@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF12721_RIPK1_HUMAN: (2014-10-18 )
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
Atome Classification :
(11 SA)
.........10........20........30........40........50........60........70........80.......------.90........100.......110.......120.........130.--......140.......150.......160.......170.......180.......190.......200.......210.......220..-...--------..230.......240...---....250.....-----..260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQPDM
S
L
N
V
I
K
MKSSDF
L
E
SAELDSGGFG
K
V
S
L
C
F
HRTQ
G
L
M
I
M
K
T
VYKGPNCI
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
EEG
K
Y
------
S
L
V
M
E
Y
M
EKGN
L
M
H
V
L
K
A
EMSTPLSVK
G
R
I
I
L
--
E
I
I
E
G
M
C
Y
LHGKG--
V
I
HKDLKPE
N
I
L
VDND
F
H
I
K
I
ADLG
L
A
S
F
K
M
W
S
KLN
N
E
E
H
N
E
L
R
E
VDGTAKKNG
G
T
L
Y
Y
M
A
P
E
HLNDVNAKPTEK
S
D
V
Y
S
F
A
V
V
L
W
A
I
FAN-KE
P
--------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
KSGN---RP
D
V
D
D
I
T
E
Y
C
P
-----
R
E
I
I
S
L
M
K
L
C
WEANPEARPTFP
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
EYSN
E
N
A
V
V
K
R
M
Q
SLQ
L
D
C
V
AVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENE
P
S
L
Q
S
K
L
Q
DEAN
Y
H
L
YGSRMD
R
Q
T
K
QQPRQNVAYN
R
E
E
E
R
R
RRVSHDP
F
A
QQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQ
P
Q
V
L
Y
QNNGLYSSHGFGTRPLDPGTAGP
R
V
W
Y
RPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDE
S
I
K
Y
T
I
YNST
G
I
Q
I
G
A
Y
N
Y
M
E
IGGTS
S
S
LLDSTNTNFKEEP
A
A
K
Y
Q
A
I
FDNTTSL
T
D
K
H
L
D
P
I
R
E
N
L
G
K
H
W
K
N
C
A
R
KLGF
T
Q
S
Q
I
D
E
ID
H
D
Y
E
RD
G
L
K
E
K
V
Y
Q
M
L
Q
K
W
V
M
REGIKGA
T
V
G
K
L
A
Q
A
L
H
Q
C
S
R
I
D
L
L
S
S
L
I
YVSQN
1
PsiBlast_PDB
90.38
100%
-108
- C1 -
4NEU
1
RIPK1_HUMAN
A:
[15-322]
-----
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
L
C
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
--
E
I
I
E
G
M
C
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
----------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
-
K
E
P
--------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
K
S
G
N
---
R
P
D
V
D
D
I
T
E
Y
C
P
-----
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.99
98%
-123
* C1 *
4ITJ
1
RIPK1_HUMAN
A:
[8-294]
-------
N
V
I
K
M
K
S
S
D
F
L
E
--------
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
--
E
I
I
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
-
K
E
P
--------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
---
R
P
D
V
D
D
I
T
E
Y
C
P
-----
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.76
98%
-124
- C1 -
4ITI
1
RIPK1_HUMAN
A:
[8-294]
-------
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
--
E
I
I
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
----------
G
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
-
K
E
P
--------
Y
E
-----
Q
Q
L
I
M
A
I
K
S
G
N
---
R
P
D
V
D
D
I
T
E
Y
C
P
-----
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_CBE
85.43
98%
-113
- C1 -
4ITJ
1
RIPK1_HUMAN
B:
[7-294]
------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
--
E
I
I
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
------------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
-
K
E
P
--------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
---
R
P
D
V
D
D
I
T
E
Y
C
P
-----
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_CBE
81.91
98%
-121
- C1 -
4ITI
1
RIPK1_HUMAN
B:
[7-294]
------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
-------
K
V
S
L
A
F
H
R
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
S
T
P
L
S
V
K
G
R
I
I
L
--
E
I
I
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-----------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
-
K
E
P
--------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
---
R
P
D
V
D
D
I
T
E
Y
C
P
-----
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
28.92
31%
-110
- C1 -
3BYU
1
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
V
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-----------------------
K
----
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
RMV
R
P
D
------
N
C
P
-----
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
28.16
31%
-98
- C1 -
2PL0
1
LCK_HUMAN
A:
[31-278]
----------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
V
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
------
N
C
P
-----
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
27.92
31%
-98
- C1 -
2OF4
1
LCK_HUMAN
A:
[21-270]
----------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
V
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
RMV
R
P
D
------
N
C
P
-----
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
27.85
31%
-103
- C1 -
3B2W
1
LCK_HUMAN
A:
[26-275]
----------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
V
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
--
G
A
K
----
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
------
N
C
P
-----
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
26.62
31%
-113
- C1 -
2OFV
1
LCK_HUMAN
A:
[26-273]
----------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
V
A
V
K
S
L
K
Q
G
----------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-----------------------------
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
------
N
C
P
-----
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
20.35
31%
-83
- C1 -
4M69
1
RIPK3_MOUSE
A:
[31-311]
-------------------------
G
G
F
G
V
V
F
R
A
H
H
R
T
W
N
H
D
V
A
V
K
-------
I
V
N
S
K
K
I
S
W
E
V
K
A
M
V
N
L
R
N
E
N
V
L
L
L
L
G
V
T
-
E
D
L
Q
W
DFVS
G
Q
A
L
V
T
R
F
M
E
N
G
S
L
A
G
L
L
Q
P
E
C
P
R
P
W
P
L
L
C
R
L
L
Q
--
E
V
V
L
G
M
C
Y
L
H
S
L
D
PP
L
L
H
R
D
L
K
P
S
N
I
L
L
D
P
E
L
H
A
K
L
A
D
F
G
L
S
T
F
Q
--------------
D
-------
S
G
G
T
L
A
Y
L
D
P
E
L
L
F
K
V
N
L
K
A
S
K
A
S
D
V
Y
S
F
G
I
L
V
W
A
V
L
A
G
-
R
E
A
E
LVDKTSL
I
R
E
T
V
C
D
R
Q
--------
S
---
R
P
P
L
T
E
L
P
P
G
S
P
E
T
P
G
L
E
K
L
K
E
L
M
I
H
C
W
G
S
Q
S
E
N
R
P
S
F
Q
D
C
E
P
K
T
N
E
V
Y
-
N
L
V
K
D
K
V
D
A
A
V
S
E
V
K
H
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------