@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_NR1D1_HUMAN: (2016-03-19 )
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.....-..170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430---------------.......440.......450.......460.......470.......480.......490.......500..-.....510...-......520.......530.......540.......550.......560.......570.......580.......590.---......600.......610..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTTLDSNNNT
G
G
V
I
T
Y
IGSSGSSPSRTS
P
E
S
LYSDNSNG
S
F
Q
S
L
TQGCPTYFPPSPTGSL
T
Q
D
P
A
R
S
FGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPG
S
L
Q
V
A
MEDSSRVSPSKSTSNITKLNG
M
V
L
L
C
K
V
C
G
D
V
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
S
I
Q
Q
N
I
Q
Y
K
-
R
CLKNEN
C
S
I
V
R
I
N
R
N
R
C
Q
Q
C
R
F
K
K
C
L
S
VGMSR
D
A
V
RFGRI
P
K
R
E
K
Q
R
M
L
A
E
M
Q
S
A
M
N
L
A
NNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPL
V
G
F
S
QF
P
Q
Q
LTPPRSPSPEP
T
V
E
D
V
I
S
Q
V
A
R
A
H
R
E
I
F
T
Y
A
H
D
KLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNN
T
L
A
A
Q
R
H
N
E
A
L
N
G
L
R
QAPSSYPPTWPPGPAHHSCHQSNSNG
H
R
LCPT
H
V
Y
AAPEGKAPANSPRQGNSK
N
V
L
L
ACPMNMYPHGRSGR
T
V
---------------
Q
E
I
W
E
DFSMSF
T
P
A
V
R
E
V
V
E
F
A
K
HIPG
F
R
DLSQHD
Q
V
T
L
L
KAG
T
F
E
V
L
M
V
R
F
A
S
L
FNVKD
Q
T
V
M
F
L
SRTT
Y
S
-
L
Q
E
L
GA--M
G
M
-
G
D
L
L
S
A
M
F
D
F
S
E
K
L
N
S
LAL
T
E
E
E
L
G
L
F
T
A
V
V
L
V
SADRSGMENSA
S
V
E
Q
L
Q
E
T
L
L
R
A
L
R
A
L
V
LKNRPL
E
T
S
R
F
T
K
L
L
L
KLP---D
L
R
T
L
N
N
M
H
S
E
K
L
L
S
F
RVDAQ
49
Fugue
88.89
33%
-85
- C2 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
----------------------------------------------------------------------------------------------------------------------
K
G
P
A
P
K
M
L
G
H
E
L
-
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
--------------------
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
S
S
A
S
G
P
---------------------------------------------
G
A
S
P
G
G
S
E
A
G
---------------
S
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
--------------------
K
V
T
P
W
P
L
G
A
D
P
------------------------
Q
S
R
D
A
R
---------------
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
-
K
D
D
F
H
R
--
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
---
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
2
PsiBlast_PDB
83.07
68%
-129
- C2 -
3CQV
1
A:
[2-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
C
P
M
S
K
S
P
Y
V
D
P
H
K
S
G
---------------
H
E
I
W
E
E
F
S
M
S
F
T
P
A
V
K
E
V
V
E
F
A
K
R
I
P
G
F
R
D
L
S
Q
H
D
Q
V
N
L
L
K
A
G
T
F
E
V
L
M
V
R
F
A
S
L
F
D
A
K
E
R
T
V
T
F
L
S
G
K
K
Y
S
-
V
D
D
L
H
S
--
M
G
A
-
G
D
L
L
N
S
M
F
E
F
S
E
K
L
N
A
L
Q
L
S
D
E
E
M
S
L
F
T
A
V
V
L
V
S
A
D
R
S
G
I
E
N
V
N
S
V
E
A
L
Q
E
T
L
I
R
A
L
R
T
L
I
M
K
N
H
P
N
E
A
S
I
F
T
K
L
L
L
K
L
P
---
D
L
R
S
L
N
N
M
H
S
E
E
L
L
A
F
K
----
1
PsiBlast_PDB
79.71
73%
-126
- C2 -
2V0V
-
NR1D2_HUMAN
A:
[396-576]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
G
------------------
H
E
I
W
E
E
F
S
M
S
F
T
P
A
V
K
E
V
V
E
F
A
K
R
I
P
G
F
R
D
L
S
Q
H
D
Q
V
N
L
L
K
A
G
T
F
E
V
L
M
V
R
F
A
S
L
F
D
A
K
E
R
T
V
T
F
L
G
S
K
K
Y
S
-
V
D
D
L
H
S
--
M
G
A
-
G
D
