@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_JAK3_MOUSE: (2014-10-13 )
MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDYLAEDLCVRAAKACGILPVYHSLFALATEDFSCWFPPSHIFCIEDVDTQVLVYRLRFYFPDWFGLETCHRFGLRKDLTSAILDLHVLEHLFAQHRSDLVSGRLPVGLSMKEQGEFLSLAVLDLAQMAREQAQRPGELLKTVSYKACLPPSLRDVIQGQNFVTRRRIRRTVVLALRRVVACQADRYALMAKYILDLERLHPAATTETFRVGLPGAQEEPGLLRVAGDNGISWSSGDQELFQTFCDFPEIVDVSIKQAPRVGPAGEHRLVTVTRMDGHILEAEFPGLPEALSFVALVDGYFRLICDSRHYFCKEVAPPRLLEEEAELCHGPITLDFAIHKLKAAGSLPGTYILRRSPQDYDSFLLTACVQTPLGPDYKGCLIRQDPSGAFSLVGLSQPHRSLRELLAACWNSGLRVDGAALNLTSCCAPRPKEKSNLIVVRRGCTPAPAPGCSPSCCALTQLSFHTIPTDSLEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDMYLRKRGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAQTLCLEADKWGFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQLPALKWTELAGLITQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTPGIPSPRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQLDALWRGRPG
Atome Classification :
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540........550.......560.......570.......580.......590........600.......610.......620.......630.......640.......650....--...660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850..-..-...860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040.-.....1050......1060......1070......1080......1090......1100
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPPSEETPLIPQRSCSLSSSEA
G
A
L
H
V
LLPPRGPGPPQ
R
L
S
F
S
F
G
D
Y
L
A
E
D
L
C
V
R
A
A
K
ACG
I
L
P
V
Y
H
S
L
F
A
L
ATEDF
S
C
WFPP
S
H
I
F
C
IEDVD
T
Q
V
L
V
Y
R
L
R
FYFPDWF
G
L
E
T
C
H
R
FGL
R
K
D
L
T
S
A
I
L
D
L
H
V
L
E
H
L
F
A
Q
H
R
S
D
L
VSGRLPVGLSMKEQGE
F
L
S
L
A
V
L
D
L
A
Q
M
A
R
E
Q
A
QR
P
G
E
L
L
K
T
VSYKACL
P
P
S
L
R
D
V
IQGQ
N
F
V
T
R
R
R
I
R
R
T
V
V
L
A
L
R
R
V
V
A
CQA
D
R
Y
A
L
M
A
K
Y
I
L
D
L
E
RLHPAATT
E
T
F
R
VGLPGAQEEP
G
L
L
R
V
AGDNGISWSSG
D
Q
E
L
F
Q
T
FCDF
P
E
I
V
D
V
S
I
KQAPRVGPAGE
H
R
L
V
T
V
TRMD
G
H
I
L
EAEFPG
L
P
E
A
L
S
F
V
A
L
V
D
G
Y
F
R
L
I
CDS
R
H
Y
F
C
K
EVA
P
P
R
L
L
E
E
E
A
E
LCHG
P
I
T
L
D
F
A
I
H
K
L
K
AAGSLP
G
T
Y
I
L
RRSPQ
D
Y
D
S
F
L
L
T
A
C
V
QTPLGPDYK
G
C
L
I
RQDPSG
A
F
S
L
V
GLS
Q
P
H
R
S
L
R
E
L
L
A
A
C
W
NSG
L
R
VDG
A
A
LNLTSCCAPRPKEKS
N
L
I
V
V
RRGCTPAPAPGCS
P
S
C
C
A
L
T
Q
L
S
F
HTIPTDS
L
E
W
H
ENLGH
G
S
F
T
K
I
F
RGRRREVVD-GETH
D
S
E
V
L
L
K
V
M
D
S
R
H
R
N
C
M
E
S
F
L
E
A
A
S
L
M
S
QVSY
P
H
L
V
L
L
H
G
V
CMAG
D
-
S
I
M
V
Q
E
F
V
Y
L
G
A
I
D
M
Y
L
R
KRG
H
L
VS
A
S
W
K
L
Q
V
T
K
Q
L
A
Y
A
L
N
Y
L
E
DKGLPHGNVS
A
R
K
V
L
L
A
R
EGG--DGNP
P
F
I
K
LSDPGVS
P
T
V
L
S
L
E
M
L
TDRIPWV
A
P
E
C
L
Q
E
A
Q
T
L
C
LEADKWGFG
A
T
T
W
E
V
FSGGP
A
H
ITSLE
P
A
K
K
L
K
F
YEDQGQLP
A
L
K
W
T
E
L
A
G
L
I
T
Q
C
MAYDPGRR
P
S
F
R
A
I
L
R
D
L
N
G
L
ITS
D
Y
E
LLSDPTPGIPS
P
R
D
ELCGG
A
Q
L
Y
ACQDP
A
I
F
E
E
R
H
L
K
Y
I
S
LLGKGNFGS
V
E
L
C
R
YDPLGDNTG
P
L
V
A
V
K
Q
L
Q-HS-GP
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
YRGVSYGP
G
R
Q
S
L
R
L
V
M
E
YLP
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
LHT
D
R
L
L
L
F
A
W
Q
I
C
K
G
M
E
Y
L
G
A
R
R
C
V
H
R
D
L
A
AR
N
I
L
VESEA
H
V
K
I
A
D
F
G
L
A
K
L
LPLGK
D
Y
Y
V
V
REPGQS
P
I
F
W
YA
P
E
SLS
D
N
I
F
SRQS
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
CDKSCS
P
S
A
E
F
L
R
MMGPEREGP
P
L
C
-
R
L
L
E
L
L
AEGRRLPPPPTC
P
T
E
V
Q
E
L
M
Q
L
CWAPSPHDRPAFGTLSP
Q
L
D
