@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF13193_ENTE_ECOLI: (2014-10-19 )
MSIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA
Atome Classification :
(9 SA)
.........10........20........30......--.--.40........50........60........70........80........90........100.......110.......120-.......130.......140.......150....-...160.......170....-...180---.........190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480........490.......500.......510.......520.......530....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSIPFTR
W
P
E
E
F
A
R
R
Y
R
EKGYWQDL
P
L
T
D
I
L
T
R
HAAS--D--
S
I
A
V
IDGERQ
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
RQGIKPG
E
T
A
L
V
QLG
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
QIE
P
A
-
L
L
I
ADRQHALFSG
D
D
F
L
N
T
F
V
TEHS
S
I
R
V
V
Q
LLN-DSGEH
N
L
Q
D
A
INHPAEDFTA-TPSP-----AD
E
V
A
Y
F
Q
LSGGTTGTPKLIPRTHN
D
Y
Y
Y
S
V
R
R
S
V
E
I
C
Q
F
T
Q
QT
R
Y
L
C
A
IPAAHNYAMSSPG
S
L
G
V
F
L
AG
G
T
V
V
L
AADPS
A
T
L
C
F
P
L
I
EKHQ
V
N
V
T
A
LV
P
P
A
V
S
L
W
L
Q
A
L
IEGESRA
Q
L
A
S
L
K
L
L
QVGG
A
R
L
S
A
T
L
A
ARI
P
A
E
I
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
TRLD
D
S
A
E
K
IIHTQGYPMCPDD
E
V
W
V
ADAEGNPLPQ
G
E
V
G
R
L
MTRGP
Y
T
F
R
GYYKSPQHNASAFDAN
G
F
Y
CSG
D
L
I
S
IDPE
G
Y
I
T
VQGRE
K
D
Q
INRGGEK
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
LMGEKS
C
A
Y
L
V
VK-E
P
L
R
A
V
Q
V
R
R
F
L
R
EQGIAEFKLP
D
R
V
E
C
V
DSLP
L
T
AVGKV
D
K
K
Q
L
R
Q
W
L
A
S
RASA
29
PsiBlast_CBE
98.27
100%
-110
- C1 -
4IZ6
2
ENTE_ECOLI
B:
[22-556]
-
S
I
P
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
--
S
I
A
V
I
D
G
E
R
Q
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
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H
Q
R
S
E
L
N
A
Y
A
S
Q
I
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P
A
-
L
L
I
A
D
R
Q
H
A
L
F
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G
D
D
F
L
N
T
F
V
T
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H
S
S
I
R
V
V
Q
L
L
N
-
D
S
G
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N
L
Q
D
A
I
N
H
P
A
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D
F
T
A
-
T
P
S
P
-----
A
D
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V
A
Y
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
Y
S
V
R
R
S
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
P
Q
G
E
V
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
2
PsiBlast_PDB
97.45
100%
-109
- C1 -
4IZ6
2
ENTE_ECOLI
A:
[22-556]
-
S
I
P
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
--
S
I
A
V
I
D
G
E
R
Q
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
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P
A
-
L
L
I
A
D
R
Q
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A
L
F
S
G
D
D
F
L
N
T
F
V
T
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H
S
S
I
R
V
V
Q
L
L
N
-
D
S
G
E
H
N
L
Q
D
A
I
N
H
P
A
E
D
F
T
A
-
T
P
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
Y
S
V
R
R
S
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
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S
L
W
L
Q
A
L
I
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G
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A
Q
L
A
S
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K
L
L
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V
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G
A
R
L
S
A
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L
A
A
R
I
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C
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Q
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L
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L
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K
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Q
G
Y
P
M
C
P
D
D
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W
V
A
D
A
E
G
N
P
L
P
Q
G
E
V
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
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D
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M
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K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
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F
K
L
P
D
R
V
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C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
8
PsiBlast_PDB
73.17
48%
-98
- C1 -
1MDB
2
DHBE_BACSU
A:
[5-532]
----
F
T
P
W
P
D
E
L
A
E
T
Y
R
K
N
G
C
W
A
G
E
T
F
G
D
L
L
R
D
R
A
A
K
YG
D
--
R
I
A
I
T
C
G
N
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
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F
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A
L
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L
G
A
L
P
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A
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S
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S
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I
T
Y
F
C
E
F
A
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A
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-
A
Y
I
I
P
D
A
---
Y
S
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F
D
Y
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LPEVK
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G
S
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G
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L
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C
W
L
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A
L
P
M
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N
Y
P
L
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Y
A
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G
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M
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Q
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L
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V
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G
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W
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D
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D
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D
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K
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T
G
H
L
L
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Y
