@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07647_TNKS2_HUMAN: (2014-10-11 )
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVDG
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGRRCAGG
G
A
A
C
A
S
A
A
A
E
AV
E
P
A
A
R
E
L
F
E
A
C
RNG
D
V
E
R
V
K
R
LV
T
P
E
KVNSRDTAGRKST
P
L
H
F
AAGF
G
R
K
D
V
V
E
Y
L
L
QNGA
N
V
Q
ARDDG
G
L
I
PLHNACSF
G
H
A
E
V
V
N
L
L
L
RHGADPNARDNWNYTP
L
H
E
A
A
IKGK
I
D
V
C
I
V
L
L
QHGAEP
T
I
RNTDG
R
T
A
L
DLADPSA
K
A
V
L
TGEY
K
K
D
E
L
L
E
S
A
RSG
N
E
E
K
M
M
A
L
LTPL
N
V
N
C
HASDGRKST
P
L
H
L
AAGY
N
R
V
K
I
V
Q
L
L
L
QHGADVHAKDKG
D
L
VPLHNACSY
G
H
Y
E
V
T
E
L
L
V
KHGACV
N
A
M
D
L
WQFT
P
L
H
E
A
ASK
N
R
V
E
V
C
S
L
L
L
SYGADP
T
L
L
NCHNKSAIDLAP
T
P
Q
L
K
E
R
L
A
Y
EFK
G
H
S
L
L
Q
A
A
R
E
A
D
V
T
R
I
K
K
H
L
S
L
E
M
VNFKHPQT
H
E
T
A
L
H
CAAASPY
P
K
R
K
Q
I
C
E
L
L
L
RKGANI
N
E
K
T
K
E
F
L
T
P
L
HVASEKAH
N
D
V
V
E
V
V
V
KHEAK
V
N
A
L
D
N
L
G
Q
T
S
L
H
R
A
A
YC
G
H
L
Q
T
C
R
L
L
L
SYGCDP
N
I
I
S
LQG
F
T
A
L
QMG
N
E
N
V
Q
Q
L
L
Q
E
G
I
SLGN
S
E
A
D
R
Q
L
L
E
A
AKAG
D
V
E
T
V
K
K
L
C
TVQSVNCRDIEGRQST
P
L
H
F
AAGY
N
R
V
S
V
V
E
Y
L
L
QHGADVHAKDKG
G
L
V
PLHNACSY
G
H
Y
E
V
A
E
L
L
V
KHG
A
V
V
N
V
A
D
L
WKFT
P
L
H
E
A
A
AK
G
K
Y
E
I
C
K
L
L
L
QHGADPTKKNRDGNTP
L
D
L
VKDGD
T
D
I
Q
D
L
L
RG
D
A
A
L
L
D
A
A
K
K
G
C
L
A
R
V
K
KLSSPDNVNCRDTQGRHST
P
L
H
L
AAGYN
N
L
E
V
A
E
Y
L
L
QHGADVNAQDKG
G
L
I
PLHNAASYG
H
V
D
V
A
A
L
L
I
KYNACVNATDKWAF
T
P
L
H
E
A
A
QK
G
R
T
Q
L
C
A
L
L
L
AHGADPTLKNQEGQTP
L
D
L
VS
A
D
D
V
S
A
L
L
T
AAMPPSALPSCY
K
P
Q
V
LNGVRSPGAT
A
D
A
LSSGPSSPSSL
S
A
A
S
S
L
D
NLSG
S
F
S
E
L
S
S
V
V
SSSGTEGASSLEKKEVPGVD
F
S
I
T
Q
F
V
R
N
L
G
L
E
H
L
M
D
I
F
E
R
E
Q
I
T
L
D
V
L
V
E
M
G
H
K
E
L
K
E
IGINAYG
H
R
H
K
L
I
K
G
V
E
R
L
ISGQQGLN
P
Y
L
T
L
NTSGS
G
T
I
L
I
DLSPD
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
HRDGGHAGGIFNR
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
EVSEENHNHANE
R
M
L
FHG
S
P
F
V
N
A
I
I
HKGF
D
E
R
H
A
Y
IGGMFG
A
G
I
Y
F
AENSSKSN
Q
Y
V
Y
G
IGGGTGCPVHKDR
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
MAHSPPGHHSVTGRPSV
N
G
L
A
L
A
E
Y
V
I
YRGEQAY
P
E
Y
L
I
T
Y
Q
I
MRPEGMVDG
13
PsiBlast_PDB
60.64
96%
-41
- C2 -
4HYF
2
TNKS2_HUMAN
A:
[14-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
E
N
L
Y
F
Q
S
M
L
N
T
S
G
S
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
----
22
PsiBlast_CBE
60.56
96%
-41
- C2 -
4HYF
2
B:
[14-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
E
N
L
Y
F
Q
S
M
L
N
T
S
G
S
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
----
21
PsiBlast_CBE
59.52
96%
-39
- C2 -
4HYF
2
?
