@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01562_ADA17_: (2014-09-25 )
MRQRLLFLTTLVPFVLAPRPPEEPGSGSHLRLEKLDSLLSDYDILSLSNIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQDFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACADTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGFEKDPFPNSSAAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
Q
R
L
L
F
L
T
T
L
V
P
F
VLAPRPPEEPGSGSH
L
R
L
E
K
L
D
S
L
L
S
DYDI
L
S
L
S
N
I
Q
Q
H
S
I
R
K
R
D
L
Q
S
A
T
H
L
E
T
L
L
T
F
S
A
L
K
R
H
F
K
L
Y
L
TSS
T
E
R
FSQN
L
R
V
V
V
VDGKEES
E
Y
S
V
K
W
Q
DFFSGHVVGEPDS
R
V
L
A
H
IGDD
D
V
T
V
R
INTDGAEY
N
I
E
P
L
W
R
F
V
NDTKD
K
R
M
L
V
Y
KSE
D
I
K
D
F
S
RLQSPK
V
C
G
Y
LNA
D
S
E
E
L
L
P
K
GLIDRE
P
S
E
E
F
V
R
R
V
K
RRAEPN
P
L
K
N
T
C
K
L
L
V
V
AD
H
R
F
Y
K
Y
MGRGEES
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
RNTSWDNAGFKGYG
V
Q
I
E
Q
I
R
I
LKSPQEVKP
G
E
R
H
F
N
M
A
K
SFPNEEKD
A
W
D
V
K
M
L
L
E
Q
FS
L
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
QDFDMG
T
L
G
L
A
Y
VGSPRANSHGGVC
P
K
A
YYNPGVK
K
N
I
Y
LNSGLTSTKNYG
K
T
I
LTKEAD
L
V
T
T
H
E
LGHNFGAEHDPD
G
L
AECAPNEDQGG
K
Y
V
M
Y
P
I
A
VSGDHEN
N
K
M
F
S
NC
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
SNKVCGNSRVDEGEECDP
G
I
M
Y
LNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQ
F
E
T
A
Q
K
K
C
Q
E
A
I
N
A
T
CKG
V
S
Y
CTGNSSECPPPGDAED
D
T
V
C
L
DLGKCKAGKCIP
F
C
K
R
E
Q
E
L
E
S
CACADTD
N
S
C
K
V
C
C
R
NLSGPCVPYVDAEQK
N
L
F
L
RKGK
P
C
T
V
G
F
CDMNG
K
C
E
K
R
V
Q
D
V
I
E
R
F
W
D
F
I
D
Q
L
S
I
N
T
F
G
K
F
L
A
D
N
I
V
G
S
V
L
V
F
S
L
I
F
W
I
P
F
S
I
L
V
H
C
V
D
K
K
L
D
K
Q
Y
E
S
L
S
L
F
HHS
N
I
E
M
L
S
SMDSA
S
V
R
I
I
KPFPAPQTPGRLQALQPAAMMPPVSAAPKL
D
H
Q
R
M
D
T
I
QEDPSTDSHVDDDGFEKDPFPNS
S
A
A
A
K
S
F
E
DLTDHPVTRSEKAA
S
F
K
L
Q
R
QSRVDSKETEC
34
PsiBlast_CBE
97.24
94%
-56
- C4 -
3LEA
2
ADA17_HUMAN
B:
[1-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
97.04
94%
-62
- C4 -
3KMC
1
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
96.83
94%
-62
- C4 -
3EWJ
1
ADA17_HUMAN
B:
[6-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
96.76
95%
-56
- C4 -
3G42
1
ADA17_HUMAN
C:
[8-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
96.66
94%
-60
- C4 -
3LGP
1
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
96.58
94%
-63
- C4 -
3L0T
2
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
96.34
94%
-57
- C4 -
3EDZ
2
ADA17_HUMAN
A:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
96.22
94%
-64
- C4 -
3KME
1
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
96.13
94%
-51
- C4 -
1BKC
1
ADA17_HUMAN
E:
[1-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
K
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.08
95%
-57
- C4 -
2I47
1
ADA17_HUMAN
A:
[9-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
96.05
95%
-57
- C4 -
2I47
1
ADA17_HUMAN
D:
[9-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
95.99
95%
-57
- C4 -
3G42
1
ADA17_HUMAN
B:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
95.99
94%
-54
- C4 -
3LEA
2
ADA17_HUMAN
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.93
94%
-57
- C4 -
2OI0
1
ADA17_HUMAN
A:
[1-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.89
94%
-57
- C4 -
1ZXC
1
ADA17_HUMAN
A:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.80
95%
-58
- C4 -
3G42
1
ADA17_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
95.71
94%
-59
