@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01471_MMP12_: (2014-09-24 )
MKFLLLILTLWVTSSGADPLKENDMLFAENYLENFYGLKVERIPMTKMKTNRNFIEEKVQEMQQFLGLNVTGQLDTSTLEMMHKPRCGVPDVYHFKTMPGRPVWRKHYITYRIKNYTPDMKREDVEYAIQKAFQVWSDVTPLKFRKITTGKADIMILFASGAHGDYGAFDGRGGVIAHAFGPGPGIGGDTHFDEDEIWSKSYKGTNLFLVAVHELGHALGLDHSNDPKAIMFPTYGYIDLNTFHLSADDIRGIQSLYGGPEQHQPMPKPDNPEPTACDHNLKFDAVTTVGNKIFFFKDSFFWWKIPKSSTTSVRLISSLWPTLPSGIEAAYEIGDRHQVFLFKGDKFWLISHLRLQPNYPKSIHSLGFPDFVKKIDAAVFNPSLRKTYFFVDNLYWRYDERREVMDAGYPKLITKHFPGIGPKIDAVFYFQRYYYFFQGPNQLEYDTFSSRVTKKLKSNSWFDC
Atome Classification :
(54 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140......-.-------150.......160.......170.......180..---.....190.......200---........210.......220.......230.......240.......250.......260.......270.-......280.......290.......300.......310.......320.......330.......340.......350.......360..-.....370.......380.......390.......400.......410.......420.......430.......440.......450.......460..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
F
L
L
L
I
L
T
L
WVTSSGADPLKEND
M
L
F
A
E
N
Y
L
E
N
F
YG
L
K
V
E
RIPMTKMKT
N
R
N
F
I
E
E
K
V
Q
E
M
Q
Q
F
LGLNVTGQL
D
T
S
T
L
E
M
MHKPRCGVPDV
Y
H
F
KTMPGRPV
W
R
K
H
Y
I
T
Y
R
IKNYTPDM
K
R
E
D
V
E
Y
A
I
Q
K
A
F
Q
V
WSDVTP
L
K
F
R
K
IT-T-------GK
A
D
I
M
I
L
F
ASGAHGDYGAFDGRG
G
V
I
A
HAFGPGP---GIGGDTHF
D
E
D
E
I
W
SK-S---YKG
T
N
L
F
L
V
A
V
H
E
L
G
H
A
LGLDHSNDP
K
A
I
M
F
PT
Y
G
Y
I
D
L
N
T
F
HL
S
A
D
D
I
R
G
I
Q
S
LYGG
P
E
QHQPMPKPDNPE-PTACDHNLK
F
D
A
V
T
TVG
N
K
I
F
F
FKD
S
F
F
W
W
KIPKSST
T
S
V
R
L
I
S
S
LWPTLP
S
G
I
E
A
A
Y
EIGDR
H
Q
V
F
L
F
KG
D
K
F
W
L
I
S
H
L
R
LQPNYP
K
S
I
H-SLG
F
P
D
F
V
K
K
I
D
A
A
VFNPSL
R
K
T
Y
F
F
VD
N
L
Y
W
R
Y
D
E
R
R
E
V
M
DAG
Y
P
K
L
I
T
K
HFPGIGPK
I
D
A
V
F
Y
F
Q
R
Y
Y
Y
F
FQGPNQLE
Y
D
T
F
S
S
R
V
T
K
K
L
KSNSWFDC
8
PsiBlast_PDB
82.34
48%
-113
- C2 -
4G0D
12
MMP13_HUMAN
A:
[1-368]
----------------------------------------------------------------------------------------------
Y
N
V
F
P
R
T
L
K
W
S
K
M
N
L
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
E
V
E
K
A
F
K
K
A
F
K
V
W
S
D
V
T
P
L
N
F
T
R
L
H
-
D
-------
G
I
A
D
I
M
I
S
F
G
I
K
E
H
G
D
F
Y
P
F
D
G
P
S
G
L
L
A
H
A
F
P
P
G
P
---
N
Y
G
G
D
A
H
F
D
D
D
E
T
W
T
S
-
S
---
S
K
G
Y
N
L
F
L
V
A
A
H
A
F
G
H
S
L
G
L
D
H
S
K
D
P
G
A
L
M
F
P
I
Y
T
Y
T
G
K
S
H
F
M
L
P
D
D
D
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
D
---
P
N
P
K
H
P
K
T
P
D
K
C
D
P
S
L
S
L
D
A
I
T
S
L
R
G
E
T
M
I
F
K
D
R
F
F
W
R
L
H
P
Q
Q
V
D
A
E
L
F
L
T
K
S
F
W
P
E
L
P
N
R
I
D
A
A
Y
E
H
P
S
H
D
L
I
F
I
F
R
G
R
K
F
W
A
L
N
G
Y
D
I
L
E
G
Y
P
K
K
I
S
-
E
L
G
L
P
K
E
V
K
K
I
S
A
A
V
H
F
E
D
T
G
K
T
L
L
F
S
G
N
Q
V
W
R
Y
D
D
T
N
H
I
M
D
K
D
Y
P
R
L
I
E
E
D
F
P
G
I
G
D
K
V
D
A
V
Y
E
K
N
G
Y
I
Y
F
F
N
G
P
I
Q
F
E
Y
S
I
W
S
N
R
I
V
R
V
M
P
A
N
S
I
L
W
C
3
PsiBlast_PDB
82.08
51%
-113
- C2 -
1FBL
1
MMP1_PIG
A:
[1-367]
----------------------------------------------------------------------------------------------
F
V
L
T
P
G
N
P
R
W
E
N
T
H
L
T
Y
R
I
E
N
Y
T
P
D
L
S
R
E
D
V
D
R
A
I
E
K
A
F
Q
L
W
S
N
V
S
