@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01833_RON_MO: (2014-09-28 )
MGLPLPLLQSSLLLMLLLRLSAASTNLNWQCPRIPYAASRDFSVKYVVPSFSAGGRVQATAAYEDSTNSAVFVATRNHLHVLGPDLQFIENLTTGPIGNPGCQTCASCGPGPHGPPKDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPRGKALHLAAPACLFSANNNKPEACTDCVASPLGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVSIRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVYSFHSGDFVYFLTVQPISVTSPPSALHTRLVRLNAVEPEIGDYRELVLDCHFAPKRRRRGAPEGTQPYPVLQAAHSAPVDAKLAVELSISEGQEVLFGVFVTVKDGGSGMGPNSVVCAFPIYHLNILIEEGVEYCCHSSNSSSLLSRGLDFFQTPSFCPNPPGGEASGPSSRCHYFPLMVHASFTRVDLFNGLLGSVKVTALHVTRLGNVTVAHMGTVDGRVLQVEIARSLNYLLYVSNFSLGSSGQPVHRDVSRLGNDLLFASGDQVFKVPIQGPGCRHFLTCWRCLRAQRFMGCGWCGDRCDRQKECPGSWQQDHCPPEISEFYPHSGPLRGTTRLTLCGSNFYLRPDDVVPEGTHQITVGQSPCRLLPKDSSSPRPGSLKEFIQELECELEPLVTQAVGTTNISLVITNMPAGKHFRVEGISVQEGFSFVEPVLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLEQVNEEQILCVTPPGAGTARVPLHLQIGGAEVPGSWTFHYKEDPIVLDISPKCGYSGSHIMIHGQHLTSAWHFTLSFHDGQSTVESRCAGQFVEQQQRRCRLPEYVVRNPQGWATGNLSVWGDGAAGFTLPGFRFLPPPSPLRAGLVELKPEEHSVKVEYVGLGAVADCVTVNMTVGGEVCQHELRGDVVICPLPPSLQLGKDGVPLQVCVDGGCHILSQVVRSSPGRASQRILLIALLVLILLVAVLAVALIFNSRRRKKQLGAHSLSPTTLSDINDTASGAPNHEESSESRDGTSVPLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLHFIRSPQRNPTVKDLVSFGLQVACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLAQGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEVKQVVASLLGDHYVQLTAAYVNVGPRAVDDGSVPPEQVQPSPQHCRSTSKPRPLSEPPLPT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080.......1090......1100......1110......1120......1130......1140......1150.--.....1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGL
P
L
P
L
L
Q
S
S
L
L
L
M
L
L
L
R
L
SAASTNLNWQCPRIPYAASR
D
F
S
V
K
Y
V
VPSFSAG
G
R
V
Q
A
T
A
A
YEDSTN
S
A
V
F
V
A
TR
N
H
L
H
VLG
P
D
L
Q
F
I
E
N
LTTGPIGN
P
G
C
Q
T
C
ASCGPGPHGPPKDT
D
T
L
V
L
V
MEPG
L
P
A
L
V
SCGSTLQG
R
C
F
L
H
ELEPRG
K
A
L
H
LAA
P
A
C
L
F
SANNNK
P
E
A
C
T
D
C
V
ASPLG
T
R
V
T
V
V
EQGH
A
S
Y
F
Y
V
ASSL
D
P
E
L
AASFSPRS
V
S
I
R
R
LKSDTSGFQPGFP
S
L
S
V
L
P
K
Y
L
A
S
Y
L
I
K
Y
V
Y
S
FHSG
D
F
V
Y
F
L
T
V
Q
P
I
SVTSP
P
S
A
L
H
T
R
L
V
R
LNAVEPEIG
D
Y
R
E
L
V
L
DCHFA
P
K
R
RRRGAPEGTQP
Y
P
V
L
Q
AAHSAPV
D
A
K
L
A
V
E
L
SISEG
Q
E
V
L
F
G
V
F
V
T
V
KDGGSGMGPN
S
V
V
C
A
F
P
I
Y
H
L
N
I
L
I
E
E
G
V
E
Y
CCHSSN
S
S
S
L
L
S
RG
L
D
F
FQTPSFCPNPPGGEASGPSSR
C
H
Y
F
P
L
M
V
H
A
S
F
T
R
V
D
L
F
N
G
L
LGS
V
K
V
T
A
L
H
V
T
RLG
N
V
T
V
A
H
MGTVDG
R
V
L
Q
V
E
I
A
RSL
N
Y
L
L
Y
V
SNFSLGSSGQ
P
V
H
R
D
V
S
R
LGN
D
L
L
FASG
D
Q
V
F
K
VPIQGPG
C
R
H
F
L
T
C
W
R
C
L
R
A
Q
R
FMGCGWCGDRCDRQKECPGSWQQDHCPP
E
I
S
EFYPHSGPLRG
T
T
R
L
T
L
CGS
N
F
Y
LRPDDVVPEGT
H
Q
I
TVGQS
P
C
RLLPKDSSSPRPG
S
L
K
E
F
I
Q
E
L
E
C
E
L
E
P
L
V
T
QAVGT
T
N
I
S
L
V
I
TNMPAG
K
H
F
R
V
E
G
I
S
V
Q
E
G
F
S
F
V
E
P
V
L
T
SIKPDFGPRAG
G
T
Y
L
T
L
EGQSLSVGT
S
R
A
V
L
VNGTQC
R
L
EQVNEE
Q
I
L
C
VTPPGAG
T
A
R
V
P
L
H
L
Q
IGGAEVPG
S
W
T
F
H
YKED
P
I
V
L
DISPKCGYSG
S
H
I
M
I
H
GQHL
T
S
A
W
H
F
T
L
S
FHDG
Q
S
T
V
E
S
R
C
A
G
Q
F
V
E
Q
Q
Q
R
RCRL
P
E
Y
V
VRNPQGWATGN
L
S
V
W
GDGAAGFTLPGFRFLPP
P
S
P
L
RA
G
L
VELKPEE
H
S
V
K
V
E
Y
V
G
LG
A
V
A
D
C
V
T
V
N
M
TV
G
G
E
V
C
Q
H
E
LRG
D
V
V
I
CPLPPSLQLGKDG
V
P
L
Q
V
C
VDG
G
C
H
I
L
S
Q
V
V
RSSPGR
A
S
Q
R
I
L
L
I
A
L
L
V
L
I
L
L
V
A
V
L
A
V
A
L
I
F
NS
R
R
R
K
K
QLGAHSLSPT
T
L
SDINDTASGAPNHEESSESRDGTSV
P
L
L
RTES
I
R
L
Q
D
L
D
R
M
L
L
A
E
V
K
D
V
LIPH
E
Q
V
V
I
H
TD
Q
V
IGKG
H
F
G
V
V
Y
HGEYTDGA-QN
Q
T
H
C
A
I
K
S
L
S
R
I
T
E
V
Q
E
V
E
A
F
L
RE
G
L
L
M
RGLHHP
N
I
L
A
L
I
G
I
MLPPEGL
P
R
V
L
L
P
Y
MRH
G
D
L
L
H
F
I
RSPQ--RNP
T
V
K
D
L
V
S
F
G
L
Q
V
A
C
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
RNCMLDES
F
T
V
K
V
A
D
F
G
L
A
R
G
V
L
D
K
E
Y
Y
S
V
R
Q
HRHARL
P
V
K
W
M
A
L
E
S
L
Q
T
Y
R
FTTK
S
D
V
W
S
F
G
V
L
L
W
E
L
L
TRGAPPYPHI
D
P
F
D
L
S
H
F
L
AQGRRLPQPEYC
P
D
S
L
Y
H
V
M
L
R
C
WEADPAA
R
P
T
F
R
A
L
V
L
E
V
K
Q
V
V
A
S
L
L
GDH
Y
V
Q
L
T
A
A
Y
VNVGPRAVDDGSV
P
P
E
QVQP
S
P
Q
H
CRSTSKPRPLSEPPLPT
2
PsiBlast_PDB
70.24
87%
-120
- C2 -
3PLS
1
A:
[1-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
R
V
V
T
H
S
D
R
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
D
Q
A
-
Q
N
R
I
Q
C
A
I
K
S
L
S
R
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
N
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
P
Q
--
R
N
P
T
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
Y
S
