@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF02375_KDM4A_: (2014-09-29 )
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
Atome Classification :
(49 SA)
.........10........20........30........40........50......----..60---........70........--80........-90........100.------.....-.110----------...------......120.....----..130.......140..-.....150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASESETLNPSA
R
I
M
T
FYP
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
ESQGAHRAGLAKVVPPKEWKPRA----SYDD---IDDLVI
P
A
P
I
Q
Q
L
VTGQS--G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
ANS------DKYCT-P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
WKNLTF----NPPIYGADVN
G
T
L
Y
E
K
H-VDEWNI
G
R
L
R
T
I
L
D
L
V
EKES
G
I
T
I
E
GVNT
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
HTED
M
D
L
Y
S
I
N
Y
L
HFGEPKSWYSVP
P
E
H
G
K
R
L
E
R
L
A
K
GFFPG
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
YGI
P
F
D
K
V
T
Q
EAG
E
F
M
I
T
F
PYGYHAGFNHGFNCAESTN
F
A
T
R
R
W
I
E
YG
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
KFQPE
R
Y
K
L
WKAGKDN
T
V
I
DHTLP
T
P
E
A
A
E
F
L
K
ESELPPRAGNEEEC
P
E
E
D
M
EGVEDGEEG
D
L
K
T
S
L
A
K
HRIG
T
K
R
H
R
V
C
L
E
I
P
Q
E
V
S
QSELFPKEDLSSEQYEMTECPAALAPVRP
T
H
S
S
V
R
Q
V
EDGLTFPDYSDST
E
V
K
F
E
E
LKNVKLEEED
E
E
E
E
Q
A
A
A
A
L
D
LSVNPASVG
G
R
L
V
FSGSKKKSSSSLGSGSSRDSISSDSETSEP
L
S
C
R
AQG
Q
T
G
V
L
T
V
H
S
YAKGDG
R
V
TVGEPCTRKKGSAARS
F
S
E
R
E
L
A
E
V
A
D
E
Y
M
F
S
L
EENKKSKGRRQ
P
L
S
KLPRHH
P
L
V
L
Q
E
CVSDDETSEQLT
P
E
E
E
A
E
E
T
E
A
W
A
K
P
L
S
Q
L
W
QNRPPN
F
E
A
E
K
E
F
N
E
T
M
A
Q
QAP
H
C
A
V
C
M
I
F
Q
T
Y
HQ
V
E
FGGFNQNCG
N
A
S
DLAPQKQRTKPLI
P
E
MCFTSTGCSTDINLSTPYLEEDG
T
S
I
L
V
S
CKK
C
S
V
R
V
H
A
S
CYGVPPAKASE
D
W
M
CSRCSANALEEDC
C
L
C
SLRGGALQRANDD
R
W
V
H
V
S
C
A
V
A
I
L
E
A
R
F
V
N
IAERSPVDVSKIPLP
R
F
K
L
K
C
I
F
C
K
K
RRKRTA
G
C
C
V
QCSHGRCP
T
A
F
H
V
S
C
A
Q
AAGVMMQPDDW
P
F
V
V
F
I
T
C
F
R
H
KIP
N
L
E
R
A
K
G
A
L
Q
S
I
T
A
G
Q
K
V
I
S
KHKNG
R
F
Y
Q
C
E
V
V
R
L
TT
E
T
F
Y
E
V
NFDDGSFSDNLY
P
E
D
I
V
S
Q
D
C
L
QFGPPAEG
E
V
V
Q
V
R
WTD
G
Q
V
Y
G
A
K
F
VASH
P
I
Q
M
Y
Q
V
E
FEDG
S
Q
L
V
V
KRDD
V
Y
T
L
D
E
E
L
P
K
R
V
K
S
R
L
S
V
ASDM
R
F
N
E
I
F
T
E
K
E
V
K
Q
E
K
K
R
Q
R
V
I
N
S
R
Y
R
E
D
YI
E
P
A
L
Y
R
A
I
ME
29
PsiBlast_CBE
97.78
100%
-77
- C5 -
2YBP
2
KDM4A_HUMAN
B:
[25-377]
--
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
97.58
100%
-83
- C5 -
2YBS
3
KDM4A_HUMAN
A:
[30-377]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
97.57
100%
-79
- C5 -
3PDQ
1
KDM4A_HUMAN
A:
[25-377]
--
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
97.50
100%
-81
- C5 -
2YBK
1
KDM4A_HUMAN
A:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
97.46
100%
-79
- C5 -
2YBK
1
KDM4A_HUMAN
B:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
97.25
100%
-80
- C5 -
3RVH
2
KDM4A_HUMAN
B:
[27-376]
----
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
97.14
100%
-79
- C5 -
4GD4
1
KDM4A_HUMAN
A:
[27-376]
----
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
97.06
100%
-82
- C5 -
4GD4
1
KDM4A_HUMAN
B:
[30-376]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
97.05
100%
-83
- C5 -
4BIS
1
?
