@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF02375_KDM4C_: (2014-09-29 )
MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDG
Atome Classification :
(49 SA)
.........10........20........30........40........50........----60..---......70........80--........90-........100...------....110.------------...------....120.......----130.......140....-...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEVAEVESPLNPS
C
K
I
M
T
FRP
S
M
E
E
F
R
E
F
N
K
Y
L
A
Y
M
ESKGAHRAGLAKVIPPKEWK
P
R
Q
----
C
Y
D
D
---
I
D
NLLIP
A
P
I
Q
Q
M
VTGQS--G
L
F
T
Q
Y
NI
Q
K
-
K
A
M
T
V
K
E
F
R
Q
L
ANS------GKYCT-PR------------YL
D
------
Y
E
D
L
E
R
K
Y
WKNL
T
F
----
V
A
P
IYGADING
S
I
Y
DEG-VDEW
N
I
A
R
L
N
T
V
L
D
V
V
E
E
EC
G
I
S
I
EGVNT
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
HTED
M
D
L
Y
S
I
N
Y
L
HFGEPK
S
W
Y
AIP
P
E
H
G
K
R
L
E
R
L
A
Q
GFFPSSSQ
G
C
D
A
F
L
R
H
K
M
T
LI
S
P
S
V
L
K
K
YGI
P
F
D
K
I
T
Q
EAG
E
F
M
I
T
F
PYGYHAGFNHGFNCAEST
N
F
A
T
V
R
W
IDY
G
K
V
A
K
L
C
T
C
R
K
D
M
V
K
I
S
M
D
I
F
V
R
KFQP
D
R
Y
Q
L
W
KQG
K
D
I
Y
T
IDHTKPTPAS
T
P
E
V
K
A
W
L
Q
R
R
R
K
V
R
K
A
S
RSF
Q
C
A
RSTSKRPKAD
E
E
E
E
VSDEVDGAEVPNPDSVTDDLKVSEKS
E
A
A
V
K
L
RNTEASSEEESS
A
S
R
M
Q
V
E
QN
L
S
D
H
I
K
LSGNSCLSTSVTEDIKTEDDK
A
Y
A
Y
RSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKS
P
E
S
C
S
S
V
A
ESNGVLTEGEES
D
V
E
SHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARS
P
M
T
L
V
K
QQAP
S
D
E
E
L
P
E
V
L
S
I
E
E
E
V
E
E
T
E
S
W
A
K
P
L
I
H
L
WQTKSPNFA
A
E
Q
EYN
A
T
V
A
RMKP
H
C
A
I
C
T
L
L
MPYHKPDSSNEEN
D
A
R
W
E
T
K
L
D
E
V
V
TSEGKTKPLI
P
E
M
C
F
I
YSEENIEYSPP
N
A
F
L
EED
G
T
S
L
L
I
S
C
A
K
C
C
V
R
V
H
A
S
CYGI
P
S
H
E
I
C
D
G
W
L
C
A
R
CKRNAW
T
A
E
C
C
L
CNLRGGALKQTKNN
K
W
A
H
V
M
C
A
VAVPE
V
R
FTNVPERTQIDVGRI
P
L
Q
R
L
K
L
K
C
I
F
C
R
H
R
V
K
R
VS
G
A
C
I
Q
CSYGRCPA
S
F
H
V
T
C
A
HAAGVLMEPDDW
P
Y
V
V
N
I
T
C
F
R
HKVNPN
V
K
S
K
A
C
E
K
V
I
S
V
G
Q
T
V
I
T
KHRN
T
R
Y
Y
S
C
R
V
M
A
V
TSQ
T
F
Y
E
V
M
FDDGSFSRDT
F
P
E
D
I
V
S
R
D
C
L
KLGPPAEG
E
V
V
Q
V
KWPD
G
K
L
Y
G
A
K
YFGSN
I
A
H
M
Y
Q
V
EFEDG
1
PsiBlast_PDB
97.84
100%
-93
- C7 -
2XML
4
KDM4C_HUMAN
A:
[11-348]
---------
L
N
P
S
C
K
I
M
T
F
R
P
S
M
E
E
F
R
E
F
N
K
Y
L
A
Y
M
E
S
K
G
A
H
R
A
G
L
A
K
V
I
P
P
K
E
W
K
P
R
Q
----
C
Y
D
D
---
I
D
N
L
L
I
P
A
P
I
Q
Q
M
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
K
E
F
R
Q
L
A
N
S
------
G
K
Y
C
T
-
P
R
------------
Y
L
D
------
Y
E
D
L
E
R
K
Y
W
K
N
L
T
F
----
V
A
P
I
Y
G
A
D
I
N
G
S
I
Y
D
E
G
-
V
D
E
W
N
I
A
R
L
N
T
V
L
D
V
V
E
E
E
C
G
I
S
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
A
I
P
P
E
H
G
K
R
L
E
R
L
A
Q
G
F
F
P
S
S
S
Q
G
C
D
A
F
L
R
H
K
M
T
L
I
S
P
S
V
L
K
K
Y
G
I
P
F
D
K
I
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
