@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
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Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF02146_SIR2_H: (2014-09-28 )
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
Atome Classification :
(28 SA)
----------------------------------------------------.........10......------..20........30........40........50........60........70........80........90........100.......110.......120.......130.......--140.......150.......160.......170.......180.......190.......200.......210....---...220...------------------.---------------------------...230.......240.......250--------.........260.......270.....-..280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------MAEPDPSHPLETQAGKV------QEAQDSDSDSEGGAAGG
E
A
D
M
D
F
L
R
N
L
F
S
Q
T
L
SLG
S
Q
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
VGAGISTSAGIPDFRSPSTG
L
Y
D
N
L
E
K
YHLPY
P
E
A
I
F
E
I
S
Y
F
K
KHP
E
P
F
F
A
L
A
K
E
LY--PGQFK
P
T
I
C
H
Y
F
M
R
L
L
KDK
G
L
L
L
R
C
YTQ
N
I
D
T
L
E
R
I
AGL
E
Q
E
D
L
V
E
A
HG
T
F
Y
T
S
HCVS
A
S
C
RHEY
P
L
S
W
M
K
E
K
I
F
S
E---VTP
K
C
E
D
C
Q
------------------
S
---------------------------LVKP
D
I
V
F
FGES
L
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
VMGTSLQ
V
Q
P
F
A
S
L
I
S
KAP-LSTP
R
L
L
I
NKEKAGQSDP
F
L
G
M
I
M
GLGGGMDFDS
K
K
A
Y
R
D
V
A
W
L
GEC
D
Q
G
C
L
A
L
A
E
L
LG
W
K
K
E
L
E
D
L
V
R
R
E
HASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
24
PsiBlast_CBE
98.71
99%
-132
- C1 -
3ZGO
2
SIR2_HUMAN
B:
[3-325]
-------------------------------------------------------------------------------------------
G
E
A
D
M
D
F
L
R
N
L
F
S
Q
-------
K
E
R
L
L
D
E
L
T
L
E
G
V
A
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Y
M
Q
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E
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C
R
R
V
I
C
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A
G
I
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T
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G
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D
F
R
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S
T
G
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Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
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Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
P
D
I
V
F
F
G
E
S
P
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
M
G
L
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
S
---------------------------------
36
HHSearch
98.12
100%
-134
- C1 -
3ZGO
3
SIR2_HUMAN
A:
[3-324]
-------------------------------------------------------------------------------------------
G
E
A
D
M
D
F
L
R
N
L
F
S
Q
-------
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
T
G
L
Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
P
D
I
V
F
F
G
E
S
P
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
M
G
L
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
----------------------------------
23
PsiBlast_CBE
96.20
99%
-132
- C1 -
3ZGO
5
SIR2_HUMAN
C:
[23-325]
---------------------------------------------------------------------------------------------------------------
Q
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
T
G
L
Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
P
D
I
V
F
F
G
E
S
P
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
M
G
L
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
S
---------------------------------
3
PsiBlast_PDB
94.37
100%
-129
- C1 -
4L3O
3
?
A:
[1-302]
----------------------------------------------------------------------------------------------------------------
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
-----
Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
P
D
I
V
F
F
G
E
S
L
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
M
G
L
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
S
---------------------------------
26
PsiBlast_CBE
93.83
100%
-132
- C1 -
4L3O
4
?
C:
[3-302]
------------------------------------------------------------------------------------------------------------------
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
------
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
P
D
I
V
F
F
G
E
S
L
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
M
G
L
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
S
---------------------------------
27
PsiBlast_CBE
93.61
100%
-132
- C1 -
4L3O
3
?
B:
[2-302]
-----------------------------------------------------------------------------------------------------------------
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
------
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
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R
C
Y
T
Q
N
I
D
T
L
E
R
I
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L
E
Q
E
D
L
V
E
A
H
G
T
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V
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A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
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D
I
V
F
F
G
E
S
L
P
A
R
F
F
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C
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Q
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D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
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D
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F
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G
M
I
M
G
L
G
G
G
M
D
F
D
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K
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D
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A
W
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E
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D
Q
G
C
L
A
L
A
E
L
L
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W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
S
---------------------------------
25
PsiBlast_CBE
92.49
100%
-127
- C1 -
4L3O
3
?