P
L
T
F
T
K
V
S
-
E
-------
G
Q
A
D
I
M
I
S
F
V
R
G
D
H
R
D
N
S
P
F
D
G
P
G
G
N
L
A
H
A
F
Q
P
G
P
---
G
I
G
G
D
A
H
F
D
E
D
E
R
W
T
K
-
N
---
F
R
D
Y
N
L
Y
R
V
A
A
H
E
L
G
H
S
L
G
L
S
H
S
T
D
I
G
A
L
M
Y
P
N
Y
I
Y
T
--
G
D
V
Q
L
S
Q
D
D
I
D
G
I
Q
A
I
Y
G
P
S
E
--
N
P
V
-
Q
P
S
G
P
Q
T
P
Q
V
C
D
S
K
L
T
F
D
A
I
T
T
L
R
G
E
L
M
F
F
K
D
R
F
Y
M
R
T
N
S
F
Y
P
E
V
E
L
N
F
I
S
V
F
W
P
Q
V
P
N
G
L
Q
A
A
Y
E
I
A
D
R
D
E
V
R
F
F
K
G
N
K
Y
W
A
V
R
G
Q
D
V
L
Y
G
Y
P
K
D
I
H
R
S
F
G
F
P
S
T
V
K
N
I
D
A
A
V
F
E
E
D
T
G
K
T
Y
F
F
V
A
H
E
C
W
R
Y
D
E
Y
K
Q
S
M
D
T
G
Y
P
K
M
I
A
E
E
F
P
G
I
G
N
K
V
D
A
V
F
Q
K
D
G
F
L
Y
F
F
H
G
T
R
Q
Y
Q
F
D
F
K
T
K
R
I
L
T
L
Q
K
A
N
S
W
F
N
C
7
PsiBlast_PDB
81.11
48%
-114
- C2 -
4FVL
14
?
A:
[1-368]
----------------------------------------------------------------------------------------------
Y
N
V
F
P
R
T
L
K
W
S
K
M
N
L
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
E
V
E
K
A
F
K
K
A
F
K
V
W
S
D
V
T
P
L
N
F
T
R
L
H
-
D
-------
G
I
A
D
I
M
I
S
F
G
I
K
E
H
G
D
F
Y
P
F
D
G
P
S
G
L
L
A
H
A
F
P
P
G
P
---
N
Y
G
G
D
A
H
F
D
D
D
E
T
W
T
S
-
S
---
S
K
G
Y
N
L
F
L
V
A
A
H
A
F
G
H
S
L
G
L
D
H
S
K
D
P
G
A
L
M
F
P
I
Y
T
Y
T
G
K
S
H
F
M
L
P
D
D
D
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
D
---
P
N
P
K
H
P
K
T
P
D
K
C
D
P
S
L
S
L
D
A
I
T
S
L
R
G
E
T
M
I
F
K
D
R
F
F
W
R
L
H
P
Q
Q
V
D
A
E
L
F
L
T
K
S
F
W
P
E
L
P
N
R
I
D
A
A
Y
E
H
P
S
H
D
L
I
F
I
F
R
G
R
K
F
W
A
L
N
G
Y
D
I
L
E
G
Y
P
K
K
I
S
-
E
L
G
L
P
K
E
V
K
K
I
S
A
A
V
H
F
E
D
T
G
K
T
L
L
F
S
G
N
Q
V
W
R
Y
D
D
T
N
H
I
M
D
K
D
Y
P
R
L
I
E
E
D
F
P
G
I
G
D
K
V
D
A
V
Y
E
K
N
G
Y
I
Y
F
F
N
G
P
I
Q
F
E
Y
S
I
W
S
N
R
I
V
R
V
M
P
A
N
S
I
L
W
C
9
PsiBlast_PDB
51.68
76%
-107
- C2 -
1JIZ
1
MMP12_HUMAN
A:
[2-165]
----------------------------------------------------------------------------------------------
F
R
E
M
P
G
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
51.42
76%
-108
- C2 -
1JIZ
1
MMP12_HUMAN
B:
[2-165]
----------------------------------------------------------------------------------------------
F
R
E
M
P
G
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
51.13
75%
-110
- C2 -
2WO8
1
MMP12_HUMAN
C:
[3-163]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
51.07
77%
-111
- C2 -
4GR3
1
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
50.94
75%
-111
- C2 -
3UVC
8
MMP12_HUMAN
B:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
50.83
75%
-107
- C2 -
2WOA
1
MMP12_HUMAN
C:
[3-163]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
50.79
77%
-111
- C2 -
3TS4
3
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
50.78
77%
-108
- C2 -
3LKA
2
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
50.78
77%
-110
- C2 -
3LJG
4
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
50.78
77%
-111
- C2 -
1RMZ
1
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.70
77%
-111
- C2 -
1UTZ
4
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.68
75%
-106
- C2 -
2WOA
1
MMP12_HUMAN
A:
[3-163]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
50.60
77%
-110
- C2 -
4H84
