@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01425_FAAH1_: (2014-09-23 )
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
Atome Classification :
(35 SA)
.........10........20........30---........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
L
S
E
V
W
T
A
L
SG
L
S
G
V
C
L
A
C
S
L
L
S
A
A
V
V
L
R
W---TRSQTAR
G
A
V
T
R
A
R
Q
K
Q
R
A
G
L
E
T
M
D
K
A
V
Q
R
F
RLQNPDL
D
S
E
A
L
L
A
L
P
L
L
Q
L
V
Q
K
L
QSGELS
P
E
A
V
L
F
T
YLGK
A
W
EVNKG
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
QAPRQG
L
L
YGVPV
S
L
K
E
C
FSYKGHA
S
T
L
G
L
SLNEGVTSES
D
C
V
V
V
Q
V
L
K
LQGAV
P
F
V
HTNV
P
Q
S
M
L
SYDCSNPLFGQTMNPWKPSKSPGGSSGGE
G
A
L
IGSGGSPLGLGTDIGGSIRF
P
S
A
F
C
GICGLKPTGN
R
L
S
K
S
G
L
K
S
C
VYGQ
T
A
V
Q
L
SVG
P
M
A
R
D
V
D
S
L
A
L
C
M
K
A
L
L
C
E
D
L
F
R
LDSTIPPLP
F
R
E
E
I
Y
RSSR
P
L
R
V
G
Y
Y
ETDNYTMP
T
P
A
M
R
R
A
V
M
E
T
K
Q
S
L
E
AAG
H
T
L
VPFLPNNI
P
Y
A
L
E
V
L
SAGGLFSD
G
G
C
S
F
L
Q
NFKGDFV
D
P
C
L
G
D
L
V
L
V
LK
L
P
R
W
F
K
K
L
L
S
F
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
MC
P
R
S
A
E
K
L
W
E
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
WKAMN
L
D
V
V
L
TPMLGPALDLNTPGRAT
G
A
I
S
Y
T
V
L
Y
N
C
LDFPAGV
V
P
V
T
T
VTAEDDA
Q
M
E
H
Y
K
G
Y
F
G
D
M
W
D
N
I
L
K
K
G
M
K
KGIGL
P
V
A
V
Q
C
VALP
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
R
LMTPEKRPS
29
PsiBlast_CBE
98.84
90%
-93
- C6 -
3K83
2
FAAH1_RAT
B:
[27-571]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
15
PsiBlast_PDB
98.40
90%
-95
- C6 -
3QJ9
12
FAAH1_RAT
A:
[37-585]
-------------------------------ELE
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
9
PsiBlast_PDB
98.34
90%
-98
- C6 -
3OJ8
1
FAAH1_RAT
A:
[27-568]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
-----
35
PsiBlast_CBE
98.08
90%
-93
- C6 -
3QJ9
13
FAAH1_RAT
B:
[42-585]
------------------------------------
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
4
PsiBlast_PDB
97.99
90%
-96
- C6 -
3K7F
1
FAAH1_RAT
A:
[26-568]
----------------------------------
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
-----
28
PsiBlast_CBE
97.97
90%
-96
- C6 -
3K84
1
FAAH1_RAT
B:
[26-568]
----------------------------------
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
-----
13
PsiBlast_PDB
97.95
90%
-94
- C6 -
3QK5
8
FAAH1_RAT
A:
[37-585]
-------------------------------ELE
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
34
PsiBlast_CBE
97.94
90%
-95
- C6 -
3QK5
10
FAAH1_RAT
B:
[40-585]
----------------------------------
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
11
PsiBlast_PDB
97.87
90%
-96
- C6 -
3PR0
2
FAAH1_RAT
A:
[27-571]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
18
PsiBlast_PDB
97.86
91%
-95
- C6 -
4DO3
2
FAAH1_RAT
A:
[23-565]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
----
6
PsiBlast_PDB
97.83
90%
-96
- C6 -
3K84
1
FAAH1_RAT
A:
[27-572]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
P
-
5
PsiBlast_PDB
97.77
90%
-96
- C6 -
3K83
1
FAAH1_RAT
A:
[27-572]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
P
-
30
PsiBlast_CBE
97.76
90%
-95
- C6 -
3K7F
1
FAAH1_RAT
B:
[27-571]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
37
PsiBlast_CBE
97.74
91%
-94
- C6 -
4DO3
2
FAAH1_RAT
B:
[22-565]
----------------------------------
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
----
23
PsiBlast_CBE
97.72
90%
-95
- C6 -
3PR0
2
FAAH1_RAT
B:
[25-572]
------------------------------
W
---
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
P
-
3
PsiBlast_PDB
97.66
90%
-94
- C6 -
2WJ2
1
FAAH1_RAT
A:
[27-572]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
P
-
10
PsiBlast_PDB
97.63
90%
-95
- C6 -
3PPM
3
FAAH1_RAT
A:
[27-572]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
P
-
17
PsiBlast_PDB
97.62
90%
-96
- C6 -
2VYA
1
FAAH1_RAT
A:
