@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_NR1I2_HUMAN: (2016-03-19 )
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80-........90........100.......110.......120.......-130.......140.......150.......160.......170...--....180.......190.......200.......210.......220--------.......230.......240.......250.......260.......270.......280.......290.......300.--.......310........320.......330.......340.......350.......360.......370.......380.......390.......400.......--410.......420........430..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEVRPKESWNHA
D
F
V
H
CEDTESVPGKPSVNADEEVG
G
P
Q
I
C
R
VCGDKAT
G
Y
H
F
N
V
M
T
C
E
G
C
K
G
F
F
R
R
A
M
KRNA
R
L
RCPFRK-
G
A
C
E
I
T
R
K
T
R
R
Q
C
Q
A
C
R
L
R
K
C
L
E
SGM
K
K
E
MIMS
D
E
A
V
E
E
R
R
A
L
I
K
R
K
K-SERTGTQPLGVQGL
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
KNFRLP--GVLSSGCEL
P
E
S
LQAP
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
RGEDGSV--------WNYKPPADS
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
RDLP
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
FNAETG
T
W
EC-G--R
L
S
Y
C
L
E
D-TA
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
QLH
E
E
E
Y
V
L
M
Q
A
I
S
LFSPDRP
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
ECNRP
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
SI
N
A
Q
H
T
Q
--
R
L
L
R
IQDIHP
F
A
-
T
P
L
M
Q
E
L
FGITGS
4
PsiBlast_PDB
97.79
100%
-136
- C2 -
4X1F
3
?
A:
[24-316]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
V
-----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
D
------
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
T
G
S
22
PsiBlast_CBE
96.01
99%
-131
- C2 -
2O9I
1
NR1I2_HUMAN
B:
[1-292]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
V
L
S
-------------
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
S
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
D
-
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
T
G
-
5
PsiBlast_PDB
95.98
99%
-133
- C2 -
2O9I
1
NR1I2_HUMAN
A:
[1-292]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
V
L
S
-------------
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
S
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
D
-
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
T
G
-
21
PsiBlast_CBE
95.92
100%
-138
- C2 -
4S0T
1
NR1I2_HUMAN
B:
[23-312]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
V
L
-------
E
S
L
Q
A
P
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
D
-
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
---
1
PsiBlast_PDB
95.06
100%
-139
- C2 -
4S0T
1
NR1I2_HUMAN
A:
[24-310]
------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
V
--------
E
S
L
Q
A
P
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
D
-
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
-----
6
PsiBlast_PDB
93.60
100%
-143
- C2 -
4NY9
2
NR1I2_HUMAN
A:
[1-290]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
------------------------
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
-------
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
---
3
PsiBlast_PDB
91.03
100%
-135
- C2 -
3R8D
1
NR1I2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
---------------------
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
------
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
---
48
Fugue
90.69
99%
-142
* C2 *
1SKX
1
NR1I2_HUMAN
A:
[25-313]
------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
V
--------------------------------
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
I
-------
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
L
---------
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
---
2
PsiBlast_PDB
90.56
100%
-145
- C2 -
2QNV
1
NR1I2_HUMAN
A:
[24-316]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
--
G
V
L
-------------------------------
K
V
S
L
Q
L
R
G
E
D
G
S
V
--------
W
N
Y
K
P
P
A
-------
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
-------
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
T
G
S
25
HHSearch
81.26
100%
-149
- C2 -
1NRL
1
NR1I2_HUMAN
A:
[116-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
--
R
L
S
Y
C
L
E
D
-
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
--
R
L
L
R
I
Q
D
I
H
P
F
A
-
T
P
L
M
Q
E
L
F
G
I
T
G
-
49
Fugue
74.49
30%
-100
- C2 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
----------------------------
K
G
P
A
P
K
M
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
S
S
A
S
G
-------------------------
P
--
G
A
S
P
G
G
S
E
A
G
S
--
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
SDQPKVTP
W
P
L
G
A
D
P
Q
S
-
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
--
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
--
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
--
Q
V
F
A
L
R
L
Q
D
K
K
L
-
P
P
L
L
S
E
I
W
D
V
---
10
PsiBlast_PDB
73.73
37%
-123
- C2 -
3DR1
1
VDRA_DANRE
A:
[2-298]
---------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
7
PsiBlast_PDB
73.11
37%
-122
- C2 -
2HBH
1
VDRA_DANRE
A:
[3-298]
----------------------------------------------------------------------------------------------------------------------------------------------
H
M
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
18
PsiBlast_PDB
72.57
37%
-124
- C2 -
4G1Z
1
VDRA_DANRE
A:
[3-296]
------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
13
PsiBlast_PDB
72.57
37%
-126
- C2 -
4Q0A
2
VDRA_DANRE
C:
[4-298]
-----------------------------------------------------------------------------------------------------------------------------------------------
M
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
14
PsiBlast_PDB
72.53
37%
-126
- C2 -
4FHH
1
VDRA_DANRE
A:
[3-296]
------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
8
PsiBlast_PDB
72.25
37%
-125
- C2 -
2HC4
1
VDRA_DANRE
A:
[3-298]
----------------------------------------------------------------------------------------------------------------------------------------------
H
M
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
17
PsiBlast_PDB
72.08
37%
-126
- C2 -
4G1Y
1
VDRA_DANRE
A:
[3-296]
------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
16
PsiBlast_PDB
71.92
37%
-125
- C2 -
4G1D
1
VDRA_DANRE
A:
[3-296]
------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----
11
PsiBlast_PDB
71.70
37%
-125
- C2 -
3O1D
1
VDRA_DANRE
A:
[3-298]
----------------------------------------------------------------------------------------------------------------------------------------------
H
M
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
VR--------------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
-
G
GP
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
--
H
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
QY
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
----