@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF13419_HYES_RAT: (2014-10-19 )
MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITFSQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTCIVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYVTVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPLMPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNKATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALGRKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKWLKTEIQNPSVTSKI
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220-........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
L
R
V
A
A
FDLD
G
V
L
A
L
P
S
I
A
G
V
L
R
H
T
E
E
A
LAL
P
R
D
F
L
L
G
A
F
Q
MKFPEG
P
T
E
Q
L
M
KGKI
T
F
S
Q
WV
P
L
M
D
E
S
C
R
K
S
S
KACGASLPENF
S
I
S
E
I
F
S
Q
A
M
A
A
RSIN
R
P
M
L
Q
A
A
A
A
L
K
KKG
F
T
T
C
I
V
TNNWLDD
S
D
K
R
D
I
L
A
Q
M
M
C
E
L
S
Q
H
F
D
F
L
I
E
SCQVGMIKPE
P
Q
I
Y
K
F
V
L
D
T
LKAKPN
E
V
V
F
LDDFGSNLKPARDM
G
M
V
T
I
L
VR
D
T
A
S
A
L
R
E
L
E
K
V
TGTQF--PEAPLPVPCSPNDVSH
G
Y
V
T
VKPG
I
R
L
H
F
V
EMGSG
P
A
I
C
L
CHGF
P
E
S
W
F
S
W
RYQI
P
A
L
A
QAG
F
R
V
L
A
I
D
M
KGYGDSSSP
P
E
I
E
E
Y
A
M
E
L
L
C
E
E
M
V
T
F
L
N
KLGIP
Q
A
V
F
IGHD
W
A
G
V
L
V
W
N
M
ALF
H
P
E
R
V
R
A
V
A
SLNTPLMPPNPEV
S
P
M
E
V
I
R
SIPVF
N
Y
Q
L
Y
F
QEPGV
A
E
A
E
L
E
K
N
M
S
R
T
F
K
S
F
FRTSDDM
G
L
L
T
VNKATEMG
G
I
L
V
GTPEDPKVSKIT
T
E
E
E
I
E
Y
Y
I
Q
Q
F
K
KSGFRGP
L
N
W
YRNTERN
W
K
W
S
C
K
ALG
R
K
I
L
V
P
A
L
M
VTAEK
D
I
V
LRP
E
M
SK
N
M
E
N
W
I
P
F
L
KRGHIEDCGHWTQIEKP
A
E
V
N
Q
I
L
I
K
W
L
K
T
EIQNPSVTSKI
24
PsiBlast_CBE
93.24
72%
-116
* C1 *
1ZD3
2
HYES_HUMAN
A:
[2-548]
-
T
L
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
21
PsiBlast_CBE
93.05
72%
-116
- C1 -
3I1Y
1
HYES_HUMAN
A:
[4-548]
---
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
20
PsiBlast_CBE
93.01
72%
-116
- C1 -
3I28
1
HYES_HUMAN
A:
[4-548]
---
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
26
PsiBlast_CBE
91.40
72%
-114
- C1 -
1VJ5
2
HYES_HUMAN
A:
[2-548]
-
T
L
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
13
PsiBlast_CBE
90.91
91%
-113
- C1 -
1EK2
1
HYES_MOUSE
B:
[4-544]
---
R
V
A
A
F
D
L
D
G
V
L
A
L
P
S
I
A
G
A
F
R
R
S
E
E
A
L
A
L
P
R
D
F
L
L
G
A
Y
Q
T
E
F
P
E
G
P
T
E
Q
L
M
K
G
K
I
T
F
S
Q
W
V
P
L
M
D
E
S
Y
R
K
S
S
K
A
C
G
A
N
L
P
E
N
F
S
I
S
Q
I
F
S
Q
A
M
A
A
R
S
I
N
R
P
M
L
Q
A
A
I
A
L
K
K
K
G
F
T
T
C
I
V
T
N
N
W
L
D
D
G
D
K
R
D
S
L
A
Q
M
M
C
E
L
S
Q
H
F
D
F
L
I
E
S
C
Q
V
G
M
I
K
P
E
P
Q
I
Y
N
F
L
L
D
T
L
K
A
K
P
N
E
V
V
F
L
D
D
F
G
S
N
L
K
P
A
R
D
M
G
M
V
T
I
L
V
H
N
T
A
S
A
L
R
E
L
E
K
V
T
G
T
Q
F
--
P
E
A
P
L
P
V
P
C
N
P
N
D
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
F
V
E
M
G
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
P
E
I
E
E
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
M
P
P
D
P
D
V
S
P
M
K
V
I
R
S
I
P
V
F
