@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01471_MMP12_: (2014-09-24 )
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Atome Classification :
(57 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.-.-------.....160.......170.......180.......---190.......200...-.---.-..210.......220.......230.......240.......250.......260.......270......-.280.......290.......300.......310.......320.......330.......340.......350.......360.......-370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
F
L
L
I
L
L
L
QATASGALPLNSSTSLEKNNV
L
F
G
E
R
Y
L
E
K
F
YG
L
E
INKLP
V
T
K
M
KYSG
N
L
M
K
E
K
I
Q
E
M
Q
H
FLG
L
K
V
T
GQLD
T
S
T
L
E
M
MHAPRCGVP
D
V
H
H
F
R
EMPGGP
V
W
R
K
H
Y
I
T
Y
R
INNYTPDMN
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
WSNVTP
L
K
F
SKIN-T-------
G
M
A
D
I
L
V
V
F
ARGAHGDFHAFDGKG
G
I
L
A
H
AFGPGS---GIGGDAHFDEDE
F
W
T
T-H---S-GG
T
N
L
F
L
T
A
V
H
E
I
G
H
SLGLGHSSDP
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
LYGDPKENQRLPNPDNSE-PALCDPNLS
F
D
A
V
T
TVG
N
K
I
F
F
F
K
D
R
F
F
W
L
K
VSERPK
T
S
V
N
L
I
S
S
L
W
PTLPSGIE
A
A
Y
E
I
EAR
N
Q
V
F
L
F
KDD
K
Y
W
L
I
SNLRPEPNYPK
S
I
H
-SFG
F
P
N
F
V
K
K
I
D
A
A
VFN
P
R
F
Y
R
T
Y
F
F
VDNQYW
R
Y
D
E
R
R
QMMDPGY
P
K
L
I
T
K
NFQGIGPK
I
D
A
V
F
Y
SK
N
K
Y
Y
Y
F
F
QGSNQ
F
E
Y
D
F
L
L
Q
R
I
T
K
T
LKSNSWFGC
3
PsiBlast_PDB
80.88
53%
-106
- C3 -
1FBL
1
MMP1_PIG
A:
[5-367]
-------------------------------------------------------------------------------------------------------
P
G
N
P
R
W
E
N
T
H
L
T
Y
R
I
E
N
Y
T
P
D
L
S
R
E
D
V
D
R
A
I
E
K
A
F
Q
L
W
S
N
V
S
P
L
T
F
T
K
V
S
-
E
-------
G
Q
A
D
I
M
I
S
F
V
R
G
D
H
R
D
N
S
P
F
D
G
P
G
G
N
L
A
H
A
F
Q
P
G
P
---
G
I
G
G
D
A
H
F
D
E
D
E
R
W
T
K
-
N
---
F
-
R
D
Y
N
L
Y
R
V
A
A
H
E
L
G
H
S
L
G
L
S
H
S
T
D
I
G
A
L
M
Y
P
N
Y
I
Y
T
--
G
D
V
Q
L
S
Q
D
D
I
D
G
I
Q
A
I
Y
G
-
P
S
E
N
P
V
Q
P
S
G
P
Q
T
--
P
Q
V
C
D
S
K
L
T
F
D
A
I
T
T
L
R
G
E
L
M
F
F
K
D
R
F
Y
M
R
T
N
S
F
Y
P
E
V
E
L
N
F
I
S
V
F
W
P
Q
V
P
N
G
L
Q
A
A
Y
E
I
A
D
R
D
E
V
R
F
F
K
G
N
K
Y
W
A
V
R
G
Q
D
V
L
Y
G
Y
P
K
D
I
H
R
S
F
G
F
P
S
T
V
K
N
I
D
A
A
V
F
E
E
D
T
G
K
T
Y
F
F
V
A
H
E
C
W
R
Y
D
E
Y
K
Q
S
M
D
T
G
Y
P
K
M
I
A
E
E
F
P
G
I
G
N
K
V
D
A
V
F
-
Q
K
D
G
F
L
Y
F
F
H
G
T
R
Q
Y
Q
F
D
F
K
T
K
R
I
L
T
L
Q
K
A
N
S
W
F
N
C
8
PsiBlast_PDB
79.59
49%
-103
- C3 -
4G0D
12
MMP13_HUMAN
A:
[10-368]
------------------------------------------------------------------------------------------------------------
W
S
K
M
N
L
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
E
V
E
K
A
F
K
K
A
F
K
V
W
S
D
V
T
P
L
N
F
T
R
L
H
-
D
-------
G
I
A
D
I
M
I
S
F
G
I
K
E
H
G
D
F
Y
P
F
D
G
P
S
G
L
L
A
H
A
F
P
P
G
P
---
N
Y
G
G
D
A
H
F
D
D
D
E
T
W
T
S
-
S
---
S
-
K
G
Y
N
L
F
L
V
A
A
H
A
F
G
H
S
L
G
L
D
H
S
K
D
P
G
A
L
M
F
P
I
Y
T
Y
T
G
K
S
H
F
M
L
P
D
D
D
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
D
---
P
N
P
K
H
P
K
T
P
D
K
C
D
P
S
L
S
L
D
A
I
T
S
L
R
G
E
T
M
I
F
K
D
R
F
F
W
R
L
H
P
Q
Q
V
D
A
E
L
F
L
T
K
S
F
W
P
E
L
P
N