B:
[30-377]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
97.03
100%
-79
- C5 -
2OS2
2
KDM4A_HUMAN
A:
[30-376]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
97.02
100%
-80
- C5 -
2OX0
2
KDM4A_HUMAN
A:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
97.01
100%
-83
- C5 -
3NJY
1
KDM4A_HUMAN
A:
[30-376]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
96.93
100%
-80
- C5 -
2OX0
2
KDM4A_HUMAN
B:
[29-376]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
96.81
100%
-77
- C5 -
2VD7
1
KDM4A_HUMAN
A:
[28-377]
-----
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
96.80
100%
-79
- C5 -
3RVH
2
KDM4A_HUMAN
A:
[25-375]
--
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
96.73
100%
-76
- C5 -
3U4S
2
KDM4A_HUMAN
B:
[28-376]
-----
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
96.62
100%
-78
- C5 -
4BIS
2
?
A:
[30-377]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
96.60
100%
-77
- C5 -
2VD7
1
KDM4A_HUMAN
B:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
96.57
100%
-81
- C5 -
4AI9
2
KDM4A_HUMAN
A:
[30-377]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
96.54
100%
-80
- C5 -
2YBS
2
KDM4A_HUMAN
B:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
96.46
100%
-81
- C5 -
2YBP
3
KDM4A_HUMAN
A:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.43
100%
-78
- C5 -
2OQ6
2
KDM4A_HUMAN
A:
[30-377]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
96.42
100%
-81
- C5 -
3PDQ
1
KDM4A_HUMAN
B:
[29-376]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
96.40
100%
-82
- C5 -
4AI9
2
KDM4A_HUMAN
B:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
96.40
100%
-80
- C5 -
2P5B
4
KDM4A_HUMAN
A:
[4-350]
-
A
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
96.35
100%
-76
- C5 -
2OS2
2
KDM4A_HUMAN
B:
[29-376]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
96.32
100%
-79
- C5 -
2OT7
2
KDM4A_HUMAN
A:
[29-377]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
96.31
100%
-82
- C5 -
3NJY
1
KDM4A_HUMAN
B:
[30-376]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
96.25
100%
-79
- C5 -
2OQ6
2
KDM4A_HUMAN
B:
[29-376]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
96.08
100%
-81
- C5 -
2WWJ
1
KDM4A_HUMAN
B:
[1-347]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
95.99
100%
-79
- C5 -
2OT7
2
KDM4A_HUMAN
B:
[29-376]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
95.97
100%
-79
- C5 -
2OQ7
1
KDM4A_HUMAN
B:
[29-375]
------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
95.79
100%
-85
- C5 -
2GP5
1
KDM4A_HUMAN
A:
[1-347]
-
A
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
