
F
N
E
L
D
Q
A
G
---------------------------------------------------------------------------
2
PsiBlast_PDB
96.63
90%
-93
- C2 -
2QPP
1
HMOX2_HUMAN
A:
[29-242]
---------------------------
R
M
A
D
L
S
E
L
L
K
E
G
T
K
E
A
H
D
R
A
E
N
T
Q
F
V
-
K
D
F
L
K
G
N
I
K
K
E
L
F
K
L
A
T
T
A
L
Y
F
T
Y
S
A
L
E
E
E
M
E
R
N
K
D
H
P
A
F
A
P
L
Y
F
P
M
E
L
H
R
K
E
A
L
T
K
D
M
E
Y
F
F
G
-
E
N
W
E
E
Q
V
Q
A
P
K
A
A
Q
K
Y
V
E
R
I
H
Y
I
G
Q
N
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
M
G
D
L
S
G
G
Q
V
L
K
K
V
A
Q
R
A
L
K
L
P
S
T
G
E
G
T
Q
F
Y
L
F
E
N
V
D
N
A
Q
Q
F
K
Q
L
Y
R
A
R
M
N
A
L
D
L
N
M
K
T
K
E
R
I
V
E
E
A
N
K
A
F
E
Y
N
M
Q
I
F
N
E
L
D
Q
A
G
S
--------------------------------------------------------------------------
24
Fugue
88.49
53%
-83
- C2 -
1N45
1
HMOX1_HUMAN
A:
[10-223]
----------------------------
P
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
T
Q
A
E
N
A
E
F
M
-
R
N
F
Q
K
G
Q
V
T
R
D
G
F
K
L
V
M
A
S
L
Y
H
I
Y
V
A
L
E
E
E
I
E
R
N
K
E
S
P
V
F
A
P
V
Y
F
P
E
E
L
H
R
K
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
R
W
Q
E
V
I
P
Y
T
P
A
M
Q
R
Y
V
K
R
L
H
E
V
G
R
T
E
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
D
L
P
S
S
G
E
G
L
A
F
F
T
F
P
N
I
A
S
A
T
K
F
K
Q
L
Y
R
S
R
M
N
S
L
E
M
T
P
A
V
R
Q
R
V
I
E
E
A
K
T
A
F
L
L
N
I
Q
L
F
E
E
L
Q
E
L
L
T
H
-------------------------------------------------------------------------
6
PsiBlast_PDB
87.89
55%
-85
- C2 -
1DVE
1
HMOX1_RAT
A:
[12-223]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
E
----------------------------------------------------------------------
9
PsiBlast_PDB
87.65
55%
-86
- C2 -
1IX4
2
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
10
PsiBlast_PDB
87.46
55%
-84
- C2 -
1J02
3
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
18
PsiBlast_PDB
87.44
55%
-83
- C2 -
4G7L
3
HMOX1_RAT
A:
[12-223]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
E
----------------------------------------------------------------------
16
PsiBlast_PDB
87.44
55%
-84
- C2 -
2E7E
1
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
8
PsiBlast_PDB
87.39
55%
-85
- C2 -
1IVJ
1
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
17
PsiBlast_PDB
87.24
55%
-81
- C2 -
2ZVU
2
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
13
PsiBlast_PDB
87.24
55%
-85
- C2 -
1ULX
4
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
15
PsiBlast_PDB
87.22
55%
-84
- C2 -
2DY5
2
HMOX1_RAT
A:
[12-223]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
E
----------------------------------------------------------------------
14
PsiBlast_PDB
87.17
55%
-83
- C2 -
1VGI
2
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
12
PsiBlast_PDB
87.11
55%
-84
- C2 -
1UBB
1
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
19
PsiBlast_PDB
87.04
55%
-84
- C2 -
4G7P
3
HMOX1_RAT
