@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF02898_NOS3_HUMAN: (2014-10-03 )
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTNSP
Atome Classification :
(60 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
N
L
K
S
V
A
QEPGPPCG
L
G
L
G
L
G
LGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPEGPKFPRVKN
W
E
V
G
S
I
T
Y
DTLS
A
Q
AQQDGPC
T
P
R
R
C
L
G
SLVF
P
R
KLQGRPSPGPP
A
P
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
RSG
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
AAT
G
T
Y
Q
L
RE
S
E
L
V
F
G
A
K
Q
A
W
RNAPR
C
V
G
R
I
QWG
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
YATNRGN
L
R
S
A
I
T
VFPQRCPGRG
D
F
R
I
W
N
S
Q
L
V
R
YAGYRQQDGSVRGDPAN
V
E
I
T
E
L
C
I
QHGWTPGNGR
F
D
V
L
P
L
L
L
QAPDEPP
E
L
F
LL
P
P
E
L
V
L
EVPLEHP
T
L
E
W
F
A
A
LGL
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
IGGLEFPAAPFSG
W
Y
M
S
TEIGTRNLC
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
MDLDTR
T
T
S
S
LWKDK
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
DH
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
KARGGCPA
D
W
A
W
I
VPPISGSL
T
P
V
F
H
Q
E
M
V
N
Y
F
LSPAFRYQPDPWKGSAAKGTGI
T
R
K
K
T
F
K
E
V
A
N
A
V
K
I
S
A
S
L
M
G
T
V
M
A
K
R
V
K
A
T
I
L
YGSETG
R
A
Q
S
Y
A
Q
Q
L
G
R
L
F
R
K
AFD
P
R
V
L
C
M
DEY
D
V
V
S
LEH
E
T
L
V
L
V
V
T
STFGNGDPPEN
G
E
S
F
A
A
A
L
M
EMSGPYNSSPRPEQH
K
S
Y
K
I
R
FNSISCS
D
P
L
V
S
S
W
R
R
K
RKESSNTDSAG
A
L
G
T
L
R
F
C
V
F
GLGSRA
Y
P
H
F
C
A
F
A
R
A
V
D
T
R
L
E
EL
G
G
E
R
L
L
QLGQGDELC
G
Q
E
E
A
F
R
G
W
A
Q
A
A
F
Q
A
A
C
E
T
FCVGE
D
A
K
A
A
A
R
D
IFSP
K
R
S
W
K
R
Q
R
Y
R
LSAQAE
G
L
Q
L
L
P
G
L
I
H
V
H
R
R
K
M
F
Q
A
T
I
R
S
V
E
N
L
Q
SSKST
R
A
T
I
L
V
R
LDTGGQEG
L
Q
YQPGDHIGVCPPNRP
G
L
V
E
A
L
L
S
RVEDPPAPTE
P
V
A
V
E
Q
L
EKGSPGGPPPGWVRDPRLP
P
C
T
L
R
Q
A
L
T
F
F
L
DITSPP
S
P
Q
L
L
R
L
L
S
T
L
A
EEP
R
E
Q
Q
E
L
E
A
L
SQD
P
R
R
Y
E
E
W
K
WFR
C
P
T
L
L
E
V
L
E
QFPSVALP
A
P
L
L
L
T
QLPLLQ
P
R
Y
YSVSSAPSTHP
G
E
I
H
L
T
V
A
V
L
A
Y
RTQDGL
G
P
L
H
Y
G
V
C
S
T
W
L
S
QLKPGDPV
P
C
F
IRGAPSFRLPPDPSL
P
C
I
L
VGPGTG
I
A
P
F
R
G
F
W
Q
E
R
L
H
D
I
E
SKGLQPT
P
M
T
L
V
F
GCR
C
S
Q
L
D
H
L
Y
R
D
E
V
Q
N
A
Q
QR
G
V
F
G
R
V
L
T
A
FSREPD
N
P
K
T
Y
V
Q
D
I
L
R
T
E
L
A
A
E
V
H
R
V
L
C
L
ERG
H
M
F
V
CG
D
V
T
M
A
T
N
V
L
Q
T
V
Q
R
I
LATEGDMELDEAG
D
V
I
G
V
L
R
D
Q
Q
R
Y
H
E
D
I
FG
L
T
L
R
T
Q
E
V
T
S
R
I
RTQSFS
L
Q
E
R
Q
LRGAVPWAFDPPGSDTNSP
38
PsiBlast_CBE
67.79
94%
-97
- C1 -
5NSE
5
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.17
94%
-97
- C1 -
8NSE
7
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.08
94%
-97
- C1 -
1DMJ
4
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
63.93
100%
-102
- C1 -
3NOS
4
NOS3_HUMAN
B:
[2-415]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
R
--------------
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.50
94%
-95
- C1 -
1DMI
6
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
62.04
94%
-97
* C1 *
7NSE
7
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.28
94%
-96
- C1 -
1NSE
6
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
59.97
94%
-97
- C1 -
6NSE
6
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.78
94%
-97
- C1 -
1D1W
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
59.06
100%
-102
- C1 -
3NOS
4
