@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF08123_DOT1L_HUMAN: (2014-10-14 )
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDE
Atome Classification :
(12 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGE
K
L
E
L
R
LKSPVGAEPAVYPWPLPVYDKH
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
EIPDL
K
L
A
ME
N
Y
V
L
I
DYDT
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
WKGTTQ
P
M
K
LNTRPS
T
G
L
L
R
H
I
L
Q
Q
V
YNHSVT
D
P
E
KLNNYEPFSPEVYGE
T
S
F
D
L
V
A
Q
M
I
D
E
IKMTDD
D
L
F
V
D
L
GS
G
V
G
Q
V
V
L
Q
V
A
AATNCKHHYGVEKADI
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
YGKKHA
E
Y
TLERGDFL
S
E
E
W
R
E
RIAN
T
S
V
I
F
V
NNFAFGPEV
D
H
Q
L
K
E
R
F
A
N
M
K
EG
G
R
IVSSKPFA
P
L
N
F
R
INSR
N
L
S
D
I
G
T
I
M
R
V
V
ELSPLKGS
V
S
WTGK
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
SLKNPKL
R
E
E
Q
E
A
A
R
R
R
Q
Q
R
ESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSP
S
K
A
R
K
K
K
L
N
K
K
G
R
K
MAGRKRGRPKKMNTANPERKPKKN
Q
T
A
L
D
A
L
H
A
Q
T
V
S
Q
TAASS
P
Q
D
A
YRSPHSPFYQLPPSVQRHSPN
P
L
L
VAPT
P
P
A
L
Q
K
L
L
E
S
F
K
I
Q
Y
L
Q
F
L
AYTKT
P
Q
Y
K
A
S
L
Q
E
L
LGQ
E
K
EK
N
A
Q
L
L
G
A
A
Q
Q
L
L
S
H
C
Q
A
Q
K
E
E
I
R
R
L
F
Q
Q
K
L
D
ELGVKAL
T
Y
N
D
L
I
Q
A
Q
K
E
I
S
A
H
N
Q
Q
L
R
E
Q
S
E
Q
L
E
Q
D
N
R
ALRG
Q
S
L
Q
L
L
K
A
R
C
E
E
L
Q
L
D
W
A
T
L
S
L
E
K
L
L
K
E
K
Q
A
L
K
S
Q
I
S
E
K
Q
R
H
C
L
E
L
Q
I
S
I
V
E
L
E
K
S
Q
R
Q
Q
E
L
L
Q
L
K
SCVPPDD
A
L
S
L
H
L
RGKGALGRELEPDA
S
R
L
H
L
E
L
DCTKFSLPHLSSMSPELSMNGQA
A
G
Y
E
L
C
G
V
LSRPSSKQN
T
P
Q
Y
L
ASPLDQEVVPCTPSHVGR
P
R
L
E
K
L
SGLAAPDYTRL
S
P
A
K
I
V
L
R
R
HLSQDHTVPGR
P
A
A
S
E
L
H
S
R
A
E
HTKENGLPYQSPSVPGSMKLSPQDPRPLSPG
A
L
Q
LAGEK
S
S
E
KG
L
R
E
RAYGSSG
E
L
I
T
SLPISIPLSTVQPNKL
P
V
SI
P
L
A
S
VVLP
S
R
A
E
RARSTPSPVLQPRD
P
S
S
T
L
E
K
Q
IGANAHGAGSR
S
L
A
LAPAGFSYA
G
S
V
A
I
S
GALAGSPASLTPGAEPATLDE
2
PsiBlast_PDB
97.72
100%
-95
- C2 -
4EQZ
1
DOT1L_HUMAN
A:
[6-343]
----
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
------
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
K
L
R
E
E
Q
E
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
97.46
100%
-100
- C2 -
4ER6
1
DOT1L_HUMAN
A:
[5-342]
---
K
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
Y
V
L
I
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
---
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
K
L
R
E
E
Q
E
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
97.22
100%
-93
- C2 -
3UWP
1
DOT1L_HUMAN
A:
[22-362]
---
K
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
Y
V
L
I
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
K
L
R
E
E
Q
E
A
A
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
96.66
100%
-97
- C2 -
4EK9
2
DOT1L_HUMAN
A:
[14-341]
----
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
Y
---
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.63
100%
-100
- C2 -
3SX0
1
DOT1L_HUMAN
A:
[5-333]
---
K
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
-----
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
96.08
100%
-98
- C2 -
3SR4
2
DOT1L_HUMAN
A:
[5-332]
----
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
Y
V
L
I
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
96.06
100%
-104
- C2 -
3QOX
1
DOT1L_HUMAN
A:
[15-342]
----
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
--
L
I
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
95.96
100%
-101
- C2 -
4ER5
2
DOT1L_HUMAN
A:
[5-342]
---
K
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
------
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
F
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
---
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
K
L
R
E
E
Q
E
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.75
100%
-97
- C2 -
4ER7
2
DOT1L_HUMAN
A:
[5-343]
---
K
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
-----
I
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
--------
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
K
L
R
E
E
Q
E
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
95.38
100%
-104
- C2 -
4EKG
1
DOT1L_HUMAN
A:
[14-340]
----
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
Y
---
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
-----
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
93.30
100%
-101
- C2 -
4EKI
1
DOT1L_HUMAN
A:
[13-339]
---
K
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
Y
---
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
-----
S
P
E
V
Y
G
E
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
S
W
T
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
92.45
100%
-99
- C2 -
4HRA
1
DOT1L_HUMAN
A:
[13-343]
---
K
L
E
L
R
L
K
S
P
V
G
A
E
P
A
V
Y
P
W
P
L
P
V
Y
D
K
H
H
D
A
A
H
E
I
I
E
T
I
R
W
V
C
E
E
I
P
D
L
K
L
A
M
E
N
Y
V
L
I
D
Y
D
T
K
S
F
E
S
M
Q
R
L
C
D
K
Y
N
R
A
I
D
S
I
H
Q
L
W
K
G
T
T
Q
P
M
K
L
N
T
R
P
S
T
G
L
L
R
H
I
L
Q
Q
V
Y
N
H
S
V
T
D
P
E
K
L
N
N
Y
E
P
--------
T
S
F
D
L
V
A
Q
M
I
D
E
I
K
M
T
D
D
D
L
F
V
D
L
G
S
G
V
G
Q
V
V
L
Q
V
A
A
A
T
N
C
K
H
H
Y
G
V
E
K
A
D
I
P
A
K
Y
A
E
T
M
D
R
E
F
R
K
W
M
K
W
Y
G
K
K
H
A
E
Y
T
L
E
R
G
D
F
L
S
E
E
W
R
E
R
I
A
N
T
S
V
I
F
V
N
N
F
A
F
G
P
E
V
D
H
Q
L
K
E
R
F
A
N
M
K
E
G
G
R
I
V
S
S
K
P
F
A
P
L
N
F
R
I
N
S
R
N
L
S
D
I
G
T
I
M
R
V
V
E
L
S
P
L
K
G
S
V
---
G
K
P
V
S
Y
Y
L
H
T
I
D
R
T
I
L
E
N
Y
F
S
S
L
K
N
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------