@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF02146_SIR2_Y: (2014-09-28 )
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.--.--.....260.......270....-.-..280.--......290.......300.......310.....--..320.......330.......340.......350.......360.......370..--.....380.......390--........400.......410.......420.......430.......440.......450.......460--------.........470.......480.....-..490.......500--------------.-------..-----....510.......520.......530.......540.......550.......560
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTIPHMKYAVSKTSENKVSNTVSPTQ
D
K
D
A
I
RKQP
D
D
IINNDEPSH
K
K
I
KVAQPDSLRETNTTDPLG
H
T
K
A
A
L
G
E
V
A
S
M
ELKPTNDMD
P
L
A
V
S
A
A
S
V
V
SMSNDVLKPETPKG
P
I
I
I
SKNPSN
G
I
F
YGPSFTKRESLN
A
R
M
F
L
K
Y
Y
G
A
H
K
F
L
D
T
YLP
E
D
L
N
S
L
Y
I
Y
Y
L
I
K
L
LGFEVK
D
Q
A
L
I
G
T
I
N
S
I
V
HIN
S
Q
E
R
V
Q
D
L
G
SAISVTNVEDP
L
A
K
K
Q
T
V
R
L
I
K
D
L
Q
R
A
I
N
K
V
L
C
T
R
L
R
L
SNF
F
T
I
D
H
F
I
Q
K
L
H
T--A--
R
K
I
L
V
L
TGAGVSTSLGIPDFRS-S-E
G
F
Y
S
K
--
I
K
HLGLD
D
P
Q
D
V
F
N
Y
N
I
F
MHD
P
S
V
F
Y
N
I
A
N
MVL
P
--
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
YAGI
S
T
D
K
L
V
Q
CHGSF
A
T
A
T
C
V
T
--
C
HWNL
P
G
E
R
I
F
N
K
I
RNL---ELPLC
P
Y
C
Y
K
K
R
R
E
YFPEGYNNKV
G
V
AASQGSMSERP
P
Y
I
LNSYGVLKP
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
----------
I
L
EC
D
L
L
I
C
IGTSLKVA
P
V
S
E
I
V
N
M
V
P
-
S
HV
P
Q
V
L
INRDPVK
H
--------------
A
-------
E
F
-----
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
KCGWTIPH
K
K
W
NDLKNKN
F
K
C
QEKDK
G
V
Y
V
V
TSDEHPKTL
29
HHSearch
100.00
100%
-128
- C2 -
4IAO
1
SIR2_YEAST
A:
[29-485]
--------------------------------------------------------------------------------------------------
S
M
S
N
D
V
L
K
P
E
T
P
K
G
P
I
I
I
S
---
S
N
G
I
F
Y
G
P
S
F
T
K
R
E
S
L
N
A
R
M
F
L
K
Y
Y
G
A
H
K
F
L
D
T
Y
L
P
E
D
L
N
S
L
Y
I
Y
Y
L
I
K
L
L
G
F
E
V
K
D
Q
A
L
I
G
T
I
N
S
I
V
---------------------
D
P
L
A
K
K
Q
T
V
R
L
I
K
D
L
Q
R
A
I
N
K
V
L
C
T
R
L
R
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
T
--
A
--
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
-
S
-
E
G
F
Y
S
K
--
I
K
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
P
--
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
S
T
D
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
---
E
L
P
L
C
P
Y
C
Y
K
K
R
R
E
Y
F
P
E
G
Y
N
N
K
--------
S
M
S
E
R
P
P
Y
I
L
N
S
Y
G
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
----------
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
--------------
A
-------
E
F
-----
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
G
W
T
I
P
H
K
K
W
N
D
L
K
N
K
N
F
K
S
Q
E
K
D
K
G
V
Y
V
V
T
S
-------
30
HHSearch
83.68
100%
-121
- C2 -
2HJH
2
SIR2_YEAST
A:
[2-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
A
K
K
Q
T
V
R
L
I
K
D
L
Q
-----
V
L
C
T
R
L
R
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
T
--
A
--
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
-
S
-
E
G
F
Y
S
K
--
I
K
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
P
--
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
S
T
D
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
---
E
L
P
L
C
P
Y
C
Y
K
K
R
R
E
Y
F
P
E
-----------------
R
P
P
Y
I
L
N
S
Y
G
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
----------
I
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
--------------
A
-------
E
F
-----
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
K
C
G
W
T
I
P
H
K
K
W
N
D
L
K
N
K
N
F
K
C
Q
E
K
D
K
G
V
Y
V
V
T
S
D
------
31
HHSearch
60.71
34%
-117
- C2 -
3ZGO
3
SIR2_HUMAN
A:
[6-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
D
F
L
R
N
L
F
S
Q
-------
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
ER
C
--
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
-
P
S
T
G
L
Y
D
N
--
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
P
--
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
AS
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
---
V
T
P
K
C
E
D
C
Q
-----------------------------------
S
L
V
K
P
D
I
V
F
F
G
E
S
P
P
A
R
F
F
S
C
M
Q
S
D
----------
F
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
SD
P
F
L
G
M
I
M
G
L
G
GG
M
DFDSKKA
Y
R
-----
D
V
A
W
L
G
E
C
D
Q
G
C
L
A
L
A
E
L
L
G
W
K
K
E
L
--------------------------------
3
PsiBlast_PDB
60.04
40%
-113
- C2 -
4I5I
2
SIR1_HUMAN
A:
[5-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
D
A
V
K
L
L
Q
E
--
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
