@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF08127_CATB_RAT: (2014-10-14 )
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MWWS
L
I
P
L
S
C
L
L
A
L
T
SAHDKPSSHPL
S
D
D
M
I
N
Y
I
NKQNTTWQAG
R
N
F
Y
NV
D
I
S
Y
L
K
K
L
C
G
T
VLGGPNL
P
E
RVGFSEDINLPES
F
D
A
R
E
Q
WSNC
P
T
I
A
Q
IRDQGSCG
S
C
W
A
F
G
A
V
E
A
MS
D
R
I
C
I
HTN
G
R
V
N
V
E
V
S
A
E
D
L
L
T
C
CGIQCGDGCNGGYPSG
A
W
N
F
W
TRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDT
P
K
C
N
K
M
C
EAGYSTSYKEDKHYG
Y
T
SYSVS
D
S
E
K
E
I
M
A
E
I
Y
KNGPV
E
G
A
F
T
V
F
S
D
F
L
T
Y
KSGVYKHEAGDVMGG
H
A
I
R
I
L
G
W
GIENG
V
P
Y
W
L
V
A
NSWNVDWGDN
G
F
F
K
I
LRGENHCG
I
E
S
E
I
V
AGIP
R
T
Q
Q
Y
WGRF
6
PsiBlast_PDB
98.48
99%
-98
- C1 -
1THE
2
CATB_RAT
A:
[7-259]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
S
N
C
P
T
I
A
Q
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
M
S
D
R
I
C
I
H
T
N
G
R
V
N
V
E
V
S
A
E
D
L
L
T
C
C
G
I
Q
C
G
D
G
C
N
G
G
Y
P
S
G
A
W
N
F
W
T
R
K
G
L
V
S
G
G
V
Y
N
S
H
I
G
C
L
P
Y
T
I
P
P
C
E
H
H
V
N
G
A
R
P
P
C
T
G
E
G
D
T
P
K
C
N
K
M
C
E
A
G
Y
S
T
S
Y
K
E
D
K
H
Y
G
Y
T
S
Y
S
V
S
D
S
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
T
V
F
S
D
F
L
T
Y
K
S
G
V
Y
K
H
E
A
G
D
V
M
G
G
H
A
I
R
I
L
G
W
G
I
E
N
G
V
P
Y
W
L
V
A
N
S
W
N
A
D
W
G
D
N
G
F
F
K
I
L
R
G
E
N
H
C
G
I
E
S
E
I
V
A
G
I
P
R
T
-------
22
PsiBlast_CBE
97.69
99%
-94
- C1 -
1CTE
1
CATB_RAT
B:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
S
N
C
P
T
I
A
Q
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
M
S
D
R
I
C
I
H
T
N
G
R
V
N
V
E
V
S
A
E
D
L
L
T
C
C
G
I
Q
C
G
D
G
C
N
G
G
Y
P
S
G
A
W
N
F
W
T
R
K
G
L
V
S
G
G
V
Y
N
S
H
I
G
C
L
P
Y
T
I
P
P
C
E
H
H
V
N
G
A
R
P
P
C
T
G
E
G
D
T
P
K
C
N
K
M
C
E
A
G
Y
S
T
S
Y
K
E
D
K
H
Y
G
Y
T
S
Y
S
V
S
D
S
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
T
V
F
S
D
F
L
T
Y
K
S
G
V
Y
K
H
E
A
G
D
V
M
G
G
H
A
I
R
I
L
G
W
G
I
E
N
G
V
P
Y
W
L
V
A
N
S
W
N
A
D
W
G
D
N
G
F
F
K
I
L
R
G
E
N
H
C
G
I
E
S
E
I
V
A
G
I
P
R
T
-------
21
PsiBlast_CBE
97.57
99%
-93
- C1 -
1THE
2
CATB_RAT
B:
[7-259]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
S
N
C
P
T
I
A
Q
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
M
S
D
R
I
C
I
H
T
N
G
R
V
N
V
E
V
S
A
E
D
L
L
T
C
C
G
I
Q
C
G
D
G
C
N
G
G
Y
P
S
G
A
W
N
F
W
T
R
K
G
L
V
S
G
G
V
Y
N
S
H
I
G
C
L
P
Y
T
I
P
P
C
E
H
H
V
N
G
A
R
P
P
C
T
G
E
G
D
T
P
K
C
N
K
M
C
E
A
G
Y
S
T
S
Y
K
E
D
K
H
Y
G
Y
T
S
Y
S
V
S
D
S
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
T
V
F
S
D
F
L
T
Y
K
S
G
V
Y
K
H
E
A
G
D
V
M
G
G
H
A
I
R
I
L
G
W
G
I
E
N
G
V
P
Y
W
L
V
A
N
S
W
N
A
D
W
G
D
N
G
F
F
K
I
L
R
G
E
N
H
C
G
I
E
S
E
I
V
A
G
I
P
R
T
-------
7
PsiBlast_PDB
96.65
99%
-88
- C1 -
1CTE
1
CATB_RAT
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
S
N
C
P
T
I
A
Q
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
M
S
D
R
I
C
I
H
T
N
G
R
V
N
V
E
V
S
A
E
D
L
L
T
C
C
G
I
Q
C
G
D
G
C
N
G
G
Y
P
S
G
A
W
N
F
W
T
R
K
G
L
V
S
G
G
V
Y
N
S
H
I
G
C
L
P
Y
T
I
P
P
C
E
H
H
V
N
G
A
R
P
P
C
T
G
E
G
D
T
P
K
C
N
K
M
C
E
A
G
Y
S
T
S
Y
K
E
D
K
H
Y
G
Y
T
S
Y
S
V
S
D
S
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
T
V
F
S
D
F
L
T
Y
K
S
G
V
Y
K
H
E
A
G
D
V
M
G
G
H
A
I
R
I
L
G
W
G
I
E
N
G
V
P
Y
W
L
V
A
N
S
W
N
A
D
W
G
D
N
G
F
F
K
I
L
R
G
E
N
H
C
G
I
E
S
E
I
V
A
G
I
P
R
T
-------
14
PsiBlast_PDB
92.76
83%
-94
- C1 -
2DC6
2
?