V
R
W
I
D
Y
G
K
V
A
K
L
C
T
C
R
K
D
M
V
K
I
S
M
D
I
F
V
R
K
F
Q
P
D
R
Y
Q
L
W
K
Q
G
K
D
I
Y
T
I
D
H
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
97.81
100%
-93
- C7 -
2XML
1
KDM4C_HUMAN
B:
[11-348]
---------
L
N
P
S
C
K
I
M
T
F
R
P
S
M
E
E
F
R
E
F
N
K
Y
L
A
Y
M
E
S
K
G
A
H
R
A
G
L
A
K
V
I
P
P
K
E
W
K
P
R
Q
----
C
Y
D
D
---
I
D
N
L
L
I
P
A
P
I
Q
Q
M
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
K
E
F
R
Q
L
A
N
S
------
G
K
Y
C
T
-
P
R
------------
Y
L
D
------
Y
E
D
L
E
R
K
Y
W
K
N
L
T
F
----
V
A
P
I
Y
G
A
D
I
N
G
S
I
Y
D
E
G
-
V
D
E
W
N
I
A
R
L
N
T
V
L
D
V
V
E
E
E
C
G
I
S
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
A
I
P
P
E
H
G
K
R
L
E
R
L
A
Q
G
F
F
P
S
S
S
Q
G
C
D
A
F
L
R
H
K
M
T
L
I
S
P
S
V
L
K
K
Y
G
I
P
F
D
K
I
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
V
R
W
I
D
Y
G
K
V
A
K
L
C
T
C
R
K
D
M
V
K
I
S
M
D
I
F
V
R
K
F
Q
P
D
R
Y
Q
L
W
K
Q
G
K
D
I
Y
T
I
D
H
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
94.85
81%
-91
- C7 -
2GP5
1
KDM4A_HUMAN
A:
[7-347]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
94.79
80%
-82
- C7 -
2VD7
1
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
94.77
80%
-82
- C7 -
2YBP
2
KDM4A_HUMAN
B:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
94.73
80%
-84
- C7 -
3PDQ
1
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.71
80%
-81
- C7 -
2OQ6
2
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
94.63
80%
-81
- C7 -
2YBK
1
KDM4A_HUMAN
B:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
94.49
80%
-84
- C7 -
2YBS
2
KDM4A_HUMAN
B:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
94.48
80%
-85
- C7 -
2YBS
3
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
94.44
81%
-87
- C7 -
2Q8E
2
KDM4A_HUMAN
A:
[10-348]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
94.43
80%
-83
- C7 -
2YBK
1
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
94.35
79%
-81
- C7 -
2OX0
2
KDM4A_HUMAN
A:
[29-377]
--------
T
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
----
P
E
A
A
E
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
94.34
80%
-83
- C7 -
3RVH
2
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
94.13
81%
-87
- C7 -
2Q8D
2
KDM4A_HUMAN
A:
[10-349]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
94.13
80%
-80
- C7 -
2VD7
1
KDM4A_HUMAN
B:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
94.09
81%
-87
- C7 -
2Q8C
2
KDM4A_HUMAN
A:
[10-349]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
94.09
80%
-86
- C7 -
4BIS
1
?
B:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
94.05
80%
-82
- C7 -
2OS2
2
KDM4A_HUMAN
A:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
94.03
80%
-81
- C7 -
4BIS
2
?