R
I
D
A
A
Y
E
H
P
S
H
D
L
I
F
I
F
R
G
R
K
F
W
A
L
N
G
Y
D
I
L
E
G
Y
P
K
K
I
S
-
E
L
G
L
P
K
E
V
K
K
I
S
A
A
V
H
F
E
D
T
G
K
T
L
L
F
S
G
N
Q
V
W
R
Y
D
D
T
N
H
I
M
D
K
D
Y
P
R
L
I
E
E
D
F
P
G
I
G
D
K
V
D
A
V
-
Y
E
K
N
G
Y
I
Y
F
F
N
G
P
I
Q
F
E
Y
S
I
W
S
N
R
I
V
R
V
M
P
A
N
S
I
L
W
C
7
PsiBlast_PDB
77.90
49%
-103
- C3 -
4FVL
14
?
A:
[10-368]
------------------------------------------------------------------------------------------------------------
W
S
K
M
N
L
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
E
V
E
K
A
F
K
K
A
F
K
V
W
S
D
V
T
P
L
N
F
T
R
L
H
-
D
-------
G
I
A
D
I
M
I
S
F
G
I
K
E
H
G
D
F
Y
P
F
D
G
P
S
G
L
L
A
H
A
F
P
P
G
P
---
N
Y
G
G
D
A
H
F
D
D
D
E
T
W
T
S
-
S
---
S
-
K
G
Y
N
L
F
L
V
A
A
H
A
F
G
H
S
L
G
L
D
H
S
K
D
P
G
A
L
M
F
P
I
Y
T
Y
T
G
K
S
H
F
M
L
P
D
D
D
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
D
---
P
N
P
K
H
P
K
T
P
D
K
C
D
P
S
L
S
L
D
A
I
T
S
L
R
G
E
T
M
I
F
K
D
R
F
F
W
R
L
H
P
Q
Q
V
D
A
E
L
F
L
T
K
S
F
W
P
E
L
P
N
R
I
D
A
A
Y
E
H
P
S
H
D
L
I
F
I
F
R
G
R
K
F
W
A
L
N
G
Y
D
I
L
E
G
Y
P
K
K
I
S
-
E
L
G
L
P
K
E
V
K
K
I
S
A
A
V
H
F
E
D
T
G
K
T
L
L
F
S
G
N
Q
V
W
R
Y
D
D
T
N
H
I
M
D
K
D
Y
P
R
L
I
E
E
D
F
P
G
I
G
D
K
V
D
A
V
-
Y
E
K
N
G
Y
I
Y
F
F
N
G
P
I
Q
F
E
Y
S
I
W
S
N
R
I
V
R
V
M
P
A
N
S
I
L
W
C
21
PsiBlast_CBE
59.75
100%
-99
- C3 -
1JIZ
1
MMP12_HUMAN
B:
[2-166]
---------------------------------------------------------------------------------------------------
F
R
E
M
P
G
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
59.62
100%
-101
- C3 -
2WO9
2
MMP12_HUMAN
C:
[2-164]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
59.60
100%
-103
- C3 -
2WO8
1
MMP12_HUMAN
B:
[2-163]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
59.43
99%
-107
- C3 -
4GR3
1
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.43
100%
-105
- C3 -
2WO8
1
MMP12_HUMAN
C:
[2-163]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.35
100%
-101
- C3 -
1JIZ
1
MMP12_HUMAN
A:
[2-166]
---------------------------------------------------------------------------------------------------
F
R
E
M
P
G
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.32
100%
-101
- C3 -
2WO9
1
MMP12_HUMAN
A:
[2-163]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
59.30
100%
-102
- C3 -
2WOA
1
MMP12_HUMAN
C:
[2-163]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
59.28
100%
-102
- C3 -
2WOA
1
MMP12_HUMAN
B:
[2-163]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.27
100%
-104
- C3 -
2WOA
1
MMP12_HUMAN
A:
[2-163]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.19
99%
-106
- C3 -
1JK3
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.12
99%
-106
- C3 -
3F16
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
59.11
99%
-104
- C3 -
4EFS
9
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
59.08
99%
-108
- C3 -
3UVC
8
MMP12_HUMAN
B:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
59.06
99%
-106
- C3 -
2W0D
1
MMP12_HUMAN
C:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.05
99%
-107
- C3 -
3F1A
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
59.05
99%
-105
- C3 -
2W0D
1
MMP12_HUMAN
B:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.05
100%
-105
- C3 -
1UTZ
4
MMP12_HUMAN
A:
[1-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
59.03
100%
-103
- C3 -
2WO9
1
MMP12_HUMAN
B:
[2-162]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.02
99%
-106
- C3 -
3F17
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.01
99%
-107
- C3 -
3EHY
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
59.01
99%
-106
- C3 -
3N2U
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
59.01
99%
-104
- C3 -
3NX7
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.97
99%
-104
- C3 -
3UVC
8
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.96
100%
-104
- C3 -
1UTT
2
MMP12_HUMAN
A:
[1-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
58.95
99%
-106
- C3 -
4GR0
1
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.91
99%
-105
- C3 -
3F15
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
58.89
99%
-108
- C3 -
4H84
7
MMP12_HUMAN
B:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
58.89
99%
-105
- C3 -
3F19
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.89
100%
-104
- C3 -
1ROS
1
MMP12_HUMAN
A:
[1-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
58.87
99%
-104
- C3 -
4H49
6
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
58.87
99%
-106
- C3 -
3LK8
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
58.82
99%
-106
- C3 -
3LKA
2
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.80
99%
-108
- C3 -
3N2V
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.74
99%
-104
- C3 -
3EHX
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.73
99%
-103
- C3 -
4H30
4
MMP12_HUMAN
B:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
58.72
99%
-106
- C3 -
3TSK
1
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
58.73
100%
-103
- C3 -
1UTZ
4
MMP12_HUMAN
B:
[1-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
58.72
99%
-106
- C3 -
4H49
3
MMP12_HUMAN
B:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.71
99%
-104
- C3 -
2W0D
1
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
58.68
99%
-107
- C3 -
4H76
8
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
58.66
99%
-106
- C3 -
3F18
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
58.64
99%
-106
- C3 -
4H30
8
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
58.61
100%
-104
- C3 -
1ROS
1
MMP12_HUMAN
B:
[1-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
58.58
99%
-103
- C3 -
4H84
16
MMP12_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
58.58
100%
-102
- C3 -
2WO8
1
MMP12_HUMAN
D:
[2-161]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
58.40
99%
-102
- C3 -
3RTT
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
58.38
99%
-102
- C3 -
3RTS
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