N
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
S
F
F
R
A
S
D
E
T
G
F
I
A
V
H
K
A
T
E
I
G
G
I
L
V
N
T
P
E
D
P
N
L
S
K
I
T
T
E
E
E
I
E
F
Y
I
Q
Q
F
K
K
T
G
F
R
G
P
L
N
W
Y
R
N
T
E
R
N
W
K
W
S
C
K
G
L
G
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
R
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
N
Q
I
L
I
K
W
L
Q
T
E
----------
15
PsiBlast_CBE
90.33
91%
-110
- C1 -
1CR6
1
HYES_MOUSE
B:
[4-544]
---
R
V
A
A
F
D
L
D
G
V
L
A
L
P
S
I
A
G
A
F
R
R
S
E
E
A
L
A
L
P
R
D
F
L
L
G
A
Y
Q
T
E
F
P
E
G
P
T
E
Q
L
M
K
G
K
I
T
F
S
Q
W
V
P
L
M
D
E
S
Y
R
K
S
S
K
A
C
G
A
N
L
P
E
N
F
S
I
S
Q
I
F
S
Q
A
M
A
A
R
S
I
N
R
P
M
L
Q
A
A
I
A
L
K
K
K
G
F
T
T
C
I
V
T
N
N
W
L
D
D
G
D
K
R
D
S
L
A
Q
M
M
C
E
L
S
Q
H
F
D
F
L
I
E
S
C
Q
V
G
M
I
K
P
E
P
Q
I
Y
N
F
L
L
D
T
L
K
A
K
P
N
E
V
V
F
L
D
D
F
G
S
N
L
K
P
A
R
D
M
G
M
V
T
I
L
V
H
N
T
A
S
A
L
R
E
L
E
K
V
T
G
T
Q
F
--
P
E
A
P
L
P
V
P
C
N
P
N
D
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
F
V
E
M
G
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
P
E
I
E
E
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
M
P
P
D
P
D
V
S
P
M
K
V
I
R
S
I
P
V
F
N
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
S
F
F
R
A
S
D
E
T
G
F
I
A
V
H
K
A
T
E
I
G
G
I
L
V
N
T
P
E
D
P
N
L
S
K
I
T
T
E
E
E
I
E
F
Y
I
Q
Q
F
K
K
T
G
F
R
G
P
L
N
W
Y
R
N
T
E
R
N
W
K
W
S
C
K
G
L
G
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
R
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
N
Q
I
L
I
K
W
L
Q
T
E
----------
16
PsiBlast_CBE
89.53
72%
-114
- C1 -
4J03
1
HYES_HUMAN
A:
[1-548]
M
T
L
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
17
PsiBlast_CBE
89.35
72%
-114
- C1 -
4HAI
1
HYES_HUMAN
A:
[1-548]
M
T
L
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
22
PsiBlast_CBE
89.30
72%
-112
- C1 -
1ZD5
1
HYES_HUMAN
A:
[2-548]
-
T
L
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
23
PsiBlast_CBE
88.88
72%
-113
- C1 -
1ZD4
1
HYES_HUMAN
A:
[2-548]
-
T
L
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
25
PsiBlast_CBE
88.79
72%
-112
- C1 -
1ZD2
1
HYES_HUMAN
P:
[2-548]
-
T
L
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
18
PsiBlast_CBE
88.78
72%
-112
- C1 -
3OTQ
1
HYES_HUMAN
A:
[4-548]
---
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
19
PsiBlast_CBE
88.37
72%
-114
- C1 -
3KOO
1
HYES_HUMAN
A:
[4-548]
---
R
A
A
V
F
D
L
D
G
V
L
A
L
P
A
V
F
G
V
L
G
R
T
E
E
A
L
A
L
P
R
G
L
L
N
D
A
F
Q
K
G
G
P
E
G
A
T
T
R
L
M
K
G
E
I
T
L
S
Q
W
I
P
L
M
E
E
N
C
R
K
C
S
E
T
A
K
V
C
L
P
K
N
F
S
I
K
E
I
F
D
K
A
I
S
A
R
K
I
N
R
P
M
L
Q
A
A
L
M
L
R
K
K
G
F
T
T
A
I
L
T
N
T
W
L
D
D
R
A
E
R
D
G
L
A
Q
L
M
C
E
L
K
M
H
F
D
F
L
I
E
S
C
Q
V
G
M
V
K
P
E
P
Q
I
Y
K
F
L
L
D
T
L
K
A
S
P
S
E
V
V
F
L
D
D
I
G
A
N
L
K
P
A
R
D
L
G
M
V
T
I
L
V
Q
D
T
D
T
A
L
K
E
L
E
K
V
T
G
I
Q
L
LN
T
P
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
