@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_VGFR2_DANRE: (2014-10-13 )
MAKTSYALLLLDILLTFNVAKAIELRFVPDPPTLNITEKTIKINASDTLQITCRGRQILEWSTPHNRTSSETRLTISDCSGDGLFCSTLTLSKAVANETGEYRCFYKSLPKEDGKTSVAVYVFIQDYRTPFVRIAQDYDVVFIREGEQVVIPCLVSVEDLNVTLYTKYPVKELSTDGKEVIWDSRRGFILPSRVVSYAGVVYCQTTIRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTVGERLILNCTAHTELNVGIDFQWTFPHEKRSVNGSMSTSRYKTSSNKKKLWNSLELSNTLTVENVTLNDTGEYICTASSGQMQKIAQASLIVYEKPFIALSDQLWQTVEAKAGDAEAKILVKYYAYPEPAVRWYKNDQLIVLRDEYRMKFYRGVHLTIYGVTEKDAGNYTVVMTNKITKEEQRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTASGGSSPVTIKWQWMPREDCPVRFLPKSDTRMAKCDKWREMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRCIATNKMGQDQRVIVFQVTRFLNLSVLPSSSPIEGQDVIMRCVADRLLYYNLRWYRVANVANHDPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATMMDQGLYACQVEIVGTNEKTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEGSGVILKRSNRVLTIQRVKKEDSGLYICTACNQQGCESSEARISVDGAEEKMNVELIMPIGAVVIAMFLWLLIVFVIRNRKRPNDGDLKTGYLSIILDSDDMPMDEHCERLTYDASKWEFPRDRLKLGEPLGRGAFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTGEQTYKTLQDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDYIPLTNGEMEEELVAPHLNVTSKRSFYAGNTEAQLHYDNAPPLGFPQQMNSSGVPVNMTGFVDIPLEHTTVMDGHVDCGVGLSREQMKALDRQAQRPLNFSPLLRCKSKESLASESSNQTSGYQSGYHSDDAEAPIYANEEMILKRDIRKKPPLPKRNDKFSAEVRYSAPPV
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000.....--.1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAK
T
S
Y
A
L
L
L
L
D
I
L
L
T
FNV
A
K
A
I
E
L
R
FVPDPPTL
N
I
T
E
K
T
I
K
INAS
D
T
L
Q
I
T
CRG
R
Q
I
L
E
WSTPHNRTSSE
T
R
L
T
I
SDCSGD
G
L
F
C
S
T
L
T
L
S
K
A
V
ANETG
E
Y
R
C
F
Y
K
SLPKEDGK
T
S
V
A
V
Y
V
F
I
QDYRTP
F
V
R
I
AQDY
D
V
V
F
I
REG
E
Q
V
V
I
P
C
L
V
S
V
E
DL
N
V
T
L
Y
TKY
P
V
K
E
LSTDG
K
E
V
I
WDSRR
G
F
I
L
P
S
R
V
V
S
Y
A
G
V
V
Y
C
Q
T
TIRNETFQSS
P
Y
I
V
A
V
VG
Y
K
I
Y
D
L
TLSPQHERLTVG
E
R
L
I
L
N
C
TAH
T
E
L
N
V
G
I
D
F
Q
W
TFPHEKRSVNGSMST
S
R
YKTSS
N
K
K
K
L
W
N
SLELS
N
T
L
T
V
E
N
V
T
LNDTG
E
Y
I
C
TASS
G
Q
M
Q
K
I
A
Q
A
S
L
I
V
Y
EK
P
F
I
A
L
S
D
Q
L
W
Q
T
V
E
AKAGDA
E
A
K
I
L
V
K
Y
YAYPE
P
A
V
R
W
YKND
Q
L
I
V
L
R
D
E
Y
R
M
K
F
YR
G
V
H
L
T
I
Y
G
VTEKDAG
N
Y
T
V
V
M
TNKI
T
K
E
E
Q
R
R
T
F
Q
L
V
V
N
D
L
P
R
I
F
E
K
DVSLDR
D
V
H
MYGSS
P
T
L
T
C
TASGGSS
P
V
T
I
K
W
Q
WMPREDCP
V
R
F
LPKSDT
R
M
A
K
C
D
K
W
R
E
MSNNTGKNPLISQTSV
D
E
R
T
L
K
T
I
S
T
L
K
I
Q
K
A
V
D
H
A
L
Y
R
C
I
ATNKMGQD
Q
R
V
I
V
F
Q
V
T
R
F
L
N
L
S
VLPSSSPI
E
G
Q
D
V
I
M
R
C
V
A
D
R
L
L
Y
YN
L
R
W
Y
R
V
ANVANHDPPPAAVPCD
T
L
T
L
S
HLHQPN
V
T
V
SGLQGT
N
V
T
L
D
MPIPN
A
T
M
M
DQG
L
Y
A
C
Q
V
E
I
V
GTNEK
T
C
L
L
HN
L
R
L
R
A
L
E
M
S
R
I
V
T
N
LTD
Q
R
VNVSDS
T
T
L
V
C
E
VSGTPT
P
T
I
V
W
TKDN
Q
T
V
MEG
S
G
V
I
L
KRS
N
R
V
L
T
I
Q
R
VKKEDS
G
L
Y
I
C
TACNQQGCESSE
A
R
I
S
VDGAEE
K
M
N
V
E
L
I
M
P
I
G
A
V
V
I
A
M
F
L
W
L
L
I
V
F
V
I
RNRKRPNDGDLK
T
G
Y
L
S
I
I
LDSDDM
P
M
D
E
H
C
E
R
LTYDASKWEF
P
R
D
R
L
KLGEPLGR
G
A
F
G
Q
V
V
E
A
T
AYGIEKAT
T
C
T
T
V
A
V
K
M
L
KEGAT
S
S
E
Y
R
A
L
M
S
E
L
K
I
L
I
HIGH
H
L
N
V
V
N
L
L
G
A
C
TKQGG
P
L
M
V
I
V
E
Y
C
KHG
N
L
S
S
Y
L
K
SKRGEYSPYKKRTPRMP
N
R
R
EVQQDEDPREGDLGLGTS
T
R
L
D
I
CTGT
A
V
CTRTG
E
Q
T
Y
K
T
L
Q
DEQESSDW--DHL
T
M
E
D
L
I
S
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
LLSEN
S
V
V
K
I
CDFGL
A
R
D
VYKDP
D
Y
VRKGDARL
P
L
K
WMA
P
E
T
I
F
D
R
VYTT
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
LGASPYP
G
V
CI
D
E
S
F
C
R
R
L
K
EGTRMRAPDYA
T
P
E
I
Y
Q
T
M
L
D
C
W
LDRPLDR
P
T
F
T
Q
L
V
E
H
L
G
N
L
L
Q
A
S
A
QQDGK
D
Y
IPLTNG
E
M
E
E
E
L
VAPHLNVTSKRSFYAGN
T
E
A
Q
L
H
YDNAPPLG
F
P
Q
QMNSSGV
P
V
N
M
T
G
F
V
D
IPLEH
T
T
VMDGHVDCGVGL
S
R
E
Q
M
K
A
L
D
R
Q
AQRPL
N
F
S
P
L
L
RCK
S
K
E
S
LASESSNQTSGYQSGYHSDDAEAPIYAN
E
E
M
I
L
K
R
D
I
RKKPPLPKRNDKF
S
A
E
V
R
YSAPPV
9
PsiBlast_PDB
94.24
74%
-103
- C2 -
3VHE
1
A:
[1-359]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
----------------------------------------------------------
D
L
YK
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
93.13
73%
-98
- C2 -
3VHK
2
A:
[11-365]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------------YK
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.03
73%
-114
- C2 -
1Y6B
1
A:
[14-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
--
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
----------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.97
73%
-115
- C2 -
1Y6A
1
A:
[15-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.60
72%
-99
- C2 -
3U6J
1
A:
[1-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
--
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.56
72%
-100
- C2 -
3EWH
2
A:
[1-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