- C4 -
3L0T
2
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
---
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
95.69
94%
-59
- C4 -
1BKC
1
ADA17_HUMAN
A:
[1-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
95.67
94%
-51
- C4 -
3B92
1
ADA17_HUMAN
A:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
95.57
94%
-59
- C4 -
2FV9
1
ADA17_HUMAN
B:
[3-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.57
94%
-55
- C4 -
2A8H
1
ADA17_HUMAN
A:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
95.55
94%
-54
- C4 -
2FV5
1
ADA17_HUMAN
A:
[1-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.51
95%
-60
- C4 -
3G42
1
ADA17_HUMAN
D:
[9-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
95.46
94%
-56
- C4 -
2FV5
1
ADA17_HUMAN
B:
[5-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
95.13
94%
-54
- C4 -
1ZXC
1
ADA17_HUMAN
B:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
94.94
94%
-57
- C4 -
3EDZ
2
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
94.90
94%
-58
- C4 -
3E8R
1
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
--
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
94.86
94%
-57
- C4 -
3E8R
2
ADA17_HUMAN
B:
[6-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
94.85
94%
-59
- C4 -
3O64
5
ADA17_HUMAN
B:
[7-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
94.81
94%
-59
- C4 -
2FV9
1
ADA17_HUMAN
A:
[1-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
94.78
94%
-60
- C4 -
2DDF
6
ADA17_HUMAN
B:
[3-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
94.69
95%
-60
- C4 -
2DDF
2
ADA17_HUMAN
A:
[2-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
94.60
94%
-58
- C4 -
3KMC
1
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
--
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
94.54
94%
-50
- C4 -
2A8H
1
ADA17_HUMAN
B:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
94.46
94%
-53
- C4 -
1BKC
1
ADA17_HUMAN
I:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
E
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
94.41
95%
-57
- C4 -
2I47
1
ADA17_HUMAN
C:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
94.37
94%
-57
- C4 -
3LGP
1
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
------
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
94.35
94%
-58
- C4 -
3KME
2
ADA17_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
94.33
95%
-52
- C4 -
2I47
1
ADA17_HUMAN
B:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
94.30
94%
-55
- C4 -
3EWJ
1
ADA17_HUMAN
A:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
G
G
S
P
----
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
94.07
94%
-56
- C4 -
1BKC
1
ADA17_HUMAN
C:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
N
T
C
K
L
L
V
V
A
D
H
R
F
Y
R
Y
M
G
R
G
E
E
S
T
T
T
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
N
T
A
W
D
N
A
G
F
K
G
Y
G
I
Q
I
E
Q
I
R
I
L
K
S
P
Q
E
V
K
P
G
E
K
H
Y
N
M
A
K
S
Y
P
N
E
E
K
D
A
W
D
V
K
M
L
L
E
Q
F
S
F
D
I
A
E
E
A
S
K
V
C
L
A
H
L
F
T
Y
Q
D
F
D
M
G
T
L
G
L
A
Y
V
G
S
P
R
A
N
S
H
G
G
V
C
P
K
A
Y
Y
S
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Y
G
K
T
I
L
T
K
E
A
D
L
V
T
T
H
E
L
G
H
N
F
G
A
E
H
D
P
D
G
L
A
E
C
A
P
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
H
E
N
N
K
M
F
S
Q
C
S
K
Q
S
I
Y
K
T
I
E
S
K
A
Q
E
C
F
Q
E
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------