@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01562_ADA17_: (2014-09-25 )
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRQ
S
L
L
F
L
T
S
V
V
P
F
VLAPRPPDDPGF
G
P
H
Q
R
L
E
K
L
D
S
L
L
S
DYDI
L
S
L
S
N
I
Q
Q
H
S
V
R
K
RDLQT
S
T
H
V
E
T
L
L
T
F
S
A
L
K
R
H
F
K
L
Y
L
TSS
T
E
R
FSQN
F
K
V
V
V
V
DGKNES
E
Y
T
V
K
W
Q
DFFTGHVVGEPDS
R
V
L
A
H
IRDD
D
V
I
I
R
INTDGAEY
N
I
E
P
L
W
R
F
V
NDTKD
K
R
M
L
V
Y
KS
E
D
I
K
N
V
S
RLQSPK
V
C
G
Y
L
K
VD
N
E
ELLPKGLVDRE
P
P
E
E
L
V
H
R
V
K
RRADPDPMKN
T
C
K
L
L
V
V
AD
H
R
F
Y
R
Y
MGRGEES
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
RNTSWDNAGFKGY
G
I
Q
I
E
Q
I
R
I
LK
S
P
QEVKP
G
E
K
H
Y
N
M
A
K
SYPNEEKD
A
W
D
V
K
M
L
L
E
Q
FS
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
QDFDMG
T
L
G
L
A
Y
VGSPRANSHGGVC
P
K
A
Y
YSPVGK
K
N
I
Y
LNSGLTSTKNYG
K
T
I
LTKEAD
L
V
T
T
H
E
LGHNFGAEHDPD
G
L
AECAPNEDQGG
K
Y
V
M
Y
P
I
A
VSGDHEN
N
K
M
F
S
NC
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
SNKVCGNSRVDEGEECDP
G
I
M
Y
LNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQ
F
E
T
A
Q
K
K
C
Q
E
A
I
N
A
T
CKG
V
S
Y
CTGNSSECPPPGNAED
D
T
V
C
L
DLGKCKDGKCIP
F
C
E
R
E
Q
Q
L
E
S
CACNETD
N
S
C
K
V
C
C
R
DLSGRCVPYVDAEQK
N
L
F
L
RKGK
P
C
T
V
G
F
CDMNG
K
C
E
K
R
V
Q
D
V
I
E
R
F
W
D
F
I
D
Q
L
S
I
N
T
F
G
K
F
L
A
D
N
I
V
G
S
V
L
V
F
S
L
I
F
W
I
P
F
S
I
L
V
H
C
V
D
K
K
L
D
K
Q
Y
E
S
LSLFHPS
N
V
E
M
L
S
SMDSA
S
V
R
I
I
KPFPAPQTPGRLQPAPVIPSAPAAPKL
D
H
Q
R
M
D
T
I
QEDPSTDSHMDEDGFEKDPFPNSSTAAK
S
F
E
DLTDHPVTRSEKAA
S
F
K
L
Q
RQNRVDSKETEC
34
PsiBlast_CBE
97.58
98%
-58
- C4 -
3LEA
2
ADA17_HUMAN
B:
[1-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
97.22
98%
-62
- C4 -
3KMC
1
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
96.78
98%
-62
- C4 -
3EWJ
1
ADA17_HUMAN
B:
[6-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
96.66
98%
-57
- C4 -
3EDZ
2
ADA17_HUMAN
A:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
96.52
98%
-63
- C4 -
3L0T
2
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
96.47
99%
-57
- C4 -
3G42
1
ADA17_HUMAN
C:
[8-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
96.45
98%
-52
- C4 -
1BKC
1
ADA17_HUMAN
E:
[1-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
K
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
96.18
98%
-60
- C4 -
3LGP
1
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
96.14
98%
-54
- C4 -
2FV5
1
ADA17_HUMAN
A:
[1-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
96.14
98%
-54
- C4 -
3LEA
2
ADA17_HUMAN
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
96.04
99%
-56
- C4 -
2I47
1
ADA17_HUMAN
D:
[9-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.00
99%
-57
- C4 -
2I47
1
ADA17_HUMAN
A:
[9-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
95.98
99%
-59
- C4 -
3G42
1
ADA17_HUMAN
B:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
95.98
99%
-59
- C4 -
1BKC
1
ADA17_HUMAN
A:
[1-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.96
99%
-57
- C4 -
1ZXC
1
ADA17_HUMAN
A:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.87
99%
-57
- C4 -
2OI0
1
ADA17_HUMAN
A:
[1-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
95.85
99%
-52
- C4 -
3B92
1
ADA17_HUMAN
A:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
95.84
98%
-64
- C4 -
3KME
1
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
95.81
98%
-59
- C4 -
2FV9
1
ADA17_HUMAN
B:
[3-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
95.34
98%
-57
- C4 -
2FV5
1
ADA17_HUMAN
B:
[5-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
95.30
98%
-58
- C4 -
3E8R
1
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
--
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.16
99%
-60
- C4 -
3G42
1
ADA17_HUMAN
D:
[9-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.16
99%
-59
- C4 -
3G42
1
ADA17_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
95.09
98%
-59
- C4 -
3E8R
2
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
95.01
98%
-58
- C4 -
3O64
5
ADA17_HUMAN
B:
[7-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.01
99%
-56
- C4 -
2A8H
1
ADA17_HUMAN
A:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
94.96
99%
-52
- C4 -
2A8H
1
ADA17_HUMAN
B:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
94.78
98%
-57
- C4 -
3EDZ
2
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
94.78
99%
-55
- C4 -
1ZXC
1
ADA17_HUMAN
B:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
94.72
99%
-53
- C4 -
2I47
1
ADA17_HUMAN
B:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
94.70
98%
-59
- C4 -
2FV9
1
ADA17_HUMAN
A:
[1-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
94.66
98%
-54
- C4 -
1BKC
1
ADA17_HUMAN
I:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
E
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
94.60
98%
-58
- C4 -
3L0T
2
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
---
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
94.54
99%
-57
- C4 -
2I47
1
ADA17_HUMAN
C:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
94.42
99%
-57
- C4 -
1BKC
1
ADA17_HUMAN
C:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
94.41
98%
-58
- C4 -
3KME
2
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
94.40
98%
-57
- C4 -
3KMC
1
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
--
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
94.34
98%
-60
- C4 -
2DDF
6
ADA17_HUMAN
B:
[3-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
94.25
98%
-57
- C4 -
3LGP
1
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
------
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
94.23
98%
-58
- C4 -
2DDF
2
ADA17_HUMAN
A:
[1-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
94.12
98%
-56
- C4 -
3EWJ
1
ADA17_HUMAN
A:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------