@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF13931_KIF11_HUMAN: (2014-10-20 )
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSEN
Atome Classification :
(44 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASQPNSSA
K
K
K
E
EKGK
N
I
Q
V
V
V
R
CRPF
N
L
A
E
RKASAHS
I
V
ECDPV
R
K
E
V
S
VRTGGLADKSS
R
K
T
Y
T
F
D
M
V
FGASTK
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
MGYN
C
T
I
F
A
YGQTGTG
K
T
F
T
MEGERSPNEEYTWEEDPL
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
LTDNG
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
LLNPS
S
D
V
S
E
R
L
Q
M
FDDPRNKR
G
V
I
I
KG
L
E
E
ITVH
N
K
D
E
V
Y
Q
I
L
E
KGAAK
R
T
T
A
A
T
L
M
N
A
Y
SSRS
H
S
V
F
S
V
T
I
H
M
K
ETTI
D
G
E
E
L
V
KIGK
L
N
L
V
D
LAGSENIGRSGAV
D
K
R
A
R
EAGN
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
ERTPHVP
Y
R
E
S
K
L
T
R
I
L
Q
D
SLGGR
T
R
T
S
I
I
A
T
ISPASL
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
ILNK
P
E
V
N
Q
K
L
T
K
K
A
L
I
K
E
Y
T
E
E
I
E
R
L
K
R
D
L
A
A
AREKN
G
V
Y
ISEE
N
F
R
V
MS
G
K
L
T
V
Q
E
E
Q
I
V
E
L
I
E
K
I
G
A
V
E
E
E
L
N
R
V
T
E
L
F
MDNK
N
E
L
D
Q
C
K
S
D
L
Q
N
K
T
Q
E
L
E
T
T
Q
K
H
L
Q
E
T
K
L
Q
L
V
K
E
E
Y
I
T
S
A
L
E
S
T
E
E
K
L
H
D
A
A
S
K
L
L
N
T
V
E
E
T
T
K
D
V
S
G
L
H
S
K
L
D
R
K
K
AVDQHN
A
E
A
Q
D
I
F
G
K
N
L
N
S
L
F
N
N
M
E
E
L
I
KDGS
S
K
Q
K
A
M
L
E
V
H
K
T
L
F
G
N
L
L
S
S
S
V
S
A
L
D
T
I
T
T
V
A
L
G
S
L
TSIP
E
N
V
S
T
H
V
S
Q
I
F
N
M
I
L
K
E
Q
SLA
A
E
S
K
T
V
L
Q
E
L
I
N
V
L
K
T
D
L
L
S
S
L
E
M
I
L
S
P
T
V
V
S
I
L
K
I
N
S
Q
L
K
H
I
F
K
T
SL
T
V
A
D
K
I
E
D
Q
K
K
E
L
D
G
F
L
S
I
L
C
N
N
L
H
E
L
Q
E
N
T
I
C
S
L
V
E
S
Q
K
Q
CG
N
L
T
E
D
L
K
T
I
K
Q
T
H
S
Q
E
L
C
K
L
M
N
L
W
T
E
R
F
C
A
L
E
E
K
C
E
N
I
Q
K
P
L
S
S
V
Q
E
N
I
Q
Q
K
S
K
D
I
V
N
K
M
T
FHSQKFCADSD
G
F
S
Q
E
L
R
N
FNQ
E
G
T
K
L
V
E
E
S
VKHSDKLNG
N
L
E
K
I
S
Q
E
T
E
Q
R
C
E
SLNT
R
T
V
Y
F
S
E
Q
W
V
S
S
L
N
E
R
E
Q
E
L
H
N
L
L
E
V
V
S
Q
C
C
EASSSDITEKSDGR
K
A
A
H
E
KQH
N
I
F
L
D
QMTI
D
E
D
K
L
I
A
QNLELN
E
T
I
K
I
G
L
T
K
L
N
C
F
L
EQD
L
K
L
DIPTGTTPQRKSYLYP
S
T
LVRTE
P
R
E
H
L
L
D
Q
L
K
RKQP
E
L
L
M
M
LNCSEN
60
PsiBlast_CBE
85.10
100%
-82
- C1 -
2IEH
2
KIF11_HUMAN
B:
[15-365]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
84.79
100%
-82
- C1 -
2X7D
2
KIF11_HUMAN
B:
[17-366]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.73
100%
-80
- C1 -
3KEN
3
KIF11_HUMAN
A:
[18-366]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
80.56
100%
-81
- C1 -
2WOG
2
KIF11_HUMAN
B:
[18-364]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
----
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
77.99
100%
-85
- C1 -
2X7E
1
KIF11_HUMAN
B:
[17-366]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
77.18
100%
-78
- C1 -
3K3B
3
KIF11_HUMAN
B:
[16-364]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
----
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
--------------
G
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
76.05
100%
-82
- C1 -
2XAE
2
KIF11_HUMAN
C:
[18-363]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
-----------------
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.38
100%
-78
- C1 -
4BBG
2
KIF11_HUMAN
A:
[17-366]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
I
--------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
75.29
100%
-81
- C1 -
2IEH
3
KIF11_HUMAN
A:
[14-363]
--------------
K
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
74.43
100%
-85
- C1 -
2UYI
2
KIF11_HUMAN
B:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
74.41
100%
-84
- C1 -
2UYM
2
KIF11_HUMAN
B:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.25
100%
-80
- C1 -
2WOG
2
KIF11_HUMAN
C:
[17-363]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
-----------------
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.18
100%
-82
- C1 -
2X7D
2
KIF11_HUMAN
A:
[17-366]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
74.04
100%
-82
- C1 -
2X2R
2
KIF11_HUMAN
B:
[17-363]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
-----
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
------------------
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
73.24
100%
-77
- C1 -
1II6
1
KIF11_HUMAN
B:
[16-365]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
I
G
---------------
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
73.15
100%
-86
- C1 -
2PG2
2
KIF11_HUMAN
B:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.73
100%
-77
- C1 -
2WOG
2
KIF11_HUMAN
A:
[17-364]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.42
100%
-84
- C1 -
2X7C
2
KIF11_HUMAN
A:
[18-364]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
71.90
100%
-84
- C1 -
3L9H
3
KIF11_HUMAN
B:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.69
