@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_COT2_HUMAN: (2016-03-18 )
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110--.......120.......130.......140.......--------150.......160.------------------------------------.....--.170.......180......-------.190.......200.......210.......220.......230.......240.......250.......260.......270.......280..--.....-290........300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
M
V
VSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGS
D
K
Q
Q
Q
Q
QH
I
E
C
V
V
CGDKSSGKHY
G
Q
F
T
C
E
G
C
K
S
F
F
K
R
S
V
R
RNL
S
--
Y
T
CRANRNCPI
D
Q
H
H
R
N
Q
C
Q
Y
C
R
L
K
K
C
L
K
V
G
M
R
R
E
A
V
--------QRGRMPPTQPTHG
Q
------------------------------------
F
ALTN--GDPL
N
C
H
S
Y
L
S
G
Y
I
S
L
L
LRA-------EPYPTSRF
G
S
QCMQPNNIM
G
I
E
N
I
C
E
L
A
A
R
M
L
F
S
A
V
E
W
A
RNIPFFPDLQI
T
D
Q
V
A
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
QCSMP
L
H
V
A
P
L
L
A
A
AGLHASPMS
A
D
R
--
V
V
A
F
M
-
D
-
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
LHVDS
A
E
Y
S
C
L
K
A
I
V
L
FTSDACGL
S
D
V
A
H
V
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
QYPNQ
P
T
R
F
G
K
L
L
L
RLPS
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
LVGKT
P
I
E
T
L
I
R
D
M
LLSGSSFNW
P
Y
M
A
IQ
4
PsiBlast_PDB
84.95
43%
-109
- C1 -
4NQA
1
RXRA_HUMAN
A:
[31-358]
----------------------------------------------------------------------
A
S
F
T
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
--
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
--------
Q
E
E
R
Q
R
G
-----------------------------------------------
S
SA
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
-------
E
T
Y
-
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
1
PsiBlast_PDB
82.48
99%
-146
- C1 -
3CJW
-
COT2_HUMAN
A:
[173-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
H
S
Y
L
S
G
Y
I
S
L
L
L
R
A
-------
E
P
Y
P
T
-------------
M
G
I
E
N
I
C
E
L
A
A
R
M
L
F
S
A
V
E
W
A
R
N
I
P
F
F
P
D
L
Q
I
T
D
Q
V
A
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
Q
C
S
M
P
L
H
V
A
P
-------------------
V
A
F
M
-
D
-
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
L
H
V
D
S
A
E
Y
S
C
L
K
A
I
V
L
F
T
S
D
A
C
G
L
S
D
V
A
H
V
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
Q
Y
P
N
Q
P
T
R
F
G
K
L
L
L
R
L
P
S
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
L
V
G
K
T
P
I
E
T
L
I
R
D
M
L
L
S
G
S
S
F
N
-------
24
HHSearch
82.32
100%
-148
- C1 -
3CJW
-
COT2_HUMAN
A:
[178-407]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
Y
I
S
L
L
L
R
A
-------
E
P
Y
P
T
-------------
M
G
I
E
N
I
C
E
L
A
A
R
M
L
F
S
A
V
E
W
A
R
N
I
P
F
F
P
D
L
Q
I
T
D
Q
V
A
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
Q
C
S
M
P
L
H
V
A
P
-------------------
V
A
F
M
-
D
-
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
L
H
V
D
S
A
E
Y
S
C
L
K
A
I
V
L
F
T
S
D
A
C
G
L
S
D
V
A
H
V
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
Q
Y
P
N
Q
P
T
R
F
G
K
L
L
L
R
L
P
S
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
L
V
G
K
T
P
I
E
T
L
I
R
D
M
L
L
S
G
S
S
F
N
-------
2
PsiBlast_PDB
80.50
41%
-117
- C1 -
3DZU
1
RXRA_HUMAN
A:
[137-460]
--------------------------------------------------------------------------
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
--
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
--------
Q
E
E
R
Q
R
-------------------------------------------------A-
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
----------------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
3
PsiBlast_PDB
80.47
41%
-120
- C1 -
3E00
1
RXRA_HUMAN
A:
[137-460]
--------------------------------------------------------------------------
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
--
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
--------
Q
E
E
R
Q
R
-------------------------------------------------A-
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
47
Fugue
79.01
32%
-95
