@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF09281_DPO1_THEAQ: (2014-10-17 )
MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGDAVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGMLPLFEPKG
R
V
L
L
VDG
H
H
L
A
Y
R
T
F
H
A
L
KGLTTSRGE
P
V
Q
A
V
Y
G
F
A
K
S
L
L
K
A
L
KEDG
D
A
V
I
V
V
F
DAKAPSF
R
H
EAYGGYKAGRAP
T
P
E
D
F
P
R
Q
L
A
L
I
K
E
L
V
D
L
L
G
L
ARLEVPGY
E
A
D
D
V
L
A
S
L
A
K
K
A
EKEG
Y
E
V
R
I
L
TA
D
K
D
L
Y
Q
L
L
SDR
I
H
V
LHPE
G
Y
L
I
T
P
A
W
L
W
E
KYGLR
P
D
Q
WADYRALTGDESDNLPGVKGI
G
E
K
T
A
R
K
L
L
E
E
W
G
S
L
E
A
L
L
K
N
L
D
R
L
K
P
A
I
R
E
K
I
L
A
H
M
D
DLKLSW
D
L
A
K
VRTDLPLEV
D
F
AKRREP
D
R
E
R
L
R
A
F
L
E
R
L
E
F
G
S
L
L
H
E
FGLLES
P
K
A
L
EEAPWPPPEG
A
F
V
G
F
V
LSRKE
P
M
W
A
D
L
L
A
L
A
A
ARGGRVHRAP
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
GLGLPPGDD
P
M
L
L
A
Y
L
LDPSNT
T
P
E
G
V
A
R
RYGGEW
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
GRLEG
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
AT
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
LAGHPFNLN
S
R
D
Q
L
E
R
V
L
F
D
ELGLPAIGKTEKTGKRS
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
TYIDP
L
P
D
LIHPRTG
R
L
H
T
R
FNQTATATGRLSSSDPNLQNIPVRT
P
L
G
Q
R
I
R
R
A
F
IAEE
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
HLSG
D
E
N
L
I
R
V
F
Q
EGRDIHTET
A
S
WMFGV
P
R
E
A
V
D
P
L
M
R
R
A
A
K
TIN
F
G
V
L
YG
M
S
A
H
R
L
S
Q
E
LAI
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
RRG
Y
V
E
T
L
FGRRRYVP
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
FNMPVQ
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
EA
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
EGVYPL
A
V
P
L
E
V
E
VGIG
E
D
W
LSAKE
8
PsiBlast_PDB
77.84
100%
-106
- C1 -
3M8S
6
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
16
PsiBlast_PDB
76.42
100%
-104
- C1 -
4DFJ
12
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
15
PsiBlast_PDB
76.34
100%
-106
- C1 -
4DF8
9
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
19
PsiBlast_PDB
75.73
100%
-105
- C1 -
4DFP
13
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
23
PsiBlast_CBE
75.44
100%
-105
- C1 -
4ELT
12
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
21
PsiBlast_CBE
74.18
100%
-105
- C1 -
4ELV
9
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
26
PsiBlast_CBE
73.47
100%
-106
- C1 -
1QTM
3
DPO1_THEAQ
A:
[1-539]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
-
20
PsiBlast_PDB
73.46
100%
-105
- C1 -
3RTV
9
DPO1_THEAQ
A:
[1-540]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
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F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
17
PsiBlast_PDB
71.19
100%
-104
- C1 -
4DFK
11
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
18
PsiBlast_PDB
70.18
100%
-104
- C1 -
4DFM
9
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
22
PsiBlast_CBE
69.70
100%
-104
- C1 -
4ELU
13
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
14
PsiBlast_PDB
68.44
100%
-105
- C1 -
4DF4
4
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
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L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
7
PsiBlast_PDB
68.00
100%
-103
- C1 -
3M8R
7
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
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L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
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E
L
T
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L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
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R
I
R
R
A
F
I
A
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E
G
W
L
L
V
A
L
D
Y
S
Q
I
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L
R
V
L
A
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L
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D
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N
L
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R
D
I
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T
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T
A
S
W
M
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G
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P
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A
V
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P
L
M
R
R
A
A
K
T
I
N
F
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V
L
Y
G
M
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A
H
R
L
S
Q
E
L
A
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P
Y
E
E
A
Q
A
F
I
E
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Y
F
Q
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F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
6
PsiBlast_PDB
64.84
100%
-104
- C1 -
3LWM
7
DPO1_THEAQ
A:
[3-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
24
PsiBlast_CBE
63.83
100%
-103
- C1 -
4DLG
5
DPO1_THEAQ
A:
[1-540]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
12
PsiBlast_PDB
63.04
100%
-105
- C1 -
3RRH
8
DPO1_THEAQ
A:
[3-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
29
PsiBlast_CBE
61.19
99%
-104
- C1 -
1QSS
3
DPO1_THEAQ
A:
[1-539]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
E
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
-
28
PsiBlast_CBE
60.51
99%
-105
- C1 -
1QSY
3
DPO1_THEAQ
A:
[1-539]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
E
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
-
3
PsiBlast_PDB
59.69
100%
-102
- C1 -
3KTQ
3
DPO1_THEAQ
A:
[1-539]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
-
1
PsiBlast_PDB
58.61
100%
-106
- C1 -
5KTQ
1
DPO1_THEAQ
A:
[1-543]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
K
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
---------
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
11
PsiBlast_PDB
57.49
100%
-103
- C1 -
3RRG
5
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
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H
P
F
N
L
N
S
R
D
Q
L
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R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
----
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
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A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
25
PsiBlast_CBE
56.36
100%
-105
- C1 -
4KTQ
2
DPO1_THEAQ
A:
[1-539]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
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S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
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G
E
E
R
L
L
W
L
Y
R
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V
E
R
P
L
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A
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L
A
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M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
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A
E
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F
R
L
A
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P
F
N
L
N
S
R
D
Q
L
E
R
V
L
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D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
10
PsiBlast_PDB
55.70
100%
-101
- C1 -
3RR8
6
DPO1_THEAQ
A:
[1-540]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
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V
E
R
P
L
S
A
V
L
A
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M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
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L
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V
A
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E
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A
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L
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A
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F
R
L
A
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H
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F
N
L
N
S
R
D
Q
L
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R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
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P
I
V
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K
I
L
Q
Y
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L
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L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
------
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
5
PsiBlast_PDB
53.73
100%
-103
- C1 -
3LWL
9
DPO1_THEAQ
A:
[3-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
----
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
30
PsiBlast_CBE
53.59
99%
-104
- C1 -
3PY8
5
DPO1_THEAQ
A:
[2-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
K
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
13
PsiBlast_PDB
51.14
100%
-103
- C1 -
3T3F
17
DPO1_THEAQ
A:
[1-540]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
-------
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
32
PsiBlast_CBE
42.63
99%
-101
- C1 -
3PO4
4
DPO1_THEAQ
A:
[3-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
K
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
33
PsiBlast_CBE
42.49
99%
-101
- C1 -
4BWM
7
DPO1_THEAQ
A:
[3-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
M
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
R
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
F
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
9
PsiBlast_PDB
39.12
100%
-102
- C1 -
3RR7
5
DPO1_THEAQ
A:
[3-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
------------------
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
27
PsiBlast_CBE
38.88
100%
-102
- C1 -
2KTQ
3
DPO1_THEAQ
A:
[1-538]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
----------
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
31
PsiBlast_CBE
33.34
99%
-101
* C1 *
3PO5
5
DPO1_THEAQ
A:
[3-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
D
L
L
A
L
A
A
A
R
G
G
R
V
H
R
A
P
E
P
Y
K
A
L
R
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
T
P
E
G
V
A
R
R
Y
G
G
E
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
K
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
----------
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
K
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E