V
Q
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
L
G
D
H
Y
V
Q
L
---------------------------------------------
12
PsiBlast_PDB
65.82
59%
-121
- C2 -
1R0P
1
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
-----
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
D
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
15
PsiBlast_PDB
65.46
59%
-130
- C2 -
3QTI
1
MET_HUMAN
A:
[6-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
-----
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
----------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
---
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
5
PsiBlast_PDB
65.40
59%
-126
- C2 -
3DKF
1
A:
[5-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
-------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
4
PsiBlast_PDB
65.31
59%
-114
- C2 -
3DKC
1
A:
[6-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
D
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
19
PsiBlast_PDB
64.89
60%
-126
- C2 -
3CD8
1
A:
[8-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
-----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
---------------------------------------------------
16
PsiBlast_PDB
64.63
60%
-130
- C2 -
2RFN
1
MET_HUMAN
A:
[11-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
----
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
-----------------------------------------------
11
PsiBlast_PDB
64.61
59%
-121
- C2 -
3L8V
1
A:
[8-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
3
PsiBlast_PDB
64.60
59%
-127
- C2 -
3DKG
1
A:
[5-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
------
C
V
Y
H
G
T
L
L
D
----
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
-----------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
-----------------------------------------
18
PsiBlast_PDB
64.42
60%
-124
- C2 -
3CCN
1
A:
[9-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------
K
I
H
C
A
V
K
S
L
N
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
---------------------------------------------------
20
PsiBlast_PDB
64.30
60%
-125
- C2 -
3EFJ
1
MET_HUMAN
A:
[8-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
-----------------------------------------------
6
PsiBlast_PDB
64.17
59%
-124
- C2 -
3C1X
1
A:
[63-372]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
10
PsiBlast_PDB
62.95
59%
-124
- C2 -
3F82
1
A:
[9-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
14
PsiBlast_PDB
62.47
59%
-121
- C2 -
3A4P
3
A:
[22-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
----
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
----------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
9
PsiBlast_PDB
62.34
59%
-119
- C2 -
3CE3
1
A:
[8-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
7
PsiBlast_PDB
62.01
59%
-121
- C2 -
3CTH
1
A:
[6-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
17
PsiBlast_PDB
61.94
60%
-122
- C2 -
2RFS
1
A:
[21-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------
K
I
H
C
A
V
K
S
L
N
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
---------------------------------------------------
8
PsiBlast_PDB
61.92
59%
-117
- C2 -
3CTJ
1
A:
[5-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
-
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
--
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
--------------------------------------
45
HHSearch
53.98
42%
-118
* C2 *
3QUP
1
A:
[16-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---
F
T
L
--
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
--------
V
K
V
A
V
K
M
L
-----
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
--
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
IP
F
N
L
P
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
-------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
H
------------------------------------------------------
53
HHSearch
45.24
35%
-95
- C2 -
3KEX
1
ERBB3_HUMAN
A:
[18-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
P
E
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
P
--
G
S
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
--
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
Q
L
L
-------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
-------------------------------------------------------