S
-
R
-
D
G
I
Y
A
R
L
A
V
D
F
P
D
L
P
D
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
K
E
I
Y
P
--
G
Q
F
Q
P
S
L
C
H
K
F
I
A
L
S
D
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
I
Q
--
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
--
C
K
Y
K
V
D
C
E
A
V
R
G
D
I
F
N
Q
---
V
V
P
R
C
P
R
C
------------------------
P
A
D
E
P
------
L
A
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
R
A
M
K
Y
D
----------
K
D
E
V
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
L
I
P
S
S
I
P
-
H
E
V
P
Q
I
L
I
N
R
E
P
L
P
H
--------------
L
-------
H
F
-----
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
L
C
C
N
P
V
K
-------------------------
34
HHSearch
57.68
35%
-110
- C2 -
1Q1A
2
HST2_YEAST
A:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
R
K
I
A
A
H
M
K
S
--
N
PN
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
-
P
G
T
G
L
Y
H
N
--
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
P
--
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
PIK
D
F
V
K
C
D
V
C
-----------------------------------
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T-
P
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
FKANK---------
R
-------
P
T
-----
D
L
I
V
H
Q
Y
S
D
E
F
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
--------------------------------
7
PsiBlast_PDB
56.41
35%
-108
- C2 -
4BVB
2
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
17
PsiBlast_PDB
56.24
35%
-108
- C2 -
3GLU
1
SIR3_HUMAN
A:
[19-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
H
PRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
14
PsiBlast_PDB
55.98
35%
-112
- C2 -
3GLR
2
SIR3_HUMAN
A:
[19-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
H
PRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
11
PsiBlast_PDB
55.98
35%
-104
- C2 -
4BVH
2
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
6
PsiBlast_PDB
55.82
35%
-106
- C2 -
4BV3
4
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
10
PsiBlast_PDB
55.58
35%
-106
- C2 -
4BVG
12
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
8
PsiBlast_PDB
55.54
35%
-110
- C2 -
4BVE
3
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
18
PsiBlast_PDB
55.44
35%
-105
- C2 -
4JSR
1
SIR3_HUMAN
A:
[19-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
19
PsiBlast_PDB
55.03
35%
-105
- C2 -
4JT8
1
SIR3_HUMAN
A:
[19-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
20
PsiBlast_PDB
54.82
35%
-106
- C2 -
4JT9
3
SIR3_HUMAN
A:
[19-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
16
PsiBlast_PDB
54.81
35%
-107
- C2 -
3GLT
1
SIR3_HUMAN
A:
[19-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
9
PsiBlast_PDB
54.66
35%
-107
- C2 -
4BVF
2
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
-
S
G
L
Y
S
N
--
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
12
PsiBlast_PDB
54.21
35%
-106
- C2 -
4C78
2
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
---------------
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
H
PRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
13
PsiBlast_PDB
53.16
35%
-109
- C2 -
4C7B
6
SIR3_HUMAN
A:
[17-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
--------------
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
5
PsiBlast_PDB
52.63
35%
-109
- C2 -
4HD8
3
SIR3_HUMAN
A:
[18-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
A
--
C
--
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
---------------
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
P
--
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
---
R
V
P
R
C
P
V
C
-----------------------------------
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
L
L
H
V
-
V
D
----------
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
--------------
L
-------
A
W
HPRSR
D
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
-----------------------------------
36
HHSearch
51.33
31%
-121
* C2 *
1YC5
2
NPD_THEMA
A:
[2-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
K
E
F
L
D
L
L
N
E
--
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
F
PM
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
--
C
E
K
K
Y
T
V
E
D
V
I
K
K
L
E
S
S
---
D
V
P
L
C
D
D
C
-----------------------------------
N
S
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
----------
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
--------------
D
D------
I
A
-----
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
G
I
------------------------------------