@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01180_PYRD_R: (2014-09-21 )
MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
Atome Classification :
(29 SA)
.........10........20........--30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160......-.170........180.......190.......200.......210.......220.......230.......240...-------------....250........260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
W
R
Q
L
R
K
RAL
D
A
V
I
I
LGGG
G
L
L
F
T
S
Y
LT--ATGD
D
H
F
Y
A
E
Y
L
M
P
G
L
Q
R
LL
D
P
E
SA
H
R
L
A
V
R
V
TSLGLLPRATFQDSD
M
L
E
V
K
V
L
G
H
KFRNPVGIAAGFDKNG
E
A
V
D
G
L
Y
K
LGF
G
F
V
E
VGSVTPQPQEGNPRP
R
V
F
RLPE
D
Q
A
V
I
N
RYGFNSH
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-QL-TADG
L
P
L
G
I
NLGKNKTS
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
GPLA
D
Y
L
V
V
NVSSPN
T
A
G
L
R
SLQ
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
LKG-------------TRK
P
A
-
V
L
V
K
IAPDLTAQ
D
K
E
D
I
A
S
V
A
R
E
LGI
D
G
L
I
VTNTTVSRPVGLQGALRSETGGLSGKP
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
TQGRI
P
I
I
G
VGGVSS
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
FLGP
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
ERGFT
T
V
T
D
AIGADHRR
1
PsiBlast_PDB
97.55
100%
-85
- C3 -
1UUM
4
PYRD_RAT
A:
[14-372]
--------------------------------------
Y
A
E
Y
L
M
P
G
L
Q
R
L
L
D
P
E
S
A
H
R
L
A
V
R
V
T
S
L
G
L
L
P
R
A
T
F
Q
D
S
D
M
L
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
F
G
F
V
E
V
G
S
V
T
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
Q
L
-
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
---------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
G
-------------
T
R
K
P
A
-
V
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
V
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
12
PsiBlast_CBE
97.33
100%
-85
- C3 -
1UUM
4
PYRD_RAT
B:
[14-372]
--------------------------------------
Y
A
E
Y
L
M
P
G
L
Q
R
L
L
D
P
E
S
A
H
R
L
A
V
R
V
T
S
L
G
L
L
P
R
A
T
F
Q
D
S
D
M
L
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
F
G
F
V
E
V
G
S
V
T
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
Q
L
-
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
---------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
G
-------------
T
R
K
P
A
-
V
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
V
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
2
PsiBlast_PDB
96.40
100%
-85
- C3 -
1UUO
3
PYRD_RAT
A:
[10-372]
----------------------------------
D
D
H
F
Y
A
E
Y
L
M
P
G
L
Q
R
L
L
D
P
E
S
A
H
R
L
A
V
R
V
T
S
L
G
L
L
P
----
Q
D
S
D
M
L
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
F
G
F
V
E
V
G
S
V
T
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
Q
L
-
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
--------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
G
-------------
T
R
K
P
A
-
V
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
V
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
23
PsiBlast_CBE
95.68
89%
-82
- C3 -
2PRH
4
PYRD_HUMAN
A:
[2-367]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
---------
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
22
PsiBlast_CBE
93.49
89%
-76
- C3 -
2PRL
4
PYRD_HUMAN
A:
[2-367]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
6
PsiBlast_PDB
93.47
89%
-78
- C3 -
2FQI
3
PYRD_HUMAN
A:
[33-395]
----------------------------------
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
-
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
9
PsiBlast_PDB
93.43
89%
-78
- C3 -
3KVK
4
PYRD_HUMAN
A:
[27-390]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
26
PsiBlast_CBE
93.41
89%
-78
- C3 -
1D3G
4
PYRD_HUMAN
A:
[2-367]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
----
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
25
PsiBlast_CBE
92.83
89%
-76
- C3 -
1D3H
3
PYRD_HUMAN
A:
[2-367]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
3
PsiBlast_PDB
92.81
89%
-74
- C3 -
2FPT
3
PYRD_HUMAN
A:
[30-395]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
11
PsiBlast_PDB
92.79
89%
-75
- C3 -