100%
-82
- C1 -
2UYI
2
KIF11_HUMAN
A:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.09
100%
-83
- C1 -
2PG2
2
KIF11_HUMAN
A:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.87
100%
-85
- C1 -
2X2R
2
KIF11_HUMAN
C:
[18-363]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
-----------------
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.66
100%
-80
- C1 -
2X2R
2
KIF11_HUMAN
A:
[17-365]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
------------------
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.63
100%
-82
- C1 -
4A50
2
KIF11_HUMAN
A:
[17-366]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
I
--------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.27
100%
-82
- C1 -
3L9H
3
KIF11_HUMAN
A:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
68.02
100%
-84
- C1 -
4AP0
3
KIF11_HUMAN
D:
[19-366]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
------
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
-----
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
---------
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
---
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
67.45
100%
-70
- C1 -
4BXN
4
KIF11_HUMAN
B:
[16-364]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
----
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
I
G
R
S
G
A
V
D
K
R
A
R
E
A
G
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
66.60
100%
-85
- C1 -
2Q2Y
2
KIF11_HUMAN
A:
[17-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
65.87
100%
-66
- C1 -
4BXN
2
KIF11_HUMAN
A:
[16-364]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
--
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
I
G
R
S
G
A
V
D
K
R
A
R
E
A
G
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.55
100%
-80
- C1 -
2UYM
2
KIF11_HUMAN
A:
[16-362]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.27
100%
-85
- C1 -
2G1Q
2
KIF11_HUMAN
B:
[18-362]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.74
100%
-82
- C1 -
2XAE
2
KIF11_HUMAN
A:
[17-364]
----------------
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
-----
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.35
100%
-82
- C1 -
3K5E
1
KIF11_HUMAN
B:
[18-362]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
-
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
--
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
---
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.35
100%
-76
- C1 -
3K3B
4
KIF11_HUMAN
A:
[16-364]
---------------
G
K
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
--------------
E
A
G
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.20
100%
-83
- C1 -
1YRS
2
KIF11_HUMAN
A:
[18-362]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
64.01
100%
-83
* C1 *
2FL6
2
KIF11_HUMAN
B:
[17-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
63.93
100%
-83
- C1 -
1YRS
2
KIF11_HUMAN
B:
[18-362]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
62.69
100%
-85
- C1 -
3CJO
2
KIF11_HUMAN
B:
[17-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.66
100%
-84
- C1 -
2G1Q
2
KIF11_HUMAN
A:
[18-362]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.63
100%
-82
- C1 -
2Q2Z
2
KIF11_HUMAN
B:
[17-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
58.77
100%
-82
- C1 -
3CJO
2
KIF11_HUMAN
A:
[17-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
55.69
100%
-81
- C1 -
2Q2Z
2
KIF11_HUMAN
A:
[17-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
53.63
100%
-80
- C1 -
2Q2Y
2
KIF11_HUMAN
B:
[17-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
N
K
R
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
E
T
T
I
D
G
E
E
L
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
N
---------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
P
H
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
L
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
37.51
100%
-88
- C1 -
4AP0
2
KIF11_HUMAN
B:
[20-361]
-----------------
N
I
Q
V
V
V
R
C
R
P
F
N
L
A
E
R
K
A
S
A
H
S
I
V
E
C
D
P
V
R
K
E
V
S
V
R
T
G
G
L
A
D
K
S
S
R
K
T
Y
T
F
D
M
V
F
G
A
S
T
K
Q
I
D
V
Y
R
S
V
V
C
P
I
L
D
E
V
I
M
G
Y
N
C
T
I
F
A
Y
G
Q
T
G
T
G
K
T
F
T
M
E
G
E
R
S
P
N
E
E
Y
T
W
E
E
D
P
L
A
G
I
I
P
R
T
L
H
Q
I
F
E
K
L
T
D
N
G
T
E
F
S
V
K
V
S
L
L
E
I
Y
N
E
E
L
F
D
L
L
N
P
S
S
D
V
S
E
R
L
Q
M
F
D
D
P
R
---
G
V
I
I
K
G
L
E
E
I
T
V
H
N
K
D
E
V
Y
Q
I
L
E
K
G
A
A
K
R
T
T
A
A
T
L
M
N
A
Y
S
S
R
S
H
S
V
F
S
V
T
I
H
M
K
---------
V
K
I
G
K
L
N
L
V
D
L
A
G
S
E
----------------
N
I
N
Q
S
L
L
T
L
G
R
V
I
T
A
L
V
E
R
T
--
V
P
Y
R
E
S
K
L
T
R
I
L
Q
D
S
L
G
G
R
T
R
T
S
I
I
A
T
I
S
P
A
S
L
N
L
E
E
T
L
S
T
L
E
Y
A
H
R
A
K
N
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------