A
LWRGRPG
4
PsiBlast_PDB
88.01
89%
-110
- C1 -
4HVG
1
A:
[4-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
----
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
R
-
6
PsiBlast_PDB
84.35
89%
-113
- C1 -
4HVI
1
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
----
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
---
7
PsiBlast_PDB
83.52
89%
-110
- C1 -
4I6Q
2
A:
[5-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
--
5
PsiBlast_PDB
82.77
89%
-112
- C1 -
4HVH
1
A:
[4-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
S
--
2
PsiBlast_PDB
82.36
89%
-108
- C1 -
3LXL
1
A:
[17-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
------
3
PsiBlast_PDB
81.45
89%
-109
- C1 -
4HVD
2
?
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
------
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
---
1
PsiBlast_PDB
75.65
89%
-107
- C1 -
3LXK
1
A:
[18-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
-
H
S
-
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
P
G
R
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
D
A
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
S
-
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
------
10
PsiBlast_PDB
72.76
59%
-109
* C1 *
4BBF
2
JAK2_HUMAN
A:
[5-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
------
9
PsiBlast_PDB
66.06
59%
-108
- C1 -
4BBE
2
JAK2_HUMAN
A:
[5-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
------
11
PsiBlast_PDB
54.65
59%
-105
- C1 -
3UGC
1
A:
[6-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
-
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
-------------
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
------
20
PsiBlast_PDB
50.99
50%
-110
- C1 -
3NZ0
1
A:
[7-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
-
A
D
C
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
------
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
------
16
PsiBlast_PDB
49.86
50%
-100
- C1 -
4GII
1
A:
[9-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
------
15
PsiBlast_PDB
49.11
51%
-103
- C1 -
4GVJ
1
A:
[8-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
------
17
PsiBlast_PDB
48.24
50%
-100
- C1 -
4GJ2
1
A:
[9-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
------
19
PsiBlast_PDB
48.09
50%
-99
- C1 -
4GIH
1
A:
[9-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
------
18
PsiBlast_PDB
47.71
50%
-99
- C1 -
4GJ3
1
A:
[9-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
-
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
------
13
PsiBlast_PDB
6.06
56%
-89
- C1 -
4FVP
2
A:
[2-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
K
I
R
N
E
D
L
I
F
N
E
S
L
G
Q
G
T
F
T
K
I
F
K
G
V
R
R
E
V
G
D
Y
G
Q
L
H
E
T
E
V
L
L
K
V
L
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
S
M
M
S
K
L
S
H
K
H
L
V
L
N
Y
G
V
C
V
C
G
D
E
N
I
L
V
Q
E
F
V
K
F
G
S
L
D
T
Y
L
K
K
N
K
N
C
I
N
I
L
W
K
L
E
V
A
K
Q
L
A
A
A
M
H
F
L
E
E
N
T
L
I
H
G
N
V
C
A
K
N
I
L
L
I
R
E
E
D
RK
T
G
N
P
P
F
I
K
L
S
D
P
G
I
S
I
T
V
L
P
K
D
I
L
Q
E
R
I
P
W
V
P
P
E
C
I
E
N
P
K
N
L
N
L
A
T
D
K
W
S
F
G
T
T
L
W
E
I
C
S
G
G
D
K
P
L
S
A
L
D
S
Q
R
K
L
Q
F
Y
E
D
R
H
Q
L
P
A
P
K
A
A
E
L
A
N
L
I
N
N
C
M
D
Y
E
P
D
H
R
P
S
F
R
A
I
I
R
D
L
N
S
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------