3KVM
4
PYRD_HUMAN
A:
[25-390]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
8
PsiBlast_PDB
92.60
89%
-77
- C3 -
3KVJ
4
PYRD_HUMAN
A:
[27-390]
---------------------------------
G
D
E
R
F
Y
A
-
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
24
PsiBlast_CBE
92.23
89%
-75
- C3 -
2BXV
3
PYRD_HUMAN
A:
[2-367]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
----
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
19
PsiBlast_CBE
92.15
89%
-76
- C3 -
3FJ6
3
PYRD_HUMAN
A:
[4-367]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
4
PsiBlast_PDB
92.10
89%
-74
- C3 -
2FPV
3
PYRD_HUMAN
A:
[32-395]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
27
PsiBlast_CBE
92.05
89%
-72
- C3 -
2WV8
4
PYRD_HUMAN
A:
[1-365]
--------------------------------
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
13
PsiBlast_CBE
91.98
88%
-74
- C3 -
3U2O
3
PYRD_HUMAN
A:
[29-394]
----------------------------
M
--
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
5
PsiBlast_PDB
91.92
89%
-75
- C3 -
2FPY
3
PYRD_HUMAN
A:
[32-395]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
17
PsiBlast_CBE
91.86
89%
-75
- C3 -
3G0U
3
PYRD_HUMAN
A:
[4-367]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
10
PsiBlast_PDB
91.75
89%
-77
- C3 -
3KVL
4
PYRD_HUMAN
A:
[31-389]
-------------------------------------
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
16
PsiBlast_CBE
91.67
89%
-78
- C3 -
3G0X
3
PYRD_HUMAN
A:
[5-367]
----------------------------------
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
21
PsiBlast_CBE
91.30
89%
-71
- C3 -
2PRM
2
PYRD_HUMAN
A:
[2-367]
-------------------------------
A
T
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
20
PsiBlast_CBE
91.19
89%
-75
- C3 -
3F1Q
5
PYRD_HUMAN
A:
[4-367]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
14
PsiBlast_CBE
91.10
89%
-76
- C3 -
3ZWT
3
PYRD_HUMAN
A:
[12-367]
-----------------------------------------
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
---
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
18
PsiBlast_CBE
91.09
89%
-75
- C3 -
3FJL
5
PYRD_HUMAN
A:
[4-367]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
7
PsiBlast_PDB
91.06
89%
-74
- C3 -
2B0M
3
PYRD_HUMAN
A:
[30-393]
---------------------------------
G
D
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
15
PsiBlast_CBE
90.57
89%
-76
- C3 -
3ZWS
3
PYRD_HUMAN
A:
[12-367]
-----------------------------------------
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
--
A
R
F
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
F
G
F
V
E
I
G
S
V
T
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
-
K
L
-
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
-------------
V
H
R
P
A
-
V
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
A
G
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
38
HHSearch
79.26
40%
-74
- C3 -
3I65
4
PYRD_PLAF7
A:
[36-413]
-------------------------
S
------
Y
N
P
E
F
F
L
Y
D
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
L
G
K
Y
N
I
L
P
Y
D
T
S
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
D
K
N
G
V
C
I
D
S
I
L
K
L
G
F
S
F
I
E
I
G
T
I
T
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
R
K
R
Q
E
-
E
D
K
L
L
S
K
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
--------
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
NIMN
D
E
F
L
W
FNT
T
K
K
K
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
D
I
K
-
S
-
F
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
39
HHSearch
79.02
40%
-64
* C3 *
1TV5
5
PYRD_PLAF7
A:
[32-440]
-----------------------------FE
S
Y
N
P
E
F
F
L
Y
D
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
L
G
K
Y
N
I
L
P
Y
D
T
S
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
D
K
N
G
V
C
I
D
S
I
L
K
L
G
F
S
F
I
E
I
G
T
I
T
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
R
K
R
Q
E
E
D
K
-
L
L
S
K
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
-FLWFNT-------
T
K
K
K
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
D
I
-
K
S
-
F
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
--