@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF02146_SIR1_H: (2014-09-28 )
MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.--......220.......230........240.......250-.--.--......260.......270...-.-...280.......290.......300.......310.....--..320.......330.......340.......350....--.--.--.360.......370--.......380.......390-........----------.400.------..----------------------....410.......420.......----------430.......440.......450....-...460.......470----..-.-----.....480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MADE
A
A
L
A
LQPGGSPSAAGADREAASSPAGE
P
L
R
KRPRRDGPGLERSPGEPGGAAPEREVPAAARGCP
G
A
A
A
A
A
L
W
R
E
AE
A
E
AAAAGGE
Q
E
A
Q
ATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEG
E
E
E
E
E
A
A
A
A
AIGYRDNLLFG
D
E
I
I
T
NGFHSCES
D
E
E
D
R
ASHASSSDWTPRPRIG
P
Y
T
F
V
Q
Q
H
LMIGT
D
P
R
T
I
L
K
D
LLPETIPPP--ELD
D
M
T
L
W
Q
I
V
I
N
I
LSEP-PK
R
K
K
RKDI
N
T
I
E
D
A
V
K
L
L
Q
--
E
--
C
--
K
K
I
I
V
L
TGAG
V
S
V
SCGIPDFRS-R-D
G
I
Y
A
R
L
A
VDFPDLP
D
P
Q
A
M
F
D
I
E
Y
F
RKD
P
R
P
F
F
K
F
A
K
E
IY--PGQF
Q
P
S
L
C
H
K
F
I
ALSDKE
G
K
L
L
R
N
Y
TQ
N
I
D
T
L
E
Q
V
A
G
I
--
Q
--
R
--
I
I
Q
CHGSFA
T
A
S
C
L
--
I
C
K
Y
KV
D
C
E
A
V
R
G
D
I
F
N
Q
---
V
VPRCPRC----------PADEP------
L
A
----------------------
I
MK
P
E
I
V
F
FGEN
L
P
E
Q
F
H
R
A
MKYD----------KDEV
D
L
L
I
V
IGSS
L
K
V
R
P
V
A
LIPSSI
P
-
H
E
V
P
Q
I
L
INREPLP
H
-----
L
H
-
F
-----
D
V
E
LLGD
C
D
V
I
I
N
E
L
C
H
R
LG
G
E
Y
A
K
LCCNP
V
K
L
S
E
I
TEKPPR
T
Q
K
E
L
A
Y
L
S
ELPPT
P
L
H
VSEDSSSPERTSPPD
S
S
V
I
V
T
L
L
D
Q
A
AKSNDDLDVSESKGC
M
E
EK
P
Q
E
V
Q
TSR
N
V
E
S
I
A
E
Q
MENP
D
L
K
NVGSSTGEKNE
R
T
S
V
A
G
T
V
R
K
CWP
N
R
V
A
K
E
Q
I
S
R
RLDGN
Q
Y
L
F
LPPN
R
Y
I
F
H
G
A
E
VYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPME
D
E
S
E
I
E
E
F
Y
NGLEDEPDVPERAGGAGFGTDG
D
D
Q
E
A
I
N
E
A
I
S
V
K
Q
E
V
TDMNYPSNKS
2
PsiBlast_PDB
96.72
99%
-130
- C1 -
4I5I
2
SIR1_HUMAN
A:
[4-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
I
E
D
A
V
K
L
L
Q
--
E
--
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
S
-
R
-
D
G
I
Y
A
R
L
A
V
D
F
P
D
L
P
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
I
Y
--
P
G
Q
F
Q
P
S
L
C
H
K
F
I
A
L
S
D
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
I
--
Q
--
R
--
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
--
I
C
K
Y
K
V
D
C
E
A
V
R
G
D
I
F
N
Q
---
V
V
P
R
C
P
R
C
----------
P
A
D
E
P
------
L
A
----------------------
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
----------
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
S
S
I
P
-
H
E
V
P
Q
I
L
I
N
R
E
P
L
P
H
-----
L
H
-
F
-----
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
L
C
C
N
P
V
K
L
S
E
I
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
96.65
99%
-130
- C1 -
4I5I
2
SIR1_HUMAN
B:
[4-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
I
E
D
A
V
K
L
L
Q
--
E
--
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
S
-
R
-
D
G
I
Y
A
R
L
A
V
D
F
P
D
L
P
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
I
Y
--
P
G
Q
F
Q
P
S
L
C
H
K
F
I
A
L
S
D
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
I
--
Q
--
R
--
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
--
I
C
K
Y
K
V
D
C
E
A
V
R
G
D
I
F
N
Q
---
V
V
P
R
C
P
R
C
----------
P
A
D
E
P
------
L
A
----------------------
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
----------
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
S
S
I
P
-
H
E
V
P
Q
I
L
I
N
R
E
P
L
P
H
-----
L
H
-
F
-----
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
L
C
C
N
P
V
K
L
S
E
I
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
96.41
99%
-132
- C1 -
4IG9
2
?
