@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07647_TNKS1_HUMAN: (2014-10-11 )
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT
Atome Classification :
(49 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAASRRS
Q
H
H
H
H
H
H
Q
Q
QLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTS
T
I
C
T
VAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGV
P
A
V
S
G
A
L
R
E
L
L
E
A
C
RNG
D
V
S
R
V
K
R
L
V
D
AANV
N
A
K
D
MAGRKSSP
L
H
F
AAGF
G
R
K
D
V
V
E
H
L
L
Q
MGA
N
V
H
ARDDG
G
L
I
PLHNACSF
G
H
A
E
V
V
S
L
L
L
CQGADPNARDNWNYTP
L
H
E
A
A
IKGKI
D
V
C
I
V
L
L
QHGADPNIRNTDGKSALDLADPSA
K
A
V
L
TGEY
K
K
D
E
L
L
E
A
A
RSG
N
E
E
K
L
M
A
L
LTPL
N
V
N
C
HASDGRKST
P
L
H
L
AAGY
N
R
V
R
I
V
Q
L
L
L
QHGADVHAKDKG
G
L
V
PLHNACSY
G
H
Y
E
V
T
E
L
L
L
KHGACV
N
A
M
D
L
WQFT
P
L
H
E
A
ASK
N
R
V
E
V
C
S
L
L
L
SHGADP
T
L
V
N
CHGKSAVDMAP
T
P
E
L
R
E
R
L
T
Y
EFK
G
H
S
L
L
Q
A
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
I
I
NFKQPQSH
E
T
A
L
H
C
A
V
A
SLH
P
K
R
K
Q
V
T
E
L
L
L
RKGANVNEKNKD
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
KHGAKM
N
A
L
D
T
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
SYGSDP
S
I
I
S
L
QG
F
T
A
A
Q
M
G
N
E
A
V
Q
Q
I
L
SESTPIRTSDV
D
Y
R
L
LEASKAG
D
L
E
T
V
K
Q
L
C
SSQNVNCRDLEGRHST
P
L
H
F
AAGY
N
R
V
S
V
V
E
Y
L
L
HHGADVHAKDKG
G
L
V
PLHNACSY
G
H
Y
E
V
A
E
L
L
V
RHGASV
N
V
A
D
L
WKFT
P
L
H
E
A
A
AK
G
K
Y
E
I
C
K
L
L
L
KHGADPTKKNRDGNT
P
L
D
L
VKEGDT
D
I
Q
D
L
L
RG
D
A
A
L
L
D
A
A
K
K
G
C
L
A
R
V
Q
K
LCTPENINCRDTQGRNST
P
L
H
L
AAGYN
N
L
E
V
A
E
Y
L
L
EHGADVNAQDKG
G
L
I
PLHNAASYG
H
V
D
I
A
A
L
L
I
KYNTCVNATDKWAF
T
P
L
H
E
A
A
QK
G
R
T
Q
L
C
A
L
L
L
AHGADPTMKNQEGQTPLDLA
T
A
D
D
I
R
A
L
L
IDAM
P
P
E
ALPTCFKPQ
A
T
V
V
S
A
SLISPAST
P
S
C
L
S
A
A
S
S
I
D
N
LT
G
P
L
A
E
L
AVGGASNAGDGAAGTERKEGEVAGLDM
N
I
S
Q
F
L
K
S
L
G
L
E
H
L
R
D
I
F
E
T
E
Q
I
T
L
D
V
L
A
DM
G
H
E
E
L
K
E
IGINAYG
H
R
H
K
L
I
K
G
V
E
R
L
LGGQQGTN
P
Y
L
T
F
H
C
VNQ
G
T
I
L
L
DLAPE
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
HRDGGNAGGIFNRY
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
EVSEENHNHHN
E
R
M
L
FHG
S
P
F
I
N
A
I
I
HKGF
D
E
R
H
A
Y
IGGMFG
A
G
I
Y
F
AENSSKSN
Q
Y
V
Y
G
IGGGTGCPTHKDR
S
C
Y
I
C
HR
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
MAHAPPGHHSVIGRPSVN
G
L
A
Y
A
E
Y
V
I
YRGEQAYP
E
Y
L
I
T
Y
Q
I
MKPEAPSQTATAAEQKT
34
PsiBlast_CBE
57.94
100%
-52
- C2 -
4MSK
1
TNKS1_HUMAN
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
6
PsiBlast_PDB
56.37
99%
-49
- C2 -
3UH4
2
TNKS1_HUMAN
A:
[2-213]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
---
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
A
P
-----------
23
PsiBlast_CBE
56.25
99%
-47
- C2 -
4LI7
1
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
---
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
25
PsiBlast_CBE
56.08
99%
-55
- C2 -
3UH4
3
B:
[2-212]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
A
------------
11
PsiBlast_PDB
55.79
100%
-48
- C2 -
4I9I
1
TNKS1_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
18
PsiBlast_PDB
55.72
100%
-49
- C2 -
4MSK
1
TNKS1_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
40
PsiBlast_CBE
55.71
100%
-47
- C2 -
4I9I
1
TNKS1_HUMAN
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
15
PsiBlast_PDB
55.30
100%
-51
- C2 -
4N4T
1
TNKS1_MOUSE
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
22
PsiBlast_CBE
55.27
99%
-53
- C2 -
4LI8
1
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
---
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
16
PsiBlast_PDB
54.61
100%
-54
- C2 -
4N4V
1
TNKS1_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
19
PsiBlast_PDB
54.44
100%
-52
- C2 -
4MT9
1
TNKS1_HUMAN
A:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
17
PsiBlast_PDB
54.40
100%
-54
- C2 -
4MSG
1
TNKS1_HUMAN
A:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
14
PsiBlast_PDB
54.16
100%
-49
- C2 -
4N3R
1
TNKS1_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
21
PsiBlast_CBE
54.07
99%
-51
- C2 -
4KRS
1
B:
[1-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
--
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
27
PsiBlast_CBE
53.46
99%
-53
- C2 -
3UDD
2
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
12
PsiBlast_PDB
52.97
100%
-52
- C2 -
4K4E
1
TNKS1_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
----
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
38
PsiBlast_CBE
52.86
100%
-53
- C2 -
4I9I
1
D:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
-
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
----
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
8
PsiBlast_PDB
52.77
99%
-48
- C2 -
4LI7
1
TNKS1_HUMAN
A:
[2-212]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
---
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
-------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
A
------------
13
PsiBlast_PDB
52.68
100%
-47
- C2 -
4K4F
1
TNKS1_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
--
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
39
PsiBlast_CBE
52.34
100%
-52
- C2 -
4I9I
1
TNKS1_HUMAN
C:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
--
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
30
PsiBlast_CBE
51.97
100%
-52
- C2 -
4N3R
1
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
2
PsiBlast_PDB
51.83
96%
-43
- C2 -
2RF5
1
A:
[37-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
----
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
5
PsiBlast_PDB
51.14
99%
-51
- C2 -
3UH2
2
TNKS1_HUMAN
A:
[2-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
---
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
-------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
--------------
26
PsiBlast_CBE
51.04
99%
-48
- C2 -
3UH2
2
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
--
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
32
PsiBlast_CBE
49.98
100%
-53
- C2 -
4MSK
1
D:
[1-210]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
---
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
------
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
--------------
24
PsiBlast_CBE
49.98
99%
-50
- C2 -
4LI6
1
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
--
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
37
PsiBlast_CBE
49.48
100%
-53
- C2 -
4K4E
1
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
-
G
H
H
S
V
I
G
R
P
------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
7
PsiBlast_PDB
49.48
99%
-52
- C2 -
4LI6
1
TNKS1_HUMAN
A:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
36
PsiBlast_CBE
49.15
100%
-45
- C2 -
4K4F
1
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
--
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
-------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
9
PsiBlast_PDB
48.72
99%
-52
- C2 -
4LI8
1
TNKS1_HUMAN
A:
[2-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
---
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
-------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
--------------
28
PsiBlast_CBE
48.14
100%
-47
- C2 -
4N4V
1
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
---------
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
4
PsiBlast_PDB
48.05
99%
-50
- C2 -
3UDD
4
TNKS1_HUMAN
A:
[2-212]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
-------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
A
------------
3
PsiBlast_PDB
47.69
99%
-49
- C2 -
4KRS
1
TNKS1_HUMAN
A:
[1-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
------
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
41
PsiBlast_CBE
46.88
100%
-43
- C2 -
4DVI
1
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
----
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
-------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
31
PsiBlast_CBE
46.67
100%
-47
- C2 -
4MT9
1
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
--------
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
10
PsiBlast_PDB
46.61
100%
-49
- C2 -
4DVI
1
TNKS1_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
-
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
---
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
-
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
35
PsiBlast_CBE
45.63
100%
-49
- C2 -
4MSG
1
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
--------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
33
PsiBlast_CBE
45.26
100%
-49
- C2 -
4MSK
1
TNKS1_HUMAN
C:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
--
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
---------
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
29
PsiBlast_CBE
42.71
100%
-50
- C2 -
4N4T
1
B:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
---
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
--
K
M
A
H
A
P
P
G
H
H
S
V
I
G
--------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
58
PsiBlast_CBE
42.66
88%
-58
- C2 -
4BUS
3
TNKS2_HUMAN
A:
[30-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-------------
54
PsiBlast_CBE
42.43
88%
-55
- C2 -
4BUU
4
TNKS2_HUMAN
A:
[30-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-------------
44
PsiBlast_CBE
42.26
88%
-49
- C2 -
4HYF
2
TNKS2_HUMAN
A:
[30-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
------------
56
PsiBlast_CBE
41.64
88%
-56
- C2 -
4BUT
3
TNKS2_HUMAN
A:
[30-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-------------
60
PsiBlast_CBE
41.53
88%
-55
- C2 -
4BUI
2
TNKS2_HUMAN
A:
[30-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-------------
50
PsiBlast_CBE
41.00
88%
-55
- C2 -
4BUW
4
TNKS2_HUMAN
A:
[30-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-------------
20
PsiBlast_PDB
40.33
88%
-47
* C2 *
3MHK
4
A:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-------------
52
PsiBlast_CBE
40.14
88%
-55
- C2 -
4BUV
3
TNKS2_HUMAN
A:
[30-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-------------
43
PsiBlast_CBE
39.73
88%
-49
- C2 -
4HYF
2
B:
[30-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
------------
42
PsiBlast_CBE
39.45
88%
-49
- C2 -
4HYF
2
?
C:
[30-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
------------