NOS3_HUMAN
A:
[2-415]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
R
--------------
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
58.96
94%
-95
- C1 -
4NSE
5
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.12
94%
-95
- C1 -
2NSE
5
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.06
94%
-97
- C1 -
1ED4
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
57.20
94%
-95
- C1 -
9NSE
7
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
56.36
100%
-99
- C1 -
3EAH
5
NOS3_HUMAN
B:
[2-415]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
-------------
P
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
55.46
94%
-103
- C1 -
3NLT
7
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
-------------
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
53.91
94%
-95
- C1 -
4NSE
4
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
53.69
94%
-94
- C1 -
9NSE
8
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.38
94%
-95
- C1 -
3NSE
6
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
52.28
94%
-93
- C1 -
6NSE
6
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
50.74
94%
-97
- C1 -
5NSE
5
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
50.50
94%
-96
- C1 -
7NSE
7
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
50.19
94%
-103
- C1 -
3NLG
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
------------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
50.13
94%
-103
- C1 -
3NLE
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
------------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
49.95
94%
-101
- C1 -
3NLD
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
-------------
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
49.43
100%
-101
- C1 -
1M9M
7
NOS3_HUMAN
A:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
48.85
94%
-94
- C1 -
8NSE
7
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
48.77
94%
-102
- C1 -
3NLF
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
------------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
48.29
94%
-94
- C1 -
3NSE
6
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
L
Q
T
R
P
S
P
G
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
48.27
100%
-100
- C1 -
1M9R
4
NOS3_HUMAN
B:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.84
94%
-103
- C1 -
3RQP
8
NOS3_BOVIN
A:
[28-443]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
47.57
100%
-100
- C1 -
1M9M
6
NOS3_HUMAN
B:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
47.23
94%
-99
- C1 -
3NLF
7
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
47.03
94%
-100
- C1 -
3NLU
8
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
46.33
94%
-102
- C1 -
3N5S
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
------------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
45.85
100%
-99
- C1 -
1M9K
2
NOS3_HUMAN
A:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
45.64
94%
-101
- C1 -
3NLE
8
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
-------------
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
45.21
100%
-99
- C1 -
1M9R
4
NOS3_HUMAN
A:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.13
94%
-100
- C1 -
4CFT
7
?