7
MMP12_HUMAN
B:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
50.54
77%
-108
- C2 -
3LIL
2
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
50.51
75%
-106
- C2 -
2WO9
2
MMP12_HUMAN
C:
[3-164]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
50.49
75%
-107
- C2 -
2WO8
1
MMP12_HUMAN
B:
[3-163]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
50.46
77%
-109
- C2 -
2HU6
2
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
50.42
75%
-107
- C2 -
2WOA
1
MMP12_HUMAN
B:
[3-163]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.37
75%
-105
- C2 -
2WO9
1
MMP12_HUMAN
A:
[3-163]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
50.35
77%
-107
- C2 -
1UTZ
4
MMP12_HUMAN
B:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
50.34
77%
-110
- C2 -
4H76
8
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
50.29
77%
-108
- C2 -
4GUY
1
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
50.24
77%
-108
- C2 -
2OXZ
2
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
50.19
77%
-112
- C2 -
4GR0
1
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
50.17
77%
-108
- C2 -
4H49
3
MMP12_HUMAN
B:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
50.16
77%
-108
- C2 -
4H84
16
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
50.10
77%
-106
- C2 -
3NX7
1
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
50.10
77%
-106
- C2 -
4H49
6
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
50.05
75%
-110
- C2 -
1ROS
1
MMP12_HUMAN
B:
[2-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
50.04
77%
-105
- C2 -
3N2U
1
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
49.99
77%
-104
- C2 -
3RTT
1
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
49.99
77%
-107
- C2 -
1UTT
2
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
49.97
77%
-106
- C2 -
4H30
8
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
49.96
77%
-110
- C2 -
3TSK
1
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
49.96
75%
-107
- C2 -
1ROS
1
MMP12_HUMAN
A:
[2-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
49.94
75%
-105
- C2 -
2WO9
1
MMP12_HUMAN
B:
[3-162]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
49.80
77%
-107
- C2 -
3N2V
1
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
49.75
77%
-106
- C2 -
2OXW
1
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
49.71
77%
-105
- C2 -
3RTS
1
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
49.68
77%
-106
- C2 -
3LIK
5
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
49.67
77%
-107
- C2 -
4EFS
9
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
49.63
77%
-106
- C2 -
1JK3
1
MMP12_HUMAN
A:
[2-158]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
49.43
75%
-105
- C2 -
2WO8
1
MMP12_HUMAN
D:
[3-161]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
49.42
77%
-105
- C2 -
4H30
4
MMP12_HUMAN
B:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
49.12
77%
-103
- C2 -
3LIR
2
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
49.05
75%
-105
- C2 -
3UVC
8
MMP12_HUMAN
A:
[3-159]
