@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_VGFR2_RAT: (2014-10-13 )
MESRALLAVALWFCVETRAASVGLPGDSLHPPKLSTQKDILTILANTTLQITCRGQRDLDWLWPNTPRDSEERVLVTECGDSIFCKTLTVPRVVGNDTGAYKCFYRDTDVSSIVYVYVQDHRSPFIASVSDEHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEKGFTIPSYMISYAGMVFCEAKINDETYQSIMYIVLVVGYRIYDVVLSPPHEIELSAGEKLVLNCTARTELNVGLDFSWQFPSSKHQHKKIVNRDVKSLPGTVAKMFLSTLTIDSVTKSDQGEYTCTAYSGLMTKKNKTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVSERDAGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPSQTNPYTCKEWRHVKDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAAYVSALYKCEAINKAGRGERVISFHVIRGPEITVQPATQPTERESMSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTVFSNSTNDILIVAFQNASLQDQGNYVCSAQDKKTKKRHCLVKQLVILERMAPMITGNLENQTTTIGETIEVVCPTSGNPTPLITWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGVQEKTNLEVIILVGTAVIAMFFWLLLVILVRTVKRANEGELKTGYLSIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRSGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDPRLPLKWMAPETIFDRIYTIQSGVWSFGVLLWEIFSLGASPYPGVKIDEKFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPAFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDSQTDSGMVLASEELKTLEDRNKLSPSFGGMMPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSDEAGLLKLVDVAGHVDSGTTLRSSPV
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MES
R
A
L
L
A
V
A
L
W
F
C
VETRAASVGLPGDSLHPPKLS
T
Q
K
D
I
L
T
I
LAN
T
T
L
Q
I
T
CRGQRD
L
D
WLWPNTPRDSE
E
R
V
L
V
T
ECGD
S
I
F
C
K
TLTVPRVVGNDTG
A
Y
K
C
F
Y
RDTDV
S
S
I
V
Y
V
Y
V
QDHRS
P
F
I
A
SVSDEH
G
I
V
Y
I
TENKN
K
T
V
V
I
PCRGSISNL
N
V
S
L
C
ARY
P
E
KRFVPDGNRISWDSEKGF
T
I
P
S
Y
M
I
S
YA
G
M
V
F
C
E
A
KIN
D
E
T
Y
Q
S
I
M
Y
I
V
L
V
VG
Y
R
I
Y
D
V
VLSPP
H
E
I
E
LSAG
E
K
L
V
L
N
C
TA
R
T
E
L
N
V
G
L
D
F
S
W
QFPSSK
H
Q
H
K
K
I
V
N
R
D
V
K
SL
P
G
T
V
A
K
M
F
L
S
T
LTIDSVTKSDQG
E
Y
T
C
T
AYSGLMTKKN
K
T
F
V
R
V
HT
K
P
F
I
A
F
G
S
G
M
K
S
L
V
E
A
TVG
S
Q
V
R
I
P
V
K
YLSYPAPD
I
K
W
YRN
G
R
PIESN
Y
T
M
I
VGD
E
L
T
I
M
E
V
SERDAG
N
Y
T
V
I
L
TNPIS
M
E
K
QS
H
M
V
S
L
V
VNVPPQIG
E
K
A
L
ISP
M
D
SYQYG
T
M
Q
T
L
T
C
T
V
YANPPLH
H
I
Q
W
Y
W
Q
L
E
E
A
CSYRPSQTNPY
T
C
K
E
W
R
H
V
K
DFQGG
N
K
I
E
VTKN
Q
Y
A
L
I
EGKNK
T
V
S
T
L
V
I
Q
A
A
Y
V
S
A
L
Y
K
C
E
AINKAGRG
E
R
V
I
S
F
H
V
IRGP
E
I
T
V
QPATQPTERE
S
M
S
L
L
C
TADRNTFEN
L
T
W
Y
KLGSQ
A
T
S
V
HMGES
L
T
P
V
C
K
N
L
D
A
L
WKLN
G
T
V
FSNSTN
D
I
L
I
V
A
FQNASLQDQG
N
Y
V
CSAQDKK
T
K
K
R
H
C
L
V
K
Q
L
V
I
L
E
R
M
A
P
M
ITGNLENQTTTIG
E
T
I
E
V
V
CPTSGNPT
P
L
I
T
W
FKDN
E
T
L
VEDS
G
I
V
L
KDGNR
N
L
T
I
R
R
V
RKEDG
G
L
Y
T
C
QACNVLGCAR
A
E
T
L
F
I
I
EGVQEKT
N
L
E
V
I
I
L
V
G
T
A
V
I
A
M
F
F
W
L
L
L
V
I
L
V
R
T
V
K
RANEGELK
T
G
Y
L
S
I
V
MDPDEL
P
L
D
E
R
C
E
RLPYDASKWEF
P
R
D
R
L
KLGKPLGRGAFG
Q
V
I
EADAFGIDKTA
T
C
K
T
V
A
V
K
M
L
K
EGAT
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
HIGH
H
L
N
V
V
N
L
L
G
A
CTKPGG
P
L
M
V
I
V
E
F
C
KFGN
L
S
T
Y
LRGKRNEFVPYKSKGARFRSGKD
Y
V
G
E
L
S
V
D
L
K
R
R
L
D
S
I
TSSQSSASSGFVEEKSLS
D
V
E
E
E
E
A
S
E
E
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
RNILLSEK
N
V
V
K
ICDF
G
L
A
R
D
I
YKDP
D
Y
VRKGDPRL
P
L
K
WM
A
P
E
T
I
F
D
R
I
Y
T
I
Q
S
G
V
W
S
F
G
V
L
L
W
E
I
F
S
LGASPYPGVKI
D
E
K
F
C
R
R
L
K
EGTRMRAPDYT
T
P
E
M
Y
Q
T
M
L
D
C
WHEDPNQR
P
A
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
AQQDGK
D
Y
I
V
L
P
M
S
E
TLSMEEDSGLSLPTSP
V
S
CM
E
E
EEVCDPKFHYDNT
A
G
I
S
H
Y
L
Q
NSKRKSRP
V
S
V
K
T
FEDIPLEEP
E
V
K
V
IPDDSQTDS
G
M
V
L
A
S
E
E
L
K
T
L
E
D
R
NKLSPSFGGMMPS
K
S
R
E
S
V
A
SEGSNQTSGYQSGYHSDDTD
T
T
V
YSSDEA
G
L
L
K
L
V
D
VAGHVDSGTTLRSSPV
6
PsiBlast_PDB
96.15
94%
-109
- C2 -
3VHE
1
A:
[1-359]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.24
94%
-105
- C2 -
3VHK
2
A:
[11-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.63
95%
-122
- C2 -
1Y6B
1
A:
[14-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
--
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.19
95%
-125
- C2 -
1Y6A
1
A:
[15-362]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
-----------------------------------------------------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
89.12
73%
-105
- C2 -
3HNG
1
A:
[5-360]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
L
D
E
Q
C
E
R
-
P
Y
D
A
S
K
W
E
F
A
R
E
R
L
K
L
G
K
S
L
G
R
G
A
F
G
K
V
V
Q
A
S
A
