@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_COT1_HUMAN: (2016-03-18 )
MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.........90........100.......110.......--120.......130.......140.......150....------...160.......170--------------------------------------...--....180.......190.....-----..200.......210.......220.......230.......240.......250.......260.......270.......280.......290-.....-.-..300.......310.......320.......---330.......340.......350.......360.......370.......380.......390.......400.......410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
M
V
VSSWRDPQDDVAGGNPGGP
N
P
A
A
Q
AARGGGGGA
G
E
Q
Q
Q
QAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQS-
Q
Q
H
I
E
C
V
V
CGDKSSGKHY
G
Q
F
T
C
E
G
C
K
S
F
F
K
R
S
V
RRN
L
T
--
Y
T
C
RANRNCPI
D
Q
H
H
R
N
Q
C
Q
Y
C
R
L
K
K
C
L
K
V
G
M
R
R
E
A
V
------QRGRMPPTQPNPG
Q
Y
A--------------------------------------LTN--GDPLN
G
H
C
Y
L
S
G
Y
I
S
L
L
LRAEP-----YPTSRYGSQCMQPNNIM
G
I
E
N
I
C
E
L
A
A
R
L
L
F
S
A
V
E
W
ARNIPFFPDLQITD
Q
V
S
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
QCSMP
L
H
V
A
P
L
L
A
A
AGLHASPMS
A
D
R
--
V
V
A
F
M
-
D
-
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
LHVDS
A
E
Y
S
C
L
K
A
I
V
L
F
T---SDACGLS
D
A
A
H
I
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
QYPN
Q
P
S
R
F
G
K
L
L
L
RLPS
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
LVGKT
P
I
E
T
L
I
R
D
M
LLSGSSFNW
P
Y
M
S
I
QCS
4
PsiBlast_PDB
83.54
44%
-107
- C2 -
4NQA
1
RXRA_HUMAN
A:
[31-358]
------------------------------------------------------------------------------
A
S
F
T
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
--
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
------
Q
E
E
R
Q
R
G
-------------------------------------------------
S
SA
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
-----
Y
-
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
1
PsiBlast_PDB
82.31
96%
-145
- C2 -
3CJW
-
COT2_HUMAN
A:
[173-407]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
H
S
Y
L
S
G
Y
I
S
L
L
L
R
A
E
P
-----
Y
P
T
-------------
M
G
I
E
N
I
C
E
L
A
A
R
M
L
F
S
A
V
E
W
A
R
N
I
P
F
F
P
D
L
Q
I
T
D
Q
V
A
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
Q
C
S
M
P
L
H
V
A
P
-------------------
V
A
F
M
-
D
-
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
L
H
V
D
S
A
E
Y
S
C
L
K
A
I
V
L
F
T
---
S
D
A
C
G
L
S
D
V
A
H
V
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
Q
Y
P
N
Q
P
T
R
F
G
K
L
L
L
R
L
P
S
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
L
V
G
K
T
P
I
E
T
L
I
R
D
M
L
L
S
G
S
S
F
N
---------
2
PsiBlast_PDB
80.87
44%
-116
- C2 -
3DZU
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
--
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
------
Q
E
E
R
Q
R
---------------------------------------------------A-
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
--------------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
3
PsiBlast_PDB
80.60
44%
-119
- C2 -
3E00
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
--
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
------
Q
E
E
R
Q
R
---------------------------------------------------A-
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
----------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
50
Fugue
78.70
30%
-94
- C2 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
---------------------------------------------------------------------
K
G
P
A
P
K
M
L
G
H
E
-
L
----
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
RR
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
LSEEQI
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQ
L
T
A
--
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
DQPKV
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
-
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