58.00
99%
-105
- C3 -
4GUY
1
MMP12_HUMAN
A:
[1-158]
---------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
-
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
53.64
57%
-92
- C3 -
3AYU
1
MMP2_HUMAN
A:
[1-166]
---------------------------------------------------------------------------------------------------
Y
N
F
F
P
R
K
P
K
W
D
K
N
Q
I
T
Y
R
I
I
G
Y
T
P
D
L
D
P
E
T
V
D
D
A
F
A
R
A
F
Q
V
W
S
D
V
T
P
L
R
F
S
R
I
H
-
D
-------
G
E
A
D
I
M
I
N
F
G
R
W
E
H
G
D
G
Y
P
F
D
G
K
D
G
L
L
A
H
A
F
A
P
G
T
---
G
V
G
G
D
S
H
F
D
D
D
E
L
W
T
L
-
G
---
K
G
V
G
Y
S
L
F
L
V
A
A
H
A
F
G
H
A
M
G
L
E
H
S
Q
D
P
G
A
L
M
A
P
I
Y
T
Y
T
K
--
N
F
R
L
S
Q
D
D
I
K
G
I
Q
E
L
Y
G
A
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
52.68
53%
-96
- C3 -
1RM8
1
MMP16_HUMAN
A:
[2-169]
----------------------------------------------------------------------------------------------------------
Q
K
W
Q
H
K
H
I
T
Y
S
I
K
N
V
T
P
K
V
G
D
P
E
T
R
K
A
I
R
R
A
F
D
V
W
Q
N
V
T
P
L
T
F
E
E
V
P
-
Y
SELENGK
R
D
V
D
I
T
I
I
F
A
S
G
F
H
G
D
S
S
P
F
D
G
E
G
G
F
L
A
H
A
Y
F
P
G
P
---
G
I
G
G
D
T
H
F
D
S
D
E
P
W
T
L
-
G
NPN
H
-
D
G
N
D
L
F
L
V
A
V
H
E
L
G
H
A
L
G
L
E
H
S
N
D
P
T
A
I
M
A
P
F
Y
Q
Y
M
E
T
D
N
F
K
L
P
N
D
D
L
Q
G
I
Q
K
I
Y
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
52.03
53%
-91
- C3 -
1I76
1
MMP8_HUMAN
A:
[1-163]
----------------------------------------------------------------------------------------------------
M
L
T
P
G
N
P
K
W
E
R
T
N
L
T
Y
R
I
R
N
Y
T
P
Q
L
S
E
A
E
V
E
R
A
I
K
D
A
F
E
L
W
S
V
A
S
P
L
I
F
T
R
I
S
-
Q
-------
G
E
A
D
I
N
I
A
F
Y
Q
R
D
H
G
D
N
S
P
F
D
G
P
N
G
I
L
A
H
A
F
Q
P
G
Q
---
G
I
G
G
D
A
H
F
D
A
E
E
T
W
T
N
-
T
---
S
-
A
N
Y
N
L
F
L
V
A
A
H
E
F
G
H
S
L
G
L
A
H
S
S
D
P
G
A
L
M
Y
P
N
Y
A
F
R
E
T
S
N
Y
S
L
P
Q
D
D
I
D
G
I
Q
A
I
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
51.36
50%
-88
* C3 *
4H1Q
2
MMP9_HUMAN
A:
[1-160]
------------------------------------------------------------------------------------------------------
F
E
G
D
L
K
W
H
H
H
N
I
T
Y
W
I
Q
N
Y
S
E
D
L
P
R
A
V
I
D
D
A
F
A
R
A
F
A
L
W
S
A
V
T
P
L
T
F
T
R
V
Y
-
S
-------
R
D
A
D
I
V
I
Q
F
G
V
A
E
H
G
D
G
Y
P
F
D
G
K
D
G
L
L
A
H
A
F
P
P
G
P
---
G
I
Q
G
D
A
H
F
D
D
D
E
L
W
S
L
G
K
---
G
-
Q
G
Y
S
L
F
L
V
A
A
H
Q
F
G
H
A
L
G
L
D
H
S
S
V
P
E
A
L
M
Y
P
M
Y
R
F
T
--
E
G
P
P
L
H
K
D
D
V
N
G
I
R
H
L
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
47.38
40%
-82
- C3 -
4IN9
6
?
A:
[5-165]
---------------------------------------------------------------------------------------------------------
G
S
K
W
N
K
T
T
L
K
Y
Y
I
Y
N
----
L
T
T
T
E
R
E
N
A
I
R
S
A
F
A
L
W
S
D
K
S
T
L
S
F
I
Q
V
Y
N
P
-------
N
Q
A
D
I
K
I
K
W
E
K
G
N
H
G
D
G
Y
P
F
D
G
N
T
G
I
L
A
H
A
F
Y
P
P
P
AGG
N
Y
A
G
H
L
H
F
D
D
D
E
N
W
S
I
-
N
---
G
-
S
G
I
D
L
I
T
V
A
A
H
E
I
G
H
L
L
G
I
E
H
S
N
V
S
S
A
L
M
Y
P
Y
Y
T
G
I
K
R
---
Q
L
D
N
D
D
C
L
A
V
W
D
L
Y
G
Y
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------