@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_ECR_AEDAE: (2016-03-18 )
MYRLNIVSTNPSGSVQQQQQAQGQQVISSVVRPQQQQPPPQLALVQTGGSGGTTTTIIGLTSLNALNATTITGLVAGAAGSSTSAIAAAGASNSGSGPSTATTKHILKAATTNNNISIVKIVDDIMLKAVKVEPLPMDTGGGGGGVSMIPSSATTSGGVTVTAIPASVAPMPPVAAGTNVSSNGSVTVYASGKRRLESNEEWISSPSPGSVPGSAPPLSPSPGSQSTTYTTTMSNGYSSPMSTGSYDPYSPNGKMGREDLSPSSSLNGYTDGSDAKKQKKGPTPRQQEELCLVCGDRESGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAIKRKEKKAQKEKDKVQTNATVSTTNSTYRSEILPILMKCDPPPHQAIPLLPEKLLQENRLRNIPLLTANQMAVIYKLIWYQDGYEQPSEEDLKRIMIGSPNEEEDQHDVHFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDAATDSILFANNRSYTRDSYRMAGMADTIEDLLHFCRQMFSLTVDNVEYALLTAIVIFSDRPGLEQAELVEHIQSYYIDTLRIYILNRHAGDPKCSVIFAKLLSILTELRTLGNQNSEMCFSLKLKNRKLPRFLEEIWDVQDIPPSMQAQMHSHGTQSSSSSSSSSSSSSNGSSNGNSSSNSNSSQHGPHPHPHGQQLTPNQQQHQQQHSQLQQVHANGSGSGGGSNNNSSSGGVVPGLGMLDQV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.....-..290.......300.......310.......320..--.....330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.----.---.....470.......480.......490.......500.......510.......520.......530.......540.......550....-...560.......570.......580.......590........600.......610.......620.......630.......640.......650......-.660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
R
L
N
I
V
STNPSG
S
V
Q
Q
Q
Q
Q
A
Q
G
Q
Q
V
I
S
S
V
VRPQQQQPPP
Q
L
A
L
V
Q
TGGSGG
T
T
T
T
I
I
G
L
T
SLNALN
A
T
T
I
T
G
L
VAGAAGSST
S
A
I
A
AAGASNSGSGPS
T
A
T
T
K
H
I
L
K
AATTNN
N
I
S
I
V
K
I
V
D
D
I
M
L
K
A
V
K
VEPLPMDTGGGGGG
V
S
MIPSSATTSG
G
V
T
V
T
AIPASVAPMPPVAAGTNVSSNG
S
V
T
V
YASGKRRLESNEEWISSPSPGSVPGSAPPLSPSPGSQS
T
T
Y
T
T
T
MSNGYSSPMSTGSYDPYSPNGKMGREDLSPSSSLNGYTDGSDAKKQKKGPT
P
R
Q
Q-E
E
L
C
L
V
CGDRESG
Y
H
YN
A
L
T
C
E
G
C
K
G
F
F
R
RSVTKN
A
V
--
Y
C
CKFGHAC
E
M
D
M
Y
M
R
R
K
C
Q
E
C
R
L
K
K
C
L
AVGMRPECVVPE
N
Q
C
A
I
K
R
K
E
K
K
A
Q
K
E
K
D
KVQTN
A
T
V
STTNS
T
Y
R
S
E
I
L
P
I
L
M
KCDPPPHQAIPL
L
P
E
K
L
L
Q
ENRLRNI
P
L
LTA
N
Q
M
A
V
I
Y
K
L
I
WYQDGYEQP
S
E
E
D
L
K
R
I----M---IGSPNEEEDQH
D
V
H
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
KGL
P
A
F
TKIPQED
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
M
A
R
R
YDAAT
D
S
I
L
FANNRSYTR
D
S
Y
RMAG
M
-
A
D
T
I
E
D
L
L
H
F
C
R
Q
M
F
S
L
T
VD
N
V
E
Y
A
L
L
T
A
I
V
I
FS-DRPGL
E
Q
A
E
L
V
E
H
I
Q
S
Y
Y
I
D
T
L
R
I
Y
I
L
NRHAGD
P
K
C
S
V
I
F
A
K
L
L
S
I
L
T
E
L
R
T
LGNQNS
E
M
C
F
S
L
K
LKN-R
K
L
P
R
F
L
E
E
IWDVQDIP
P
S
M
Q
A
Q
M
H
SHGTQSSSSSSSSSSSSSNGSSNGNSSSNSNSSQHGPHPHPHGQQLTP
N
Q
Q
Q
H
Q
Q
Q
H
S
Q
L
Q
Q
V
HANGSGSGGGSNNNSSSGGVVPGLGMLDQV
45
Fugue
90.54
41%
-106
- C3 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
A
P
K
M
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
RR
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
-
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
S
S
A
-----------
S
G
P
G
A
S
P
G
G
S
E
A
G
S
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
----
T
PWP
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
---
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.63
72%
-141
- C3 -
1R1K
1
D:
[21-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T---
Q
---
T
W
-------
D
S
D
M
P
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
N
-
R
K
L
P
P
F
L
E
E
I
W
D
V
A
--------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.15
72%
-141
- C3 -
4UMM
1
?
G:
[21-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T---
Q
---
T
W
-------
D
S
D
M
P
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
N
-
R
K
L
P
P
F
L
E
E
I
W
D
V
A
--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.12
72%
-145
- C3 -
2R40
1
D:
[21-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T---
Q
---
T
----------
D
M
P
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
N
-
R
K
L
P
P
F
L
E
E
I
W
D
V
A
--------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.24
71%
-140
- C3 -
3IXP
1
?
D:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
Y
Y
Q
E
G
Y
E
Q
-----------------------------
M
P
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
S
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
S
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
S
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
N
-
R
K
L
P
P
F
L
E
E
I
W
D
V
A
--------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.79
68%
-131
- C3 -
2NXX
1
?
E:
[10-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
H
P
S
E
E
D
V
K
R
I
--------
I
N
---
D
G
E
D
Q
C
D
V
R
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
K
R
L
P
G
F
D
K
L
L
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
V
Q
T
D
S
I
L
F
V
N
N
Q
P
Y
S
R
D
S
Y
N
L
A
G
M
-
G
E
T
I
E
D
L
L
H
F
C
R
T
M
Y
S
M
R
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
A
L
I
E
G
W
K
V
E
K
I
Q
E
I
Y
L
E
A
L
R
A
Y
V
D
N
R
R
--
K
P
K
P
G
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
Q
N
S
E
M
C
F
S
L
K
L
K
N
-
K
K
L
P
P
F
L
A
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.62
67%
-136
- C3 -
4OZT
1
?
E:
[4-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
Q
P
S
D
E
D
L
K
R
I
----
S
----
N
T
P
S
E
G
E
D
Q
S
D
L
N
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
K
R
L
P
G
F
D
K
L
L
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
L
R
M
A
R
R
Y
D
V
G
S
D
S
I
L
F
A
N
N
Q
P
Y
T
R
D
S
Y
S
L
A
G
M
-
G
E
T
V
D
D
L
L
R
F
C
R
Q
M
Y
G
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
I
E
G
W
K
V
E
K
I
Q
E
I
Y
L
E
A
L
K
V
Y
V
D
N
R
R
--
K
P
A
S
G
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
L
N
S
E
M
C
F
S
L
K
L
K
N
-
K
K
L
P
P
F
L
A
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.15
71%
-136
- C3 -
1R20
1
D:
[20-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
Y
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
--------------------
D
M
P
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
S
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
S
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
S
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
N
-
R
K
L
P
P
F
L
E
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
23
HHSearch
82.80
65%
-126
- C3 -
1Z5X
1
?
E:
[73-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
T
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
H
P
S
P
E
D
I
K
R
I
----
V
---
N
A
A
P
E
-
E
E
N
V
A
E
E
R
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
S
K
R
L
P
G
F
D
K
L
I
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
A
E
T
D
S
I
L
F
A
T
N
Q
P
Y
T
R
E
S
Y
T
V
A
G
M
-
G
D
T
V
E
D
L
L
R
F
C
R
H
M
C
A
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
S
E
G
W
K
V
E
K
I
Q
E
I
Y
I
E
A
L
K
A
Y
V
E
N
R
R
K
P
--
Y
A
T
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
M
N
S
E
T
C
F
S
L
K
L
K
N
-
R
K
V
P
S
F
L
E
E
I
W
D
V
V
--------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.50
60%
-127
- C3 -
1Z5X
1
?
E:
[73-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
---
T
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
H
P
S
P
E
D
I
K
R
I
----
V
---
N
A
A
P
-
E
E
E
N
V
A
E
E
R
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
S
K
R
L
P
G
F
D
K
L
I
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
A
E
T
D
S
I
L
F
A
T
N
Q
P
Y
T
R
E
S
Y
T
V
A
G
M
-
G
D
T
V
E
D
L
L
R
F
C
R
H
M
C
A
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
S
E
G
W
K
V
E
K
I
Q
E
I
Y
I
E
A
L
K
A
Y
V
E
N
R
R
K
--
P
Y
A
T
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
M
N
S
E
T
C
F
S
L
K
L
K
N
-
R
K
V
P
S
F
L
E
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.67
38%
-131
- C3 -
3IPU
1
NR1H3_HUMAN
A:
[40-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
TPWP-------
P
H
S
R
E
A
R
Q
Q
-
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
---
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.23
38%
-127
- C3 -
3FAL
1
NR1H3_MOUSE
B:
[23-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
----
T
PWP----
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.88
38%
-136
- C3 -
5AVL
1
?
A:
[40-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
V
TPW-----------
R
E
A
R
Q
Q
-
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
---
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
-------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.84
38%
-139
- C3 -
3IPS
1
NR1H3_HUMAN
A:
[41-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
V
TPWP---------
S
R
E
A
R
Q
Q
-
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
---
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
H
--------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.39
38%
-127
- C3 -
3FC6
1
NR1H3_MOUSE
B:
[24-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
----
T
PWP
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.57
38%
-140
- C3 -
5AVI
1
?
A:
[40-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-----------
R
V
TPWP-------
P
H
S
R
E
A
R
Q
Q
-
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
---
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
H
--------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.06
38%
-139
- C3 -
3IPQ
1
NR1H3_HUMAN
A:
[41-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-------------TPWP-----------
E
A
R
Q
Q
-
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
---
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.90
38%
-126
- C3 -
2ACL
-
NR1H3_MOUSE
B:
[3-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
----
T
PWP
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
26
HHSearch
67.05
42%
-138
- C3 -
3IPQ
1
NR1H3_HUMAN
A:
[87-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
---
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
-
K
K
L
P
P
L
L
S
E
I
W
D
V
---------------------------------------------------------------------------------------------------------
44
HHSearch
66.44
31%
-137
* C3 *
1FCY
2
RARG_HUMAN
A:
[44-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
-
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
---
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
----------------------------------------------------------------------------------------------------------