--
A
G
L
Q
V
-
E
-
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
---
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
-
K
L
P
P
L
L
S
E
I
W
D
V
--------------
19
PsiBlast_PDB
71.85
42%
-112
- C2 -
1XLS
1
RXRA_HUMAN
A:
[19-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
11
PsiBlast_PDB
70.80
42%
-115
- C2 -
1FM9
1
RXRA_HUMAN
A:
[21-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
14
PsiBlast_PDB
70.64
42%
-109
- C2 -
1K74
1
RXRA_HUMAN
A:
[21-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
10
PsiBlast_PDB
70.17
42%
-112
- C2 -
1FM6
1
RXRA_HUMAN
A:
[21-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
18
PsiBlast_PDB
68.97
42%
-105
- C2 -
1XVP
1
RXRA_HUMAN
A:
[19-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
6
PsiBlast_PDB
68.96
45%
-134
- C2 -
4LOG
-
NR2E3_HUMAN
A:
[375-566]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
I
H
E
T
S
A
R
L
L
F
M
A
V
K
W
A
K
N
L
P
V
F
S
S
L
P
F
R
D
Q
V
I
L
L
E
E
A
W
S
E
L
F
L
L
G
A
I
Q
W
S
L
P
L
D
S
C
P
L
L
A
P
P
-------------
L
T
L
A
S
-
M
-
E
T
R
V
L
Q
E
T
I
S
R
F
R
A
L
A
V
D
P
T
E
F
A
C
M
K
A
L
V
L
F
K
---
P
E
T
R
G
L
K
D
P
E
H
V
E
A
L
Q
D
Q
S
Q
V
M
L
S
Q
H
S
K
A
H
H
P
S
Q
P
V
R
F
G
K
L
L
L
L
L
P
S
L
R
F
I
T
A
E
R
I
E
L
L
F
F
R
K
T
I
G
N
T
P
M
E
K
L
L
S
D
M
F
----------------
17
PsiBlast_PDB
68.82
42%
-101
- C2 -
1XV9
1
RXRA_HUMAN
A:
[19-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
36
HHSearch
68.66
39%
-125
- C2 -
2NXX
-
?
A:
[35-231]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
T
V
N
N
I
C
Q
A
T
H
K
Q
L
F
Q
L
V
Q
W
A
K
L
V
P
H
F
T
S
L
P
L
T
D
Q
V
Q
L
L
R
A
G
W
N
E
L
L
I
A
A
F
S
H
R
S
M
Q
A
Q
-
D
A
I
V
L
A
T
G
L
T
V
N
K
S
T
A
H
---
A
V
G
V
G
-
N
I
Y
D
R
V
L
S
E
L
V
N
K
M
K
E
M
K
M
D
K
T
E
L
G
C
L
R
A
I
I
L
Y
N
---
P
D
V
R
G
I
K
S
V
Q
E
V
E
M
L
R
E
K
I
Y
G
V
L
E
E
Y
T
R
T
T
H
P
N
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
V
P
I
D
T
F
L
M
E
M
L
E
G
--------------
9
PsiBlast_PDB
68.19
42%
-114
- C2 -
4J5X
-
D:
[19-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
---
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
38
HHSearch
67.21
37%
-128
* C2 *
1PZL
1
HNF4A_HUMAN
A:
[39-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
A
S
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
-
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
---
L
A
E
M
S
R
V
-
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
---
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
-------------
20
PsiBlast_PDB
67.08
41%
-131
- C2 -
4XAJ
-
MALE_ECO57 (first)
A:
[376-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
C
E
S
A
A
R
L
L
F
M
S
I
K
W
A
K
S
V
P
A
F
S
T
L
S
L
Q
D
Q
L
M
L
L
E
D
A
W
R
E
L
F
V
L
G
I
A
Q
W
A
I
P
V
D
A
N
T
L
L
A
V
S
G
M
N
G
D
N
T
D
S
Q
R
--
L
T
L
I
I
-
S
-
E
I
Q
A
L
Q
E
V
V
A
R
F
R
Q
L
R
L
D
A
T
E
F
A
C
L
K
C
I
V
T
F
K
AVP--
L
R
S
F
R
N
A
A
A
I
A
A
L
Q
D
E
A
Q
L
T
L
N
S
Y
I
H
T
R
Y
P
T
Q
P
V
R
F
G
K
L
L
L
L
L
P
A
L
R
S
I
S
P
S
T
I
E
E
V
F
F
K
K
T
I
G
N
V
P
I
T
R
L
L
S
D
M
Y
K
S
--------------
12
PsiBlast_PDB
66.47
42%
-105
- C2 -
1G5Y
-
RXRA_HUMAN
A:
[21-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
13
PsiBlast_PDB
65.38
42%
-104
- C2 -
1G1U
-
RXRA_HUMAN
A:
[245-455]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
-----
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
25
HHSearch
64.33
25%
-121
- C2 -
1XDK
1
RARB_MOUSE
B:
[71-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
-
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
---
N
A
G
F
G
-
P
-
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
---
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
---------
8
PsiBlast_PDB
64.09
42%
-113
- C2 -
4N8R
1
RXRA_HUMAN
A:
[45-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
---
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------