@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01234_PNMT_B: (2014-09-22 )
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
Atome Classification :
(61 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGTDRSQAAGAVPDSDP
G
L
A
A
V
S
S
A
Y
Q
RFE
P
R
A
Y
L
RNNYAPPRGDLSCPDGVG
P
W
K
L
R
C
L
A
Q
T
FATGEVSG
R
T
L
I
DIGSG
P
T
I
Y
Q
L
L
S
A
CAHFEDI
T
M
T
D
F
L
E
V
N
R
Q
E
L
R
L
W
L
REEPGAFDW
S
V
YS
Q
H
V
C
L
IEGKGES
W
Q
E
K
E
C
Q
L
R
A
R
V
K
RILPIDVHRPQPLGAGGLAPL
P
A
D
A
L
V
S
A
F
C
L
E
AVS
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
LRPGG
H
L
L
L
I
GALEE
S
W
Y
LAGE
A
R
L
A
V
V
PV
R
E
E
E
V
R
E
A
L
V
R
T
A
T
RCGICARTPM
P
A
H
L
Q
TG
V
D
D
V
K
G
I
F
F
T
R
A
Q
K
KVGV
45
PsiBlast_CBE
98.61
84%
-110
- C2 -
3KPY
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
44
PsiBlast_CBE
98.36
84%
-111
- C2 -
3KQM
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
43
PsiBlast_CBE
98.20
84%
-109
- C2 -
3KQO
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
21
PsiBlast_CBE
98.02
84%
-110
- C2 -
4DM3
3
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
52
PsiBlast_CBE
97.85
84%
-111
- C2 -
3HCC
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
51
PsiBlast_CBE
97.78
84%
-110
- C2 -
3HCD
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
53
PsiBlast_CBE
97.63
84%
-108
- C2 -
3HCB
1
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
37
PsiBlast_CBE
97.61
84%
-108
- C2 -
3KQS
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
46
PsiBlast_CBE
97.44
84%
-109
- C2 -
3KPW
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
41
PsiBlast_CBE
97.14
84%
-109
- C2 -
3KQP
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
59
PsiBlast_CBE
97.10
84%
-109
- C2 -
2AN5
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
33
PsiBlast_CBE
97.08
84%
-110
- C2 -
3KQV
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
8
PsiBlast_PDB
97.04
84%
-110
- C2 -
2G72
1
PNMT_HUMAN
A:
[17-279]
----------------
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
47
PsiBlast_CBE
96.98
84%
-110
- C2 -
3KPV
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
48
PsiBlast_CBE
96.91
84%
-109
- C2 -
3KPU
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
39
PsiBlast_CBE
96.90
84%
-109
- C2 -
3KQQ
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
29
PsiBlast_CBE
96.87
84%
-109
- C2 -
3KQY
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
23
PsiBlast_CBE
96.86
84%
-108
- C2 -
3KR2
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
3
PsiBlast_PDB
96.75
84%
-113
- C2 -
2AN4
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
31
PsiBlast_CBE
96.73
84%
-110
- C2 -
3KQW
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
25
PsiBlast_CBE
96.63
84%
-109
- C2 -
3KR1
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
35
PsiBlast_CBE
96.57
84%
-106
- C2 -
3KQT
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
49
PsiBlast_CBE
96.52
84%
-108
- C2 -
3KPJ
1
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
60
PsiBlast_CBE
96.40
84%
-109
- C2 -
2AN4
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
27
PsiBlast_CBE
96.32
84%
-107
- C2 -
3KR0
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
57
PsiBlast_CBE
96.29
84%
-109
- C2 -
2G71
3
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
58
PsiBlast_CBE
96.23
84%
-112
- C2 -
2G70
1
PNMT_HUMAN
B:
[16-279]
---------------
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
55
PsiBlast_CBE
96.04
84%
-108
- C2 -
2G8N
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
61
Fugue
95.91
85%
-108
- C2 -
1HNN
2
PNMT_HUMAN
A:
[22-282]
---------------------
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
-
V
G
L
1
PsiBlast_PDB
95.90
84%
-112
- C2 -
1YZ3
2
PNMT_HUMAN
A:
[18-279]
-----------------
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
56
PsiBlast_CBE
95.85
84%
-109
- C2 -
2G72
1