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R
G
Y
Y
K
A
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N
A
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F
Y
R
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G
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L
L
A
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P
A
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A
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S
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P
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Q
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I
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E
A
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A
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K
A
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L
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Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
---
10
PsiBlast_PDB
70.32
47%
-95
- C1 -
1MD9
2
DHBE_BACSU
A:
[5-532]
----
F
T
P
W
P
D
E
L
A
E
T
Y
R
K
N
G
C
W
A
G
E
T
F
G
D
L
L
R
D
R
A
A
K
Y
G
D
--
R
I
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N
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S
Y
R
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L
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R
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D
R
L
A
A
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Q
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A
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A
L
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F
C
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F
A
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A
A
Y
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I
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D
----
A
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S
S
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L
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G
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G
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L
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L
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V
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A
L
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P
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A
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V
W
M
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A
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A
S
S
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R
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D
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N
Y
T
R
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
Y
D
E
S
R
V
W
D
D
H
D
R
D
V
K
P
G
E
T
G
H
L
L
T
R
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
P
K
A
A
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
---
5
PsiBlast_PDB
64.84
55%
-106
- C1 -
3O84
2
?
A:
[8-439]
--
I
E
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
--
H
PH
S
L
A
I
I
C
G
E
R
Q
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
-
L
L
I
G
S
R
Q
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
L
M
L
N
H
Q
A
T
D
F
G
L
L
D
W
I
E
T
P
A
E
T
F
V
D
F
S
S
T
P
-----
A
D
E
V
A
F
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
Y
S
V
R
A
S
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
N
C
K
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
P
E
G
E
I
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
---------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.56
55%
-105
- C1 -
3U16
2
?
A:
[8-439]
--
I
E
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
--
H
PH
S
L
A
I
I
C
G
E
R
Q
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
-
L
L
I
G
S
R
Q
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
L
M
L
N
H
Q
A
T
D
F
G
L
L
D
W
I
E
T
P
A
E
T
F
V
D
F
S
S
T
P
-----
A
D
E
V
A
F
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
Y
S
V
R
A
S
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
N
C
K
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
P
E
G
E
I
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
---------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.38
55%
-106
- C1 -
3U17
2
?
A:
[8-439]
--
I
E
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
--
H
PH
S
L
A
I
I
C
G
E
R
Q
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
-
L
L
I
G
S
R
Q
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
L
M
L
N
H
Q
A
T
D
F
G
L
L
D
W
I
E
T
P
A
E
T
F
V
D
F
S
S
T
P
-----
A
D
E
V
A
F
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
Y
S
V
R
A
S
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
N
C
K
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
P
E
G
E
I
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
---------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.30
55%
-103
- C1 -
3O82
1
?
A:
[8-439]
--
I
E
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
--
H
PH
S
L
A
I
I
C
G
E
R
Q
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
-
L
L
I
G
S
R
Q
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
L
M
L
N
H
Q
A
T
D
F
G
L
L
D
W
I
E
T
P
A
E
T
F
V
D
F
S
S
T
P
-----
A
D
E
V
A
F
F
Q
L
S
G
G
S
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
Y
S
V
R
A
S
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
N
C
K
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
P
E
G
E
I
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
---------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.23
55%
-106
- C1 -
3O83
3
?
A:
[8-439]
--
I
E
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
--
H
PH
S
L
A
I
I
C
G
E
R
Q
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
-
L
L
I
G
S
R
Q
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
L
M
L
N
H
Q
A
T
D
F
G
L
L
D
W
I
E
T
P
A
E
T
F
V
D
F
S
S
T
P
-----
A
D
E
V
A
F
F
Q
L
S
G
G
--
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
Y
S
V
R
A
S
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
N
C
K
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
P
E
G
E
I
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
---------------------------------------------------------------------------------------------------------