D:
[3-302]
------------------------------------------------------------------------------------------------------------------
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
-------
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
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H
C
V
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
P
D
I
V
F
F
G
E
S
L
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
M
G
L
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
S
---------------------------------
22
PsiBlast_CBE
92.39
100%
-128
- C1 -
3ZGV
4
SIR2_HUMAN
B:
[24-324]
----------------------------------------------------------------------------------------------------------------
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
T
G
L
Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
----
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
------------------
S
---------------------------
L
V
K
P
D
I
V
F
F
G
E
S
L
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
S
D
P
F
L
G
M
I
M
G
L
G
G
G
M
D
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
D
A
Q
----------------------------------
15
PsiBlast_PDB
78.65
50%
-123
- C1 -
4BVB
2
SIR3_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
4
PsiBlast_PDB
78.31
50%
-124
- C1 -
3GLR
2
SIR3_HUMAN
A:
[8-280]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
7
PsiBlast_PDB
78.10
50%
-126
- C1 -
3GLU
1
SIR3_HUMAN
A:
[8-280]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
8
PsiBlast_PDB
77.82
50%
-122
- C1 -
4JSR
1
SIR3_HUMAN
A:
[8-280]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
6
PsiBlast_PDB
77.59
50%
-120
- C1 -
3GLT
1
SIR3_HUMAN
A:
[8-280]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
16
PsiBlast_PDB
77.55
50%
-125
- C1 -
4BVE
3
SIR3_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
10
PsiBlast_PDB
77.47
50%
-123
- C1 -
4JT9
3
SIR3_HUMAN
A:
[8-279]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
--------------------------------------
17
PsiBlast_PDB
77.41
50%
-119
- C1 -
4BVF
2
SIR3_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
20
PsiBlast_PDB
77.35
50%
-122
- C1 -
4C78
2
SIR3_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
------------
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
14
PsiBlast_PDB
77.21
50%
-119
- C1 -
4BV3
4
SIR3_HUMAN
A:
[7-276]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
----------------------------------------
19
PsiBlast_PDB
77.12
50%
-120
- C1 -
4BVH
2
SIR3_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
---------------------------------------
18
PsiBlast_PDB
76.94
50%
-122
- C1 -
4BVG
13
SIR3_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-------------------------------------
12
PsiBlast_PDB
76.73
50%
-123
- C1 -
4C7B
6
SIR3_HUMAN
A:
[6-277]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-----------
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
--------------------------------------
9
PsiBlast_PDB
76.68
50%
-121
- C1 -
4JT8
1
SIR3_HUMAN
A:
[8-279]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
--------------------------------------
13
PsiBlast_PDB
76.60
50%
-126
- C1 -
4HD8
3
SIR3_HUMAN
A:
[7-278]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
------------
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
--------------------------------------
30
Fugue
76.59
30%
-84
- C1 -
4IAO
1
SIR2_YEAST
A:
[29-485]
SMSNDVLKPETPKGPIIISSNGIFYGPSFT
K
R
E
S
L
N
A
R
M
F
L
K
Y
YG
A
H
K
F
L
D
T
Y
L
P
E
D
L
N
S
L
Y
I
Y
Y
L
I
K
L
L
GFEVK
D
Q
A
L
I
G
T
I
N
S
I
V
D
P
L
A
K
K
Q
T
V
R
L
I
K
D
L
Q
R
A
I
N
K
V
L
C
T
R
L
R
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
T
--
A
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
-
S
E
G
F
Y
S
K
I
K
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
S
T
D
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
---
E
L
P
L
C
P
Y
C
Y
------------------
K
K
R
R
E
Y
F
PEGYNNKSMSERPPYILNSYG
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
----------
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
A
E
F
---------------------
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
G
W
T
---------------------
I
P
H
K
K
W
N
D
L
K
N
K
N
F
K
S
Q
E
K
D
K
G
V
Y
V
V
T
S
--
11
PsiBlast_PDB
75.97
50%
-123
- C1 -
4FZ3
1
SIR3_HUMAN
A:
[6-275]
----------------------------------------------------------------------------------------------------------------------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
----------
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
--
T
V
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
T
------------------
G
---------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
--------------
L
V
G
P
L
A
W
H
P
R
S
--
R
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
----------------------------------------
38
HHSearch
74.85
47%
-112
- C1 -
1Q1A
2
HST2_YEAST
A:
[7-288]
------------------------------------------------------------------------------------------------------------------------
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
--
G
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
PIK
D
F
V
K
C
D
V
C
G
------------------
E
---------------------------
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T-
P
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
-------------------------------------------
40
HHSearch
70.49
37%
-115
- C1 -
2HJH
2
SIR2_YEAST
A:
[28-322]
-----------------------------------------------------------------------------------------------------------------
L
R
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
T
--
A
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
S
E
-
G
F
Y
S
K
I
K
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
S
T
D
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
--
T
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
---
E
L
P
L
C
P
Y
C
Y
K
K
R
R
E
Y
F
PERPPYILNSY
G
---------------------------
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
----------
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
A
---------------------
E
F
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
G
W
T
I
P
H
------------------------------------------------
43
HHSearch
61.69
33%
-120
* C1 *
1YC5
2
NPD_THEMA
A:
[2-245]
------------------------------------------------------------------------------------------------------------------------
K
M
K
E
F
L
D
L
L
N
E
--
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
FP
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
--
R
C
E
K
K
Y
T
V
E
D
V
I
K
K
L
E
S
S
---
D
V
P
L
C
D
D
C
N
------------------
S
---------------------------
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
----------
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
--------------------
D
D
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
G
I
----------------------------------------------------