B:
[30-443]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
44.88
100%
-101
- C1 -
1M9Q
6
NOS3_HUMAN
A:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
44.64
94%
-101
- C1 -
3N5R
7
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
----------
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
44.52
100%
-100
- C1 -
1M9J
2
NOS3_HUMAN
A:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
44.48
94%
-99
- C1 -
3N5Q
5
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
-----------
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
44.44
94%
-99
- C1 -
3N5Q
5
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
-------------
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
44.42
100%
-100
- C1 -
1M9Q
5
NOS3_HUMAN
B:
[1-414]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
43.43
94%
-99
- C1 -
3N5T
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
42.86
94%
-100
- C1 -
3N5S
8
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
42.73
94%
-100
- C1 -
3RQO
8
NOS3_BOVIN
B:
[30-443]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
------------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
42.73
94%
-100
- C1 -
3RQO
8
NOS3_BOVIN
A:
[28-443]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
------------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
41.88
94%
-99
- C1 -
3N5T
8
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
41.65
94%
-100
- C1 -
3NLU
8
NOS3_BOVIN
A:
[29-444]
----------------------------------------------------------------
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
41.05
100%
-99
- C1 -
1M9K
2
NOS3_HUMAN
B:
[1-415]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
40.81
94%
-99
- C1 -
3NLG
8
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
----------
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
40.34
100%
-100
- C1 -
3EAH
5
NOS3_HUMAN
A:
[3-415]
-------------------------------------------------------------------
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
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Y
Q
L
A
K
V
T
I
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D
H
H
A
A
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A
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F
M
K
H
L
E
N
E
Q
K
A
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G
G
C
P
A
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W
A
W
I
V
P
P
I
S
G
S
L
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V
F
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M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
40.01
94%
-99
- C1 -
3N5R
7
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
---------
P
P
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
39.46
94%
-99
- C1 -
3RQP
8
NOS3_BOVIN
B:
[30-443]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
39.38
94%
-98
- C1 -
3NLT
7
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
38.91
100%
-98
- C1 -
1M9J
2
NOS3_HUMAN
B:
[1-415]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
V
G
S
I
T
Y
D
T
L
S
A
Q
A
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
F
P
--------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
Q
R
L
Q
E
V
E
A
E
V
A
A
T
G
T
Y
Q
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
R
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
C
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
P
P
E
L
F
L
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
P
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
V
A
V
L
H
S
Y
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
A
S
F
M
K
H
L
E
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
F
L
S
P
A
F
R
Y
Q
P
D
P
W
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
37.33
94%
-98
- C1 -
3E7S
4
NOS3_BOVIN
A:
[7-426]
------------------------------------------------------------
R
P
P
E
G
P
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
K
------------
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
-----
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
34.84
94%
-96
- C1 -
3NLD
7
NOS3_BOVIN
B:
[31-444]
------------------------------------------------------------------
K
F
P
R
V
K
N
W
E
L
G
S
I
T
Y
D
T
L
C
A
Q
S
Q
Q
D
G
P
C
T
P
R
R
C
L
G
S
L
V
L
P
R
-----------
P
A
E
Q
L
L
S
Q
A
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
S
Q
A
H
E
E
R
L
Q
E
V
E
A
E
V
A
S
T
G
T
Y
H
L
R
E
S
E
L
V
F
G
A
K
Q
A
W
R
N
A
P
R
C
V
G
R
I
Q
W
G
K
L
Q
V
F
D
A
R
D
C
S
S
A
Q
E
M
F
T
Y
I
C
N
H
I
K
Y
A
T
N
R
G
N
L
R
S
A
I
T
V
F
P
Q
R
A
P
G
R
G
D
F
R
I
W
N
S
Q
L
V
R
Y
A
G
Y
R
Q
Q
D
G
S
V
R
G
D
P
A
N
V
E
I
T
E
L
C
I
Q
H
G
W
T
P
G
N
G
R
F
D
V
L
P
L
L
L
Q
A
P
D
E
A
P
E
L
F
V
L
P
P
E
L
V
L
E
V
P
L
E
H
P
T
L
E
W
F
A
A
L
G
L
R
W
Y
A
L
P
A
V
S
N
M
L
L
E
I
G
G
L
E
F
S
A
A
P
F
S
G
W
Y
M
S
T
E
I
G
T
R
N
L
C
D
P
H
R
Y
N
I
L
E
D
V
A
V
C
M
D
L
D
T
R
T
T
S
S
L
W
K
D
K
A
A
V
E
I
N
L
A
V
L
H
S
F
Q
L
A
K
V
T
I
V
D
H
H
A
A
T
V
S
F
M
K
H
L
D
N
E
Q
K
A
R
G
G
C
P
A
D
W
A
W
I
V
P
P
I
S
G
S
L
T
P
V
F
H
Q
E
M
V
N
Y
I
L
S
P
A
F
R
Y
Q
P
D
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------