14
PsiBlast_CBE
87.00
91%
-110
- C1 -
1EK1
1
HYES_MOUSE
B:
[4-544]
---
R
V
A
A
F
D
L
D
G
V
L
A
L
P
S
I
A
G
A
F
R
R
S
E
E
A
L
A
L
P
R
D
F
L
L
G
A
Y
Q
T
E
F
P
E
G
P
T
E
Q
L
M
K
G
K
I
T
F
S
Q
W
V
P
L
M
D
E
S
Y
R
K
S
S
K
A
C
G
A
N
L
P
E
N
F
S
I
S
Q
I
F
S
Q
A
M
A
A
R
S
I
N
R
P
M
L
Q
A
A
I
A
L
K
K
K
G
F
T
T
C
I
V
T
N
N
W
L
D
D
G
D
K
R
D
S
L
A
Q
M
M
C
E
L
S
Q
H
F
D
F
L
I
E
S
C
Q
V
G
M
I
K
P
E
P
Q
I
Y
N
F
L
L
D
T
L
K
A
K
P
N
E
V
V
F
L
D
D
F
G
S
N
L
K
P
A
R
D
M
G
M
V
T
I
L
V
H
N
T
A
S
A
L
R
E
L
E
K
V
T
G
T
Q
F
--
P
E
A
P
L
P
V
P
C
N
P
N
D
V
S
H
G
Y
V
T
V
K
P
G
I
R
L
H
F
V
E
M
G
S
G
P
A
L
C
L
C
H
G
F
P
E
S
W
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
P
E
I
E
E
Y
A
M
E
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
M
P
P
D
P
D
V
S
P
M
K
V
I
R
S
I
P
V
F
N
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
K
N
M
S
R
T
F
K
S
F
F
R
A
S
D
E
T
G
F
I
A
V
H
K
A
T
E
I
G
G
I
L
V
N
T
P
E
D
P
N
L
S
K
I
T
T
E
E
E
I
E
F
Y
I
Q
Q
F
K
K
T
G
F
R
G
P
L
N
W
Y
R
N
T
E
R
N
W
K
W
S
C
K
G
L
G
R
K
I
L
V
P
A
L
M
V
T
A
E
K
D
I
V
L
R
P
E
M
S
K
N
M
E
K
W
I
P
F
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
I
E
K
P
T
E
V
N
Q
I
L
I
K
W
L
Q
T
E
----------
3
PsiBlast_PDB
42.55
75%
-109
- C1 -
3PDC
1
HYES_HUMAN
A:
[22-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
30
PsiBlast_CBE
42.08
75%
-109
- C1 -
3PDC
1
HYES_HUMAN
B:
[22-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
P
T
S
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
1
PsiBlast_PDB
39.87
74%
-108
- C1 -
3ANS
1
HYES_HUMAN
A:
[13-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
----------
2
PsiBlast_PDB
38.93
74%
-107
- C1 -
3ANT
1
HYES_HUMAN
A:
[13-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
----------
29
PsiBlast_CBE
38.66
74%
-105
- C1 -
3ANS
1
HYES_HUMAN
B:
[13-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
----------
4
PsiBlast_PDB
38.21
75%
-105
- C1 -
4JNC
1
HYES_HUMAN
A:
[2-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
A
R
N
-------
28
PsiBlast_CBE
38.16
74%
-105
- C1 -
3ANT
1
HYES_HUMAN
B:
[13-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
N
P
S
D
M
S
H
G
Y
V
T
V
K
P
R
V
R
L
H
F
V
E
L
G
S
G
P
A
V
C
L
C
H
G
F
P
E
S
W
Y
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
Y
R
V
L
A
M
D
M
K
G
Y
G
E
S
S
A
P
P
E
I
E
E
Y
C
M
E
V
L
C
K
E
M
V
T
F
L
D
K
L
G
L
S
Q
A
V
F
I
G
H
D
W
G
G
M
L
V
W
Y
M
A
L
F
Y
P
E
R
V
R
A
V
A
S
L
N
T
P
F
I
P
A
N
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
D
Y
Q
L
Y
F
Q
E
P
G
V
A
E
A
E
L
E
Q
N
L
S
R
T
F
K
S
L
F
R
A
S
D
E
-
S
V
L
S
M
H
K
V
C
E
A
G
G
L
F
V
N
S
P
E
E
P
S
L
S
R
M
V
T
E
E
E
I
Q
F
Y
V
Q
Q
F
K
K
S
G
F
R
G
P
L
N
W
Y
R
N
M
E
R
N
W
K
W
A
C
K
S
L
G
R
K
I
L
I
P
A
L
M
V
T
A
E
K
D
F
V
L
V
P
Q
M
S
Q
H
M
E
D
W
I
P
H
L
K
R
G
H
I
E
D
C
G
H
W
T
Q
M
D
K
P
T
E
V
N
Q
I
L
I
K
W
L
D
S
D
----------