@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07647_EPHA3_HUMAN: (2014-10-11 )
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQ
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.---......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDC
Q
L
S
I
L
L
L
L
S
C
S
V
L
D
S
F
G
E
LIPQPSNEVNLLDSKTIQGELGWISYPSH
G
W
E
EISGVDEHYTP
I
R
T
Y
Q
V
C
N
VMDHSQNN
W
L
R
TNWVPRNSA
Q
K
I
Y
V
E
L
K
F
T
LRDCNSI
P
L
V
LGTCKE
T
F
N
L
Y
Y
M
ESDDDHG
V
K
F
R
EHQ
F
T
K
I
D
T
IAADESFTQMDLG
D
R
I
L
KLNT
E
I
REVGPVNKK
G
F
Y
L
A
F
Q
D
V
G
A
C
V
A
L
V
S
V
R
V
Y
F
K
KCPF
T
V
K
N
LAMFPDTVPMD
S
Q
S
L
V
E
V
R
G
S
CVNNSKEEDPP
R
M
Y
CSTEG
E
W
L
V
P
IGKCSCNAGYEERG
F
M
CQACRPG
F
Y
K
ALDGNMKCAKCPPHSSTQEDG
S
M
N
C
R
CENNYFRADKDPPSMACTRPPS
S
P
R
N
V
I
SNINE
T
S
V
I
L
DWSWPLDTGGRK
D
V
T
F
N
I
I
C
K
KCGWNIKQCEPCSPN
V
R
F
L
P
R
QFGLTN
T
T
V
T
V
T
D
L
LAHT
N
Y
T
F
E
I
D
AVN
G
V
S
E
LSSPPR
Q
F
A
A
V
S
I
TTNQAAPS
P
V
L
T
I
KKDRTSRN
S
I
S
L
SWQEPEHPN
G
I
I
L
D
Y
E
V
K
Y
Y
E
K
QEQET
S
Y
T
I
L
R
ARGT
N
V
T
I
SSLKP
D
T
I
Y
V
F
Q
I
R
A
R
T
AAGYGTNS
R
K
F
E
F
ETSPD
S
F
S
ISGES
S
Q
V
V
M
I
A
I
S
A
A
V
A
I
I
L
L
T
V
V
I
Y
V
L
I
G
R
FCGYKSKHGADE
K
R
L
HFGNG
H
L
KLPGLRTYVDPHTYE
D
P
T
Q
A
V
H
E
F
A
K
E
LDATN
I
S
I
D
K
V
VGAG
E
F
G
E
VCSGRLKLPSKK
E
I
S
V
A
I
K
T
L
KVGY
T
E
K
Q
R
R
D
FLGE
A
S
IMGQFDHP
N
I
I
R
L
E
G
V
VTKSK
P
V
M
I
V
T
E
Y
M
ENG
S
L
D
S
F
L
R
K
HDA
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
LAA
R
N
I
L
INS
N
L
V
C
K
VSDF
G
L
S
R
V
LED---DPEAAYTTRG
G
K
I
P
I
R
WTSPE
A
I
A
Y
RKFTS
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
YGERPYWEMS
N
Q
D
V
I
K
A
V
DEGYRLPPPMD
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
KDRNNRP
K
F
E
Q
I
V
S
I
L
D
K
L
IRNPG
S
L
K
I
I
T
SAAARPS
N
L
L
L
DQSN
V
D
I
T
T
F
RTTG
D
W
L
N
G
V
W
T
A
H
C
K
E
I
F
TGVEYSSCD
T
I
A
KIST
D
D
M
K
KV
G
V
T
V
VG
P
Q
K
K
I
I
S
S
I
K
ALETQ
6
PsiBlast_PDB
72.19
99%
-112
- C2 -
3FXX
2
A:
[30-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
---
D
---------
G
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
--
A
A
R
P
S
N
L
L
L
D
-----------------------------------------------------------------------
7
PsiBlast_PDB
71.50
99%
-113
- C2 -
3FY2
1
A:
[31-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
G
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---
A
R
P
S
N
L
L
L
D
-----------------------------------------------------------------------
9
PsiBlast_PDB
70.57
99%
-111
- C2 -
2QOC
2
A:
[10-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
--------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
A
R
P
S
N
L
L
L
D
Q
S
---------------------------------------------------------------------
11
PsiBlast_PDB
69.94
99%
-112
- C2 -
4G2F
1
A:
[23-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
------------------------------------------------------------------------
10
PsiBlast_PDB
69.23
99%
-115
- C2 -
3DZQ
1
A:
[23-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--
L
K
I
I
T
-------
N
L
L
L
D
-----------------------------------------------------------------------
28
PsiBlast_CBE
60.64
85%
-114
- C2 -
2XYU
7
A:
[1-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
R
F
T
V
I
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
--------------------------------------------------------------------------------------
24
PsiBlast_CBE
60.63
85%
-113
- C2 -
2Y6O
1
A:
[4-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
R
F
T
V
I
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
--------------------------------------------------------------------------------------
22
PsiBlast_CBE
60.13
80%
-105
- C2 -
3DKO
1
A:
[19-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
I
D
P
E
T
Y
E
D
P
N
R
A
V
H
Q
F
A
K
E
L
D
A
S
C
I
K
I
E
R
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
K
L
P
G
K
R
D
V
A
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
R
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