F
G
I
K
K
S
P
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
Y
K
A
L
M
T
E
L
K
I
L
T
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
Q
G
G
P
L
M
V
I
V
E
Y
C
K
Y
G
N
L
S
N
Y
L
K
S
K
R
----------------------------------------------------------------
K
E
P
I
T
M
E
D
L
I
S
Y
S
F
Q
V
A
R
G
M
E
F
L
S
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
N
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
N
P
D
Y
V
R
K
--
T
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
I
Y
S
T
K
S
D
V
W
S
Y
G
V
L
L
W
E
I
F
S
L
G
G
S
P
Y
P
G
V
Q
M
D
E
D
F
C
S
R
L
R
E
G
M
R
M
R
A
P
E
Y
S
T
P
E
I
Y
Q
I
M
L
D
C
W
H
R
D
P
K
E
R
P
R
F
A
E
L
V
E
K
L
G
D
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.36
83%
-107
- C2 -
4ASD
1
A:
[39-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
E
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.33
81%
-110
- C2 -
3EWH
2
A:
[1-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.91
82%
-107
- C2 -
3VNT
4
A:
[9-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.90
81%
-107
- C2 -
3U6J
1
A:
[1-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
--
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.61
82%
-112
- C2 -
2XIR
1
A:
[11-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.01
82%
-110
- C2 -
3VO3
2
A:
[9-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.84
82%
-109
- C2 -
4AG8
1
A:
[11-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.64
80%
-113
- C2 -
3BE2
1
A:
[1-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
84.55
80%
-116
- C2 -
2P2H
1
A:
[1-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
---------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
84.36
80%
-114
- C2 -
2QU5
1
A:
[2-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
-------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
84.31
80%
-121
- C2 -
3B8R
2
VGFR2_HUMAN
A:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
84.05
80%
-110
- C2 -
2RL5
1
A:
[1-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
--------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.94
81%
-115
- C2 -
2P2I
1
VGFR2_HUMAN
A:
[3-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.65
80%
-113
- C2 -
3DTW
1
VGFR2_HUMAN
A:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
83.60
80%
-117
- C2 -
3B8Q
1
VGFR2_HUMAN
A:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.60
81%
-111
- C2 -
3EFL
1
VGFR2_HUMAN
A:
[3-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
--
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
83.45
80%
-116
- C2 -
3CP9
1
VGFR2_HUMAN
A:
[3-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.13
80%
-121
- C2 -
3CPB
1
VGFR2_HUMAN
A:
[5-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.98
80%
-120
- C2 -
3CPC
1
VGFR2_HUMAN
A:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
82.32
80%
-124
- C2 -
3B8R
1
B:
[7-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
82.14
80%
-119
- C2 -
3CP9
1
B:
[5-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.78
81%
-126
- C2 -
2P2I
1
B:
[6-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-----------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
81.73
80%
-118
- C2 -
3B8Q
1
B:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
81.07
80%
-125
- C2 -
2QU6
1
B:
[8-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
-------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
80.41
80%
-121
- C2 -
3CPC
1
B:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
----------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.34
81%
-124
- C2 -
3EFL
1
B:
[7-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-----------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
80.01
80%
-122
- C2 -
3CPB
1
B:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------------------------------------------------------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
59.51
80%
-12
* C2 *
3CJG
1
A:
[11-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
-
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
------------------------------------------
F
V
P
Y
K
------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
--------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------