C:
[14-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
E
N
L
Y
F
Q
S
M
L
N
T
S
G
S
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
----
20
PsiBlast_PDB
46.63
96%
-51
- C2 -
4BU8
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
38
PsiBlast_CBE
45.80
96%
-52
- C2 -
4BUI
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
17
PsiBlast_PDB
45.78
96%
-53
- C2 -
4BU5
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
42
PsiBlast_CBE
45.36
96%
-53
- C2 -
4BUE
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
48
PsiBlast_CBE
45.02
96%
-53
* C2 *
4BU9
5
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
19
PsiBlast_PDB
44.95
96%
-52
- C2 -
4BU7
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
32
PsiBlast_CBE
44.76
96%
-49
- C2 -
4BUU
4
TNKS2_HUMAN
A:
[29-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
36
PsiBlast_CBE
44.66
96%
-53
- C2 -
4BUS
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
8
PsiBlast_PDB
44.59
96%
-50
- C2 -
3U9H
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
18
PsiBlast_PDB
44.48
96%
-53
- C2 -
4BU6
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
16
PsiBlast_PDB
44.38
96%
-48
- C2 -
4BU3
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
34
PsiBlast_CBE
44.27
96%
-52
- C2 -
4BUT
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
44
PsiBlast_CBE
44.13
96%
-46
- C2 -
4BUD
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
28
PsiBlast_CBE
44.11
96%
-51
- C2 -
4BUW
4
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
12
PsiBlast_PDB
44.05
96%
-51
- C2 -
4AVW
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
6
PsiBlast_PDB
43.98
96%
-51
- C2 -
3P0P
1
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
----
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
7
PsiBlast_PDB
43.77
96%
-51
- C2 -
3P0Q
1
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
46
PsiBlast_CBE
43.76
96%
-54
- C2 -
4BUA
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
30
PsiBlast_CBE
43.70
96%
-52
- C2 -
4BUV
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
10
PsiBlast_PDB
42.99
96%
-47
- C2 -
3UA9
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
---
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
9
PsiBlast_PDB
42.83
96%
-47
- C2 -
3U9Y
2
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
40
PsiBlast_CBE
42.81
96%
-48
- C2 -
4BUF
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
4
PsiBlast_PDB
42.79
96%
-45
- C2 -
3MHJ
1
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
11
PsiBlast_PDB
42.71
96%
-50
- C2 -
4AVU
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
5
PsiBlast_PDB
42.44
96%
-54
- C2 -
3P0N
1
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
---
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
56
PsiBlast_CBE
42.42
96%
-44
- C2 -
4BJB
2
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
-------
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
---
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
3
PsiBlast_PDB
42.01
96%
-46
- C2 -
3KR8
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
----
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
15
PsiBlast_PDB
41.75
96%
-51
- C2 -
4BS4
3
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
---
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
58
PsiBlast_CBE
41.51
96%
-42
- C2 -
4BJ9
2
TNKS2_HUMAN
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
---
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
62
PsiBlast_CBE
41.32
96%
-44
- C2 -
3UA9
2
B:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
55
PsiBlast_CBE
37.77
96%
-38
- C2 -
4BJC
1
A:
[30-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
--------
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
-----
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----