95.65
100%
-79
- C5 -
2Q8D
2
KDM4A_HUMAN
A:
[3-349]
M
A
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
95.49
100%
-80
- C5 -
2Q8E
2
KDM4A_HUMAN
A:
[5-348]
--
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
95.24
100%
-80
- C5 -
2PXJ
2
KDM4A_HUMAN
A:
[1-347]
-
A
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
95.13
100%
-86
- C5 -
2GP5
1
KDM4A_HUMAN
B:
[9-345]
---------
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
95.10
100%
-80
- C5 -
2Q8C
2
KDM4A_HUMAN
A:
[5-349]
--
S
E
S
E
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
94.75
100%
-83
- C5 -
2P5B
4
KDM4A_HUMAN
B:
[12-348]
---------
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
94.70
100%
-84
- C5 -
2Q8E
2
KDM4A_HUMAN
B:
[11-347]
--------
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
94.54
100%
-82
- C5 -
2Q8D
2
KDM4A_HUMAN
B:
[11-348]
--------
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
94.30
100%
-84
- C5 -
2PXJ
2
KDM4A_HUMAN
B:
[9-345]
---------
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
94.28
100%
-75
- C5 -
2WWJ
1
KDM4A_HUMAN
A:
[2-347]
-------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
93.96
100%
-85
- C5 -
2Q8C
2
KDM4A_HUMAN
B:
[14-348]
-----------
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
89.64
81%
-81
- C5 -
2XML
1
KDM4C_HUMAN
B:
[11-347]
-------
L
N
P
S
C
K
I
M
T
F
R
P
S
M
E
E
F
R
E
F
N
K
Y
L
A
Y
M
E
S
K
G
A
H
R
A
G
L
A
K
V
I
P
P
K
E
W
K
P
R
Q
----
C
Y
D
D
---
I
D
N
L
L
I
P
A
P
I
Q
Q
M
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
K
E
F
R
Q
L
A
N
S
------
G
K
Y
C
T
-
P
R
------------
Y
L
D
------
Y
E
D
L
E
R
K
Y
W
K
N
L
T
F
----
V
A
P
I
Y
G
A
D
I
N
G
S
I
Y
D
E
G
-
V
D
E
W
N
I
A
R
L
N
T
V
L
D
V
V
E
E
E
C
G
I
S
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
A
I
P
P
E
H
G
K
R
L
E
R
L
A
Q
G
F
F
P
S
S
S
Q
G
C
D
A
F
L
R
H
K
M
T
L
I
S
P
S
V
L
K
K
Y
G
I
P
F
D
K
I
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
V
R
W
I
D
Y
G
K
V
A
K
L
C
T
C
R
K
D
M
V
K
I
S
M
D
I
F
V
R
K
F
Q
P
D
R
Y
Q
L
W
K
Q
G
K
D
I
Y
T
I
D
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
89.61
81%
-81
- C5 -
2XML
4
KDM4C_HUMAN
A:
[11-347]
-------
L
N
P
S
C
K
I
M
T
F
R
P
S
M
E
E
F
R
E
F
N
K
Y
L
A
Y
M
E
S
K
G
A
H
R
A
G
L
A
K
V
I
P
P
K
E
W
K
P
R
Q
----
C
Y
D
D
---
I
D
N
L
L
I
P
A
P
I
Q
Q
M
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
K
E
F
R
Q
L
A
N
S
------
G
K
Y
C
T
-
P
R
------------
Y
L
D
------
Y
E
D
L
E
R
K
Y
W
K
N
L
T
F
----
V
A
P
I
Y
G
A
D
I
N
G
S
I
Y
D
E
G
-
V
D
E
W
N
I
A
R
L
N
T
V
L
D
V
V
E
E
E
C
G
I
S
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