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
50
PsiBlast_CBE
95.71
84%
-106
- C2 -
3HCF
2
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
11
PsiBlast_PDB
95.67
84%
-112
- C2 -
3HCC
2
PNMT_HUMAN
A:
[23-279]
----------------------
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
4
PsiBlast_PDB
95.65
84%
-113
- C2 -
2AN5
2
PNMT_HUMAN
A:
[23-279]
----------------------
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
12
PsiBlast_PDB
95.49
84%
-113
- C2 -
3HCD
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
2
PsiBlast_PDB
95.48
84%
-113
- C2 -
2AN3
2
PNMT_HUMAN
A:
[23-279]
----------------------
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
54
PsiBlast_CBE
95.33
84%
-109
- C2 -
2ONY
1
PNMT_HUMAN
B:
[14-279]
-------------
P
D
S
A
P
G
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
5
PsiBlast_PDB
95.24
84%
-112
- C2 -
2G8N
2
PNMT_HUMAN
A:
[23-279]
----------------------
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
7
PsiBlast_PDB
95.23
84%
-112
- C2 -
2G71
2
PNMT_HUMAN
A:
[21-279]
--------------------
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
38
PsiBlast_CBE
94.92
84%
-111
- C2 -
3KQS
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
34
PsiBlast_CBE
94.80
84%
-111
- C2 -
3KQV
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
42
PsiBlast_CBE
94.48
84%
-108
- C2 -
3KQP
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
6
PsiBlast_PDB
94.37
84%
-113
- C2 -
2G70
2
PNMT_HUMAN
A:
[20-279]
-------------------
Q
A
A
V
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
32
PsiBlast_CBE
94.36
84%
-111
- C2 -
3KQW
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
13
PsiBlast_PDB
94.21
84%
-112
- C2 -
3HCF
3
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
19
PsiBlast_PDB
93.98
84%
-111
- C2 -
3KQM
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
18
PsiBlast_PDB
93.90
84%
-109
- C2 -
3KPY
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
36
PsiBlast_CBE
93.82
84%
-109
- C2 -
3KQT
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
16
PsiBlast_PDB
93.81
84%
-109
- C2 -
3KPV
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
26
PsiBlast_CBE
93.76
84%
-110
- C2 -
3KR1
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
9
PsiBlast_PDB
93.64
84%
-109
- C2 -
2ONY
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
10
PsiBlast_PDB
93.57
84%
-109
- C2 -
3HCB
1
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
22
PsiBlast_CBE
93.52
84%
-110
- C2 -
4DM3
3
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
17
PsiBlast_PDB
93.46
84%
-110
- C2 -
3KPW
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
24
PsiBlast_CBE
93.33
84%
-109
- C2 -
3KR2
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
30
PsiBlast_CBE
93.19
84%
-108
- C2 -
3KQY
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
28
PsiBlast_CBE
92.84
84%
-108
- C2 -
3KR0
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
14
PsiBlast_PDB
92.79
84%
-109
- C2 -
3KPJ
1
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
20
PsiBlast_PDB
92.41
84%
-108
- C2 -
3KQO
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
15
PsiBlast_PDB
91.66
84%
-108
- C2 -
3KPU
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----
40
PsiBlast_CBE
91.61
84%
-109
- C2 -
3KQQ
2
PNMT_HUMAN
A:
[24-279]
-----------------------
A
S
A
Y
Q
R
F
E
P
R
A
Y
L
R
N
N
Y
A
P
P
R
G
D
L
C
N
P
N
G
V
G
P
W
K
L
R
C
L
A
Q
T
F
A
T
G
E
V
S
G
R
T
L
I
D
I
G
S
G
P
T
V
Y
Q
L
L
S
A
C
S
H
F
E
D
I
T
M
T
D
F
L
E
V
N
R
Q
E
L
G
R
W
L
Q
E
E
P
G
A
F
N
W
S
M
Y
S
Q
H
A
C
L
I
E
G
K
G
E
C
W
Q
D
K
E
R
Q
L
R
A
R
V
K
R
V
L
P
I
D
V
H
Q
P
Q
P
L
G
A
G
S
P
A
P
L
P
A
D
A
L
V
S
A
F
C
L
E
A
V
S
P
D
L
A
S
F
Q
R
A
L
D
H
I
T
T
L
L
R
P
G
G
H
L
L
L
I
G
A
L
E
E
S
W
Y
L
A
G
E
A
R
L
T
V
V
P
V
S
E
E
E
V
R
E
A
L
V
R
S
G
Y
K
V
R
D
L
R
T
Y
I
M
P
A
H
L
Q
T
G
V
D
D
V
K
G
V
F
F
A
W
A
Q
K
----