-----------------------------------------------------------------------------------------------------
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-
T
-------
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
-
H
---
S
G
G
T
N
L
F
L
T
A
V
H
A
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
46.10
56%
-92
- C2 -
3AYU
1
MMP2_HUMAN
A:
[1-165]
----------------------------------------------------------------------------------------------
Y
N
F
F
P
R
K
P
K
W
D
K
N
Q
I
T
Y
R
I
I
G
Y
T
P
D
L
D
P
E
T
V
D
D
A
F
A
R
A
F
Q
V
W
S
D
V
T
P
L
R
F
S
R
I
H
-
D
-------
G
E
A
D
I
M
I
N
F
G
R
W
E
H
G
D
G
Y
P
F
D
G
K
D
G
L
L
A
H
A
F
A
P
G
T
---
G
V
G
G
D
S
H
F
D
D
D
E
L
W
T
L
-
G
K--
G
V
G
Y
S
L
F
L
V
A
A
H
A
F
G
H
A
M
G
L
E
H
S
Q
D
P
G
A
L
M
A
P
I
Y
T
Y
T
K
--
N
F
R
L
S
Q
D
D
I
K
G
I
Q
E
L
Y
G
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
45.59
56%
-99
- C2 -
1RM8
1
MMP16_HUMAN
A:
[2-169]
-----------------------------------------------------------------------------------------------------
Q
K
W
Q
H
K
H
I
T
Y
S
I
K
N
V
T
P
K
V
G
D
P
E
T
R
K
A
I
R
R
A
F
D
V
W
Q
N
V
T
P
L
T
F
E
E
V
P
-
Y
SELENGK
R
D
V
D
I
T
I
I
F
A
S
G
F
H
G
D
S
S
P
F
D
G
E
G
G
F
L
A
H
A
Y
F
P
G
P
---
G
I
G
G
D
T
H
F
D
S
D
E
P
W
T
L
-
G
NPN
H
D
G
N
D
L
F
L
V
A
V
H
E
L
G
H
A
L
G
L
E
H
S
N
D
P
T
A
I
M
A
P
F
Y
Q
Y
M
E
T
D
N
F
K
L
P
N
D
D
L
Q
G
I
Q
K
I
Y
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
44.75
51%
-92
- C2 -
1I76
1
MMP8_HUMAN
A:
[1-163]
-----------------------------------------------------------------------------------------------
M
L
T
P
G
N
P
K
W
E
R
T
N
L
T
Y
R
I
R
N
Y
T
P
Q
L
S
E
A
E
V
E
R
A
I
K
D
A
F
E
L
W
S
V
A
S
P
L
I
F
T
R
I
S
-
Q
-------
G
E
A
D
I
N
I
A
F
Y
Q
R
D
H
G
D
N
S
P
F
D
G
P
N
G
I
L
A
H
A
F
Q
P
G
Q
---
G
I
G
G
D
A
H
F
D
A
E
E
T
W
T
N
-
T
---
S
A
N
Y
N
L
F
L
V
A
A
H
E
F
G
H
S
L
G
L
A
H
S
S
D
P
G
A
L
M
Y
P
N
Y
A
F
R
E
T
S
N
Y
S
L
P
Q
D
D
I
D
G
I
Q
A
I
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
43.31
50%
-91
* C2 *
4H1Q
2
MMP9_HUMAN
A:
[1-160]
-------------------------------------------------------------------------------------------------
F
E
G
D
L
K
W
H
H
H
N
I
T
Y
W
I
Q
N
Y
S
E
D
L
P
R
A
V
I
D
D
A
F
A
R
A
F
A
L
W
S
A
V
T
P
L
T
F
T
R
V
Y
-
S
-------
R
D
A
D
I
V
I
Q
F
G
V
A
E
H
G
D
G
Y
P
F
D
G
K
D
G
L
L
A
H
A
F
P
P
G
P
---
G
I
Q
G
D
A
H
F
D
D
D
E
L
W
S
L
G
K
---
G
Q
G
Y
S
L
F
L
V
A
A
H
Q
F
G
H
A
L
G
L
D
H
S
S
V
P
E
A
L
M
Y
P
M
Y
R
F
T
--
E
G
P
P
L
H
K
D
D
V
N
G
I
R
H
L
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
40.16
42%
-89
- C2 -
4IN9
6
?
A:
[5-165]
----------------------------------------------------------------------------------------------------
G
S
K
W
N
K
T
T
L
K
Y
Y
I
Y
N
----
L
T
T
T
E
R
E
N
A
I
R
S
A
F
A
L
W
S
D
K
S
T
L
S
F
I
Q
V
Y
N
P
-------
N
Q
A
D
I
K
I
K
W
E
K
G
N
H
G
D
G
Y
P
F
D
G
N
T
G
I
L
A
H
A
F
Y
P
P
P
AGG
N
Y
A
G
H
L
H
F
D
D
D
E
N
W
S
I
-
N
---
G
S
G
I
D
L
I
T
V
A
A
H
E
I
G
H
L
L
G
I
E
H
S
N
V
S
S
A
L
M
Y
P
Y
Y
T
G
I
K
R
---
Q
L
D
N
D
D
C
L
A
V
W
D
L
Y
G
Y
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------