L
L
N
S
M
F
E
F
S
E
K
L
N
A
L
Q
L
S
D
E
E
M
S
L
F
T
A
V
V
L
V
S
A
D
R
S
G
I
E
N
V
N
S
V
E
A
L
Q
E
T
L
I
R
A
L
R
T
L
I
M
K
N
H
P
N
E
A
S
I
F
T
K
L
L
L
K
L
P
---
D
L
R
S
L
N
N
M
H
S
E
E
L
L
A
F
K
----
15
PsiBlast_PDB
71.62
39%
-122
- C2 -
1S0X
1
A:
[66-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
-
S
-
P
D
V
F
K
S
--
L
G
C
-
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
-
E
D
G
I
L
T
K
L
I
C
K
V
S
---
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
----
28
HHSearch
70.97
38%
-114
- C2 -
1N83
1
A:
[61-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
R
---------------
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
-
D
G
K
Y
A
S
-
P
D
V
F
K
S
--
L
G
C
-
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
-
D
G
I
L
T
K
L
I
C
K
V
S
---
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
-
40
HHSearch
70.64
33%
-116
- C2 -
1FCY
2
RARG_HUMAN
A:
[42-223]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
-
R
T
Q
M
H
N
--
A
G
F
-
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
---
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
-
14
PsiBlast_PDB
70.19
39%
-116
- C2 -
1N83
1
A:
[66-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
-
S
-
P
D
V
F
K
S
--
L
G
C
-
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
-
E
D
G
I
L
T
K
L
I
C
K
V
S
---
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
----
10
PsiBlast_PDB
69.50
40%
-123
- C2 -
1N4H
1
RORB_RAT
A:
[58-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
Q
Q
C
A
I
Q
I
T
H
A
I
Q
Y
V
V
E
F
A
K
R
I
T
G
F
M
E
L
C
Q
N
D
Q
I
L
L
L
K
S
G
C
L
E
V
V
L
V
R
M
C
R
A
F
N
P
L
N
N
T
V
L
F
E
G
K
Y
G
-
G
-
M
Q
M
F
K
A
--
L
G
S
-
D
D
L
V
N
E
A
F
D
F
A
K
N
L
C
S
L
Q
L
T
E
E
E
I
A
L
F
S
S
A
V
L
I
S
P
D
R
A
W
L
L
E
P
R
K
V
Q
K
L
Q
E
K
I
Y
F
A
L
Q
H
V
I
Q
K
N
H
-
L
D
D
E
T
L
A
K
L
I
A
K
I
P
---
T
I
T
A
V
C
N
L
H
G
E
K
L
Q
V
F
K
----
13
PsiBlast_PDB
69.15
39%
-116
- C2 -
4S15
2
RORA_HUMAN
A:
[52-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
-
S
-
P
D
V
F
K
S
--
L
G
C
-
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
-
E
D
G
I
L
T
K
L
I
C
K
V
S
---
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
----
11
PsiBlast_PDB
68.85
40%
-123
- C2 -
1K4W
1
RORB_RAT
A:
[58-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
Q
Q
C
A
I
Q
I
T
H
A
I
Q
Y
V
V
E
F
A
K
R
I
T
G
F
M
E
L
C
Q
N
D
Q
I
L
L
L
K
S
G
C
L
E
V
V
L
V
R
M
C
R
A
F
N
P
L
N
N
T
V
L
F
E
G
K
Y
G
-
G
-
M
Q
M
F
K
A
--
L
G
S
-
D
D
L
V
N
E
A
F
D
F
A
K
N
L
C
S
L
Q
L
T
E
E
E
I
A
L
F
S
S
A
V
L
I
S
P
D
R
A
W
L
L
E
P
R
K
V
Q
K
L
Q
E
K
I
Y
F
A
L
Q
H
V
I
Q
K
N
H
-
L
D
D
E
T
L
A
K
L
I
A
K
I
P
---
T
I
T
A
V
C
N
L
H
G
E
K
L
Q
V
F
K
----
12
PsiBlast_PDB
68.75
40%
-125
- C2 -
1NQ7
1
RORB_RAT
A:
[51-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
Q
Q
C
A
I
Q
I
T
H
A
I
Q
Y
V
V
E
F
A
K
R
I
T
G
F
M
E
L
C
Q
N
D
Q
I
L
L
L
K
S
G
C
L
E
V
V
L
V
R
M
C
R
A
F
N
P
L
N
N
T
V
L
F
E
G
K
Y
G
-
G
-
M
Q
M
F
K
A
--
L
G
S
-
D
D
L
V
N
E
A
F
D
F
A
K
N
L
C
S
L
Q
L
T
E
E
E
I
A
L
F
S
S
A
V
L
I
S
P
D
R
A
W
L
L
E
P
R
K
V
Q
K
L
Q
E
K
I
Y
F
A
L
Q
H
V
I
Q
K
N
H
-
L
D
D
E
T
L
A
K
L
I
A
K
I
P
---
T
I
T
A
V
C
N
L
H
G
E
K
L
Q
V
F
K
----
24
HHSearch
68.38