- C1 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
-----------------------------
K
G
P
A
P
-------------------------------------
K
M
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
RR
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
LSEEQIRK
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEG
V
Q
L
T
A
--
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
FSDQPKV
T
P
W
P
L
G
A
--
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
-
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
--
A
G
L
Q
V
-
E
-
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
-
K
L
P
P
L
L
S
E
I
W
D
V
------------
19
PsiBlast_PDB
69.13
43%
-112
- C1 -
1XLS
1
RXRA_HUMAN
A:
[19-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
15
PsiBlast_PDB
68.82
43%
-116
- C1 -
1FM9
1
RXRA_HUMAN
A:
[21-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
6
PsiBlast_PDB
68.29
45%
-135
- C1 -
4LOG
-
NR2E3_HUMAN
A:
[375-566]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
I
H
E
T
S
A
R
L
L
F
M
A
V
K
W
A
K
N
L
P
V
F
S
S
L
P
F
R
D
Q
V
I
L
L
E
E
A
W
S
E
L
F
L
L
G
A
I
Q
W
S
L
P
L
D
S
C
P
L
L
A
P
P
-------------
L
T
L
A
S
-
M
-
E
T
R
V
L
Q
E
T
I
S
R
F
R
A
L
A
V
D
P
T
E
F
A
C
M
K
A
L
V
L
F
K
P
E
T
R
G
L
K
D
P
E
H
V
E
A
L
Q
D
Q
S
Q
V
M
L
S
Q
H
S
K
A
H
H
P
S
Q
P
V
R
F
G
K
L
L
L
L
L
P
S
L
R
F
I
T
A
E
R
I
E
L
L
F
F
R
K
T
I
G
N
T
P
M
E
K
L
L
S
D
M
F
--------------
38
HHSearch
68.06
40%
-125
- C1 -
2NXX
-
?
A:
[35-231]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
T
V
N
N
I
C
Q
A
T
H
K
Q
L
F
Q
L
V
Q
W
A
K
L
V
P
H
F
T
S
L
P
L
T
D
Q
V
Q
L
L
R
A
G
W
N
E
L
L
I
A
A
F
S
H
R
S
M
Q
A
Q
-
D
A
I
V
L
A
T
G
L
T
V
N
K
S
T
A
H
---
A
V
G
V
G
-
N
I
Y
D
R
V
L
S
E
L
V
N
K
M
K
E
M
K
M
D
K
T
E
L
G
C
L
R
A
I
I
L
Y
N
P
D
V
R
G
I
K
S
V
Q
E
V
E
M
L
R
E
K
I
Y
G
V
L
E
E
Y
T
R
T
T
H
P
N
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
V
P
I
D
T
F
L
M
E
M
L
E
G
------------
18
PsiBlast_PDB
67.96
43%
-110
- C1 -
1K74
1
RXRA_HUMAN
A:
[21-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
14
PsiBlast_PDB
67.95
43%
-113
- C1 -
1FM6
1
RXRA_HUMAN
A:
[21-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
11
PsiBlast_PDB
67.88
43%
-114
- C1 -
4J5X
-
D:
[19-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
---
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
37
HHSearch
66.56
37%
-130
- C1 -
1PZL
1
HNF4A_HUMAN
A:
[39-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
A
S
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
-
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
---
L
A
E
M
S
R
V
-
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
-----------
9
PsiBlast_PDB
66.52
43%
-102
- C1 -
1XV9
1
RXRA_HUMAN
A:
[19-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
10
PsiBlast_PDB
66.47
43%
-105
- C1 -
1XVP
1
RXRA_HUMAN
A:
[19-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
26
HHSearch
65.03
25%
-121
- C1 -
1XDK
1
RARB_MOUSE
B:
[71-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
-
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
---
N
A
G
F
G
-
P
-
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
--------
31
HHSearch
64.63
30%
-123
* C1 *
2E2R
4
ERR3_HUMAN
A:
[46-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
-
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
-
S
K
--
L
A
G
L
L
-
D
-
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
A
G
Q
H
M
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
-----------
16
PsiBlast_PDB
63.85
43%
-105
- C1 -
1G5Y
-
RXRA_HUMAN
A:
[21-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
-------
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
-
D
---
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------
41
HHSearch
63.07
27%
-125
- C1 -
1FCY
2
RARG_HUMAN
A:
[43-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
-
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
---
N
A
G
F
G
-
P
-
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------