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
26
PsiBlast_CBE
92.53
83%
-95
- C1 -
2DCD
2
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
13
PsiBlast_PDB
92.48
83%
-93
- C1 -
1ITO
1
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
19
PsiBlast_PDB
92.38
83%
-95
- C1 -
2DCB
2
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
23
PsiBlast_CBE
92.31
82%
-92
- C1 -
1GMY
3
?
C:
[1-253]
------------------------------------------------------------------------------
K
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
A
H
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
--------
15
PsiBlast_PDB
92.27
83%
-94
- C1 -
2DC7
2
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
17
PsiBlast_PDB
92.20
83%
-93
- C1 -
2DC9
2
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
16
PsiBlast_PDB
92.19
83%
-93
- C1 -
2DC8
2
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
25
PsiBlast_CBE
92.08
83%
-89
- C1 -
3AI8
1
CATB_HUMAN
A:
[1-255]
-----------------------------------------------------------------------------
L
K
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
A
H
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
T
-------
10
PsiBlast_PDB
91.95
82%
-92
- C1 -
1GMY
5
?
A:
[1-254]
------------------------------------------------------------------------------
K
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
A
H
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
T
-------
20
PsiBlast_PDB
91.84
83%
-92
- C1 -
2DCC
2
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
11
PsiBlast_PDB
91.56
83%
-89
- C1 -
3AI8
1
?
B:
[1-255]
-----------------------------------------------------------------------------
L
K
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
A
H
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
T
-------
18
PsiBlast_PDB
91.45
83%
-91
- C1 -
2DCA
2
CATB_BOVIN
A:
[1-253]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
--
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
24
PsiBlast_CBE
90.99
82%
-92
* C1 *
1GMY
5
?
B:
[1-253]
------------------------------------------------------------------------------
K
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
A
H
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
--------
31
PsiBlast_CBE
75.96
83%
-94
- C1 -
1SP4
1
?
B:
[1-205]
-------------------------------------------------------------------------------------------------------------------------------
R
V
N
V
E
V
S
A
E
D
M
L
T
C
C
G
G
E
C
G
D
G
C
N
G
G
F
P
S
G
A
W
N
F
W
T
K
K
G
L
V
S
G
G
L
Y
N
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
N
K
T
C
E
P
G
Y
S
P
S
Y
K
E
D
K
H
F
G
C
S
S
Y
S
V
A
N
N
E
K
E
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
S
G
E
I
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
G
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
I
V
A
G
M
P
C
T
-------
28
PsiBlast_CBE
74.75
83%
-97
- C1 -
2IPP
1
?
B:
[1-205]
--------------------------------------------------------------------------------------------------------------------------------
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
T
D
------
29
PsiBlast_CBE
74.40
83%
-96
- C1 -
1CSB
2
?
E:
[1-205]
--------------------------------------------------------------------------------------------------------------------------------
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
T
D
------
30
PsiBlast_CBE
74.28
83%
-94
- C1 -
1CSB
2
?
B:
[1-205]
--------------------------------------------------------------------------------------------------------------------------------
V
S
V
E
V
S
A
E
D
L
L
T
C
C
G
S
M
C
G
D
G
C
N
G
G
Y
P
A
E
A
W
N
F
W
T
R
K
G
L
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
S
I
P
P
C
E
H
H
V
N
G
S
R
P
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
E
P
G
Y
S
P
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
K
D
I
M
A
E
I
Y
K
N
G
P
V
E
G
A
F
S
V
Y
S
D
F
L
L
Y
K
S
G
V
Y
Q
H
V
T
G
E
M
M
G
G
H
A
I
R
I
L
G
W
G
V
E
N
G
T
P
Y
W
L
V
A
N
S
W
N
T
D
W
G
D
N
G
F
F
K
I
L
R
G
Q
D
H
C
G
I
E
S
E
V
V
A
G
I
P
R
T
D
------
32
PsiBlast_CBE
15.26
89%
-56
- C1 -
1SP4
1
A:
[1-48]
-------------------------------------------------------------------------------
L
P
E
S
F
D
A
R
E
Q
W
P
N
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
S
N
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
14.65
87%
-52
- C1 -
2IPP
1
?
A:
[1-47]
-------------------------------------------------------------------------------
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
13.37
87%
-47
- C1 -
1CSB
2
D:
[1-47]
-------------------------------------------------------------------------------
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
13.09
87%
-46
- C1 -
1CSB
2
CATB_HUMAN
A:
[1-47]
-------------------------------------------------------------------------------
L
P
A
S
F
D
A
R
E
Q
W
P
Q
C
P
T
I
K
E
I
R
D
Q
G
S
C
G
S
C
W
A
F
G
A
V
E
A
I
S
D
R
I
C
I
H
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------