C:
[4-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
K
K
R
K
D
I
N
T
I
E
D
A
V
K
L
L
Q
--
E
--
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
S
-
R
-
D
G
I
Y
A
R
L
A
V
D
F
P
D
L
P
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
I
Y
--
P
G
Q
F
Q
P
S
L
C
H
K
F
I
A
L
-
D
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
I
--
Q
--
R
--
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
--
I
C
K
Y
K
V
D
C
E
A
V
R
G
D
I
F
N
Q
---
V
V
P
R
C
P
R
C
----------
P
A
D
E
P
------
L
A
----------------------
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
----------
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
S
S
I
P
-
H
E
V
P
Q
I
L
I
N
R
E
P
L
P
H
-----
L
H
-
F
-----
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
L
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
95.92
99%
-130
- C1 -
4IG9
3
?
E:
[3-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
R
K
K
R
K
D
I
N
T
I
E
D
A
V
K
L
L
Q
--
E
--
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
S
-
R
-
D
G
I
Y
A
R
L
A
V
D
F
P
D
L
P
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
I
Y
--
P
G
Q
F
Q
P
S
L
C
H
K
F
I
A
L
-
D
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
I
--
Q
--
R
--
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
--
I
C
K
Y
K
V
D
C
E
A
V
R
G
D
I
F
N
Q
---
V
V
P
R
C
P
R
C
----------
P
A
D
E
P
------
L
A
----------------------
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
----------
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
S
S
I
P
-
H
E
V
P
Q
I
L
I
N
R
E
P
L
P
H
-----
L
H
-
F
-----
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
L
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.58
99%
-134
- C1 -
4IG9
1
?
G:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
K
K
R
K
D
I
N
T
I
E
D
A
V
K
L
L
Q
--
E
--
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
S
-
R
-
D
G
I
Y
A
R
L
A
V
D
F
P
D
L
P
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
I
Y
--
P
G
Q
F
Q
P
S
L
C
H
K
F
I
A
L
-
D
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
I
--
Q
--
R
--
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
--
I
C
K
Y
K
V
D
C
E
A
V
R
G
D
I
F
N
Q
---
V
V
P
R
C
P
R
C
----------
P
A
D
E
P
------
L
A
----------------------
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
----------
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
S
S
I
P
-
H
E
V
P
Q
I
L
I
N
R
E
P
L
P
H
-----
L
H
-
F
-----
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
L
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
88.91
32%
-74
- C1 -
4IAO
1
SIR2_YEAST
A:
[29-485]
---------------------------------------------------------------------------------------------------------------------------
S
M
S
N
D
V
L
K
P
E
T
P
K
G
P
I
I
I
S
S
N
G
I
F
Y
G
P
S
F
T
K
R
E
S
L
N
A
R
M
F
L
K
Y
Y
G
A
H
K
F
L
D
T
Y
L
P
E
D
L
-
N
S
L
Y
I
Y
Y
L
I
K
L
L
G
F
E
V
K
D
Q
A
L
I
G
T
I
N
S
I
V
D
P
LA
K
K
Q
T
V
R
L
I
K
D
L
Q
R
A
I
N
K
V
L
C
T
R
L
R
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
--
T
--
A
--
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
-
S
-
E
G
F
Y
S
K
I
K
--
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
ST
D
--
K
--
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
--
T
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
---
E
L
P
L
C
P
Y
C
----------
Y
K
K
R
R
------
E
Y
F
PEGYNNKSMSERPPYILNSYG
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
----------
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
-----
A
E
-
F
-----
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
G
W
T
I
-----
P
H
K
K
W
N
D
L
K
N
K
N
F
K
S
Q
E
K
D
K
G
V
Y
V
V
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.12
40%
-114
- C1 -
2HJH
2
SIR2_YEAST
A:
[27-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
R
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
--
T
--
A
--
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
-
S
-
E
G
F
Y
S
K
--
I
K
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
--
S
TD
K
--
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
--
T
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
---
E
L
P
L
C
P
Y
C
Y
K
K
R
R
E
Y
F
PE---
R
P
PYILNS
Y
G
----------------------
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