A
I
P
P
E
H
G
K
R
L
E
R
L
A
Q
G
F
F
P
S
S
S
Q
G
C
D
A
F
L
R
H
K
M
T
L
I
S
P
S
V
L
K
K
Y
G
I
P
F
D
K
I
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
V
R
W
I
D
Y
G
K
V
A
K
L
C
T
C
R
K
D
M
V
K
I
S
M
D
I
F
V
R
K
F
Q
P
D
R
Y
Q
L
W
K
Q
G
K
D
I
Y
T
I
D
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
82.81
65%
-72
* C5 *
3DXT
4
KDM4D_HUMAN
A:
[11-341]
------
A
Q
N
P
N
C
N
I
M
I
F
H
P
T
K
E
E
F
N
D
F
D
K
Y
I
A
Y
M
E
S
Q
G
A
H
R
A
G
L
A
K
I
I
P
P
K
E
W
K
A
R
E
----
T
Y
D
N
---
I
S
E
I
L
I
A
T
P
L
Q
Q
V
A
S
G
R
A
--
G
V
F
T
Q
Y
H
K
K
K
-
K
A
M
T
V
G
E
Y
R
H
L
A
N
S
------
K
K
Y
Q
T
-
P
P
------------
H
Q
N
------
F
E
D
L
E
R
K
Y
W
K
N
R
I
Y
----
N
S
P
I
Y
G
A
D
I
S
G
S
L
F
D
E
N
-
T
K
Q
W
N
L
G
H
L
G
T
I
Q
D
L
L
E
K
E
C
G
V
V
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
L
G
E
P
K
T
W
Y
V
V
P
P
E
H
G
Q
R
L
E
R
L
A
R
E
L
F
P
G
S
S
R
G
C
G
A
F
L
R
H
K
V
A
L
I
S
P
T
V
L
K
E
N
G
I
P
F
N
R
I
T
Q
E
A
G
E
F
M
V
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
A
I
N
F
A
T
P
R
W
I
D
Y
G
K
M
A
S
Q
C
S
C
G
E
A
R
V
T
F
S
M
D
A
F
V
R
I
L
Q
P
E
R
Y
D
L
W
K
R
G
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
66.93
42%
-59
- C5 -
3OPT
1
RPH1_YEAST
A:
[6-341]
-----
A
P
S
E
I
V
G
G
V
P
V
F
K
P
T
Y
E
Q
F
E
D
F
Y
A
Y
C
K
A
I
N
K
Y
G
M
-
K
S
G
V
V
K
V
I
P
P
K
E
W
K
D
K
L
DLPY
S
A
E
T
---
L
Q
K
I
K
I
K
S
P
I
Q
Q
H
I
S
G
N
K
--
G
L
F
M
V
Q
N
V
E
K
N
K
T
Y
N
I
I
Q
W
K
D
L
S
K
D
YVPPED-
S
S
F
N
-
I
D
D
F
E
Q
F
R
TEYTID
L
S
D
FQN
T
E
R
L
K
F
L
E
E
Y
Y
W
K
T
L
N
F
----
T
T
P
M
Y
G
A
D
T
P
G
S
I
F
P
E
G
-
L
N
V
W
N
V
A
K
L
P
------------------
D
S
Y
L
Y
A
G
L
W
K
A
S
F
S
W
H
L
E
D
Q
D
L
Y
S
I
N
Y
I
H
F
G
A
P
K
Q
W
Y
S
I
P
Q
E
D
R
F
K
F
Y
K
F
M
Q
E
Q
F
P
E
E
A
K
N
C
P
E
F
L
R
H
K
M
F
L
A
S
P
K
L
L
Q
E
N
G
I
R
C
N
E
I
V
H
H
E
G
E
F
M
I
T
Y
P
Y
G
Y
H
A
G
F
N
Y
G
Y
N
L
A
E
S
V
N
F
A
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
61.97
34%
-49
- C5 -
4IGQ
2
?
A:
[15-360]
------------
E
A
P
V
F
Y
P
T
E
E
E
F
E
D
T
L
K
Y
I
E
S
I
R
P
M
-
A
E
P
Y
G
I
C
R
I
V
P
P
S
S
W
K
P
---------
D
K
S
I
W
E
G
S
K
F
S
T
R
V
Q
K
V
D
K
L
Q
N
RK-----
F
G
F
E
P
G
P
E
F
T
L
Q
T
F
Q
K
Y
A
D
D
------
F
S
K
Q
Y
F--------------
V
P
S
------
V
E
D
I
E
G
E
Y
W
R
I
V
E
V
PT
E
E
I
E
V
I
Y
G
A
D
L
E
T
G
-----A
Q
S
G
W
N
L
N
N
L
P
R
L
---------------
L
V
P
W
V
Y
V
G
M
C
F
S
S
F
C
W
H
V
E
D
H
H
L
Y
S
L
N
Y
M
H
W
G
A
P
K
L
W
Y
G
V
P
G
K
D
A
V
N
L
E
S
A
M
R
K
H
L
P
E
L
F
E
E
Q
P
D
L
L
H
N
L
V
T
Q
F
S
P
S
L
L
K
S
E
G
V
H
V
Y
R
C
V
Q
H
E
G
E
F
V
L
T
F
P
R
A
Y
H
A
G
F
N
C
G
F
N
C
A
E
A
V
N
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------