@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF13288_DXR_MYCTU: (2014-10-19 )
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80..---------......90........100.......110.......120.......130.......140.--......150.......160-----......----..170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNSTDGRAD
G
R
L
R
V
V
V
LGSTGS
I
G
T
Q
A
L
Q
V
IADNPD
R
F
E
V
V
G
LAAG
G
A
H
L
D
T
L
L
R
Q
R
A
QTGV
T
N
I
A
VA
D
E
H
A
A
Q
RVGDIPYH---------G
S
D
A
A
T
R
L
V
E
QT
E
A
D
V
V
L
N
A
L
V
G
ALGL
R
P
T
L
A
A
L
KTG
A
R
L
ALAN
K
E
S
LVAG
G
S
L
V
L
R
AAR--PG
Q
I
V
PVD
S
E
H
S
A
L
A
Q
C
L
------RGG
T
P
D
----
E
V
A
K
L
V
L
TASGGPFRGWSAADLEHVT
P
E
QAGAHPTWSMGPMNTL
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
LFGI
P
Y
D
R
I
D
V
V
VH
P
Q
S
I
I
H
S
M
V
T
FIDGSTIAQASPPD
M
K
L
P
I
S
L
ALGWPRRVSG
A
A
A
A
C
D
FHTASSWEFEPLDTD
V
F
P
A
V
E
L
A
R
QAGVA
G
G
C
M
T
A
V
YNAA
N
E
E
A
A
A
A
F
L
AGRI
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
QWAVEP
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
A
S
V
A
I
ASTAKPGAAGRHASTLERS
33
PsiBlast_CBE
93.10
99%
-115
* C1 *
2JCV
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
39
PsiBlast_CBE
92.69
99%
-116
- C1 -
2JCX
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
23
PsiBlast_CBE
91.39
99%
-116
- C1 -
4AIC
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
16
PsiBlast_PDB
90.76
99%
-111
- C1 -
2JCX
2
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
4
PsiBlast_PDB
90.68
99%
-112
- C1 -
3RAS
3
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
11
PsiBlast_PDB
90.37
99%
-112
- C1 -
4AIC
2
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
27
PsiBlast_CBE
90.29
99%
-115
- C1 -
2Y1F
1
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
1
PsiBlast_PDB
89.61
99%
-109
- C1 -
2JCV
2
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
25
PsiBlast_CBE
89.38
99%
-116
- C1 -
3RAS
3
DXR_MYCTU
B:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
24
PsiBlast_CBE
88.07
99%
-112
- C1 -
4A03
2
DXR_MYCTU
B:
[20-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
15
PsiBlast_PDB
87.07
99%
-113
- C1 -
3ZHX
1
DXR_MYCTU
A:
[19-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
-------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
9
PsiBlast_PDB
86.10
99%
-113
- C1 -
2Y1G
1
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
2
PsiBlast_PDB
85.87
99%
-109
- C1 -
2JD1
1
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
18
PsiBlast_PDB
85.85
99%
-111
- C1 -
2JD0
1
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
8
PsiBlast_PDB
85.85
99%
-114
- C1 -
2Y1F
2
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
------
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
10
PsiBlast_PDB
84.42
99%
-111
- C1 -
4A03
3
DXR_MYCTU
A:
[20-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
14
PsiBlast_PDB
80.90
99%
-113
- C1 -
3ZHY
2
DXR_MYCTU
A:
[19-396]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
13
PsiBlast_PDB
77.78
99%
-113
- C1 -
3ZHZ
1
DXR_MYCTU
A:
[19-397]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
-------
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
-------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
35
PsiBlast_CBE
74.06
99%
-114
- C1 -
3ZHY
2
DXR_MYCTU
B:
[19-396]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
-------------------------
6
PsiBlast_PDB
71.37
99%
-116
- C1 -
2Y1D
1
DXR_MYCTU
A:
[20-398]
----------
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
----------
D
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
----------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
M
------------------------
12
PsiBlast_PDB
70.85
99%
-120
- C1 -
3ZI0
1
DXR_MYCTU
A:
[20-395]
-----------
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
-----------
I
P
Y
H
---------
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
--
P
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
------
R
G
G
T
P
D
----
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
--------------------------
19
PsiBlast_PDB
6.75
39%
-94
- C1 -
2EGH
2
DXR_ECOLI
A:
[12-410]
------------
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
-
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
A
D
LEQN
G
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
--
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
S
A
----------------
20
PsiBlast_PDB
3.04
39%
-92
- C1 -
3ANL
2
DXR_ECOLI
A:
[12-410]
------------
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
K
-
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
GSR
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
L
G
Y
A
D
LEQN
G
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
--
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
S
A
----------------