84.89
72%
-111
- C2 -
3B8R
2
VGFR2_HUMAN
A:
[4-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.88
72%
-101
- C2 -
4ASD
1
A:
[39-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
E
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
------------------------------------------------
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.75
72%
-106
- C2 -
2P2H
1
A:
[1-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
---------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.48
72%
-102
- C2 -
2RL5
1
A:
[1-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
--------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.36
73%
-100
- C2 -
3VNT
4
A:
[9-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-----------------------------------------------
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
82.86
72%
-111
- C2 -
3CPB
1
VGFR2_HUMAN
A:
[5-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.59
73%
-101
- C2 -
3VO3
2
A:
[9-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------------------------------------------
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.52
72%
-103
- C2 -
3BE2
1
A:
[1-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
82.19
72%
-104
- C2 -
2P2I
1
VGFR2_HUMAN
A:
[3-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.18
72%
-105
- C2 -
2XIR
1
A:
[11-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
------------------------------------------------
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
82.11
72%
-106
- C2 -
2QU5
1
A:
[2-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
-------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.01
72%
-111
- C2 -
3CPC
1
VGFR2_HUMAN
A:
[6-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.85
72%
-102
- C2 -
4AG8
1
A:
[11-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
------------------------------------------------
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
81.62
72%
-106
- C2 -
3B8Q
1
VGFR2_HUMAN
A:
[4-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
81.58
72%
-102
- C2 -
3DTW
1
VGFR2_HUMAN
A:
[4-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.16
72%
-101
- C2 -
3EFL
1
VGFR2_HUMAN
A:
[3-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
--
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
80.89
72%
-107
- C2 -
3CP9
1
VGFR2_HUMAN
A:
[3-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------
A
P
E
D
L
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
78.22
72%
-114
- C2 -
3B8R
1
B:
[7-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-----------------------------------------------
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
77.69
72%
-117
* C2 *
2QU6
1
B:
[8-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
-----------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
77.27
72%
-108
- C2 -
3B8Q
1
B:
[6-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-----------------------------------------------
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
77.17
72%
-111
- C2 -
3CP9
1
B:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
-----------------------------------------------
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.83
72%
-117
- C2 -
2P2I
1
B:
[6-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.13
72%
-113
- C2 -
3CPC
1
B:
[6-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
-------------------------------------------------
Y
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.19
72%
-115
- C2 -
3EFL
1
B:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
75.01
72%
-113
- C2 -
3CPB
1
B:
[6-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------
K
-------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
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L
L
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A
S
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Y
P
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K
I
D
E
E
F
C
R
R
L
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E
G
T
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M
R
A
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Y
T
T
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M
Y
Q
T
M
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C
W
H
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Q
R
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F
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L
V
E
H
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N
L
L
Q
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