[41-583]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
----
38
PsiBlast_CBE
97.59
91%
-95
- C6 -
2WAP
1
FAAH1_RAT
B:
[1-543]
------------------------------
W
---
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
------
32
PsiBlast_CBE
97.58
90%
-94
- C6 -
2WJ1
1
FAAH1_RAT
B:
[28-571]
------------------------------------
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
7
PsiBlast_PDB
97.55
90%
-96
- C6 -
3LJ6
1
FAAH1_RAT
A:
[28-568]
------------------------------------
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
-----
22
PsiBlast_CBE
97.52
90%
-95
- C6 -
4J5P
4
FAAH1_RAT
B:
[27-571]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
31
PsiBlast_CBE
97.51
90%
-95
- C6 -
2WJ2
1
FAAH1_RAT
B:
[27-571]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
27
PsiBlast_CBE
97.37
90%
-95
- C6 -
3LJ6
1
FAAH1_RAT
B:
[26-568]
----------------------------------
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
-----
26
PsiBlast_CBE
97.37
90%
-94
- C6 -
3LJ7
1
FAAH1_RAT
B:
[26-572]
----------------------------------
T
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
P
-
24
PsiBlast_CBE
97.33
90%
-94
- C6 -
3PPM
4
FAAH1_RAT
B:
[27-571]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
2
PsiBlast_PDB
97.31
90%
-95
- C6 -
2WJ1
1
FAAH1_RAT
A:
[28-570]
------------------------------------
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
---
25
PsiBlast_CBE
97.19
90%
-94
- C6 -
3OJ8
1
FAAH1_RAT
B:
[27-573]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
P
S
19
PsiBlast_PDB
97.19
91%
-95
- C6 -
2WAP
1
FAAH1_RAT
A:
[3-543]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
------
33
PsiBlast_CBE
97.17
90%
-94
- C6 -
3QKV
1
FAAH1_RAT
B:
[43-585]
-------------------------------------
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
8
PsiBlast_PDB
97.17
90%
-95
- C6 -
3LJ7
1
FAAH1_RAT
A:
[27-571]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
12
PsiBlast_PDB
97.16
90%
-97
- C6 -
4J5P
3
FAAH1_RAT
A:
[27-570]
-----------------------------------
G
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
---
36
PsiBlast_CBE
96.74
90%
-95
- C6 -
2VYA
1
FAAH1_RAT
B:
[42-582]
------------------------------------
R
Q
K
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
E
T
Q
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
T
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
N
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
V
S
Y
T
M
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
-----
21
PsiBlast_CBE
96.50
91%
-97
- C6 -
4HBP
1
FAAH1_RAT
B:
[8-548]
---------------------------------------
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
T
D
C
------
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
P
Q
K
Q
--
1
PsiBlast_PDB
95.95
91%
-97
- C6 -
4HBP
1
FAAH1_RAT
A:
[8-544]
---------------------------------------
A
R
G
A
A
T
R
A
R
Q
K
Q
R
A
S
L
E
T
M
D
K
A
V
Q
R
F
R
L
Q
N
P
D
L
D
S
E
A
L
L
T
L
P
L
L
Q
L
V
Q
K
L
Q
S
G
E
L
S
P
E
A
V
F
F
T
Y
L
G
K
A
W
E
V
N
K
G
T
N
C
V
T
S
Y
L
------
L
S
Q
A
P
R
Q
G
L
L
Y
G
V
P
V
S
L
K
E
C
F
S
Y
K
G
H
D
S
T
L
G
L
S
L
N
E
G
M
P
S
E
S
D
C
V
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
L
K
G
C
V
Y
G
Q
T
A
V
Q
L
S
L
G
P
M
A
R
D
V
E
S
L
A
L
C
L
K
A
L
L
C
E
H
L
F
T
L
D
P
T
V
P
P
L
P
F
R
E
E
V
Y
R
S
S
R
P
L
R
V
G
Y
Y
E
T
D
N
Y
T
M
P
S
P
A
M
R
R
A
L
I
E
T
K
Q
R
L
E
A
A
G
H
T
L
I
P
F
L
P
N
N
I
P
Y
A
L
E
V
L
S
A
G
G
L
F
S
D
G
G
R
S
F
L
Q
N
F
K
G
D
F
V
D
P
C
L
G
D
L
I
L
I
L
R
L
P
S
W
F
K
R
L
L
S
L
L
L
K
P
L
F
P
R
L
A
A
F
L
N
S
M
R
P
R
S
A
E
K
L
W
K
L
Q
H
E
I
E
M
Y
R
Q
S
V
I
A
Q
W
K
A
M
N
L
D
V
L
L
T
P
M
L
G
P
A
L
D
L
N
T
P
G
R
A
T
G
A
I
S
Y
T
V
L
Y
N
C
L
D
F
P
A
G
V
V
P
V
T
T
V
T
A
E
D
D
A
Q
M
E
L
Y
K
G
Y
F
G
D
I
W
D
I
I
L
K
K
A
M
K
N
S
V
G
L
P
V
A
V
Q
C
V
A
L
P
W
Q
E
E
L
C
L
R
F
M
R
E
V
E
Q
L
M
T
------