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
93.95
80%
-85
- C7 -
3RVH
2
KDM4A_HUMAN
A:
[30-375]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
93.94
80%
-84
- C7 -
4AI9
2
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
93.93
80%
-84
- C7 -
4GD4
1
KDM4A_HUMAN
A:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
93.90
80%
-86
- C7 -
3NJY
1
KDM4A_HUMAN
A:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
93.88
80%
-79
- C7 -
2OS2
2
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
93.82
80%
-85
- C7 -
4AI9
2
KDM4A_HUMAN
B:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
93.79
80%
-81
- C7 -
2OQ6
2
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.75
80%
-85
- C7 -
4GD4
1
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
93.73
81%
-84
- C7 -
2P5B
4
KDM4A_HUMAN
A:
[10-350]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
93.68
81%
-89
- C7 -
2GP5
1
KDM4A_HUMAN
B:
[9-345]
-----------
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.64
80%
-81
- C7 -
2OT7
2
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
93.63
80%
-80
- C7 -
3U4S
2
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
93.59
80%
-81
- C7 -
2OQ7
1
KDM4A_HUMAN
B:
[30-375]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
93.40
80%
-82
- C7 -
2OX0
2
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
93.33
81%
-84
- C7 -
2PXJ
2
KDM4A_HUMAN
A:
[7-347]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
93.33
80%
-83
- C7 -
3NJY
1
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.17
80%
-83
- C7 -
2YBP
3
KDM4A_HUMAN
A:
[30-377]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
93.16
80%
-83
- C7 -
3PDQ
1
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
93.12
80%
-79
- C7 -
2OT7
2
KDM4A_HUMAN
B:
[30-376]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
E
A
A
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
92.98
81%
-86
- C7 -
2P5B
4
KDM4A_HUMAN
B:
[12-348]
-----------
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
92.87
81%
-86
- C7 -
2Q8D
2
KDM4A_HUMAN
B:
[11-348]
----------
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
92.65
81%
-85
- C7 -
2PXJ
2
KDM4A_HUMAN
B:
[9-345]
-----------
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
92.65
81%
-89
- C7 -
2Q8E
2
KDM4A_HUMAN
B:
[11-347]
----------
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
92.62
81%
-88
- C7 -
2WWJ
1
KDM4A_HUMAN
B:
[2-342]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
92.45
81%
-89
- C7 -
2Q8C
2
KDM4A_HUMAN
B:
[14-348]
-------------
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
91.80
81%
-80
- C7 -
2WWJ
1
KDM4A_HUMAN
A:
[2-342]
---------
L
N
P
S
A
R
I
M
T
F
Y
P
T
M
E
E
F
R
N
F
S
R
Y
I
A
Y
I
E
S
Q
G
A
H
R
A
G
L
A
K
V
V
P
P
K
E
W
K
P
R
A
----
S
Y
D
D
---
I
D
D
L
V
I
P
A
P
I
Q
Q
L
V
T
G
Q
S
--
G
L
F
T
Q
Y
N
I
Q
K
-
K
A
M
T
V
R
E
F
R
K
I
A
N
S
------
D
K
Y
C
T
-
P
R
------------