----------
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
-----
A
E
-
F
-----
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.38
40%
-114
- C1 -
4BVB
2
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.83
40%
-106
- C1 -
4BVH
2
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
74.27
39%
-105
- C1 -
1Q1A
2
HST2_YEAST
A:
[6-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
R
K
I
A
A
H
M
K
--
S
--
N
PN
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
-
P
G
T
G
L
Y
H
N
L
A
--
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
KD
D
--
L
--
I
I
E
A
H
G
S
F
A
H
C
H
C
I
--
G
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
PIK
D
F
V
K
C
D
V
C
----------
G
-----------
E
----------------------
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T-
P
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
FKANK
R
P
-
T
-----
D
L
I
V
H
Q
Y
S
D
E
F
A
E
Q
L
V
E
E
L
G
W
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.02
40%
-112
- C1 -
4BVE
3
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.66
40%
-109
- C1 -
4BV3
4
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.29
40%
-107
- C1 -
3GLT
1
SIR3_HUMAN
A:
[10-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.29
40%
-114
- C1 -
3GLR
2
SIR3_HUMAN
A:
[10-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
H
PRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.16
40%
-114
- C1 -
4HD8
3
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.13
40%
-113
- C1 -
4C78
2
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
---------------
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
H
PRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.94
40%
-110
- C1 -
4BVG
12
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.69
40%
-112
- C1 -
4FZ3
1
SIR3_HUMAN
A:
[8-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
-----------
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.06
40%
-107
- C1 -
4BVF
2
SIR3_HUMAN
A:
[9-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.83
40%
-112
- C1 -
3GLU
1
SIR3_HUMAN
A:
[10-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
D
V
A
E
L
I
R
--
A
RA
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
L
Q
Q
Y
--
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
PA
S
--
K
--
L
V
E
A
H
G
T
F
A
S
A
T
C
T
--
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
----------
T
-----------
G
----------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
-----
L
A
-
W
H
PRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.35
42%
-91
- C1 -
3ZGO
3
SIR2_HUMAN
A:
[4-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
D
M
D
F
L
R
N
L
F
S
Q
--------
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
SE
R
--
C
--
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
-
T
G
L
Y
D
N
L
--
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
--
E
--
Q
ED
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
SA
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
----------
Q
-----------
S
----------------------
L
V
K
P
D
I
V
F
F
G
E
S
P
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.65
43%
-92
- C1 -
4L3O
3
?
A:
[1-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
SE
R
--
C
--
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
------
Y
D
N
L
--
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
--
E
--
Q
ED
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
SA
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
----------
Q
-----------
S
----------------------
L
V
K
P
D
I
V
F
F
G
E
S
L
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
65.45
34%
-108
- C1 -
1YC5
2
NPD_THEMA
A:
[3-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
--
E
--
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
FP
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
S
--
K
--
K
--
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
--
R
C
E
K
K
Y
T
V
E
D
V
I
K
K
L
E
S
S
---
D
V
P
L
C
D
D
C
----------
N
-----------
S
----------------------
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
----------
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
-----
D
D
I
A
-----
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------