32%
-111
- C2 -
1XDK
1
RARB_MOUSE
B:
[69-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
-
R
T
Q
M
H
N
--
A
G
F
-
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
---
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
-
23
HHSearch
68.04
33%
-115
- C2 -
3KMR
1
RARA_HUMAN
A:
[65-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
---------------
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
-
R
T
Q
M
H
N
--
A
G
F
-
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
---
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
--
27
HHSearch
67.39
33%
-113
- C2 -
3IPQ
1
NR1H3_HUMAN
A:
[85-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
---------------
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
-
R
E
D
F
A
K
--
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
---
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
19
PsiBlast_PDB
67.37
37%
-108
- C2 -
4YMQ
1
?
A:
[64-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
Q
R
K
S
M
---------------
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
-
G
-
M
E
L
F
R
A
--
L
G
C
-
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
-----
E
L
A
F
H
H
H
L
C
K
T
H
R
-
Q
S
I
L
A
K
L
P
PKG
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
----
50
Fugue
67.26
26%
-92
- C2 -
1BSX
1
THB_HUMAN
A:
[10-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
RKFLPEDIGQAPKVD
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
-
R
G
Q
L
K
N
--
G
G
L
-
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
---
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
35
HHSearch
66.88
35%
-124
- C2 -
3U9Q
-
PPARG_HUMAN
A:
[277-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
---------------
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
--
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
LR
K
P
F
-
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
---
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
----
20
PsiBlast_PDB
66.41
37%
-105
- C2 -
3L0L
1
RORG_HUMAN
A:
[48-228]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
Q
R
K
S
M
---------------
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
-
G
-
M
E
L
F
R
A
--
L
G
C
-
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
-----
E
L
A
F
H
H
H
L
C
K
T
H
R
-
Q
S
I
L
A
K
L
P
PKG
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
----
18
PsiBlast_PDB
65.95
37%
-100
- C2 -
4S14
1
A:
[48-228]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
Q
R
K
S
M
---------------
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
-
G
-
M
E
L
F
R
A
--
L
G
C
-
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
-----
E
L
A
F
H
H
H
L
C
K
T
H
R
-
Q
S
I
L
A
K
L
P
PKG
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
----
16
PsiBlast_PDB
65.51
37%
-101
- C2 -
4NB6
1
RORG_HUMAN
A:
[48-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
Q
R
K
S
M
---------------
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
-
G
-
M
E
L
F
R
A
--
L
G
C
-
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
-----
E
L
A
F
H
H
H
L
C
K
T
H
R
-
Q
S
I
L
A
K
L
P
PKG
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
-----