A:
[12-223]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
E
----------------------------------------------------------------------
4
PsiBlast_PDB
86.89
55%
-86
- C2 -
3I9T
2
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
11
PsiBlast_PDB
86.88
55%
-82
- C2 -
1J2C
1
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
20
PsiBlast_PDB
86.80
55%
-86
- C2 -
4G7T
3
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
5
PsiBlast_PDB
86.36
55%
-83
- C2 -
3I9U
2
HMOX1_RAT
A:
[12-222]
------------------------------
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
M
-
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
M
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
M
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
M
A
L
P
S
S
G
E
G
L
A
F
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
M
N
T
L
E
M
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
---
A
L
L
T
-----------------------------------------------------------------------
37
HHSearch
82.14
47%
-86
- C2 -
1WE1
3
HO1_SYNY3
A:
[2-223]
----------------------------
S
V
N
L
A
S
Q
L
R
E
G
T
K
K
S
H
S
M
A
E
N
V
G
F
V
-
K
C
F
L
K
G
V
V
E
K
N
S
Y
R
K
L
V
G
N
L
Y
F
V
Y
S
A
M
E
E
E
M
A
K
F
K
D
H
P
I
L
S
H
I
Y
F
P
-
E
L
N
R
K
Q
S
L
E
Q
D
L
Q
F
Y
Y
G
-
S
N
W
R
Q
E
V
K
I
S
A
A
G
Q
A
Y
V
D
R
V
R
Q
V
A
A
T
A
P
E
L
-
L
V
A
H
S
Y
T
R
Y
L
G
D
L
S
G
G
Q
I
L
K
K
I
A
Q
N
A
M
N
L
H
D
G
--
G
T
A
F
Y
E
F
A
D
I
D
D
E
K
A
F
K
N
T
Y
R
Q
A
M
N
D
L
P
I
D
Q
A
T
A
E
R
I
V
D
E
A
N
D
A
F
A
M
N
M
K
M
F
N
E
L
E
G
N
L
I
K
A
I
G
I
M
V
F
N
S
L
T
--------------------------------------------------------------
25
Fugue
76.97
55%
-57
- C2 -
1DVG
1
HMOX1_RAT
A:
[10-223]
----------------------------
S
Q
D
L
S
E
A
L
K
E
A
T
K
E
V
H
I
R
A
E
N
S
E
F
-
M
R
N
F
Q
K
G
Q
V
S
R
E
G
F
K
L
V
T
A
S
L
Y
H
I
Y
T
A
L
E
E
E
I
E
R
N
K
Q
N
P
V
Y
A
P
L
Y
F
P
E
E
L
H
R
R
A
A
L
E
Q
D
L
A
F
W
Y
G
-
P
H
W
Q
E
A
I
P
Y
T
P
A
T
Q
H
Y
V
K
R
L
H
E
V
G
G
T
H
P
E
L
-
L
V
A
H
A
Y
T
R
Y
L
G
D
L
S
G
G
Q
V
L
K
K
I
A
Q
K
A
L
A
L
P
S
S
G
E
G
L
A
S
F
T
F
P
S
I
D
N
P
T
K
F
K
Q
L
Y
R
A
R
-
N
T
L
E
L
T
P
E
V
K
H
R
V
T
E
E
A
K
T
A
F
L
L
N
I
E
L
F
E
E
L
Q
A
L
L
T
E
-------------------------------------------------------------------------
38
HHSearch
72.06
35%
-78
* C2 *
1WZD
3
HMUO_CORDI
A:
[7-214]
------------------------------
G
L
A
V
E
L
K
Q
S
T
A
Q
A
H
E
K
A
E
H
S
T
F
M
-
S
D
L
L
K
G
R
L
G
V
A
E
F
T
R
L
Q
E
Q
A
W
L
F
Y
T
A
L
E
Q
A
V
D
A
V
R
A
S
G
F
A
E
S
L
L
D
P
-
A
L
N
R
A
E
V
L
A
R
D
L
D
K
L
N
G
S
S
E
W
R
S
R
I
T
A
S
P
A
V
I
D
Y
V
N
R
L
E
E
I
R
D
N
V
D
G
P
A
L
V
A
H
H
Y
V
R
Y
L
G
D
L
S
G
G
Q
V
I
A
R
M
M
Q
R
H
Y
G
V
D
--
P
E
A
L
G
F
Y
H
F
E
G
I
A
K
L
K
V
Y
K
D
E
Y
R
E
K
L
N
N
L
E
L
S
D
E
Q
R
E
H
L
L
K
E
A
T
D
A
F
V
F
N
H
Q
V
F
A
D
L
G
K
G
----------------------------------------------------------------------------