Y
S
E
------
F
E
E
L
E
R
K
Y
W
K
N
L
T
F
----
N
P
P
I
Y
G
A
D
V
N
G
T
L
Y
E
K
H
-
V
D
E
W
N
I
G
R
L
R
T
I
L
D
L
V
E
K
E
S
G
I
T
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
S
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
S
W
Y
S
V
P
P
E
H
G
K
R
L
E
R
L
A
K
G
F
F
P
G
S
A
Q
S
C
E
A
F
L
R
H
K
M
T
L
I
S
P
L
M
L
K
K
Y
G
I
P
F
D
K
V
T
Q
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
S
T
N
F
A
T
R
R
W
I
E
Y
G
K
Q
A
V
L
C
S
C
R
K
D
M
V
K
I
S
M
D
V
F
V
R
K
F
Q
P
E
R
Y
K
L
W
K
A
G
K
D
N
T
V
I
D
H
T
L
P
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
87.40
66%
-80
- C7 -
3DXT
4
KDM4D_HUMAN
A:
[11-341]
--------
A
Q
N
P
N
C
N
I
M
I
F
H
P
T
K
E
E
F
N
D
F
D
K
Y
I
A
Y
M
E
S
Q
G
A
H
R
A
G
L
A
K
I
I
P
P
K
E
W
K
A
R
E
----
T
Y
D
N
---
I
S
E
I
L
I
A
T
P
L
Q
Q
V
A
S
G
R
A
--
G
V
F
T
Q
Y
H
K
K
K
-
K
A
M
T
V
G
E
Y
R
H
L
A
N
S
------
K
K
Y
Q
T
-
P
P
------------
H
Q
N
------
F
E
D
L
E
R
K
Y
W
K
N
R
I
Y
----
N
S
P
I
Y
G
A
D
I
S
G
S
L
F
D
E
N
-
T
K
Q
W
N
L
G
H
L
G
T
I
Q
D
L
L
E
K
E
C
G
V
V
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
F
A
W
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
L
G
E
P
K
T
W
Y
V
V
P
P
E
H
G
Q
R
L
E
R
L
A
R
E
L
F
P
G
S
S
R
G
C
G
A
F
L
R
H
K
V
A
L
I
S
P
T
V
L
K
E
N
G
I
P
F
N
R
I
T
Q
E
A
G
E
F
M
V
T
F
P
Y
G
Y
H
A
G
F
N
H
G
F
N
C
A
E
A
I
N
F
A
T
P
R
W
I
D
Y
G
K
M
A
S
Q
C
S
C
G
E
A
R
V
T
F
S
M
D
A
F
V
R
I
L
Q
P
E
R
Y
D
L
W
K
R
G
Q
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
72.65
43%
-68
- C7 -
3OPT
1
RPH1_YEAST
A:
[7-341]
--------
P
S
E
I
V
G
G
V
P
V
F
K
P
T
Y
E
Q
F
E
D
F
Y
A
Y
C
K
A
I
N
K
Y
G
M
-
K
S
G
V
V
K
V
I
P
P
K
E
W
K
D
K
L
DLPY
S
A
E
T
---
L
Q
K
I
K
I
K
S
P
I
Q
Q
H
I
S
G
N
K
--
G
L
F
M
V
Q
N
V
E
K
N
K
T
Y
N
I
I
Q
W
K
D
L
S
K
D
YVPPED-
S
S
F
N
-
I
D
D
F
E
Q
F
R
TEYTID
L
S
D
FQN
T
E
R
L
K
F
L
E
E
Y
Y
W
K
T
L
N
F
----
T
T
P
M
Y
G
A
D
T
P
G
S
I
F
P
E
G
-
L
N
V
W
N
V
A
K
L
P
------------------
D
S
Y
L
Y
A
G
L
W
K
A
S
F
S
W
H
L
E
D
Q
D
L
Y
S
I
N
Y
I
H
F
G
A
P
K
Q
W
Y
S
I
P
Q
E
D
R
F
K
F
Y
K
F
M
Q
E
Q
F
P
E
E
A
K
N
C
P
E
F
L
R
H
K
M
F
L
A
S
P
K
L
L
Q
E
N
G
I
R
C
N
E
I
V
H
H
E
G
E
F
M
I
T
Y
P
Y
G
Y
H
A
G
F
N
Y
G
Y
N
L
A
E
S
V
N
F
A
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
67.13
33%
-58
* C7 *
4IGQ
2
?
A:
[15-360]
--------------
E
A
P
V
F
Y
P
T
E
E
E
F
E
D
T
L
K
Y
I
E
S
I
R
P
M
-
A
E
P
Y
G
I
C
R
I
V
P
P
S
S
W
K
P
---------
D
K
S
I
W
E
G
S
K
F
S
T
R
V
Q
K
V
D
K
L
Q
N
RK-----
F
G
F
E
P
G
P
E
F
T
L
Q
T
F
Q
K
Y
A
D
D
------
F
S
K
Q
Y
F--------------
V
P
S
------
V
E
D
I
E
G
E
Y
W
R
I
V
E
V
PT
E
E
I
E
V
I
Y
G
A
D
L
E
T
G
-----A
Q
S
G
W
N
L
N
N
L
P
R
L
---------------
L
V
P
W
V
Y
V
G
M
C
F
S
S
F
C
W
H
V
E
D
H
H
L
Y
S
L
N
Y
M
H
W
G
A
P
K
L
W
Y
G
V
P
G
K
D
A
V
N
L
E
S
A
M
R
K
H
L
P
E
L
F
E
E
Q
P
D
L
L
H
N
L
V
T
Q
F
S
P
S
L
L
K
S
E
G
V
H
V
Y
R
C
V
Q
H
E
G
E
F
V
L
T
F
P
R
A
Y
H
A
G
F
N
C
G
F
N
C
A
E
A
V
N
V
A
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