K
H
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
G
I
L
D
K
M
I
R
N
P
N
S
----------------------------------------------------------------------------------------
25
PsiBlast_CBE
59.57
85%
-109
- C2 -
2Y6M
3
A:
[4-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
R
F
T
V
I
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
--------------------------------------------------------------------------------------
27
PsiBlast_CBE
59.43
77%
-108
- C2 -
1JPA
1
EPHB2_MOUSE
A:
[8-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
---
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
-------------------------------------------------------------------------------------
26
PsiBlast_CBE
59.07
77%
-107
- C2 -
1JPA
1
B:
[8-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
----
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
-
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
--------------------------------------------------------------------------------------
39
PsiBlast_CBE
58.40
73%
-106
* C2 *
2VX1
1
A:
[11-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
43
PsiBlast_CBE
58.15
73%
-104
- C2 -
2VWX
1
A:
[11-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
40
PsiBlast_CBE
57.40
73%
-105
- C2 -
2VX0
1
A:
[11-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
---------
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
42
PsiBlast_CBE
57.37
73%
-104
- C2 -
2VWY
1
A:
[11-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
36
PsiBlast_CBE
57.34
73%
-110
- C2 -
4BB4
1
A:
[9-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
----------------
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
30
PsiBlast_CBE
57.01
76%
-112
- C2 -
2YN8
1
B:
[12-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
41
PsiBlast_CBE
56.91
73%
-102
- C2 -
2VWZ
1
A:
[11-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
32
PsiBlast_CBE
56.55
79%
-106
- C2 -
2HEN
1
D:
[1-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
------------------------------------------------------------------------------------
38
PsiBlast_CBE
56.46
73%
-107
- C2 -
2X9F
1
A:
[11-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
--------------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
31
PsiBlast_CBE
56.34
76%
-114
- C2 -
2YN8
1
EPHB4_HUMAN
A:
[14-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-----
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
44
PsiBlast_CBE
56.08
76%
-108
- C2 -
4AW5
1
A:
[8-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
34
PsiBlast_CBE
55.94
79%
-107
- C2 -
2HEN
1
EPHB2_MOUSE
B:
[1-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
------------------------------------------------------------------------------------
35
PsiBlast_CBE
55.81
79%
-107
- C2 -
2HEN
1
EPHB2_MOUSE
A:
[1-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
------------------------------------------------------------------------------------
33
PsiBlast_CBE
55.39
79%
-105
- C2 -
2HEN
1
EPHB2_MOUSE
C:
[1-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
------------------------------------------------------------------------------------
45
PsiBlast_CBE
54.35
72%
-107
- C2 -
1MQB
1
B:
[35-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
---
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
-------------------------------------------------------------------------------------
37
PsiBlast_CBE
54.14
73%
-103
- C2 -
2XVD
1
A:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
----------
S
S
L
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-----------------------------------------------------------------------------------
46
PsiBlast_CBE
52.09
72%
-106
- C2 -
1MQB
1
EPHA2_HUMAN
A:
[38-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
---------------------------------------------------------------------------------